Clinical trials: Arthropathy of Knee
Osteoarthritis, Knee
VItamin D Effect on Osteoarthritis Study
Observational evidence suggests that vitamin D deficiency may have a role in the causes of osteoarthritis (OA) and there are biologically plausible mechanisms to explain this.
- Trial name
- VIDEO (NCT01176344)
- Testing
- Vitamin D
- Where
- 2 sites in Australia
- Volunteers
- 413 people
- Sponsor
- Menzies Institute for Medical Research
Bone Malalignment
CT Imaging Study for Knee Osteotomy (CISKO)
Malalignment of the knee joint causes arthritis in later life. Currently there are three surgical ways to treat knee arthritis: total knee replacement, partial knee replacement, and high tibial osteotomy (HTO).
- Trial name
- CISKO (NCT02717845)
- Testing
- Ellipse, Tomofix
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- North Cumbria University Hospitals NHS Trust
Osteoarthritis, Knee, Arthritis of Knee
Treatment of Knee Osteoarthritis With Allogenic Mesenchymal Stem Cells
In this study we want to evaluate the clinical use of allogenic mesenchymal stem cells (MSC), obtained from bone marrow of healthy donors, for treatment of knee osteoarthritis.
- Conditions
- Osteoarthritis, Knee, Arthritis of Knee, Knee Osteoarthritis
- Trial name
- MSV_allo (NCT01586312)
- Testing
- Allogenic mesenchymal stromal cells injection, Hyaluronic Acid
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Red de Terapia Celular
Pain, Acute, Knee Osteoarthritis
Comparison of the Analgesic Effect of Subsartorial Saphenous Block and Popliteal Sciatic vs Subsartorial Saphenous Block and IPACK in Total Knee Replacement Surgery.
Total knee replacement surgery is associated with significant pain in the immediate postoperative period, especially in movement. In turn, this is associated with more subsequent chronic pain.
- Conditions
- Pain, Acute, Knee Osteoarthritis, Anesthesia
- Trial name
- NCT06514365
- Testing
- IPACK block with Bupivacaine 0.25% with adrenaline
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Germans Trias i Pujol Hospital
Necrosis of Femoral Head, Knee Osteoarthritis
Ketamine Prevent POCD
Previous study demonstrated that neuroinflammation induced by surgery is the main cause of the postoperative cognitive dysfunction. As an agonist of NMDA receptor, ketamine is proved to be an anti-inflammation agent.
- Trial name
- KPPOCD (NCT02220400)
- Testing
- Ketamine
- Where
- 3 sites in China
- Volunteers
- 484 people
- Sponsor
- RenJi Hospital
Knee Osteoarthritis
Cemented vs Cementless TKA
The purpose of this study is to compare cemented and cementless versions of the Triathlon total knee arthroplasty/replacement (TKA) in terms of clinical outcomes, perioperative course, and outcome scores including function and…
- Trial name
- NCT03683992
- Testing
- Triathlon total knee system
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Osteoarthritis, Knee
APOS Therapy for Osteoarthritis of the Knee: a Randomized Controlled Trial BIOTOK
Painful knee osteoarthritis is common and treatments, short of knee replacement, are limited. The investigators plan to test the efficacy of a novel promising device for treatment of knee osteoarthritis affecting the inner part…
- Trial name
- BIOTOK (NCT02363712)
- Testing
- APOS shoe
- Where
- Switzerland
- Volunteers
- 220 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Knee Osteoarthritis
Comparison of Conventional and Cooled Radiofrequency Ablation in Knee Osteoarthritis
The aim of this study was to examine and compare the effects of conventional and cooled radiofrequency ablation on pain and disability levels in patients with knee pain resistant to other treatments due to knee osteoarthritis.
- Trial name
- NCT06863181
- Testing
- Radiofrequency ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Knee Osteoarthritis, Pain, Postoperative
Premedication with Intranasal Dexmedetomidine in Sedation of Patients Undergoing Total Knee Arthroplasty
This study aims to find out if preoperatively given dexmedetomidine is effective analgesic adjuvant for treating postoperative pain in patients undergoing elective total knee arthroplasty (TKA).
- Trial name
- TKADEX (NCT04859283)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Turku University Hospital
Knee Arthropathy, Hip Injuries
A Study to Evaluate Virtual Reality As Adjunct to Anesthesia During Orthopedic Surgery
The purpose of this study is to obtain feedback from patients and orthopedic surgeons who agree to use virtual reality (VR ) as an adjunct to standard of care in orthopedic cases under regional or central neuraxial nerve block.
- Trial name
- NCT05112302
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis
Comparison of Proprioception for HTO (High Tibial Osteotomy) and UKA (Unicompartmantal Knee Arthroplasty)
Osteoarthritis of the knee (KOA), a common degenerative joint disease, affects a significant part of the world's population. Although it can hold all the compartments in the knee joint, isolated medial compartment involvement has…
- Trial name
- NCT05993637
- Testing
- Examination of propriception
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Knee Osteoarthritis
The Effects of Ultrasound Guided Genicular Nerve Block for Knee Osteoarthritis
Goal: Comparison of the effects of genicular nerve block with usg and physical therapy on pain, physical function for patients with knee osteoarthritis.
- Trial name
- NCT04782401
- Testing
- Ultrasound guided genicular nerve block + exercise treatment, Physical therapy + exercise treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Turkish League Against Rheumatism
Knee Osteoarthritis, Arthropathy of Knee Joint
Outcome After Total Knee Arthroplasty Under General or Spinal Anesthesia
Previous retrospective database studies suggest that total knee arthroplasty (TKA) surgery under spinal anesthesia has less complications than when performed under general anesthesia.
- Conditions
- Knee Osteoarthritis, Arthropathy of Knee Joint, Knee Pain Chronic, Rheumatoid Arthritis
- Trial name
- NCT03364088
- Testing
- Spinal anesthesia with tourniquet, Spinal anesthesia without tourniquet, General anesthesia with tourniquet
- Where
- Finland
- Volunteers
- 402 people
- Sponsor
- Riku Antero Palanne
Osteoarthritis Knees
Adipose-tissue-derived Total-Stromal-cells (TOST) Therapy in Knee Osteoarthritis
In this phase II Randomized Clinical Trial (RCT), impacts of a single Intra-articular injection of autologous adipose tissue derive total-stromal-cells (TOST) on knee pain, physical function, stiffness, and cartilage thickness…
- Trial name
- NCT05280002
- Testing
- Adipose Tissue derived Total-Stromal-Cells (TOST)
- Where
- Bangladesh
- Volunteers
- 30 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Knee Osteoarthritis, Postoperative Rehabilitation
Paraspinal NMES and Spinopelvic Alignment After Knee Arthroplasty
Total knee arthroplasty (TKA) is a widely performed surgical procedure for patients with severe knee osteoarthritis. Following TKA, changes in lower extremity alignment and gait mechanics may influence the spinopelvic sagittal…
- Trial name
- NCT07741162
- Testing
- Standard Postoperative Rehabilitation Program, Quadriceps Neuromuscular Electrical Stimulation, Paraspinal Neuromuscular Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Osteoarthritis, Knee
The Blood Saving Effect of Tranexamic Acid in Total Knee Arthroplasty With Rivaroxaban as Thromboprophylaxis
The aim of this study was to conduct a prospective, randomized, double-blind study and assess the efficacy of and safety for thromboprophylaxis of rivaroxaban in total knee arthroplasty patients when tranexamic acid is used for…
- Trial name
- NCT02458729
- Testing
- Tranexamic Acid 5%,5ml/amp (intraoperative), Tranexamic Acid 5%,5ml/amp (3 hours after operation), 0.9% Normal Saline (intraoperative)
- Where
- Taiwan
- Volunteers
- 294 people
- Sponsor
- Chang Gung Memorial Hospital
Knee Osteoarthritis
Impact of Volunteerism in the Acute Setting
Rehabilitation, with a particular emphasis on physiotherapy and exercise, is widely promoted and strongly recommended after total knee replacement (TKR).
- Trial name
- NCT04063553
- Testing
- Volunteers Service, Exercise brochure
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- Tan Tock Seng Hospital
Knee Osteoarthritis, Osteoarthritis, Knee
Autologous Conditioned Serum: Functional and Clinical Results
The purpose of this study was to investigate the potential ability of autologous conditioned serum (ACS) to decrease the pain and improve the joint functionality in patients affected by knee osteoarthritis (OA).
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Cartilage Degeneration
- Trial name
- NCT03850080
- Testing
- Autologous Conditioned Serum
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Ospedale San Raffaele
Arthroplasty, Replacement
Walking Stick Exercise in Patients Underwent Total Knee Arthroplasty
The purpose of this study is to examine whether the effect of "hiking poles exercise" on lower extremity muscular strength, knee range of motion, and quality of life in elderly patients underwent total knee arthroplasty
- Conditions
- Arthroplasty, Replacement, Knee Osteoarthritis
- Trial name
- NCT05030662
- Testing
- Walking stick exercise
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Osteoarthritis
Effect of Kinesio Taping and Sham Taping in Knee Osteoarthritis
The prevalence of knee osteoarthritis has been increasing in recent decades as the number of obese people has increased. Various interventions are used to improve the functional condition of patients, but it is still not clear…
- Trial name
- OA (NCT05320562)
- Testing
- Kinesio taping
- Where
- Lithuania
- Volunteers
- 30 people
- Sponsor
- Lithuanian Sports University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.