Clinical trials: Arthropathy of Knee
Knee Osteoarthritis, Amplification
Somatosensory Amplification and Psychological and Functional Status In Patients With Knee Osteoarthritis
As modern society enters the age of an aging population, the prevalence of knee OA continues to increase, which necessitates multi-faceted research.
- Conditions
- Knee Osteoarthritis, Amplification, Kinesiophobia, Psychological Disability
- Trial name
- NCT06753019
- Testing
- survey assessment tools
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Suleyman Demirel University
Knee Osteoarthritis
Sensor-based Physiotherapy Intervention With Virtual Reality
This study is looking at the how the use of non-immersive virtual reality technology can be used to help people that have pain in their knees caused by osteoarthritis.
- Trial name
- SPIN-VR (NCT06639867)
- Testing
- VR-based home physiotherapy, Standard physiotherapy care
- Where
- 2 sites in United Kingdom
- Volunteers
- 52 people
- Sponsor
- Cardiff University
Knee Osteoarthritis
Pulsed Electromagnetic Field Therapy on Muscle Strength and Function in Patients With End-stage of Knee Osteoarthritis
End-stage OA knee is one of the most common musculoskeletal complaints, with over 34,000 patients waiting for joint replacement in Hong Kong and is expected to increase as the population continues to age constantly.
- Trial name
- NCT06196567
- Testing
- PEMF, exercise
- Where
- Hong Kong
- Volunteers
- 43 people
- Sponsor
- Chinese University of Hong Kong
Osteoarthritis of Knee
A Study to Evaluate the Safety and Efficacy of Humia Inj. in Patients With Symptomatic Osteoarthritis of the Knee
A Multi-Centre, Parallel, Double-Blind, Active comparator, Randomised phase III Clinical Trial
- Trial name
- NCT02893098
- Testing
- Humia inj., High hyal Plus inj.
- Where
- South Korea
- Volunteers
- 232 people
- Sponsor
- Huons Co., Ltd.
Knee Osteoarthritis
MRI Study to Evaluate the Safety and Efficacy of SM04690 for Knee Osteoarthritis
The purpose of this study was to evaluate the safety and efficacy of lorecivivint (LOR) injected in the target knee joint of moderately to severely symptomatic osteoarthritis (OA) subjects.
- Trial name
- NCT03706521
- Testing
- lorecivivint
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Biosplice Therapeutics, Inc.
Arthroplasty, Replacement, Knee
Evaluation of Triathlon - A New Total Knee Prosthesis System - Triathlon PA vs. Triathlon Pressfit
The objective is to investigate the Clinical, Radiographic, Roentgen Stereophotogrammetric behaviour and patient outcome when using the Triathlon total knee prosthesis in a prospective randomized clinical trial.
- Trial name
- TriathlonRSA (NCT03198533)
- Testing
- Triathlon PA, Triathlon Pressfit
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Stryker Orthopaedics
Knee Osteoarthritis
A Study of NCR100 Injection for the Treatment of Knee Osteoarthritis（ KOA）
This clinical study is to investigate the safety and efficacy of NCR100 injection in subjects with knee osteoarthritis (KOA). It contains two parts dose-escalating, and blind random study in adult KOA subjects.
- Trial name
- NCT06741098
- Testing
- NCR100, 0.9% Normal saline
- Volunteers
- 162 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Gonarthrosis; Primary, Varus Gonarthrosis
Safety of Bilateral HTO: One-Stage vs.Two-Stage: A Randomized Controlled Study
In this study, bilateral simultaneous high tibial osteotomy (HTO) was compared with staged bilateral HTO in terms of complications.
- Trial name
- NCT04399304
- Testing
- simultaneous bilateral high tibial osteotomy, Staged bilateral high tibial osteotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Bezmialem Vakif University
Osteo Arthritis of the Knee
Clinical Investigation of Sensovisc
This clinical investigation aims to investigate the safety and performance of Sensovisc. Sensovisc is used to reduce osteoarthritis (OA) related pain in the joints by supporting synovial fluid by intra-articular injection and…
- Trial name
- NCT07237711
- Testing
- Sensovisc®
- Volunteers
- 75 people
- Sponsor
- Ankara City Hospital Bilkent
Osteoarthritis
Intra-articular Tranexamic Acid in the Reduction of Blood Transfusions in Primary Total Hip and Total Knee Arthroplasty
This is a randomized, double blinded, controlled trial in patients undergoing elective Total Knee Arthroplasty (TKA) and Total Hip Arthroplasty (THA).
- Trial name
- NCT02393963
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Orthopaedic Innovation Centre
Osteoarthritis
Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis
The present study will aim to evaluate the efficacy of milnacipran in the treatment of pain due to osteoarthritis (OA), that is, to determine whether milnacipran provides superior efficacy to placebo in patients with OA.
- Trial name
- NCT01329406
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Analgesic Solutions
Patellofemoral Pain Syndrome
Compressive Myofascial Release of the Vastus Lateralis on Lateral Patellar Tracking in Patellofemoral Pain Syndrome
Patellofemoral Pain Syndrome is a prevalent condition characterized by anterior knee pain, often exacerbated by activities such as squatting, running, and stair climbing.
- Trial name
- NCT06875804
- Testing
- baseline physical therapy treatment, Compressive myofascial release of vastus lateralis.
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Rehabilitation, Treatment Outcome
Effects of Exercise Therapy and Soft Brace on Knee Osteoarthritis
The primary aim of the study is to investigate the effects of supervised exercise therapy and education on the immediate response to using a soft knee brace in patients with knee osteoarthritis (OA).
- Conditions
- Rehabilitation, Treatment Outcome, Pain, Knee Brace
- Trial name
- NCT03949400
- Testing
- Exercise therapy and education.
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University College of Northern Denmark
Osteoarthritis, Knee
Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis
This is a pivotal study to evaluate the efficacy and safety of a single injection of autologous adipose-derived SVF produced using the GID SVF-2 device system for treatment of pain with concomitant improvement in function…
- Trial name
- NCT04440189
- Testing
- GID SVF-2 Device System
- Where
- 9 sites in United States
- Volunteers
- 114 people
- Sponsor
- GID BIO, Inc.
Osteoarthritis of the Knee
Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain
This study valuates the safety and efficacy of treatment with 3% Diclofenac Nano-Emulsion Cream versus Placebo in subjects with osteoarthritis of the knee.
- Trial name
- NCT00484120
- Testing
- 3%-Diclofenac-Nano-Emulsion Cream
- Where
- 4 sites in Israel
- Volunteers
- 123 people
- Sponsor
- Pharmos
Surgery, Knee Arthropathy
Evaluation of Arthroplasty Treatment
The aim of the study is to examine patients after knee and hip endoprosthesis in the longitudinal section and to evaluate the surgical outcome.
- Conditions
- Surgery, Knee Arthropathy, Hip Arthropathy, Prosthetic-joint Infection
- Trial name
- Endo-GEP (NCT07799818)
- Testing
- Joint replacement
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bonn
Osteoarthritis of the Knee
Effects of Perioperative Intravenous Dexamethasone on the Severity of Persistent Postsurgical Pain After Total Knee Arthroplasty : A Prospective, Randomized, Double-blind, Placebo-controlled Trial
To compare the effects of perioperative intravenous Dexamethasone with a placebo on the severity of persistent postsurgical pain after total knee arthroplasty.
- Trial name
- NCT02760459
- Testing
- Dexamethasone, Normal saline solution
- Where
- Thailand
- Volunteers
- 70 people
- Sponsor
- Chiang Mai University
Healthy Volunteers, Osteoarthritis
Safety, Tolerability & Pharmacokinetics of LEVI-04 in Healthy Volunteers and Patients With Osteoarthritis Knee Pain
This is a first-in-human, phase 1, single centre, placebo-controlled, double-blind, single ascending dose study of LEVI-04 in heathy volunteers and osteoarthritis patients (with pain attributed to osteoarthritis of the knee)
- Trial name
- NCT03227796
- Testing
- LEVI-04
- Where
- 2 sites in United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Levicept
Osteoarthritis, Knee, Pain
A Study to Evaluate ONO-4474 in Patients With Pain Due to Osteoarthritis of the Knee
The purpose of this phase 2, randomised, double-blind, placebo controlled, parallel group, multicentre study is to investigate the efficacy, safety, tolerability and pharmacokinetics of a compound ONO-4474 in patients with…
- Trial name
- MOTION (NCT02997696)
- Testing
- ONO-4474
- Where
- 47 sites in Denmark, Hungary and 3 more
- Volunteers
- 70 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Knee Osteoarthritis
Efficacy and Safety of Glucosamine Sulfate and Chondroitin Sulfate Combination in Treatment of Knee Osteoarthritis
The purpose of this study is to determine whether 500 mg Glucosamine Sulfate / 400 mg Chondroitin Sulfate Capsules and 1500 mg Glucosamine Sulfate / 1200 mg Chondroitin Sulfate Sachet is effective and safe compared Cosamin DS ®…
- Trial name
- NCT02010918
- Testing
- glucosamine sulfate /chondroitin sulfate - capsules, glucosamine sulfate /chondroitin sulfate - sachet, Cosamin DS®
- Where
- Brazil
- Volunteers
- 922 people
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
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