Clinical trials: Arthropathy of Knee
Knee Osteoarthritis
Kinematics of Contemporary Knee Arthroplasty
Total joint replacement is an efficacious treatment for osteoarthritis of hips and knees. Both total knee replacement (TKR) and total hip replacements (THR) have excellent implant survivorship.
- Trial name
- NCT02965690
- Testing
- Zimmer Biomet NexGen CR, Medacta International GMK Sphere
- Where
- Norway
- Volunteers
- 26 people
- Sponsor
- Oslo University Hospital
Osteoarthritis, Knee
Single-Dose Hybrid Hyaluronic Acid and Sodium Chondroitin with Rehabilitation for Sports Adults with Knee Osteoarthritis
: This observational case-control study aims to evaluate the efficacy of a single-dose intra-articular injection of a hybrid purified hyaluronic acid with high molecular weight and sodium chondroitin of biotechnological origin…
- Trial name
- NCT06890247
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Knee Osteoarthritis
Manual Therapy Versus Exercise on Knee Osteoarthritis
Earlier research has shown that exercising while receiving manual therapy improves function and reduces pain in people with knee osteoarthritis.
- Trial name
- NCT00988468
- Testing
- Manual Therapy, Therapeutic Exercise, Video Observation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Knee Osteoarthritis
Clinical Importance of Occult Suprapatellar Effusion in Knee Osteoarthritis
Small amounts of fluid in the knee joint may not always be visible during a standard ultrasound examination performed while the leg is relaxed.
- Trial name
- NCT07876752
- Testing
- Static and Dynamic Suprapatellar Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Mardin Artuklu University
Hemi Knee Arthroplasty, Patello-femoral Osteoarthritis
Evaluation of Orthopedic Knee Measurement Using Lunar iDXA
This study is to compare scans of the knee performed using new software designed specifically to look at the knee joint with those performed using approved software designed for scans of the hip.
- Trial name
- NCT01348958
- Testing
- iDXA knee software
- Where
- New Zealand
- Volunteers
- 36 people
- Sponsor
- GE Healthcare
Osteoarthritis, Knee, Osteoarthritis
Phase 4 Study of Laybon Tab. in Knee Osteoarthritis
This Phase 4, multicenter, randomized, double-blind, active-controlled, parallel study aims to evaluate the non-inferiority of Laybon Tab. compared to Layla Tab. (PMG Pharm Co., Ltd.) in patients with knee osteoarthritis.
- Trial name
- NCT07203547
- Testing
- Layla Tab., Laybon Tab.
- Volunteers
- 172 people
- Sponsor
- Mather's Pharm. Co., Ltd.
Anterior Knee Pain Syndrome
Neuromuscular Training Compared to Progressive Resistance Training for Patients With Anterior Knee Pain
The primary aim of this randomized control trial is to investigate patients' with anterior knee pain if a neuromuscular training program (NMT) has better results in pain and functionality, than an ordinary progressive resistance…
- Trial name
- NCT06110455
- Testing
- Neuromuscular Training exercises, Hip and Knee Muscular Strength exercises
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Thessaly
Osteoarthritis
Efficacy of Lower Tourniquet Pressure During Total Knee Arthroplasty
This study aims to determine whether the lower tourniquet pressure, which is set by adding 120mmHg (millimeter of mercury) on the systolic blood pressure just before tourniquet inflation, are efficient and safe during total knee…
- Trial name
- NCT01993758
- Testing
- Low tourniquet pressure, Conventional tourniquet pressure
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Adjunctive Use in OA of Hip or Knee, PAI3001
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as adjunctive therapy compared with placebo in participants with chronic moderate to severe pain and functional impairment from knee…
- Trial name
- NCT02336685
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg, Opioid
- Where
- 53 sites in United States, Canada and 4 more
- Volunteers
- 79 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis, Knee, Knee Pain Chronic
Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain
As the aging and obese populations continue to increase, there is a rapidly growing number of people at risk for knee osteoarthritis. Treatment typically starts conservatively with analgesics, physical therapy, and bracing.
- Trial name
- NCT04989660
- Testing
- 6% aqueous phenol, Isotonic saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Gonarthrosis
Prospective Cohort Study Evaluating a Thermal Spa Programme in Symptomatic Knee Osteoarthritis
Knee osteoarthritis is a common cause of pain, functional limitation, and reduced quality of life in older adults. Thermal spa treatment is widely used as a non-pharmacological intervention for the management of osteoarthritis…
- Trial name
- THERMOG (NCT07534189)
- Testing
- X-sens sensor, Transcriptomic, Self-questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Osteo Arthritis Knee
A Study to Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee
The purpose of this study is to evaluate the analgesic efficacy of V120083 twice daily compared to placebo in subjects with moderate to severe chronic pain due to OA of the knee.
- Trial name
- NCT03028870
- Testing
- V120083, Naproxen
- Where
- 30 sites in United States
- Volunteers
- 291 people
- Sponsor
- Purdue Pharma LP
Knee Osteoarthritis
Evaluate Safety and Explore Efficacy of SMUP-IA-01 in Patients With Knee Osteoarthritis
This clinical trial is performed with patients with knee osteoarthritis who were radiologically diagnosed with Kellgren-Lawrence (K\&L) grade 2 or 3.
- Trial name
- NCT04037345
- Testing
- SMUP-IA-01(low-dose), SMUP-IA-01(mid-dose), SMUP-IA-01(high-dose)
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Medipost Co Ltd.
Knee Osteoarthritis
Study of Biomechanical Parameters of Unloading Braces Used in the Treatment of Knee Osteoarthritis (BIOoSE)
Osteoarthritis is a chronic disease affecting millions of people worldwide, and knee is the second most affected site. Knee osteoarthritis is characterized by knee pain, loss of motion, disability, and muscle weakness, all…
- Trial name
- BIOoSE (NCT04524845)
- Testing
- Unloading brace, Rebel Reliever (RR), Action Reliever
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Thuasne
Osteoarthritis, Knee
Safety and Efficacy of RHH646 for Knee Osteoarthritis
The purpose of this study was to evaluate the articular cartilage-regenerating capacity of RHH646 in the knee as well as to assess safety and tolerability in participants with knee osteoarthritis.
- Trial name
- NCT05816395
- Testing
- RHH646
- Where
- 10 sites in United States, Argentina and 3 more
- Volunteers
- 82 people
- Sponsor
- Novartis Pharmaceuticals
Osteoarthritis, Knee
SVF Cellular Composition, Secretome, and Responses in Knee Osteoarthritis
This prospective, single-center observational study will enroll 20 adults aged 40 to 75 years with Kellgren-Lawrence grade II or III knee osteoarthritis who have already been scheduled for an intra-articular injection of…
- Trial name
- NCT07898501
- Testing
- Autologous adipose-derived stromal vascular fraction intra-articular injection
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Osteoarthritis
The Use of Platelet Derived Growth Factors in Total Knee Arthroplasty, a Randomized Trial
The objective of this study is to evaluate the effect of autologous platelet concentrate on blood loss (post-operative decrease of haemoglobin concentration), wound healing complications, range of motion, pain reduction and…
- Trial name
- NCT00167895
- Testing
- Adding platelet concentrate to the wound
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Westfries Hospital
Knee Osteoarthritis
Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis
The clinical trial will be carried out at the Dr. Moh. Hoesin Central Hospital, Palembang and planned from October 2022 to March 2023.
- Trial name
- NCT05579665
- Testing
- Platelet-rich Plasma, Conditioned Medium From Umbilical Cord Mesenchymal Stem Cell Culture (MSCs) Secretome, Low Molecular Weight Hyaluronic Acid
- Where
- Indonesia
- Volunteers
- 45 people
- Sponsor
- Universitas Sriwijaya
Osteoarthritis of the Knee, Osteoarthritis of the Hip
Cardiovascular And Metabolic Risk After Arthroplasty
Osteoarthritis is a chronic joint disease that lacks curative therapy. Epidemiological studies show increase in the burden of disease. Total joint arthroplasty is one of the best treatment options for end-stage osteoarthritis.
- Conditions
- Osteoarthritis of the Knee, Osteoarthritis of the Hip, Cardiovascular Diseases, Metabolic Syndrome
- Trial name
- CAMERA (NCT06211465)
- Testing
- Total joint arthroplasty
- Where
- Estonia
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Knee Osteoarthritis
Comparison of Conventional and Cooled Radiofrequency Ablation in Knee Osteoarthritis
The aim of this study was to examine and compare the effects of conventional and cooled radiofrequency ablation on pain and disability levels in patients with knee pain resistant to other treatments due to knee osteoarthritis.
- Trial name
- NCT06863181
- Testing
- Radiofrequency ablation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
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