Clinical trials: Arthropathy of Knee
Osteoarthritis of the Knee
Pilot Study to Identify and Validate Digital Biomarkers in Osteoarthritis of the Knee
To date, treatment options for knee osteoarthritis remain limited, and their clinical evaluation is complex due to the day-to-day fluctuations in symptoms.
- Trial name
- DigitOAK (NCT07031518)
- Testing
- Syde, The Self-Paced 40-meter Walk Test (SPWT), 30-second chair stand test (30s-CST)
- Where
- Belgium
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Haemophilic Arthropathy of Knee
Plyometric-Based Hydro-Kinesio Therapy in Children With Hemophilic Arthropathy
This study was designed to assess the effect of an 8-week plyometric-based hydro-kinesio therapy (Plyo-HKT) on pain, muscle strength, postural control, and functional performance in a convenience sample of children with…
- Trial name
- NCT05947110
- Testing
- Plyometric-based hydro-kinesio therapy, Standard exercise therapy
- Where
- Saudi Arabia
- Volunteers
- 48 people
- Sponsor
- Cairo University
Knee Osteoarthritis
EFFECT OF ADDING BLOOD FLOW RESTRICTION TRAINING TO CLOSED CHAIN EXERCISE IN KNEE OSTEOARTHRITIS
Knee osteoarthritis is a common joint condition that causes knee pain, stiffness, muscle weakness, and difficulty performing daily activities such as walking, climbing stairs, and standing up from a chair.
- Trial name
- NCT07917559
- Testing
- Traditional and Closed Kinetic Chain Exercise Program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Rasha Abdel Kader Abdel Azeem Khtab
Osteoarthritis, Osteoarthritis (OA) of the Knee
Effect of Autologous Ear Cartilage Micrografting in Knee Osteoarthritis
The goal of this clinical trial is to learn if a single injection of autologous cartilage micrografts suspension, obtained through processing with a specialized technology patient's own small piece of ear cartilage, can improve…
- Conditions
- Osteoarthritis, Osteoarthritis (OA) of the Knee, Moderate Osteoarthritis
- Trial name
- EAR2KNEE (NCT07755579)
- Testing
- Mytocel MSK - Autologous Ear Cartilage Micrografting
- Where
- Hungary
- Volunteers
- 33 people
- Sponsor
- Regenera Activa Worldwide S.L.
Osteoarthritis
Weight-bearing Recommendation After Replacement of the Hip or Knee Joint
Despite the widespread use of total hip and knee arthroplasty, there is a notable lack of consensus regarding postoperative treatment, mostly because of the lack of well-designed studies testing the efficacy and effectiveness of…
- Trial name
- NCT00266396
- Testing
- Recommend full weight-bearing, Recommend parital weight-bearing
- Where
- 4 sites in Germany
- Volunteers
- 352 people
- Sponsor
- Verein zur Förderung der Rehabilitationsforschung in Schleswig-Holstein
Knee Osteoarthritis
Platelet-rich Plasma and Synovial Cytokines in Knee Osteoarthritis
A prospective study was performed on 90 patients were included and categorized into mild (30 cases, moderate (30 cases) and severe (30 cases) knee OA. Three intra-articular (I.A) injections of PRP, 2 weeks a part, were received.
- Trial name
- NCT04754685
- Testing
- Intra-articular injection of platelet-rich plasma
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- South Valley University
Knee Osteoarthritis
Does Addition of a Functional Knee Brace Improve Rehabilitation Outcome in Subjects With Osteoarthritis of the Knee?
The purpose of this study is to investigate the effect of functional knee brace in the subjects with medial compartment knee OA.
- Trial name
- NCT02712710
- Testing
- functional knee brace
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Osteoarthritic Knee Pain, Osteo Arthritis of the Knee
Effects of High-Intensity Laser Therapy Combined With Exercise in Patients With Knee Osteoarthritis
The goal of this clinical trial was to determine whether high-intensity laser therapy (HILT) combined with exercise improves pain, physical function, and muscle strength in people with knee osteoarthritis.
- Conditions
- Osteoarthritic Knee Pain, Osteo Arthritis of the Knee, Osteoarthitis, Osteoarthritis (OA) of the Knee
- Trial name
- HILT-KOA (NCT07630259)
- Testing
- High Intensity Laser Therapy, Exercise
- Where
- Chile
- Volunteers
- 31 people
- Sponsor
- Universidad Metropolitana de Ciencias de la Educacion
Osteoarthritis, Knee
Performance of CCoat Intra-Articular Injections in Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Multi-center Trial
Performance of CCoat Intra-Articular Injections in Mild to Moderate Knee Osteoarthritis: A Prospective, Randomized, Double-Blind, Multi-center Trial
- Trial name
- NCT07052851
- Testing
- CCoat, Liposphere Ltd, Synvisc-One® (hylan G-F 20)
- Volunteers
- 200 people
- Sponsor
- Lipo-Sphere
Osteoarthritis, Knee
Unicompartmental Knee Arthroplasty (UKA) Versus Total Knee Arthroplasty (TKA) of Medial Osteoarthritis
This study allows patients to take part of the decision making between a unicompartment knee (partial ) or a total Knee replacement .
- Trial name
- NCT03457051
- Testing
- Total Knee Arthroplasty (TKA), Unicompartmental Knee Arthroplasty (UKA)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Acupuncture, Knee Osteoarthritis
Acupuncture Treatment for Knee Osteoarthritis With Sensitive Acupoints and Tender Points
The investigators plan to investigate the effectiveness of acupuncture at highly sensitive points, compared with lowly/non-sensitive points or no acupuncture (waiting-list), in improving pain, joint function and quality of life…
- Conditions
- Acupuncture, Knee Osteoarthritis, Sensitive Acupoints, Tender Points
- Trial name
- NCT03299439
- Testing
- acupuncture
- Where
- 4 sites in China
- Volunteers
- 666 people
- Sponsor
- West China Hospital
Knee Osteoarthritis, Pain, Joint
Pain Function and QOL Undergoing Whole-Body Vibration and Exercise in End-Stage Knee Osteoarthritis
Knee osteoarthritis (KOA) is a chronic progressive disease that imparts substantial socioeconomic burden to society and healthcare systems.
- Trial name
- NCT06183177
- Testing
- Whole-Body Vibration, Exercise
- Where
- Hong Kong
- Volunteers
- 517 people
- Sponsor
- Chinese University of Hong Kong
Osteearthritis, OA
Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis
This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis
- Conditions
- Osteearthritis, OA, OA Knee
- Trial name
- T2 mapping OS (NCT07316257)
- Testing
- MRI
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arthropathy of Hip, Arthropathy of Knee
Incidence and Risk Factors for Post-Anesthetic Morphine Titration in Recovery Room After Hip and Knee Arthroplasties
Despite the use of multimodal analgesia combining nerve block (NB) and systemic analgesia, intravenous (IV) morphine titration in the post-anesthetic care unit (PACU) after total hip (THA) and knee (TKA) arthroplasty is required…
- Trial name
- PAMTA (NCT06832995)
- Testing
- IV morphine administered during the PACU stay
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Hôpital Privé Sévigné
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-II (NCT02928679)
- Testing
- Liraglutide 3 mg (Saxenda)
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Henrik Gudbergsen
Osteoarthritis, Knee
Study to Evaluate the Efficacy and Safety of EP-104IAR in Patients With Osteoarthritis of the Knee
The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of EP-104IAR in patients with osteoarthritis (OA) of the knee
- Trial name
- SPRINGBOARD (NCT04120402)
- Testing
- EP-104IAR 25 mg, Vehicle
- Where
- 12 sites in Czechia, Denmark and 1 more
- Volunteers
- 318 people
- Sponsor
- Eupraxia Pharmaceuticals Inc.
Knee Osteoarthritis
Immediate Effects of Manual Therapy Versus TENS in Patients With Knee Osteoarthritis
Patients with knee Osteoarthritis have high prevalence of pain , requiring ever more precise interventions in their management. This study aims to investigate the immediate effects of manual therapy and TENS on pain in patients…
- Trial name
- NCT02947451
- Testing
- Manual Therapy, TENS
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Gabriel Peixoto Leão Almeida
Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome
Hamstring Strengthening in Hypermobile Conditions
The goal of this clinical trial is to determine how strengthening the hamstring muscles affects the knee joint in people living with hypermobility spectrum disorders (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).
- Conditions
- Hypermobile EDS (hEDS), Hypermobile Ehlers-Danlos Syndrome, Hypermobile Spectrum Disorder, Hypermobility Type Ehlers-Danlos Syndrome
- Trial name
- NCT07626957
- Testing
- Progressive resistance exercise with an emphasis on eccentric hamstring loading.
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Knee Osteoarthritis, Knee Injuries
Clinical Study of Novel Diagnostic Techniques for Knee Osteoarthritis
The purpose of this study is to clarify the potential of intra-articular ultrasound imaging, non-invasive ultrasound imaging, quantitative MRI imaging, contrast-enhanced CT imaging and arthroscopy for diagnostics of knee…
- Trial name
- NCT01359553
- Testing
- Intra-articular ultrasound imaging of knee joint during arthroscopy, Non-invasive ultrasound imaging of knee, Quantitative MRI imaging of knee
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- University of Oulu
Knee Osteoarthritis (Knee OA)
A Study to Assess the Efficacy and Safety of Vutiglabridin in Knee Osteoarthritis Patients
1. Study Objective To Explore the Efficacy and Evaluate the Safety of Vutiglabridin in Knee Osteoarthritis Patients 2. Background Glaceum Inc.
- Trial name
- NCT06845553
- Testing
- Vutiglabridin
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Glaceum
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