Clinical trials: Arthropathy of Knee
Osteoarthritis
An Intervention of Electrical Stimulation in Osteoarthritis
Patients with knee osteoarthritis (OA) often have decreased thigh muscle strength. This muscle weakness is thought to originate from centers in the brain and spinal cord that restrict recruitment of fibers responsible for muscle…
- Trial name
- NCT00500448
- Testing
- Electrical Stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Michigan
Pain, Osteoarthritis, Knee
Transdermal Ketoprofen to Treat Mild to Moderate Osteoarthritis (OA) Pain of the Knee
The purpose of the study is to evaluate the safety and effectiveness of the investigational ketoprofen patch with a controlled heating patch, compared to placebo (inactive substance) for the treatment of pain caused by…
- Trial name
- NCT00108810
- Testing
- Transdermal Ketoprofen Patch with CHADD
- Where
- 5 sites in United States
- Volunteers
- 118 people
- Sponsor
- ZARS Pharma Inc.
Osteoarthritis of the Knee
A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee
To evaluate the safety and efficacy of ABT-652 in combination with a Non-steroidal Anti-inflammatory Drug (NSAID) compared to NSAID alone in adults with osteoarthritis (OA) of the knee.
- Trial name
- NCT01444365
- Testing
- ABT-652 NSAID
- Where
- 31 sites in United States
- Volunteers
- 202 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Osteoarthritis of the Knee
3-year, Open-Label Study Evaluating Safety, Tolerability, and Efficacy of Lorecivivint in Knee Osteoarthritis
This study is designed as a 3-year, multicenter, open-label study evaluating the safety, tolerability, and efficacy of intra-articular (IA) Lorecivivint (LOR) in subjects with osteoarthritis of the knee in a real-world setting.
- Trial name
- NCT04931667
- Testing
- Lorecivivint
- Where
- 4 sites in United States
- Volunteers
- 72 people
- Sponsor
- Biosplice Therapeutics, Inc.
Osteoarthritis, Intraoperative Bleeding
Weighted Versus Uniform Dose of Tranexamic Acid in Patients Undergoing Primary, Knee Arthroplasty
Hypotheses: Primary - A weighted dose of 20 mg/kg of tranexamic acid will be more efficacious than a single uniform dose of 1 gram in primary total knee arthroplasty (TKA) cases.
- Trial name
- NCT01651806
- Testing
- Tranexamic Acid standard dose, Females Tranexamic Acid weighted dose, Females receiving a uniform dose of TA
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Arthropathy of Knee
Protocol for a Multicenter Study on (Cost)Effectiveness of the Back At Work After Surgery (BAAS): a Clinical Pathway for Knee Arthroplasty
Background Optimizing return to work (RTW) after knee arthroplasty (KA) is becoming increasingly important due to a growing incidence of KA and poor RTW outcomes after KA.
- Trial name
- NCT05690347
- Testing
- Back At work After Surgery (BAAS)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Defect of Articular Cartilage, Cartilage Injury
Synovium Brushing to Augmented Microfracture for Improved Cartilage Repair
This is a proof-of-concept study to determine the safety and efficacy of a novel device to increase the reparative capacity of the knee.
- Conditions
- Defect of Articular Cartilage, Cartilage Injury, Osteoarthritis, Knee
- Trial name
- AURA (NCT02696876)
- Testing
- Arthroscopic synovial brushing, Microfracture
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- University of Leeds
Knee Osteoarthritis, Knee Pain Chronic
Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
The objective of this investigation is to evaluate the safety of the geniculate artery embolization (GAE) procedure with HydroPearl® Microspheres in 30 patients with knee pain caused by osteoarthritis with 24 months follow-up.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Pain Swelling, Knee Arthritis
- Trial name
- NCT04472091
- Testing
- Genicular artery embolization (GAE)
- Where
- United States
- Sponsor
- Andrew Picel
Patellofemoral Pain Syndrome
Effect of Hip Adductors Isometric Contraction on Knee Extensors Isokinetic Torque in Patellofemoral Pain Syndrome
the study will be done to investigate the effect of hip adduction isometric contraction on the pain level by VAS and knee extensors peak torque by using the isokinetic dynamometer in patients with unilateral patellofemoral pain…
- Trial name
- NCT05083897
- Testing
- hip adduction isometric contraction
- Volunteers
- 30 people
- Sponsor
- Badr University
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Vibration on Patellofemoral Joint Pain After ACLR
Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Patellofemoral Pain
- Trial name
- NCT05501210
- Testing
- WBV, PEMF
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Knee Arthritis, Knee Arthropathy
ESPB vs iPACK+ACB in Total Knee Arthroplasty
Effect of iPACK block with Adductor Canal Block and ESPB on pain management, and NLR and PLR following knee arthroplasty
- Conditions
- Knee Arthritis, Knee Arthropathy, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT06302218
- Testing
- Ropivacaine 0.2% Injectable Solution, control group
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis
A Comparison of Wear Among Mobile and Fixed Bearing Knee Replacements
The purpose of this study is to determine the amount of polyethylene wear associated with knee replacement designs that incorporate either a fixed or mobile bearing.
- Trial name
- NCT01165957
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Anderson Orthopaedic Research Institute
Osteoarthritis, Hip Osteoarthritis
Wharton's Jelly-derived Mesenchymal Stem Cells in Osteoarthritis
This phase I/II study will enroll 100 subjects with mild to moderate osteoarthritis of the hip/knee/ glenohumeral joint will be enrolled according to strict inclusion and exclusion criteria.
- Conditions
- Osteoarthritis, Hip Osteoarthritis, Knee Osteoarthritis, Glenohumeral Osteoarthritis
- Trial name
- NCT03866330
- Testing
- Intraarticular injection of WJMSC
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Osteoarthritis
Application of Radiostereometric Analysis (RSA) to Triathlon Knee Components Inserted Using the OtisMed Custom-fit Total Knee Replacement System
The OtisMed Custom-fit system for total knee replacements replaces conventional surgical techniques for templating and intra-operative instrumentation with a preoperative virtual surgery process that utilizes 3D models of the…
- Trial name
- NCT01262430
- Testing
- OtisMed, Computer Assisted Surgery (CAS)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- Dalhousie University
Knee Osteoarthritis, Hyaluronic Acid
Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee Osteoarthritis
The French Society of Rheumatology cannot rule on the value of intra-articular injections of PRP due to the lack of hindsight and insufficient data.
- Conditions
- Knee Osteoarthritis, Hyaluronic Acid, Platelet Rich Plasma
- Trial name
- ISPAG (NCT05039463)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Knee Osteoarthritis, Knee Pain Chronic
The Effect of Physical Therapy Modalities and Kinesio Taping in Patients With Knee Osteoarthritis
Osteoarthritis (OA) is the most common degenerative joint disease with pathological structural and functional disorders all over the world. 27 million patients diagnosed with osteoarthritis in the USA alone.(1-2)
- Trial name
- NCT05211544
- Testing
- physical therapy modalities and exercise, kinesio taping and exercise, exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Osteo Arthritis Knee
"Ready-to-use" Intra-articular Formulation of Mesenchymal Stromal Cells
The goal of this clinical trial is to compare a newly developed off-the-shelf cryopreserved "ready to inject" Mesenchymal Stem Cell (MSC) product with the usual MSC preparation the investigators have used in knee osteoarthritis…
- Trial name
- PANLAR-II (NCT05751564)
- Testing
- "Ready to inject" Umbilical cord-derived Mesenchymal Stromal Cell (MSC) product, Resuspended Umbilical cord-derived Mesenchymal Stromal Cell (MSC) product
- Volunteers
- 60 people
- Sponsor
- Universidad de los Andes, Chile
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-I (NCT02928471)
- Testing
- Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Henrik Gudbergsen
Knee Osteoarthritis
Effects of Sensory Motor Training and Kinesthetic Exercises in Knee Osteoarthritis.
In this study i will see the effects of kinesthetic exercises and sensory motor training on pain and range of motion in patients with knee OA.
- Trial name
- NCT06339944
- Testing
- sensory motor training, kinesthetic exercises
- Where
- Pakistan
- Volunteers
- 34 people
- Sponsor
- Riphah International University
Knee Osteoarthritis
Combined Kinetic Chain Exercises on Knee Osteoarthritis
study will be conducted at faculty of physical therapy cairo university to investigate the effect of combined kinetic chain exercises on static and dynamic hamstring and quadriceps strength in knee osteoarthritis patients
- Trial name
- NCT06233175
- Testing
- combined kinetic chain exercises, conventional
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
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