Clinical trials: Arthropathy of Knee Joint
Osteoarthritis
A Single Center 2-way Crossover Study to Investigate the Mechanism of Action of Etoricoxib in Subjects With Osteoarthritis Knee Pain
The purpose of this study is to investigate which pain mechanisms that can be affected by etoricoxib compared to placebo (inactive medication)in subjects with painful knee osteoarthritis af 4 weeks of treatment.
- Trial name
- NCT01619150
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- C4Pain
Osteoarthritis, Knee, Joint Disease
Matched Pair Study - Kinematic Vs Mechanical Alignment
The aim of this study is to evaluate postoperative knee function after total knee arthroplasty performed according to the anatomical alignment and compare these results to those of a matched historical cohort of patients operated…
- Trial name
- NCT03446391
- Testing
- Kinematic alignment, Mechanical alignment, GMK Sphere®
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Medacta International SA
Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee
Ketogenic Diet to Reduce Osteoarthritis Pain in MCI
Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation.
- Conditions
- Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis
- Trial name
- KDROP-MCI (NCT07417891)
- Testing
- Well-formulated ketogenic diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Osteoarthritis, Knee
The Effect of Weight Loss and Exercise on Knee Osteoarthritis
This study will evaluate whether a program of weight loss and exercise can help individuals with knee osteoarthritis (OA).
- Trial name
- NCT00061490
- Testing
- Behavioral weight control and lifestyle exercise
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Opioid Use, Arthropathy of Knee
Opioid Consumption After Hospital Discharge in Orthopedic Surgery
At the Ohio State University, and across the country, surgical patients admitted to the hospital are over-prescribed a significant amount of opioid medications upon discharge to home.
- Conditions
- Opioid Use, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT03185117
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Ohio State University
Osteoarthritis, Knee
The Effect of Lateral Wedge Insole for Knee Osteoarthritis Patient in Plantar Pressure, Quadriceps Thickness, Gait and Walking Speed
Investigators would let knee osteoarthritis patient dressing lateral wedge insole and evaluate the effect for foot pressure modification, quadriceps thickness detected with ultrasound and gait.
- Trial name
- NCT04629040
- Testing
- Lateral wedge insole, Ordinary insole
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- China Medical University Hospital
Patellofemoral Pain Syndrome, Patellofemoral Pain
Long-term Effects of the Addition of Diathermy by Emission of Radiofrequency to Therapeutic Exercise in Patellofemoral Pain Syndrome Patients
Introduction: the management of Patellofemoral Pain (PFP) is focused on therapeutic exercise (TE) to improve muscle strength and motor control.
- Conditions
- Patellofemoral Pain Syndrome, Patellofemoral Pain, Patello Femoral Syndrome
- Trial name
- NCT05471089
- Testing
- Diathermy by emission of Radiofrequency, Therapeutic exercise
- Where
- Spain
- Volunteers
- 86 people
- Sponsor
- University of Jaén
Osteoarthritis, Knee
Efficacy and Safety Study of Transdermal Therapeutic System (TTS) Fentanyl in Participants With Osteoarthritis Knee Pain
The purpose of this study is to evaluate the efficacy and safety of Transdermal therapeutic system (TTS) fentanyl patches (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01742897
- Testing
- TTS-fentanyl
- Where
- Thailand
- Volunteers
- 35 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Osteoarthritis
Ergometer Cycling After Replacement of the Hip or Knee Joint
Despite the widespread use of hip and knee replacement surgery, there is a considerable lack of consensus regarding postoperative treatment and rehabilitation, mostly because of the lack of well-designed studies testing the…
- Trial name
- NCT00951990
- Testing
- Ergometer Cycling, No ergometer cycling
- Where
- 5 sites in Germany
- Volunteers
- 457 people
- Sponsor
- Verein zur Förderung der Rehabilitationsforschung in Schleswig-Holstein
Juvenile Idiopathic Arthritis (JIA)
Short-Term Effects of Intra-Articular Corticosteroid Injection on Knee Function in Juvenile Idiopathic Arthritis
The purpose of this study is to evaluate the short-term clinical effects of intra-articular corticosteroid injections on knee joint functions in children and adolescents diagnosed with Juvenile Idiopathic Arthritis (JIA).
- Trial name
- NCT07709026
- Testing
- Intra-articular Corticosteroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Necmettin Erbakan University
Osteoarthritis of the Knee
A Study of the Efficacy and Safety of CF101 to Patients With Osteoarthritis of the Knee
This study will test the effectiveness of CF101 in treating the symptoms of osteoarthritis (OA) of the knee. Eligible patients will be given either CF101 or matching placebo tablets and their symptoms will be evaluated over the…
- Trial name
- NCT00837291
- Testing
- CF101
- Where
- Israel
- Sponsor
- Can-Fite BioPharma
Knee Arthritis, Osteoarthritis, Osteo Arthritis of the Knee
Quadriceps Muscle Quality and Clinical Outcomes in Knee Osteoarthritis
The purpose of this cross-sectional, observational study is to evaluate the relationship between quadriceps muscle quality-specifically muscle echogenicity and thickness change during isometric contraction-and clinical outcomes…
- Trial name
- NCT07541274
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Izmir City Hospital
Osteoarthritis, Knee
A Phase 2b/3a Study to Evaluate the Efficacy and Safety of JointStem in Patients Diagnosed as Knee Osteoarthritis
This study is a double-blind, randomized, placebo controlled, multi-center, superiority study to evaluate the efficacy and safety of JointStem, autologous adipose tissue derived mesenchymal stem cells (AdMSC), in patients…
- Trial name
- NCT04368806
- Testing
- JointStem
- Where
- 9 sites in United States, South Korea
- Volunteers
- 173 people
- Sponsor
- Nature Cell Co. Ltd.
Osteoarthritis, Knee
A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain
Background: Duloxetine provides an analgesic effect of patients with OA. The mode of action of duloxetine is partly believed to act through modulating the descending inhibitory pain pathways from the brainstem towards the spinal…
- Trial name
- NCT04224584
- Testing
- Duloxetine
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Kristian Kjær Petersen
Knee Osteoarthritis
Home Based Hip Strengthening for Knee OA Patients
In knee osteoarthritis patients, weakness of hip abductor muscles is considered an important contributing factor leading to the progression of the disease.
- Trial name
- NCT05131048
- Testing
- conventional group, experimental group
- Volunteers
- 90 people
- Sponsor
- University of Lahore
Osteoarthritis of the Knee
A Phase 1, Double-Blind, Randomized, Single Dose Escalation Safety Study of Intra-articular OP-1 in Subjects With Osteoarthritis of the Knee
The purpose of this research study is to investigate the safety and tolerability of OP-1 when it is injected into the knee joint of patients who have osteoarthritis on the knee.
- Trial name
- Knee OA (NCT00456157)
- Testing
- Intra-articular Injection of OP-1 to affected knee
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Stryker Biotech
Osteoarthritis, Chronic Pain
A Study of Embeda (Kadian NT, ALO-01) in Subjects With Pain Due to Osteoarthritis of the Hip or Knee
The purpose of this study is to evaluate the efficacy of Kadian NT (ALO-01) compared with placebo for treating moderate to severe chronic pain over a 12 week period.
- Trial name
- NCT00420992
- Testing
- ALO-01 (Morphine Sulfate Plus Naltrexone Hydrochloride Extended Release)
- Where
- 81 sites in United States
- Volunteers
- 547 people
- Sponsor
- Pfizer
Osteoarthritis, Knee Pain
Combined Vibrations, Passive Motion and Thermotherapy for Knee Osteoarthritis
The study evaluated the efficacy of combined mechanical vibrations, continuous passive motion and heat on the severity of pain in management of osteoarthritis of the knee
- Trial name
- KC-01 (NCT00858416)
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Kineticure
Osteoarthritis, Knee
An Exploratory Clinical Study to Investigate Biomarkers of Senescence in Patients With Osteoarthritis of the Knee
This is an exploratory non-drug, interventional biomarker study in approximately 30 eligible patients with active osteoarthritis to investigate the degree of senescence-associated disease.
- Trial name
- NCT03100799
- Testing
- Arthroscopy, Arthrocentesis, MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Unity Biotechnology, Inc.
Osteoarthritis, Varus Malalignment
Ellipse Intramedullary Nail High Tibial Osteotomy Study
This study further evaluates the safety profile and efficacy of the Ellipse IM HTO Nail system in subjects with osteoarthritis and varus malalignment of the knee.
- Trial name
- IM HTO (NCT02412163)
- Testing
- Ellipse IM HTO Nail
- Where
- 11 sites in Germany, Netherlands and 2 more
- Volunteers
- 41 people
- Sponsor
- Ellipse Technologies, Inc.
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