Clinical trials: Arthropathy of Knee Joint
Knee Osteoarthritis
Effect of Combined Quadriceps and Calf Strengthening Program on Gait in Knee Osteoarthritis Patients
The aim of this study is to determine the effects of a combined quadriceps and calf strengthening program on gait, strength, pain, disability, functional mobility, and sleep quality in patients with knee osteoarthritis.
- Trial name
- NCT07402447
- Testing
- Group A (Combined Quadriceps and Calf Strengthening), Group B( Conventional)
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Riphah International University
Osteoarthritis
Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe
Using the concept of an implant acting as a spacer and stabilizer, the proposed study will evaluate the use of allograft knee meniscus in the treatment of MTP joint osteoarthritis of the great toe.
- Trial name
- MTP (NCT01673347)
- Testing
- Meniscal Allograft
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Paul Fortin, MD
Knee Osteoarthritis
Effects of Genicular Nerve Block in Knee Osteoarthritis
Genicular nerve block is a safe and effective therapeutic procedure for intractable pain associated with chronic knee osteoarthritis (OA). There is increasing support for the neuropathic component to the knee OA pain.
- Trial name
- NCT03781843
- Testing
- Genicular nerve block with lidocaine, Genicular nerve block with saline, Genicular nerve block with dextrose
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Osteoarthritis of the Knee
Bone Marrow Aspirate Concentrate (BMAC) vs Corticosteroid Injection
Prospective single-masked (study participant will be masked), randomized controlled trial to examine the influence of BMAC on patient-reported outcomes (PROs) in patients with primary knee osteoarthritis.
- Trial name
- BMAC (NCT05985785)
- Testing
- Autologous bone marrow aspirate concentrate (BMAC), Corticosteroid injections, Crossover Autologous bone marrow aspirate concentrate (BMAC)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Knee Osteoarthritis
Mulligan Rotational Movement Versus Medial Gapping Technique in Patients With Knee Osteoarthritis
Knee osteoarthritis is a progressive degenerative and non-inflammatory joint disorder. Due to the extensive use and stress placed on knee joint, it is a common site for painful disorders such as knee osteoarthritis.
- Trial name
- NCT05338840
- Testing
- MULLIGAN ROTATIONAL MOVEMENT, Medial gapping technique
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Prehabilitation, Knee Osteoarthritis
Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.
We live in an increasingly aging society in which the incidence of osteoarticular diseases increases, among which osteoarthritis (OA) stands out.
- Conditions
- Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities
- Trial name
- Preoperative (NCT06721897)
- Testing
- Prehabilitation Program, Non prehabilitation Program
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Jaén
Osteoarthritis
A Study for Moderate Osteoarthritis of the Knee
This is a study to determine whether Flexsure is Safe, Tolerable and Effective in relieving symptoms of Moderate Osteoarthritis of the Knee.
- Trial name
- Flexsure (NCT01478997)
- Testing
- Flexsure Capsules
- Where
- 2 sites in India
- Volunteers
- 76 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Arthroplasty, Replacement, Knee, Osteoarthritis, Knee
Knee Kinematics for Subjects With Zimmer-Biomet Posterior Cruciate Retaining or Posterior Stabilizing Total Knee Arthroplasty
25 subjects implanted with a Zimmer-Biomet Posterior Cruciate Retaining (PCR) total knee arthroplasty (TKA) and 25 subjects implanted with a Zimmer-Biomet Posterior Stabilizing (PS) TKA will be asked to perform stepping up and…
- Trial name
- PCR PS TKA (NCT04103515)
- Testing
- Zimmer-Biomet Posterior Cruciate Retaining total knee arthroplasty, Zimmer-Biomet Posterior Stabilizing total knee arthroplasty
- Where
- 3 sites in United States, France
- Volunteers
- 50 people
- Sponsor
- The University of Tennessee, Knoxville
Knee Osteoarthritis
Evaluation of the Effect of Pro Resolve® Sports on Treatment of Patients With Symptomatic Knee Osteoarthritis
The GAUDI study was a randomized, multicentre, double-blind, placebo-controlled, parallel-group pilot study conducted in 5 Spanish sites.
- Trial name
- GAUDÍ (NCT05633849)
- Testing
- SMP group
- Where
- 5 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Solutex GC S.L.
Knee Osteoarthritis, Knee Pain
The Effect of AposTherapy on Knee Pain
AposTherapy is a home based exercise program utilizing footwear that causes exercise with normal activity that may significantly improve function in patients with knee osteoarthritis since patients with knee osteoarthritis have…
- Trial name
- AposKnee (NCT03171168)
- Testing
- AposTherapy, Traditional Physical Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Montefiore Medical Center
Knee Osteoarthritis, Pain, Postoperative
Influence of Patient Sex on Pain Control and Multimodal Analgesia in Total Knee Arthroplasty
The purpose of this study is to examine the influence of sex on postoperative pain, following total knee arthroplasty (TKA). Patients will first be stratified by sex and then be randomized into one of two multimodal analgesic…
- Trial name
- NCT04471233
- Testing
- Multimodal analgesia including pregabalin, Multimodal analgesia not including pregabalin
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Northwell Health
Chronic Pain, Osteoarthritis
Effects of tDCS and tUS on Pain Perception in OA of the Knee
The purpose of this study is to investigate the effects of transcranial direct current stimulation (tDCS) in conjunction with transcranial ultrasound (TUS) on pain perception and functional limitations in people with…
- Trial name
- NCT02330315
- Testing
- transcranial direct current stimulation (tDCS), transcranial ultrasound (TUS)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Spaulding Rehabilitation Hospital
Osteoarthritis, Knee
Intraosseous With Intra-articular Injection of Platelet Rich Plasma in Treatment of Knee Osteoarthritis
The aim of this study was to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given a combination of intraosseous with intra-articular injection of platelet rich plasma (PRP)…
- Trial name
- NCT03329235
- Testing
- PRP, HA
- Volunteers
- 86 people
- Sponsor
- Cangzhou Central Hospital
Hip Arthropathy, Knee Arthropathy
Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications
Vitamin D status has been shown to have an effect on post-operative outcomes in total joint arthroplasty. The goal of this study is to determine if pre-operative supplementation and correction of Vitamin D deficiency can reduce…
- Conditions
- Hip Arthropathy, Knee Arthropathy, Vitamin D Deficiency
- Trial name
- NCT04229368
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Brigham and Women's Hospital
Knee Osteoarthritis
Assessment of Safety and Efficacy of ARTHRUM 2.5% for Treatment of Painful Osteoarthritis of the Knee
ARTHRUM 2.5% MONO-INJECTION as symptomatic treatment by joint injection extends the conservative therapeutic arsenal in Knee osteoarthritis.
- Trial name
- ART-ONE75 (NCT06228274)
- Testing
- ARTHRUM 2.5%
- Volunteers
- 218 people
- Sponsor
- LCA Pharmaceutical
Osteoarthritis, Knee
Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN
A previous multicenter trial led by Bioiberica S.A. has confirmed the efficacy and safety of DROGLICAN for the treatment of osteoarthritis (OA) in patients with severe pain.
- Trial name
- DRIP (NCT02821468)
- Testing
- Droglican, Paracetamol or oral NSAIDs excluding COX2 inhibitors
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Bioiberica
Arthropathy of Knee Joint
Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (the knee joint) is more effective at obtaining adequate tissue levels of the antibiotic than…
- Trial name
- NCT03506347
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Knee Osteoarthritis, Osteearthritis
Effect of 0° and 50° N-K Table Load Angles on Quadriceps Activation in Knee Osteoarthritis
Knee osteoarthritis (OA) is a common degenerative joint disease that leads to pain, reduced mobility, and functional limitation. Quadriceps femoris weakness plays a significant role in disease progression and disability.
- Trial name
- NCT07456254
- Testing
- Isotonic Quadriceps Exercise Using NK Table
- Where
- Indonesia
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Recruitment
Effect of the Infrapatellar Strap and Elastic Band Iin Athletes With Patellofemoral Pain Syndrome
Patellofemoral Pain Syndrome (PPS) is common in athletes, especially when performing jumps. To reduce pain and improve functionality, orthoses such as the infrapatellar strip (IPS) and functional bandage (FB) are indicated, but…
- Trial name
- NCT04264429
- Testing
- Infrapatellar strap, Elastic band
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Universidade Estadual de Londrina
Osteoarthritis (OA) of the Knee
Impact of Blood-Flow-Restriction Prehabilitation on Pre- and Postoperative Rehabilitation After Total Knee Arthroplasty
Degenerative and traumatic diseases of the musculoskeletal system lead to increased immobility of a patient, which in turn results in muscle atrophy.
- Trial name
- NCT06964022
- Testing
- BFR
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- University Hospital, Bonn
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