Clinical trials: Arthroplasties, Replacement
Osteoarthritis
Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery
This study is undertaken to investigate the effect of navigated knee implantation surgery on physical function, joint stiffness, pain, quality of life and coordinative abilities.
- Trial name
- NCT00431509
- Testing
- conventional vs. navigated total knee arthroplasty
- Where
- 8 sites in Germany
- Volunteers
- 477 people
- Sponsor
- University Hospital Schleswig-Holstein
Arthritis
Fascial Manipulation® Associated With Standard Care Versus Standard Post-surgical Care for Total Hip Arthroplasty
Post-surgical physiotherapy programs following to total hip arthroplasty (THA) show important differences between types and numbers of treatment sessions.
- Trial name
- NCT02576028
- Testing
- Fascial Manipulation® (FM), standard active exercises
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Bolognini di Seriate Bergamo
Venous Thromboembolism, Arthroplasty, Replacement, Hip
A Study Evaluating Efficacy and Safety of YM150 Compared to Enoxaparin in Subjects Undergoing Hip Replacement Surgery
The purpose of this study is to evaluate the efficacy and safety of various doses of YM150 (the experimental drug) compared to enoxaparin in the prevention of venous thromboembolism in patients that are undergoing elective hip…
- Trial name
- ONYX-3 (NCT00902928)
- Testing
- YM150, enoxaparin
- Where
- 156 sites in United States, Australia and 26 more
- Volunteers
- 1,992 people
- Sponsor
- Astellas Pharma Europe B.V.
Muscular Atrophy
A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
The primary objective of this study is to test the hypothesis that appendicular lean body mass (aLBM) will increase after 12 weeks of LY2495655 treatment versus placebo in older participants undergoing elective total hip…
- Trial name
- NCT01369511
- Testing
- LY2495655
- Where
- 45 sites in United States, Austria and 9 more
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company
Arthroplasty, Replacement
Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty Procedures
Background: REAL INTELLIGENCE™ CORI™ (CORI Robotics) is a computer-assisted orthopaedic surgical navigation and burring system. CORI Robotics is designed to help surgeons in planning and executing certain types of knee surgery…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- NCT04786119
- Testing
- CORI Robotics
- Where
- 8 sites in United States, Germany and 2 more
- Volunteers
- 126 people
- Sponsor
- Smith & Nephew, Inc.
Edematous, Synovitis
Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements
This research study is being conducted to determine if taking oral (by mouth in pill form) Apatone®B (a combination of Vitamins C and K3) will reduce chronic joint discomfort and improve function of non-infected symptomatic…
- Conditions
- Edematous, Synovitis, Foreign Body Reaction, Osteolysis
- Trial name
- Apatone-B (NCT01272830)
- Testing
- Apatone®B
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- IC-MedTech Corporation
Infections Joint Prosthetic, Overweight or Obesity
Antibiotic Prophylaxis in High-Risk Arthroplasty Patients
To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk…
- Conditions
- Infections Joint Prosthetic, Overweight or Obesity, MSSA Colonization, MRSA
- Trial name
- NCT04297592
- Testing
- Cephalexin, Doxycycline, Cefadroxil
- Where
- 2 sites in United States
- Volunteers
- 4,618 people
- Sponsor
- Mayo Clinic
Arthroplasty, Replacement, Knee, Total Knee Replacement
X-3 Polyethylene Survival Outcomes Study
The goal of this clinical trial is to compare two types of polyethylene (Stryker Orthopaedics N2Vac and their X3 polyethylene) prostheses that are used in total knee replacements.
- Trial name
- NCT00493792
- Testing
- X3 Polyethylene, N2Vac Polyethylene
- Where
- 3 sites in United States
- Volunteers
- 518 people
- Sponsor
- Mayo Clinic
Arthroplasty, Replacement, Knee, Pain, Postoperative
Pharmacogenomics Information in Enhancing Post-operative Total Joint Replacement Pain Management: a Pilot Study
The objective of this study is to see how pain management and its outcomes are effected when pharmacogenomic testing is used to determine patient specific pain medication and dosing.
- Trial name
- NCT02711592
- Testing
- Genetic Panel for Analgesics
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- TriHealth Inc.
Arthroplasty, Replacement, Knee
Wearable Sensors for Monitoring Recovery After Total Knee Arthroplasty
The goal of this observational study is to investigate the potential of wearable sensors for monitoring the postoperative recovery of patients after TKA.
- Trial name
- NCT05992064
- Testing
- Measuring gait
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Aalborg University Hospital
Osteoarthritis
Functional Outcome in Two Types of Total Knee Replacement Surgery for People With Osteoarthritis
When performing total knee replacement surgery, the surgeon has a choice as to which type of surgical technique to use. The standard technique at the Royal Infirmary in Edinburgh is the so-called 'medial parapatellar' exposure.
- Trial name
- NCT01576445
- Testing
- Mid-vastus approach, medial parapatellar approach
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Queen Margaret University
Arthroplasty, Replacement, Knee
Signature Personalised Patient Care System With the Vanguard Knee System Study
The purpose of this study is to determine whether the percentage cases which have ideal mechanical axial alignment using the Vanguard total Knee implant with the Signature cutting blocks is higher than those without the use of…
- Trial name
- NCT01092312
- Testing
- Vanguard Knee System with Signature Knee Guide, Vanguard Knee System with conventional Instruments
- Where
- 12 sites in United States, Australia and 8 more
- Volunteers
- 325 people
- Sponsor
- Zimmer Biomet
Arthroplasty, Replacement, Knee, Pain
Liposomal Bupivacaine in Simultaneous Bilateral Total Knee Arthroplasty
The purpose of this study is to evaluate the serum levels (pharmacokinetics) of bupivacaine in a series of patients undergoing simultaneous bilateral total knee arthroplasty with the use of a standardized periarticular injection…
- Trial name
- NCT02349542
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Knee Osteoarthritis
Study Comparing Traditional and Gender-specific Total Knee Replacement Designs
The purpose of this study is to compare results obtained with gender-specific and traditional knee replacement systems design among women undergoing total knee replacement surgery.
- Trial name
- NCT00937170
- Testing
- Zimmer LPS flex Gender Specific Implant (Total knee replacement), Zimmer High Flex LPS Implant (Total knee replacement), Stryker Triathlon Implant (Total knee replacement)
- Sponsor
- UConn Health
Elbow Joint Destruction, Post-traumatic Lesions
Clinical Outcomes Study of the Nexel Total Elbow
The objectives of the study are to confirm safety and performance of the Zimmer Nexel Total Elbow when used in primary or revision total elbow replacement.
- Conditions
- Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis
- Trial name
- NCT02469662
- Testing
- Nexel Total Elbow
- Where
- 11 sites in United States, Australia and 6 more
- Volunteers
- 134 people
- Sponsor
- Zimmer Biomet
Arthropathy of Knee Joint
Motion Analysis of EMP Knee Versus Posterior Stabilized Knee Arthroplasty for Osteoarthritis
The purpose of the current study is to analyze and compare the lower-limb joint motions and muscle activation patterns during activities of daily living as well as self reported health related functional outcomes for patients…
- Trial name
- NCT00967161
- Testing
- Total Knee Arthroplasty, Motion analysis
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Hematoma, Arthroplasty Complications
The Effect of Releasing the Tourniquet in Total Knee Replacement Before Closure on the Blood Loss , Joint Effusion , Hematoma Formation and Wound Complication
The study , observe the effect of releasing the Tourniquet in total knee replacement surgery before closure in comparison with releasing it after wound closure The effect was assessed by Hb drop post operative and Hematoma…
- Trial name
- NCT04810000
- Testing
- tourniquet
- Where
- Jordan
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Yazan Saleh Rajab Hammad
Osteoarthritis
Efficacy of Intravenous Versus Topical Tranexamic Acid in Primary Total Hip Arthroplasty
Bleeding during and after total hip replacement surgery is a primary concern to the surgical and anaesthetic team. Tranexamic acid is a commonly-used drug that helps blood clotting and decreases surgical bleeding.
- Trial name
- TeACH-R (NCT02056444)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
Study of Patient Outcomes 5 Years After Partial Knee Replacement
The study seeks to evaluate the condition of patients 5 years after having undergone partial knee replacement for localized osteoarthritis of the knee.
- Trial name
- NCT01620892
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Athens Orthopedic Clinic, P.A.
Osteoarthritis, Hip, Coxarthrosis; Primary
Osseointegration of THA Grafted by PolyNASS (ACTISURF-CERAFIT® ) Versus Non-grafted THA (CERAFIT®)
The infection rate after Total Hip Arthroplasty (THA) is about 1%. It is a serious condition, with high morbidity, sometimes fatal, requiring costly treatment.
- Conditions
- Osteoarthritis, Hip, Coxarthrosis; Primary, Coxarthrosis; Secondary, Osteonecrosis; Aseptic, Idiopathic
- Trial name
- NCT03113981
- Testing
- Total Hip Arthroplasty
- Where
- 7 sites in France
- Volunteers
- 340 people
- Sponsor
- Societe ACTIVBIOMAT
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