Clinical trials: Arthroplasty, Hip Revision
Infection, Drainage
Comparison of Negative Pressure Wound Therapy vs. Conventional Dressings for Prevention of Wound Complications After Revision THA
Wound complications and surgical site infections following revision total joint arthroplasty result in significant morbidity and cost.
- Trial name
- NCT03321799
- Testing
- Negative Pressure Wound Therapy (NPWT), Sterile Antimicrobial Dressings
- Where
- United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Total Hip Replacement
Randomized Clinical Trial of Ceramic Bearing Primary Total Hip Arthroplasty
Primary total hip arthroplasty (THA) has been a very successful surgical intervention in the geriatric population. Numerous studies have reported good mid and long term results of THA in patients over the age of 60 years.
- Trial name
- NCT01522014
- Testing
- Secure-Fit™ arc-deposited Hydroxylapatite (HA) shell - surface ceramic and an Alumina Bearing Couple (ABC) ceramic insert and Ceramic C-taper head, Secure-Fit™ arc-deposited hydroxylapatite shell, a Crossfire® insert and a Ceramic C-taper head
- Where
- 2 sites in Canada
- Volunteers
- 92 people
- Sponsor
- University of Alberta
Hip Arthroplasty
A Comparison of Two Type of Stems in Revision Hip Arthroplasty
This study compares two different hip stem components. Both hip stems used in this study allow the femur bone to attach and grow into them for stability.
- Trial name
- NCT00253838
- Testing
- Restoration HA stem, Solution stem
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Ottawa Hospital Research Institute
Aseptic Loosening, Arthroplasty Complications
Total Hip Arthoplastry Revision by Dual-mobility Acetabular Cup Cemented in a Metal Reinforcement
Total hip arthroplasty (THA) requires bone reconstruction in case of severe acetabular injury, with risk of dislocation, especially postoperatively.
- Trial name
- PTH (NCT03680443)
- Testing
- assembly in THA revision
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos
Observational Study Evaluating Outcomes of Hip Arthroplasty Using Tornier Dual Mobility Acetabular Cup
The purpose of this study is to demonstrate the performance and reliability of Tornier "Dual Mobility Cup" used during primary total hip replacement or hip replacement revision surgery at least 24 months post-insertion.
- Conditions
- Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos, Femur Head Necrosis, Femur Neck Fracture
- Trial name
- NCT02062450
- Testing
- Primary surgery with Dual Mobility Cup, Revision surgery with Dual Mobility Cup
- Volunteers
- 379 people
- Sponsor
- Stryker Trauma and Extremities
Revision Hip Arthroplasty
M-Vizion™ Macroscopic Radiographic Study
Study of the patient's subsidence after revision hip arthroplasty by assessing gross stem subsidence in the femoral canal.
- Trial name
- NCT05721859
- Testing
- revision hip arthroplasty
- Where
- 7 sites in United States
- Volunteers
- 70 people
- Sponsor
- Medacta USA
Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee
Antibiotic Prophylaxis in Primary Joint Arthroplasty of the Hip and Knee.
A retrospective study will be performed to compare the incidence of revision procedures performed for the treatment of postoperative periprosthetic joint infection (PJI) between patients treated with a single preoperative…
- Conditions
- Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Antibiotic Prophylaxis
- Trial name
- NCT03348254
- Testing
- Single shot antibiotic prophylaxis, Multiple shot antibiotic prophylaxis
- Where
- Netherlands
- Volunteers
- 242,179 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Survival, Prosthesis
Prevision® PMCF Study
Monocentric, non-interventional Post-Market Clinical Follow-Up (PMCF) Study on past implantations of the Prevision® prosthesis; the survival rate of the Prevision® prosthesis shall be evaluated and compared to literature results…
- Trial name
- NCT03510065
- Testing
- Prevision®
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Aesculap AG
Osteoarthritis, Avascular Necrosis
Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect Reconstruction
The study is a multi-center, prospective, non-controlled, consecutive cohort post market surveillance study. The objective of this study is to obtain survival and clinical outcome data on the Hyperion® system in primary and…
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Functional Deformities
- Trial name
- NCT03382665
- Where
- 3 sites in Germany
- Volunteers
- 70 people
- Sponsor
- Zimmer Biomet
Revision Total Hip Arthroplasty
Exercise Intervention Targeting Hip Strengthening Compared to Usual Care in Patients Undergoing Revision Hip Replacement
There is sparse evidence on revision total hip replacement (THR), regarding the effectiveness on pain and function, and no consensus exists on optimal rehabilitation after revision THR.
- Trial name
- StrongHip (NCT05657054)
- Testing
- Exercise Intervention Targeting Hip Strengthening, Usual Care
- Where
- 9 sites in Denmark
- Volunteers
- 84 people
- Sponsor
- University of Aarhus
Total Hip Arthroplasty (THA), Revision Hip Arthroplasty
Cementation of Cup and the Risk of Second Revision
Background: The fixation method of the acetabular component during the primary total hip arthroplasty (THA) affects the surgical techniques implemented in the revision surgery and may influence the risk of second revision.
- Trial name
- NCT06583382
- Volunteers
- 60,000 people
- Sponsor
- Bispebjerg Hospital
Revision Surgery of Total Hip Arthroplasty
Effect of Denosumab on Inflammatory Osteolytic Lesion Activity in Total Hip Arthroplasty
Although hip replacement surgery is a successful way of dealing with the pain and immobility caused by hip arthritis, 10% of the hip replacements carried out in the UK fail within 10 years.
- Trial name
- NCT01358669
- Testing
- Denosumab
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Pinnacle Metal-on-Metal, Revised Pinnacle Metal-on-Metal
Pinnacle Metal-on-Metal 522 Post-Market Surveillance Study
The purpose of this clinical study is to evaluate blood metal ion levels as a function of time of implantation for the Pinnacle Acetabular MoM system.
- Conditions
- Pinnacle Metal-on-Metal, Revised Pinnacle Metal-on-Metal, Adverse Local Tissue Reaction, Metal Ions
- Trial name
- NCT01828801
- Testing
- Pinnacle Metal-on Metal
- Where
- 8 sites in United States
- Volunteers
- 276 people
- Sponsor
- DePuy Orthopaedics
Prosthesis-Related Infections, Hip Prosthesis Infection
Effect of Sonication on Periprosthetic Joint Infection Treatment Strategy.
It is not known in the literature how much sonication affects the patient's treatment. Another important issue is that the place of this method in diagnosis is not clear.
- Conditions
- Prosthesis-Related Infections, Hip Prosthesis Infection, Joint Infection, Biofilm
- Trial name
- NCT04304885
- Testing
- Sonication method
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Bezmialem Vakif University
Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee
ROADMAP Clinical Trial
Artificial joint infections are treated with different types of antibiotics and surgery. The ROADMAP study aims to find out which treatments currently used work best in regards to surgery, antibiotic choice as well as the time…
- Conditions
- Prosthetic Joint Infections of Hip, Prosthetic Joint Infections of Knee, Large Joint Prosthetic Joint Infections
- Trial name
- ROADMAP (NCT06771050)
- Testing
- Debridement and Implant Retention (DAIR), Antibiotic Choice, Antibiotic duration Part A - Single stage revision
- Where
- 43 sites in Australia, New Zealand
- Volunteers
- 2,500 people
- Sponsor
- University of Newcastle, Australia
Hip Osteoarthritis, Hip Disease
MDR - G7 Neutral and G7 Freedom Constrained Neutral Acetabular Liners
The objective of this consecutive series PMCF study is to collect data confirming safety, performance and clinical benefits of the G7 Freedom Constrained Liners when used for primary and revision total hip arthroplasty (implants…
- Conditions
- Hip Osteoarthritis, Hip Disease, Hip Fractures, Hip Injuries
- Trial name
- NCT04093739
- Testing
- G7 Freedom Constrained Liners
- Sponsor
- Zimmer Biomet
Arthroplasty, Hip Revision
Trident II Revision Outcomes Study
The purpose of this study is to review the performance and success rate of an FDA cleared cementless hip replacement part called the Trident II Tritanium Acetabular Shell.
- Trial name
- NCT04317586
- Testing
- Trident II Tritanium Acetabular Shell for Revision
- Where
- 10 sites in United States
- Volunteers
- 17 people
- Sponsor
- Stryker Orthopaedics
Hip Osteoarthritis, Arthroplasty Complications
DELTA Multihole TT Study
A retrospective study evaluating clinical and radiographic early outcomes of total hip arthroplasty and revision hip arthroplasty with DELTA Multihole TT cup.
- Conditions
- Hip Osteoarthritis, Arthroplasty Complications, Hip Dysplasia
- Trial name
- NCT04375345
- Testing
- hip arthroplasty
- Where
- Slovakia
- Volunteers
- 40 people
- Sponsor
- University Hospital Bratislava
PJI, Bone and Joint Infection
Periarticular Penetration of Cefazolin and Clindamycin in Second Stage Revision Arthroplasty of the Hip
To prevent periprosthetic joint infection (PJI), optimal penetration of antibiotics into the joint-space is needed. In revision arthroplasty, the incidence of PJI is increased compared to primary arthroplasty.
- Conditions
- PJI, Bone and Joint Infection, Pharmacokinetics
- Trial name
- CONCENTRATE (NCT05421312)
- Testing
- sampling blood, Sampling synovial fluid, Sampling bone tissue
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Loosening, Prosthesis, Hip Arthropathy
Radiographic Stability of Hip Prosthesis Prior to Revision Surgery
The goal of this validation study is to compare the preoperative implant stability, assessed by Implant Movement Analysis (IMA), provocation dual CT scans, with the intraoperative stability evaluation in revision hip arthoplasty.
- Trial name
- MULTICIMA (NCT06924567)
- Testing
- Implant motion provocation CT
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 600 people
- Sponsor
- Georgios Tsikandylakis, MD PhD