Clinical trials: Arthroplasty
Osteo Arthritis Knee, Psychological Distress
Are Perception of Pain and Psychological Distress Before Knee Arthroplasty Associated With Reason for Revision?
The aim of our study is to identify the influence of preoperative pain (NRS pain score and EQ5D pain score) and higher levels of anxiety and depression (EQ5D anxiety/depression score) and their interaction before primary total…
- Trial name
- NCT05105646
- Testing
- Knee Arthroplasty, knee revision arthoplasty
- Where
- Netherlands
- Volunteers
- 70,754 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Hip Prosthesis Infection, Knee Prosthesis Infection
CERAMENTTM|G and V in the Management of Hip and Knee Arthroplasty Revisions (Revision Arthroplasty Italy)
Open-label, multicentre, prospective cohort, observational clinical trial with a retrospective control group to evaluate the effectiveness and safety of CERAMENTTM| G or V used for filling of bone defects in the tibia and / or…
- Trial name
- NCT03389646
- Testing
- CERAMENT G V
- Where
- Italy
- Volunteers
- 135 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Total Knee Arthroplasty
Single-injection Adductor Canal Block for Total Knee Arthroplasty Under Spinal Anesthesia
This study evaluates the effect of the single-injection adductor canal block in patients receiving total knee arthroplasty under spinal anesthesia.
- Trial name
- NCT04400708
- Testing
- adductor canal block, control group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Arthroplasty, Replacement
Evaluate the Performance of JOURNEY II CR in TKA Populations
Background: The JOURNEY II CR Total Knee System consists of femoral component made from oxidized zirconium (OXINIUM) Purpose: Post-market evidence generation for JOURNEY II CR Total Knee System Objectives: Evaluate the…
- Conditions
- Arthroplasty, Replacement, Knee
- Trial name
- JIICRTKA (NCT04818840)
- Testing
- Resurfaced Patella, Un-resurfaced Patella
- Where
- 8 sites in China, India and 3 more
- Volunteers
- 62 people
- Sponsor
- Smith & Nephew, Inc.
Arthroplasty, Replacement, Knee, Anesthesia, Conduction
Femoral Triangle Block: Early Mobilization and Postoperative Analgesia After Total Knee Arthroplasty
The objective of this trial is to compare the efficacy of three different nerve blocks as an analgesic option after total knee arthroplasty (TKA), based on muscle strength, mobilization and pain.
- Conditions
- Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Pain, Postoperative, Ultrasonography, Interventional
- Trial name
- NCT03518450
- Testing
- Apex Femoral Triangle Block, Femoral Nerve Block, Adductor Canal Block
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Blood Loss
The Efficacy and Safety of Using Tranexamic Acid to Reduce Blood Loss In Simultaneous Bilateral Total Knee Arthroplasty
A randomized, double-blind, single-center and controlled study comparing the efficacy and safety of intravenous administration of tranexamic acid to reduce blood loss in simultaneous bilateral total knee arthroplasty.
- Trial name
- NCT02504125
- Testing
- Tranexamic Acid, Normal saline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
Total Knee Arthroplasty, Anterior Cruciate Ligament Reconstruction
Impact of Crutch Type on Gait and Functional Outcomes Post-knee Surgery
Study withdrawn
- Trial name
- NCT04258917
- Testing
- Study withdrawn
- Sponsor
- University of Calgary
Prosthetic Joint Infection
Diagnostic Utility of a Novel Point-of-Care Test of Calprotectin for Revision Total Knee Arthroplasty
The purpose of this study is to investigate whether there are quantifiable differences in the level of calprotectin in the synovial fluid that allow separation of different modes of joint implant failure (e.g.
- Trial name
- NCT03694925
- Testing
- Calprotectin test
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- The Cleveland Clinic
Osteoarthritis
14022 ATTUNE Cementless RP Clinical Performance Evaluation
The primary objective of this study is to examine the change from pre-operative baseline to two year postoperative functional performance improvement for the ATTUNE primary, cementless TKA RP system as measured with the KOOS…
- Trial name
- NCT02839850
- Testing
- Cementless Total Knee Arthroplasty
- Where
- 20 sites in United States, Austria and 7 more
- Volunteers
- 540 people
- Sponsor
- DePuy Orthopaedics
Diphosphonates
Bisphosphonates Use After Total Joint Arthroplasty
Background Bisphosphonates has been associated with a decreased risk of revision total joint replacements because of its effects on decreased periprosthetic bone loss and prosthetic migration.
- Trial name
- NCT05623540
- Testing
- Bisphosphonates, Combinations
- Where
- Taiwan
- Volunteers
- 27,405 people
- Sponsor
- National Defense Medical Center, Taiwan
Total Knee Arthroplasty, Knee Disease
Observational Study to Evaluate Clinical Performance and Safety in Total Knee Arthroplasty
The aim of this study is to assess the long-term performance and safety of HLS KneeTec cementless and hybrid fixation knee prosthesis when used in standard medical practice.
- Conditions
- Total Knee Arthroplasty, Knee Disease, Total Knee Replacement, Osteo Arthritis Knee
- Trial name
- NCT04872855
- Testing
- patient with knee arthroplasty
- Where
- 3 sites in France
- Volunteers
- 163 people
- Sponsor
- Corin
Total Knee Arthroplasty
Dexamethasone in Total Knee Arthroplasty
The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative…
- Trial name
- NCT05018091
- Testing
- Dexamethasone 4mg, Dexamethasone 8 Mg/mL Injectable Suspension, Dexamethasone 16mg
- Where
- 10 sites in United States
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis
Sigma CR150 Versus Sigma CR Knee RCT
This study will compare two very similar designs of knee replacement device. One device (Sigma CR150) is a slightly modified version of the original (Sigma CR) and has been modified to enhance/accommodate higher flexion.
- Trial name
- NCT01418378
- Testing
- Sigma CR150, Sigma CR
- Where
- 4 sites in India, Singapore and 1 more
- Volunteers
- 191 people
- Sponsor
- DePuy International
Total Knee Arthroplasty
Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural, with or without a femoral nerve block, or FNB.
- Trial name
- NCT01333943
- Testing
- Study Group: Experimental, Control Group
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Hospital for Special Surgery, New York
Acute Pain, Total Hip Arthroplasty
Auricular Acupuncture for Analgesia During Total Hip Arthroplasty
The aim is to investigate whether auricular acupuncture is superior to sham acupuncture in relief of acute pain and in reduction of analgesics in patients during total hip arthroplasty
- Trial name
- NCT00334165
- Testing
- Auricular acupuncture (procedure)
- Where
- 2 sites in Germany
- Volunteers
- 360 people
- Sponsor
- University Medicine Greifswald
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Tranexamic Acid Dosing for Major Joint Replacement Surgery
Over 1.7 million hip and knee replacements are performed every year worldwide. These surgeries are associated with high blood loss and transfusion rates. In older patients, the high blood loss can result in postoperative anemia.
- Trial name
- TXA-Dosing (NCT05075200)
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Sunnybrook Health Sciences Centre
Osteoarthritis, Avascular Necrosis
Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect Reconstruction
The study is a multi-center, prospective, non-controlled, consecutive cohort post market surveillance study. The objective of this study is to obtain survival and clinical outcome data on the Hyperion® system in primary and…
- Conditions
- Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Functional Deformities
- Trial name
- NCT03382665
- Where
- 3 sites in Germany
- Volunteers
- 70 people
- Sponsor
- Zimmer Biomet
Prosthetic-joint Infection
Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty
The goal of this clinical trial is to evaluate whether the investigational drug PLG0206 can help reduce recurrence of infection in adults who have undergone total knee replacement and are receiving a DAIR (Debridement…
- Trial name
- RETAIN (NCT07214311)
- Testing
- PLG0206
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 240 people
- Sponsor
- Peptilogics
Knee Arthropathy
Ligament Tension Measurement in Knee Arthroplasty
1. To develop a new type of knee joint pressure detection device and demonstrate its feasibility 2. To analyze individual differences of knee ligament tension using the new device and explore the influencing factors of ligament…
- Trial name
- NCT05583630
- Testing
- A gap plate with the function of knee joint pressure detection
- Where
- China
- Volunteers
- 110 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Knee Arthroplasty
Hospital for Special Surgery Knee Arthroplasty Cohort
Total joint replacements are some of the most successful medical devices developed over the last fifty years. They enable millions of people to remain ambulatory and pain free, with minimal risk.
- Trial name
- NCT00454467
- Testing
- Baseline Questionnaire, Operative Data, Intra-operative data will be collected post-operatively
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Hospital for Special Surgery, New York
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