Clinical trials: Arthroplasty Replacement, Knee
Knee Osteoarthritis
Development and Improvement of an Acceptance and Commitment-based Treatment for the Prevention of Chronic Pain After Total Knee Arthroplasty
Reducing the incidence of chronic post-surgical pain after Total Knee Arthroplasty (TKA) is paramount. NOPAIN, a technology-enhanced Acceptance and Commitment-based treatment, will be developed, tested and improved for this…
- Trial name
- NOPAIN (NCT05769998)
- Testing
- Acceptance and Commitment-based treatment, Treatment as usual
- Where
- Italy
- Volunteers
- 210 people
- Sponsor
- Istituto Auxologico Italiano
Arthroplasty, Replacement, Knee
Fitbit and Social Support in Knee Replacement Patients & Buddies
Patients undergoing knee replacement typically report improved health-related quality of life, increased physical function, and reduced pain.
- Trial name
- NCT03037619
- Testing
- Fitbit, Fitbit+Support
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Osteoarthritis
Medacta GMK Sphere® Multicenter Post-Market Outcomes Study
This study is to average Forgotten Knee Score (FJS) of those patients receiving the Medacta GMK Sphere® knee at the two and five year time points.
- Trial name
- NCT02501733
- Testing
- Medacta GMK Sphere® Medial Knee Prosthesis
- Where
- 5 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Medacta USA
Knee Osteoarthritis, Total Knee Arthroplasty\(TKA\)
Comparison of Image Based Robotic Total Knee Arthroplasty vs Imageless Augmented Reality Assisted Total Knee Arthroplasty
This study compares the accuracy of two different techniques in placing a total knee replacement. In one technique, accurate instrument placement is facilitated by a robot, and in the other technique, augmented reality is used…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty\(TKA\), Total Knee Replacement Surgery
- Trial name
- RobAR (NCT06891807)
- Testing
- Robotics Assisted TKA, Augmented Reality assisted TKA
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Medisch Centrum Latem
Osteoarthritis, Knee, Total Knee Replacement
Cooling of the Knee After Total Knee Arthroplasty
This study investigates whether cooling the knee after total knee replacement surgery can reduce pain and improve early recovery.
- Trial name
- NCT07416721
- Testing
- Cool Down Liquid with Bandage ( CoolDown, CH), Ice package cooling system, Standard Postoperative Protocol Without Cooling
- Where
- Serbia
- Volunteers
- 99 people
- Sponsor
- Clinical Center of Vojvodina
Knee Osteoarthristis
Skeletal Muscle Atrophy and Dysfunction Following Total Knee Arthroplasty
Total knee replacement, or arthroplasty, is the final clinical intervention available to relieve pain and functional limitations related to advanced stage knee osteoarthritis.
- Trial name
- NCT03051984
- Testing
- Neuromuscular electrical stimulation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Osteoarthritis
Effective Rehabilitation of Patients Operated With Total Knee Arthroplasty
The purpose of this study is to investigate the effect of maximal strength training (MST) compared to standard rehabilitation in patients operated with total knee arthroplasty.
- Trial name
- NCT01877733
- Testing
- Maximal strength training
- Where
- Norway
- Volunteers
- 41 people
- Sponsor
- Norwegian University of Science and Technology
Hip Arthropathy Associated With Other Conditions
Socio-professional Categories and Return to Work After Hip or Knee Replacement Surgery
A significant proportion of patients (15 to 45%) who have benefited from a total hip or knee replacement surgery (THKA), are put on sick leave (SL).
- Trial name
- ARRET-Pro (NCT04262908)
- Testing
- Telephone call
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Knee Osteoarthritis, Pain, Postoperative
NOCTURNAL PAIN After Knee Arthroplasty : Incidence and Risk Factor: an Observational Study
In prosthetic knee surgery, there is a certain number of patients with post-operative nocturnal pain. The purpose of our study is to determine the impact of this problem and to better understand its risk factors.
- Conditions
- Knee Osteoarthritis, Pain, Postoperative, Prosthesis (Internal) Complications, Nocturnal Frequency
- Trial name
- NOCTURN-PAIN (NCT03998943)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Arthropathy of Knee Joint
Postoperative Pain Management in Hospital and Following Discharge From Hospital.
To investigate postoperative pain management in patients undergoing knee or hip replacement while they are in the hospital and following discharge to their home.
- Trial name
- NCT01907178
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Trinity Health Of New England
Postoperative Pain, Recovery
COMPARISON OF THE EFFECT OF DISTAL ADDUCTOR CANAL BLOCK COMBINED WITH GENICULAR NERVE BLOCK OR PERIARTICULAR INJECTION ON POSTOPERATIVE QOR-15 IN TOTAL KNEE ARTHROPLASTIES
Objective: This study compares the effects of genicular nerve block (GNB) and periarticular injection (PAI), added to distal adductor canal block (ACB), on postoperative recovery quality (QoR-15), morphine use, and pain scores…
- Trial name
- NCT07077720
- Testing
- genicular nerve block, periarticular injection, Addukctor canal block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Arthroplasty, Replacement, Knee, Anesthesia, Conduction
Femoral Triangle Block: Early Mobilization and Postoperative Analgesia After Total Knee Arthroplasty
The objective of this trial is to compare the efficacy of three different nerve blocks as an analgesic option after total knee arthroplasty (TKA), based on muscle strength, mobilization and pain.
- Conditions
- Arthroplasty, Replacement, Knee, Anesthesia, Conduction, Pain, Postoperative, Ultrasonography, Interventional
- Trial name
- NCT03518450
- Testing
- Apex Femoral Triangle Block, Femoral Nerve Block, Adductor Canal Block
- Where
- Spain
- Volunteers
- 78 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Arthritis, Obesity & Overweight
GLP-1s in Hip and Knee Arthroplasty
The number of people living with hip and knee arthritis continues to grow. A large amount of these people are also overweight and diagnosed with obesity.
- Conditions
- Arthritis, Obesity & Overweight, GLP - 1
- Trial name
- NCT07755085
- Testing
- GLP-1 Receptor Agonists + Behavioral modification
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Nova Scotia Health Authority
Total Knee Arthroplasty
Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Currently, the regional anesthetic standard of care for total knee replacement surgery is combined spinal/epidural, with or without a femoral nerve block, or FNB.
- Trial name
- NCT01333943
- Testing
- Study Group: Experimental, Control Group
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Hospital for Special Surgery, New York
Postoperative Pain, Analgesia
Evaluation of Dexketoprofen in Total Knee Arthroplasty
Pain is a global public health issue and represents the most common reason for both physician consultation and hospital admissions. Dexketoprofen is a new NSAID treating acute postoperative pain.
- Trial name
- NCT04161690
- Testing
- Dexketoprofen Trometamol, Ropivacaine Hydrochloride 7.5 MG/ML
- Where
- Greece
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KAT General Hospital
Arthroplasties, Replacement, Knee
Stryker Triathlon Total Knee System for Total Knee Arthroplasty Implanted Using Shapematch Cutting Guides:Sub-Study A
This is a prospective, non-randomized, study of the clinical outcomes of participants that receive the Stryker Triathlon® Total Knee System for Total Knee Arthroplasty implanted using ShapeMatch® Cutting Guides.
- Trial name
- NCT02516163
- Testing
- Shapematch Cutting Guides
- Volunteers
- 55 people
- Sponsor
- Stryker South Pacific
Total Knee Arthroplasty Recovery
Effects of Progressive Restricted Blood Flow Exercises in Post Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a commonly performed procedure for advanced knee osteoarthritis. Despite successful surgery, many patients experience postoperative impairments including pain, reduced range of motion (ROM)…
- Trial name
- TKA PBFR (NCT07601906)
- Testing
- Blood Flow Restriction Exercises and Conventional Physical Therapy, Conventional Physical Therapy alone
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Venous Thromboembolism
Xarelto for VTE Prophylaxis After Hip or Knee Arthroplasty
The main goal is to provide additional information to the risk-benefit assessment of the drug.
- Trial name
- XAMOS (NCT00831714)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Standard care treatment for VTE prophylaxis
- Where
- 42 sites in Australia, Austria and 40 more
- Volunteers
- 19,076 people
- Sponsor
- Bayer
Obesity, Osteoarthritis
Surgical Weight-Loss to Improve Functional Status Trajectories Following Total Knee Arthroplasty (SWIFT Trial)
The purpose of the SWIFT Trial is to answer two research questions. 1. Does bariatric surgery before total knee arthroplasty (TKA) improve both perioperative and long-term outcomes of TKA in extreme obesity? 2.
- Trial name
- SWIFT (NCT02598531)
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Geisinger Clinic
Knee Osteoarthritis
Electroacupuncture Treatment for Those With End Stage Knee Osteoarthritis on a Total Knee Arthroplasty Waitlist
A 3-armed pilot randomized controlled trial: electroacupuncture, sham acupuncture and waitlist groups.
- Trial name
- NCT05374330
- Testing
- Electroacupuncture
- Where
- Canada
- Sponsor
- University of Manitoba
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