Clinical trials: Articular Disease
Osteoarthritis, Knee, Arthroscopy
Evaluating the Effectiveness of Subchondroplasty for Treating Bone Marrow Lesions of the Knee
The primary objective of this randomized pilot study is to evaluate whether subchondroplasty combined with knee arthroscopy is more effective at reducing knee pain and improving knee function compared to knee arthroscopy alone.
- Conditions
- Osteoarthritis, Knee, Arthroscopy, Musculoskeletal Disease, Bone Marrow Edema
- Trial name
- NCT03699046
- Testing
- Subchondroplasty and Knee Arthroscopy, Knee Arthroscopy Alone, Subchondroplasty
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- University of Calgary
Rheumatoid Arthritis
Phase Ⅰ Clinical Trial of Gerilimzumab Injection in Healthy Subjects
The primary objectives of this study are to evaluate the safety, tolerability and pharmacokinetic (PK) profiles of single-dose, dose-escalated, abdominal subcutaneous injection of GB224 in Chinese healthy adult subjects.
- Trial name
- NCT04178070
- Testing
- GB224 2mg, GB224 5mg, GB224 10mg
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Genor Biopharma Co., Ltd.
Osteoarthritis, Knee
Outcome Comparison of Two Total Knee Arthroplasty Systems: e.Motion-Pro Versus Genesis II
Recently, E.Motion-PS-Pro (B.Braun-Aesculap, Tuttlingen, Germany), a new mobile bearing knee system with a unique ball and socket post-cam mechanism was developed for use in total knee arthroplasty.
- Trial name
- NCT02276118
- Testing
- device: e.motion PS Pro, device : Genesis II
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Total Knee Arthroplasty Guidance Systems Study
In total knee replacement operations, the surgeon uses techniques and instruments to guide the operation and ensure that all parts of the prosthesis (the artificial knee surfaces) are placed into the correct position.
- Trial name
- NCT02830997
- Testing
- Stereotactic guidance system
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ormonde M. Mahoney, MD
Knee Osteoarthritis
Long-term Study of The Press Fit Condylar (P.F.C.) Sigma Total Knee Replacement System
The main purpose of this study is to record information from clinical and radiographic examinations and patient assessment questionnaires before surgery and at suitable postoperative intervals to assess the functioning and…
- Trial name
- NCT00734110
- Testing
- P.F.C. Sigma Total Knee System
- Where
- United Kingdom
- Volunteers
- 723 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Live and Interactive Fitness Training Program (Vivo Knee OA)
Potential participants will be screened at clinic. Patients who meet eligibility criteria will be considered for study. After written informed consent is obtained, participants will complete baseline testing and participants who…
- Trial name
- LIFT-OA (NCT06462560)
- Testing
- Vivo Online Exercise Program, Medbridge Home program
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- Intermountain Health Care, Inc.
Knee Osteoarthritis
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis
To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.
- Trial name
- NCT05398874
- Testing
- Ginkgo biloba extract + standard treatment( paracetamol+Diclofenac100mg SR)
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Kufa University
Rhizolysis, Diagnosis of Facet Joint Origin Lumbago
Determination of Predictive Clinical Signs of Effective Rhizolysis Using the DFL Questionnaire.
Rhizolysis or lumbar thermocoagulation is a therapeutic proposal for certain types of chronic lower back pain that is resistant to medical treatment and outside the field of surgical indications.
- Trial name
- Rhizolyse (NCT04118218)
- Testing
- Rhizolysis pain analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Comparative Study of Total Knee Arthroplasty Using a Customized-patient Specific Instrument System.
Patient-specific instrumentation (PSI) has been introduced in total knee arthroplasty (TKA) as a new technology for improving accuracy in restoration of the alignment and biomechanics of the lower limb.
- Trial name
- NCT02500160
- Testing
- Patient specific instrumentation (MRI), Patient specific instrumentation (CT)
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kyung Hee University Hospital at Gangdong
Rheumatoid Arthritis
An Open-Label Extension Study Assessing the Long-Term Efficacy and Safety of ALX-0061 in Subjects With Rheumatoid Arthritis
This was a multicenter, open-label extension (OLE) Phase II study designed to evaluate the long-term efficacy and safety of ALX-0061 (i.e., vobarilizumab) administered subcutaneously (s.c.) in subjects with active rheumatoid…
- Trial name
- NCT02518620
- Testing
- ALX-0061
- Where
- 57 sites in Belgium, Bulgaria and 10 more
- Volunteers
- 406 people
- Sponsor
- Ablynx, a Sanofi company
Inflammatory Arthritis
Abatacept in Individuals Who aRe Considered At Risk of Developing Inflammatory Arthritis
Phase II, single-centre, open label, two parallel arm cohort randomised controlled trial (RCT) testing abatacept in a population of anti-CCP Ab positive individuals at moderate to high risk of developing IA according to a…
- Trial name
- ARCADIA (NCT04261023)
- Testing
- Orencia 125 MG Per 1 ML Prefilled Syringe
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University of Leeds
Patella Subluxation, Patellofemoral Pain Syndrome
Translation, Cross-cultural Validity and Reliability of a Danish Version of the Anterior Knee Pain Scale
The Anterior Knee Pain Scale (Kujala) is a questionnaire designed to assess adults with patellofemoral disorders and is widely used in both anterior knee pain and patellar dislocation patients.The questionnaire is a…
- Trial name
- Kujala-DK (NCT06257862)
- Where
- Denmark
- Volunteers
- 130 people
- Sponsor
- Aarhus University Hospital
Rheumatoid Arthritis
A Study to Observe Characteristics of Rheumatoid Arthritis in Patients Using Infliximab (Study P04250)
This 14-week non-interventional study will observe patients with rheumatoid arthritis (RA) who are being treated with infliximab for the first time, in order to learn about their disease characteristics.
- Trial name
- REMARK (NCT00705289)
- Testing
- Infliximab
- Volunteers
- 728 people
- Sponsor
- Merck Sharp & Dohme LLC
Knee Osteoarthritis, Osteoarthritis
Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis
This study is designed to evaluate the effects of intra-articular injections of polyacrylamide hydrogel (Arthrosamid®) in patients with knee osteoarthritis.
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteoarthritis of the Knee, Degenerative Joint Disease of the Knee
- Trial name
- HYDRO-KNEE (NCT07193368)
- Testing
- Polyacrylamide hydrogel 2.5% intra-articular injection
- Where
- Turkey (Türkiye)
- Volunteers
- 387 people
- Sponsor
- Feza Korkusuz MD
Rheumatoid Arthritis
A Study of Japanese Rheumatoid Arthritis Participants
The objective of this study is to evaluate the safety and tolerability of 48 weeks subcutaneous (SC) dosing with LY2127399 for participants who have participated in a prior LY2127399 clinical study.
- Trial name
- NCT01253291
- Testing
- LY2127399
- Where
- 9 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Eli Lilly and Company
Osteoarthritis, Knee, Osteoarthritis
Intra-articular Pulsed Radiofrequency in Chronic Knee Pain
The aim of this study is to investigate the additional effect of Intra-articular Pulsed Radiofrequency (IAPRF) on pain and functional activities in addition to intra-articular steroids in patients with grade II and III knee…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Pain, Chronic
- Trial name
- NCT06017674
- Testing
- Intra-articular Pulsed Radiofrequency, Steroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Knee Osteoarthritis
Strengthening Program for Foot-ankle Muscles in People With Knee Osteoarthritis
The main objective of this trial is To evaluate the effect of an ankle and foot muscle strengthening program on pain, analgesic consumption, functionality, and lower limb biomechanics during gait in individuals with knee…
- Trial name
- NCT04154059
- Testing
- Intervention Group
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Sao Carlos
Osteoarthritis
Effect of Genicular Nerve Block on Proprioception in Knee Osteoarthritis
The study was conducted to investigate the effect of genicular nerve block on pain, quality of life, and proprioception, which are already diminished due to the impact of osteoarthritis in individuals with knee osteoarthritis.
- Trial name
- NCT06744842
- Testing
- genicular nerve block, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara City Hospital Bilkent
Arthritis, Rheumatoid
Study To Evaluate The Response To Enbrel And The Impact Of Rheumatoid Factor(RF) And Anti-Cyclic Citrullinated Peptide(Anti-CCP) In Rheumatoid Arthritis(RA) Patients
This study is to evaluate available local data in Iraqi patients with rheumatoid arthritis on Enbrel treatment with regards to the impact of Rheumatoid factor and Anti-cyclic citrullinated peptide using data from the Baghdad…
- Trial name
- NCT04428424
- Testing
- Enbrel
- Where
- Iraq
- Volunteers
- 1,493 people
- Sponsor
- Pfizer
Osteoarthritis of the Knee
Effect Of Meloxicam Versus Placebo In Mainland Chinese Patients With Osteoarthritis Of The Knee
This study is to validate the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) tool in mainland Chinese patients with osteoarthritis of the knee .
- Trial name
- NCT01430559
- Testing
- Meloxicam
- Where
- 25 sites in China
- Volunteers
- 408 people, healthy volunteers welcome
- Sponsor
- Pfizer
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