Clinical trials: Articular Disease
Rheumatoid Arthritis (RA
A Study of Iguratimod in Combination With Tofacitinib in RA Patients
Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease characterized by synovitis, which can cause joint pain, deformity, and extra-articular symptoms, seriously affecting the quality of life and lifespan…
- Trial name
- NCT06945666
- Testing
- Combined therapy of Iguratimod and tofacitinib
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jie Chang
Osteoarthritis
Home Telerehabilitation for Deconditioned Older Adults
The purpose of this study is to develop a home exercise program for patients 60 years of age and over who are deconditioned following their discharge from the hospital, or recruited from GLA outpatient clinics.
- Trial name
- NCT00386256
- Testing
- Health Buddy, Home telehealth technology, Telephone counseling
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- US Department of Veterans Affairs
Ankylosing Spondylitis
Galectin-3 Level in Ankylosing Spondylitis Patients
Forty-five AS patients and 35 healthy controls were enrolled in this study. Patients diagnosed with AS according to Modified New York criteria were included in the study.
- Trial name
- NCT04746196
- Testing
- Serum galectin-3 concentration was measured.
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Pain, Osteoarthritis
Adductor Canal Block With Posterior Capsular Injection for Total Knee Replacement
To compare early ambulation and ability to participate in rehabilitation in patients undergoing total knee replacement using two different nerve block techniques for pain control.
- Trial name
- NCT01805661
- Testing
- Canal Block and Capsular Injection, Femoral with Tibial Nerve Block
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Trinity Health Of New England
Joint Disease
Post Market Clinical Follow-Up Study Protocol for CONSERVE® Press-Fit Femoral Components
MicroPort Orthopedics (MPO) is conducting this PMCF study to evaluate the safety and efficacy of its THA and resurfacing components marketed in the EU.
- Trial name
- NCT02285842
- Testing
- Primary hip resurfacing device
- Where
- Canada
- Volunteers
- 143 people
- Sponsor
- MicroPort Orthopedics Inc.
Gout, Hyperuricemia
Safety and Efficacy Study of Intravenous Uricase-PEG 20
The purpose of this study is to assess the safety, pharmacokinetics and pharmacodynamics of single intravenous doses of Uricase-PEG 20.
- Trial name
- NCT01021241
- Testing
- Uricase-PEG 20
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- EnzymeRx
Rheumatoid Arthritis
Italian Registry of Arthritis on Biologic Therapy
The biologic drugs targeting TNFa, IL-6, IL-1, T cells, B cells have represented a fundamental discovery to treat rheumatic patients whose disease appears to be refractory to conventional therapy.
- Trial name
- GISEA (NCT01543594)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Gruppo Italiano Studio Early Arthritis
Rheumatoid Arthritis
Safety Study of Abatacept to Treat Rheumatoid Arthritis
The purpose of this study is to compare the incidence rates of infection, malignancy and death among patients with rheumatoid arthritis who are treated with abatacept and those who are treated with other anti-rheumatic…
- Trial name
- NCT01247766
- Volunteers
- 6,367 people
- Sponsor
- Bristol-Myers Squibb
Osteoarthritis
A Study on Rosa Roxburghii for Knee Replacement Recovery
This clinical trail is to investigates the effect of Rosa roxburghii juice freeze-dried powder on the recovery of patients undergoing total knee arthroplasty due to knee osteoarthritis.
- Trial name
- NCT07395856
- Testing
- Rosa roxburghii
- Volunteers
- 184 people
- Sponsor
- Shuguang Gao
Ankylosing Spondylitis
Dose Ranging Study to Evaluate the Efficacy and Safety of SAR153191 (REGN88) in Patients With Ankylosing Spondylitis
Primary objective: to evaluate the efficacy of Sarilumab in participants with Ankylosing Spondylitis (AS) using the assessment in AS working group criteria (ASAS) 20% response criteria (ASAS20) Secondary objectives: to…
- Trial name
- ALIGN (NCT01061723)
- Testing
- Sarilumab
- Where
- 80 sites in United States, Australia and 12 more
- Volunteers
- 301 people
- Sponsor
- Sanofi
Hip Arthropathy
Anterior Iliopsoas Muscle Space Block Versus Supra-iliac Anterior Quadratus Lumborum Block in Total Hip Arthroplasty
Approximately 1.66 million hip fractures happen in a year worldwide. About 95% of these fractures happen in individuals older than 60 years.
- Trial name
- NCT05556759
- Testing
- control, IPS, Supra-iliac QL
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Zagazig University
Rotator Cuff-related Shoulder Pain, Shoulder Osteoarthritis
Could a Feedback Device Help Manage Work-related Shoulder Disorders?
Work-related shoulder pain is a common problem with significant socio-economic repercussions. The impact of these disorders on workers is considerable, particularly in terms of pain, disability and reduced quality of life.
- Conditions
- Rotator Cuff-related Shoulder Pain, Shoulder Osteoarthritis, Rheumatoid Arthritis (RA)
- Trial name
- NCT06693479
- Testing
- Shoulder watch load (SWL) feedback, Education
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Laval University
Rheumatoid Arthritis
The AMPK Modulator Metformin as a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Patients
Metformin, a traditional antidiabetic medication, exerts glucose lowering effects by activating AMP-activated protein kinase (AMPK), a critical enzyme involved in the lipid and glucose metabolism.
- Trial name
- NCT04068246
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sadat City University
High Intensity Laser, Shoulder Impingement Syndrome
Effect of High Intensity Laser on Shoulder Impingement.
Treatment for shoulder impingement is conservative initially, Rehabilitation programs generally consist of exercise therapy and manual therapy that provide relief from symptoms of impingement.
- Conditions
- High Intensity Laser, Shoulder Impingement Syndrome, Shoulder Pain
- Trial name
- lasershoulder (NCT06732570)
- Testing
- high intensity laser, manual therapy, exercise therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Hallux Rigidus
Efficacy of First MTPJ Arthrodesis as a Treatment in Hallux Rigidus
A randomised, controlled trial will be performed by allocating 40 years or older patients with symptomatic hallux rigidus to arthrodesis or watchful waiting group in a ratio of 1:1.
- Trial name
- HARD (NCT04590313)
- Testing
- Arthrodesis
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Knee Osteoarthritis
Strength Training for ARthritis Trial
The primary purpose of this study is to compare the effects of a high and low intensity strength training programs vs. a control group on knee pain and compressive joint forces.
- Trial name
- START (NCT01489462)
- Testing
- High Intensity Strength Training, Low Intensity Strength Training, Attention Control
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- Wake Forest University
Dry Eye Syndrome, Sjogren's Syndrome
VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren's Syndrome
To evaluate the Chinese herbal tea VGH-DESJS-1 in ocular and oral dryness symptoms of Dry eye syndrome and Sjögren's syndrome
- Conditions
- Dry Eye Syndrome, Sjogren's Syndrome, Xerophthalmia
- Trial name
- NCT05656196
- Testing
- Chinese herbal tea VGH-DESJS-1
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Rheumatoid Arthritis
A Study is to Assess Efficacy and Safety of Tacrolimus in Active Rheumatoid Arthritis Patients Who Showed Unsuccessful Response to Existing Disease Modifying Antirheumatic Drugs (DMARDs)
This study is to assess efficacy and safety of tacrolimus in active rheumatoid arthritis patients who showed unsuccessful response to existing DMARDs.
- Trial name
- TREASURE (NCT01511003)
- Testing
- Tacrolimus
- Where
- 4 sites in South Korea
- Volunteers
- 128 people
- Sponsor
- Astellas Pharma Inc
Sacroiliac Joint Dysfunction
Effect of High Power Pain Threshold Ultrasound on Postnatal Sacroiliac Joint Pain
This study will be conducted to investigate the effect of high-power pain threshold ultrasound on postnatal sacroiliac joint pain.
- Trial name
- NCT06820827
- Testing
- Myofascial release, High-power pain threshold ultrasound
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Cairo University
Necrosis of Femoral Head, Knee Osteoarthritis
MRI Maker of Perioperative Neurocognitive Disorder
Periperative neurocognitive disorder(PND) is consistently associated with increased morbidity and mortality, but its mechanisms remain unclear.
- Conditions
- Necrosis of Femoral Head, Knee Osteoarthritis, Fracture of Lower Limb
- Trial name
- MRIPND (NCT03773627)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
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