Clinical trials: Articular Disease
Femoroacetabular Impingement Syndrome
Exercise Therapy for Femoroacetabular Impingement Syndrome
The aim of the clinical trial is to investigate the characteristics of patients, who respond vs. not respond to exercise therapy for the nonsurgical management of femoroacetabular impingement syndrome (FAIS).
- Trial name
- SWEaT (NCT04502043)
- Testing
- Exercise therapy
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Schulthess Klinik
Ankylosing Spondylitis
An Open-Label Multicentre Long-Term Extension Study of Etanercept for Ankylosing Spondylitis
This study is an extension trial of 0881A3-312-EU and is designed to provide information on the safety and efficacy of etanercept in patients with ankylosing spondylitis for up to 3 additional years.
- Trial name
- NCT00444340
- Testing
- Enbrel (Etanercept)
- Volunteers
- 70 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Rheumatoid Arthritis
Evaluation of the Effectiveness and Safety of Two Dosing Regimens of Olokizumab (OKZ), Compared to Placebo, in Subjects With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate But Have Active Disease
The purpose of this study was to determine how effective and safe the study drug Olokizumab was in patients with Rheumatoid Arthritis (RA) who had been already receiving, but not fully responding to treatment with methotrexate…
- Trial name
- CREDO 1 (NCT02760368)
- Testing
- Olokizumab
- Where
- 40 sites in Belarus, Bulgaria and 1 more
- Volunteers
- 428 people
- Sponsor
- R-Pharm International, LLC
Rheumatoid Arthritis (RA) and Sjögren's Disease (SjD)
A Study to Assess Safety, Cellular Kinetics and Exploratory Efficacy of Rapcabtagene Autoleucel in Rheumatoid Arthritis and Sjogren's Disease
A study to assess safety, cellular kinetics and exploratory efficacy of rapcabtagene autoleucel in rheumatoid arthritis and Sjogren's disease
- Trial name
- NCT07048197
- Testing
- Rapcabtagene autoleucel
- Where
- 12 sites in France, Germany and 2 more
- Volunteers
- 27 people
- Sponsor
- Novartis Pharmaceuticals
Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA
A Multicenter, Postmarketing Study Evaluating the Concentration of Cimzia® in Mature Breast Milk of Lactating Mothers
The primary objectives of this study are to assess whether there is transfer of Certolizumab Pegol (CZP) into breast milk of lactating mothers who are receiving an established dosing regimen of CZP by evaluating the concentration…
- Conditions
- Axial Spondyloarthritis (AxSpA), Non-radiographic Evidence-AxSpA, Ankylosing Spondylitis, Crohn's Disease
- Trial name
- CRADLE (NCT02154425)
- Testing
- Breast milk sampling, Certolizumab Pegol
- Where
- 6 sites in United States, Netherlands and 1 more
- Volunteers
- 17 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Anti-CCP Positive Early Rheumatoid Arthritis
Effect Assessment of Periodontal Prophylaxis on Rheumatoid Arthritis Activity.
The purpose of this study is to assess the impact of an intervention (scaled every 06 months associated with the use of mouthwash with essential oils (toothpaste and Listerine® 2 times / day containing polymer Triclosan (Colgate…
- Trial name
- BHYRRA (NCT01706874)
- Testing
- Periodontal prophylaxis
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Interstitial Lung Disease with Progressive Fibrotic Phenotype in Diseases Classified Elsewhere, Systemic Sclerosis Pulmonary
Home Based Clinical Management of Interstitial Lung Disease in Systemic Rheumatic Diseases
The RMD-mILDer trial is a home monitoring strategy trial aiming to improve management of interstitial lung disease related to rheumatic diseases applying eHealth technology.
- Conditions
- Interstitial Lung Disease with Progressive Fibrotic Phenotype in Diseases Classified Elsewhere, Systemic Sclerosis Pulmonary, Dermatomyositis, Rheumatoid Arthritis
- Trial name
- RMD-mILDer (NCT06732674)
- Testing
- A home monitoring strategy with event driven management
- Where
- Norway
- Volunteers
- 218 people
- Sponsor
- Oslo University Hospital
Knee Osteoarthritis
To Evaluate the Performance and Safety of the Medical Device IRADYN in Subjects With Osteoarthritis of the Knee
The benefits of single or repetitive administration (1 to 6) can have similar result in terms of muscular strength and patients' quality of life improvement, benefiting of the advantages of polymerized polynucleotides (IRADYN)…
- Trial name
- IRADYN (NCT05206474)
- Testing
- IRADYN
- Where
- 2 sites in Romania
- Volunteers
- 50 people
- Sponsor
- I.R.A. Istituto Ricerche Applicate S.p.A.
Joint Diseases, Arthritis Knee
Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA
Osteoarthritis is the most common cause of chronic joint disease, and its incidence has increased due to the high average life expectancy, in addition to the high incidence of obesity.
- Conditions
- Joint Diseases, Arthritis Knee, Arthroplasty Complications
- Trial name
- NCT05696418
- Testing
- Total knee arthroplasty with a Mobile Bearing system., Total knee arthroplasty with a Fixed Bearing system.
- Where
- Syria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Damascus University
Metabolic Syndrome, Osteoarthritis, Hip
Effects of a Clinical Dietary Intervention During Inpatient Treatment
The purpose of the study is a scientific and prospective documentation of the clinical effects of an inpatient treatment at the Immanuel Hospital of Berlin, in the department for complementary and integrative medicine, with the…
- Conditions
- Metabolic Syndrome, Osteoarthritis, Hip, Osteoarthritis, Knee, Rheumatoid Arthritis
- Trial name
- FASTA (NCT03785197)
- Testing
- Prolonged modified fasting
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Charite University, Berlin, Germany
Osteoarthrosis
A Comparison of Two Total Hip Replacements: Hip Resurfacing System Versus Mallory-Head/Exeter
The purpose of this study is to compare two total hip replacement systems: Hip Resurfacing System (ReCap) versus Mallory-Head/Exeter.
- Trial name
- NCT00116948
- Testing
- ReCap, Hip resurfacing system, Biomet
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Plaque Psoriasis, Psoriatic Arthritis
Real-World Study of Xeligekimab for Moderate to Severe Plaque Psoriasis(XP-Real)
Xeligekimab Injection was approved in China on August 20, 2024, for treating adults with moderate to severe plaque psoriasis who are candidates for systemic treatment or phototherapy.
- Conditions
- Plaque Psoriasis, Psoriatic Arthritis, Scalp Psoriasis, Nail Psoriasis
- Trial name
- NCT06802848
- Testing
- Xeligekimab injection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chongqing Genrix Biopharmaceutical Co., Ltd
Arthritis, Rheumatoid
The Clinical Efficacy of Immunomodulators in RA Patients
This study includes naive patients and csDMARDs-IR RA patients, treated with different regimens such as Iguratimod combination of different csDMARDs, or csDMARD with TNF inhibitors for 24 weeks.
- Trial name
- NCT05626348
- Testing
- Iguratimod, Methotrexate, Adalimumab Injection
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Qilu Hospital of Shandong University
Hip Developmental Dysplasia
Effect of Cross-legged Sitting Among Patients With Unilateral Hip Developmental Dysplasia
One of the most common infant developmental diseases is Hip dysplasia which is mostly seen among female' babies and leads to hip instability due to partial or full hip dislocation [1].
- Trial name
- NCT07002840
- Testing
- Cross- legged sitting position, Physical Therapy Rehabilitation Program
- Volunteers
- 16 people
- Sponsor
- Jouf University
Sjögren's Disease
a Salivary Cell-free RNA Liquid Biopsy Model for Non-invasive Diagnosis in Sjögren's Disease
The goal of this observational study is to learn whether salivary cell-free RNA (cfRNA) can be used as a non-invasive liquid biopsy test to help diagnose Sjögren's disease (SjD) and understand disease-related changes in the…
- Trial name
- cell-free RNA (NCT07824440)
- Where
- China
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Rheumatoid Arthritis, Pregnancy Related
Treatment of Pregnancy RA
It is important to control the disease of pregnant women with rheumatoid arthritis to ensure the fetal and maternal health. Frequent disease flare can increase the risk of adverse pregnancy outcomes, including abortion, premature…
- Trial name
- NCT04569890
- Testing
- Certolizumab Pegol 200 MG/ML [Cimzia], Hydroxychloroquine, Prednisone
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Axial Spondyloarthritis
The Effect of Exercise on Disease Activity and Cardiovascular Risk for Patients With Axial SpondyloArthritis
The overall aim of this multicenter randomised controlled trial (RCT) is to investigate if exercise can modify the disease course and prevent comorbidity in patient with spondyloarthritis (SpA).
- Trial name
- ESpA (NCT02356874)
- Testing
- Exercise
- Where
- 4 sites in Norway, Sweden
- Volunteers
- 100 people
- Sponsor
- Diakonhjemmet Hospital
Crohn Disease, Ulcerative Colitis
Expanded Access to Upadacitinib
This is an expanded access program (EAP) for eligible participants. This program is designed to provide access to upadacitinib prior to approval by the local regulatory agency. Availability will depend on territory eligibility.
- Conditions
- Crohn Disease, Ulcerative Colitis, Idiopathic Arthritis (Including sJIA, pJIA, or JPsA), Atopic Dermatitis
- Trial name
- NCT04159597
- Testing
- Upadacitinib
- Sponsor
- AbbVie
Gout
Combining Lesinurad With Allopurinol in Inadequate Responders
This study that compare the serum uric acid lowering effects, clinical benefits, and safety of lesinurad in combination with allopurinol to allopurinol alone in subjects with gout who have had an inadequate response to…
- Trial name
- CLEAR 1 (NCT01510158)
- Testing
- Lesinurad, Allopurinol
- Where
- 165 sites in United States
- Volunteers
- 607 people
- Sponsor
- Ardea Biosciences, Inc.
Osteoarthritis
Safety of Diclofenac Sodium Gel in Knee Osteoarthritis
This study will test the efficacy and safety of topical Voltaren in the treatment of knee osteoarthritis.
- Trial name
- NCT00171691
- Testing
- Diclofenac Topical Sodium Gel 1%
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Novartis
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