Clinical trials: Articular Disease
Cartilage Diseases
Molecular Biomarkers Associated With Degenerative Joint Disease in the Knee
This investigation describes a novel complex of structural degradation proteins that is associated with pain in individuals with meniscal pathology undergoing arthroscopic partial meniscectomy.
- Trial name
- NCT01006278
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Scuderi, Gaetano J., M.D.
Knee Osteoarthritis
Evaluation of Functional Improvement After Spa Therapy in Fontcaude Center
Evaluation of functional improvement after spa therapy in Fontcaude center, for knee osteoarthritis Background. Knee osteoarthritis is the first indication of spa therapy in rheumatology.
- Trial name
- FONTCAUDE (NCT03289078)
- Testing
- Spa Treatment
- Sponsor
- University Hospital, Montpellier
Rheumatic Arthritis
Exercise Training and Knee Joint Proprioception in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic disorder that affects 0.5% to 1% of adults and is the result of an autoimmune attack against joint tissues.
- Trial name
- NCT06887725
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Aysima Barlak
Osteoarthritis, Osteoarthritis, Knee
A Study to Evaluate the Efficacy, Safety and Tolerability of EVI-01 Intra-Articular Injection in Osteoarthritis of the Knee
Objective: Identifying the dose of EVI-01 with the best clinical response, balancing the efficacy, safety, and tolerability of the investigational product.
- Trial name
- NCT05337540
- Testing
- EVI-01, Active comparator Synvisc-One
- Where
- 2 sites in Brazil
- Volunteers
- 120 people
- Sponsor
- Aptissen SA
Knee Osteoarthritis
Effects Of Native Collagen Type 2 Treatment
The aim of this study was to evaluate symptomatic efficacy of native collagen type 2 on joint pain and function and its effects on urinary biological markers related to cartilage degeneration in patients with knee osteoarthritis.
- Trial name
- NCT02237989
- Testing
- paracetamol, paracetamol+native collagen type 2
- Volunteers
- 39 people
- Sponsor
- Eskisehir Osmangazi University
Ankylosing Spondylitis
A Phase III Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis
This is a randomized, double-blind, placebo-controlled, multi-center phase III clinical study to evaluate the efficacy and safety of AK111 in the treatment of subjects with active ankylosing spondylitis.
- Trial name
- NCT06378697
- Testing
- AK111
- Where
- 60 sites in China
- Volunteers
- 510 people
- Sponsor
- Akeso
Femoroacetabular Impingement
the Horsens Aarhus FemoroAcetabular Impingement Syndrome Training Pilot Study
The aim of the study is to investigate the feasibility of a training intervention in patients with femoroacetabular impingement syndrome (FAIS).
- Trial name
- NCT05031390
- Testing
- Physiotherapist-led training
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Horsens Hospital
Knee Osteoarthritis
Radio-frequency Ablation in Knee Osteoarthritis by Three Needles Technique
The study is designed to evaluate and compare the efficacy of three needles approach as a new technique in radiofrequency neurotomy of genicular nerve versus the traditional single needle approach as a treatment of advanced knee…
- Trial name
- NCT03613610
- Testing
- Radio-frequency ablation of genicular nerves
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alaa Fouli Gaber Ebrahim
Arthritis, Psoriatic
A Study of Guselkumab Administered Subcutaneously in Bio-naive Participants With Active Psoriatic Arthritis Axial Disease
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) axial disease by assessing reduction in axial symptoms and inflammation.
- Trial name
- STAR (NCT04929210)
- Testing
- Guselkumab
- Where
- 240 sites in United States, Argentina and 24 more
- Volunteers
- 411 people
- Sponsor
- Janssen Research & Development, LLC
Tendinitis of Shoulder, Hyaluronic Acid
Oral Supplementation Compared With Hyaluronic Acid Infiltration in Rotator Cuff Tendinopathies
The present study aims to investigate the effectiveness of oral supplementation with a nutraceutical containing Collagen, Hyaluronic Acid, Vitamin C, and Manganese in functional outcome and pain reduction in cases of shoulder…
- Conditions
- Tendinitis of Shoulder, Hyaluronic Acid, Dietary Supplements, Shoulder Pain
- Trial name
- NCT06379997
- Testing
- Collagen, Hyaluronic Acid, Vitamin C, and Manganese, Intra-articular infiltration
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Prehabilitation, Knee Osteoarthritis
Effectiveness of a Prehabilitation Program for Hip or Knee Arthroplasty Surgery.
We live in an increasingly aging society in which the incidence of osteoarticular diseases increases, among which osteoarthritis (OA) stands out.
- Conditions
- Prehabilitation, Knee Osteoarthritis, Hip Osteoarthritis, Physical Therapy Modalities
- Trial name
- Preoperative (NCT06721897)
- Testing
- Prehabilitation Program, Non prehabilitation Program
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Jaén
Rheumatoid Arthritis
Relation of IL23R and IL17A Gene Polymorphisms Plus Serum Levels of IL23 and IL17A to Rheumatoid Arthritis Susceptibility and Activity
Assess the impact of rs2201841 and rs2275913 single nucleotide polymorphism of host genes IL-23R and IL-17A respectively on susceptibility of rheumatoid arthritis .
- Trial name
- NCT05570513
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Analgesia
Analgesia After Knee Arthroscopy :Dexmedetomidine vs Fentanyl
The aim of this study is to evaluate analgesic effects Bupivacaine, Bupivacaine plus Dexmedetomidine and Bupivacaine plus Fentanyl in relieving pain after knee arthroscopic surgery.
- Trial name
- NCT04442906
- Testing
- Dexmedetomidine, Fentanyl, Bupivacain
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Aortic Diseases, Osteoarthritis, Hip
Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair
The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery.
- Trial name
- KEEP-HB (NCT00851149)
- Testing
- Sangvia blood sampling system
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Sykehuset i Vestfold HF
Hip Dysplasia, Hip Injuries
PENG Block vs. ESP Block for Pediatric Hip Surgery
The study compares the effectiveness and safety of the pericapsular nerve blockade vs. ESPB in pediatric patients who underwent hip surgeries.
- Conditions
- Hip Dysplasia, Hip Injuries, Hip Fractures, Hip Disease
- Trial name
- NCT06087549
- Testing
- Pericapsular nerve group block using 0.2% ropivacaine, Erector Spinae Plane Block using 0.2% ropivacaine, Standard care
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Rheumatoid Arthritis
Evaluation of Effectiveness of Two Dosing Regimens of Fostamatinib Compared to Placebo in Patients With Rheumatoid Arthritis (RA) Who Are Taking Methotrexate and Have Had Inadequate Response to Single TNF-alpha Antagonist
The purpose of the study is to evaluate the effectiveness of two dosing regimens of fostamatinib compared to placebo, in patients with rheumatoid arthritis (RA) who are taking methotrexate and have had an inadequate response to a…
- Trial name
- OSKIRA - 3 (NCT01197755)
- Testing
- fostamatinib
- Where
- 135 sites in United States, Argentina and 14 more
- Volunteers
- 323 people
- Sponsor
- AstraZeneca
Gout
Safety/Efficacy Study to Evaluate of MBX-102 in Combination With Allopurinol in Gout Patients
The purpose of this study is to evaluate the efficacy, safety and tolerability of MBX-102 in combination with allopurinol compared to allopurinol alone when administered orally once a day for four weeks to gout patients with an…
- Trial name
- NCT01399008
- Testing
- Arhalofenate, Allopurinol, Colchicine
- Where
- 24 sites in United States, Canada and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Osteoarthritis, Knee
Effects of Corrective Exercise Training for Improving Neuropathic Pain and Function in Knee Osteoarthritis
Patients with neuropathic pain had longer duration of symptoms increased severity of pain, functional limitation and disability as compare to the patient with general knee osteoarthritis.
- Trial name
- NCT04995250
- Testing
- corrective exercise training for knee
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Osteoarthritis of the Knee
Serum and Synovium Protease Inhibitor Levels in Primary and Secondary Osteoarthritic Joints
Osteoarthritis (OA) is the irreversible degeneration of articular cartilage and underlying bone. It poses a major healthcare problem as it is the leading cause of joint disease and disability in the United States.
- Trial name
- NCT01613833
- Testing
- Blood Draw, Joint Aspirate Harvest
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Scuderi, Gaetano J., M.D.
Osteoarthritis, Gait Disorders, Neurologic
Effect of Flamingo Exercises on Balance
The aim of this study is to determine the effect of flamingo exercise on balance in patients with balance impairment due to senil osteoarthritis
- Trial name
- NCT03361449
- Testing
- Flamingo exercise, training with kinesthetic ability trainer
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ufuk University
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