Clinical trials: Artificial Respiration
Acute Respiratory Failure, Respiration, Artificial
Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation
This study will evaluate the heart, lungs and diaphragm of patients who fail a trial of spontaneous breathing to determine the physiological mechanism of weaning failure.
- Conditions
- Acute Respiratory Failure, Respiration, Artificial, Weaning
- Trial name
- USEFUL (NCT02723565)
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Artificial Respiration, Surgery
Effects of Mechanical Ventilation Guided by Transpulmonary Pressure on Gas Exchange During Robotic Surgery: a Pilot Study
Laparoscopy and robotic techniques are widespread procedures for pelvic gynecologic, urologic and abdominal surgery often performed in Trendelenburg position, with the application of pneumoperitoneum by inflating carbon dioxide.
- Conditions
- Artificial Respiration, Surgery, Atelectasis
- Trial name
- Vetrapo (NCT03153592)
- Testing
- Transpulmonary pressure driven ventilation strategy, Conventional ventilation strategy
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Infections Associated With Mechanical Ventilation, Pneumonia Associated With Mechanical Ventilation
Efficacy of Mouth-rinse With Chlorhexidine for the Prevention of Ventilator-associated Infections in Intensive Care Unit
Background: Infections associated with mechanical ventilation are associated with high rates of morbidity and mortality, which results not only in an increase in hospitalization days and care costs, but also in an increase in…
- Trial name
- NCT04165356
- Testing
- Mouth-rinse with 0.12% clorhexidine, Mouth-rinse with isotonic solution with 1.5% sodium bicarbonate
- Where
- Mexico
- Volunteers
- 80 people
- Sponsor
- Universidad Autónoma de Yucatán
Acute Respiratory Distress Syndrome
Artificial Increase in Chest Wall Elastance as an Alternative to Prone Positioning in Moderate-to-severe ARDS.
During moderate to severe ARDS, sessions of prone positioning lead to lung and chest wall mechanics changes that modify regional ventilation, with a final redistribution of tidal volume and PEEP towards dependent lung regions…
- Trial name
- ALTERPRONE (NCT03719937)
- Testing
- weight on the anterior chest of the patient
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Catholic University of the Sacred Heart
Cardiovascular Diseases, Medical Device
Validation of PMcardio AI-assisted Clinical Assistant in Primary Care
This study aimed to analyze and investigate whether the use of the PMcardio clinical assistant leads to a more efficient patient management in primary care and more accessible specialised care compared to usual standards of care…
- Conditions
- Cardiovascular Diseases, Medical Device, Primary Health Care, Electrocardiogram
- Trial name
- PMCARDIO-PT1 (NCT05329246)
- Testing
- AI-assisted Clinical Assistant PMcardio
- Where
- 56 sites in Slovakia
- Volunteers
- 836 people
- Sponsor
- Powerful Medical
Respiratory Insufficiency, Respiration, Artificial
Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients
Sedation is widely used in mechanically ventilated patients. Propofol, benzodiazepines and opioids are the most used drugs. The study hypothesis is that sedation with remifentanil (an opioid drug) could improved respiratory…
- Conditions
- Respiratory Insufficiency, Respiration, Artificial, Conscious Sedation
- Trial name
- NCT00665119
- Testing
- remifentanil
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Anesthesia, General/Methods, Laparoscopy
Transpulmonary Driving Pressure and Intra-abdominal Pressure Relationship During Laparoscopic Surgery
Objective: The aim of this project is to evaluate how intra-abdominal pressure paired coupled with different ventilatory positive end-expiratory pressure levels affects the transpulmonary driving pressure during pneumoperiteneum…
- Conditions
- Anesthesia, General/Methods, Laparoscopy, Respiration, Artificial, Positive-Pressure Respiration
- Trial name
- NCT03435913
- Testing
- Standard PEEP ventilation, Matched PEEP ventilation
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario La Fe
Hernia, DIaphragmatic, Congenital
Work of Breathing Description in Neonates With Congenital Diaphragmatic Hernia in NAVA and in Conventional Ventilation.
Congenital diaphragmatic hernia (CDH) is a congenital malformation associated with significant mortality and respiratory morbidity, particularly related to prolonged mechanical ventilation.
- Trial name
- NAVA-DIAPH (NCT03250793)
- Testing
- Physiologic study measuring work of breathing which can be estimated by the esophageal and trans-diaphragmatic pressure-time product obtained by an esophageal transducer
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Hospices Civils de Lyon
Respiration Disorders, Swallowing Disorder
Artificial Intelligence in Diagnosing Dysphagia Patients
In this prospective study we extracted acoustic parameters using PRAAT from patient's attempt to phonate during the clinical evaluation using a digital smart device.
- Conditions
- Respiration Disorders, Swallowing Disorder, Phonation Disorder, Stroke
- Trial name
- NCT05098808
- Testing
- Acoustic features (from signals obtained during phonation)
- Where
- South Korea
- Volunteers
- 449 people
- Sponsor
- The Catholic University of Korea
Respiration, Artificial, Respiratory Insufficiency
24-Hour NAVA Ventilation in Acute Respiratory Failure
Neurally Adjusted Ventilatory Assist (NAVA) is a new mode of mechanical ventilation that is controlled by the electrical activity of the diaphragm (EAdi).
- Trial name
- NCT00583037
- Testing
- Neurally Adjusted Ventilatory Assist (NAVA)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Unity Health Toronto
Respiratory Failure, Critical Illness
Combining Chest X-Ray and Arterial Blood Gas Findings to Predict Need for Mechanical Ventilation in Critically Ill Patients
This prospective cross-sectional study aims to develop and validate a machine learning model that combines chest X-ray findings with arterial blood gas (ABG) analysis to assess the necessity for mechanical ventilation in…
- Conditions
- Respiratory Failure, Critical Illness, Mechanical Ventilation
- Trial name
- NCT07001696
- Where
- Egypt
- Volunteers
- 2,160 people
- Sponsor
- Zagazig University
Bronchopulmonary Dysplasia, Respiratory Distress Syndrome
Minimal Breathing Support and Early Steroids to Prevent Chronic Lung Disease in Extremely Premature Infants (SAVE)
This multicenter clinical trial tested whether minimal ventilation decreases death or BPD. Infants with birth weight 501g to 1000g and mechanically ventilated before 12 hours were randomly assigned to minimal ventilation (partial…
- Conditions
- Bronchopulmonary Dysplasia, Respiratory Distress Syndrome, Infant, Newborn, Infant, Low Birth Weight
- Trial name
- SAVE (NCT00005777)
- Testing
- Minimal mechanical ventilation management, Routine mechanical ventilation management, Dexamethasone
- Where
- 13 sites in United States
- Volunteers
- 220 people
- Sponsor
- NICHD Neonatal Research Network
Acute Respiratory Distress Syndrome, Barotrauma
Imaging Biomarkers to Stratify the Risk of Barotrauma in ARDS
The high incidence of barotrauma in patients with COVID-19-related acute respiratory distress syndrome (ARDS) (16.1%, with a mortality rate >60%) provides rationale for considering COVID-19 ARDS a paradigm for lung frailty.
- Trial name
- FRAIL ARDS (NCT05816954)
- Testing
- Chest Computed Tomography Scan per normal clinical practice
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Università Vita-Salute San Raffaele
Respiratory Disease
Validation of an Artificial Intelligence Enabled Diagnostic Support Software (ArtiQ.Spiro) in Primary Care Spirometry Datasets - a Retrospective Analysis
A retrospective study to evaluate the diagnostic performance of an Artificial Intelligence enabled software (ArtiQ.Spiro) in UK primary care spirometry datasets.
- Trial name
- NCT05648227
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Circulatory Failure, Respiratory Failure
Assessment of Organ Failure Risk Predictions in ICU
During this observational study, the investigators aim to assess the ability of ICU clinicians to predict the risk of impending organ failure and retrospectively compare it to the performance of previously published machine…
- Conditions
- Circulatory Failure, Respiratory Failure, Renal Failure
- Trial name
- AI4ICU-Obs (NCT06814327)
- Where
- Switzerland
- Volunteers
- 499 people
- Sponsor
- ETH Zurich
Electric Stimulation, Respiration, Artificial
Breath Synchronized Abdominal Muscle Stimulation to Facilitate Ventilator Weaning: a Pilot Study
The primary objective of this study is to determine whether neuromuscular electrical stimulation applied to the abdominal wall muscles in synchrony with exhalation can increase the strength of the respiratory muscles in prolonged…
- Conditions
- Electric Stimulation, Respiration, Artificial, Ventilator Weaning
- Trial name
- NCT03019107
- Testing
- Breath synchronized abdominal NMES
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Liberate Medical
Deep Sedation, Respiration, Artificial
Fluid Leakage Past Tracheal Tube Cuff : Effect of Suctioning Manoeuvre
The leakage of oropharyngeal secretions around high-volume low-pressure tracheal tube cuffs is usually considered as a major risk factor for bacterial tracheal colonization and subsequent development of ventilator-associated…
- Trial name
- NCT01170156
- Testing
- Hi-Lo Evac tube (Mallinckrodt Inc, USA) (Instilled blue dye)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier de Roanne
Carcinomatous Disease
Establishment of an Artificial Larynx After Total Laryngectomy
This study aims to evaluate the effectiveness of an artificial larynx on the restoration of laryngeal functions, mainly breathing and swallowing.
- Trial name
- LA (NCT01474005)
- Testing
- PROTIP MEDICAL ( Artificial larynx prosthesis)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Strasbourg, France
Sleep-Disordered Breathing, Sleep Architecture
Belun Ring Platform With an Improved Algorithm for OSA Assessment
OSA is commonly diagnosed with either attended in-lab polysomnography (PSG) or unattended home sleep apnea testing (HSAT). The BLS-100 (Belun Technology Company Limited, Hong Kong) is a novel neural network-based HSAT platform…
- Trial name
- NCT04885062
- Testing
- Belun Ring, PSG
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Belun Technology Company Limited
Coronary Heart Disease, Artificial Intelligence
Effects of AI Assisted Follow-up Strategy on Secondary Prevention in CABG Patients
The present study is trying to find out whether artificial intelligence assisted follow-up strategy will improve secondary prevention in CABG patients.
- Conditions
- Coronary Heart Disease, Artificial Intelligence, Sleep Apnea
- Trial name
- NCT04636996
- Testing
- artificial intelligence assisted follow-up
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital