Clinical trials: Ascites
Ascites, Fluid Loss
Utility of 2- Octyl Cyanoacrylate (2-OCA)
Paracentesis is a commonly performed procedure in the inpatient and outpatient settings for treatment of ascites. The most frequent complication of paracentesis is fluid leak.
- Trial name
- NCT05278013
- Testing
- Dermabond
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Methodist Health System
Hepatitis B, HIV Infection
Adefovir Dipivoxil to Treat Hepatitis B in HIV-Infected Patients
This study will evaluate the safety and effectiveness of adding the experimental drug adefovir dipivoxil to lamivudine for treating hepatitis B virus (HBV) infection in HIV-infected patients with liver cirrhosis.
- Trial name
- NCT00013702
- Testing
- Adefovir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Critical Illness, Cardiac Complication
The INSIGHT Feasibility Study Ultrasound in the Intensive Care Unit: A Randomised Controlled Feasibility Trial
Point-of-care ultrasound (PoCUS) is a rapidly evolving method of clinical assessment within the intensive care unit (ICU) with training predominantly aimed at physicians.
- Conditions
- Critical Illness, Cardiac Complication, Pleural Effusion, Consolidation
- Trial name
- INSIGHT (NCT05569798)
- Testing
- Whole body point of care ultrasound scan
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- King's College Hospital NHS Trust
Portal Hypertension
Austrian Registry on Transjugular Intrahepatic Portosystemic Shunts
Patients with TIPS will be recruited in this prospective registry study. The clinical course will be documented and biomarkers for prediction of complicatiosn will be assessed.
- Trial name
- AUTIPS (NCT03409263)
- Testing
- Observational study
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Thomas Reiberger
Lung Cancer, Breast Cancer
Exploratory Study of Precise Therapy for Advanced Tumor Patients With Malignant Hydrothorax or Ascites by Using PTC Drug Sensitivity Testing
To explore the consistency between result of PTC drug screening tests and actual clinical outcome for patients with advanced malignancy.
- Conditions
- Lung Cancer, Breast Cancer, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT06413212
- Testing
- Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing.
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Liu Huang
Tense Ascites, Liver Cirrhosis
Acute Hemodynamic Changes During Paracentesis
The aim of our study was to evaluate hemodynamic changes during routine paracentesis in tense ascites using non-invasive inert gas rebreathing.
- Trial name
- NCT02996188
- Testing
- routine therapeutic paracentesis
- Volunteers
- 36 people
- Sponsor
- Universitätsmedizin Mannheim
Cirrhosis, Liver, Liver Fibrosis
Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics
This 2-part study will evaluate PHIN-214 given as a single one-time dose (Part 1) and in multiple doses (given as daily doses for 28-days) (in Part 2).
- Conditions
- Cirrhosis, Liver, Liver Fibrosis, Ascites Hepatic
- Trial name
- NCT05490888
- Testing
- PHIN-214 Subcutaneous injection
- Where
- 9 sites in United States
- Volunteers
- 74 people
- Sponsor
- PharmaIN
Abdominal Neoplasm, Abdominal Injury
Pediatric Intravenous Contrast-Enhanced Ultrasound(CEUS) in China
The goal of this clinical trial is to evaluate the application of intravenous contrast-enhanced ultrasound examination in children with intra-abdominal diseases that require clear diagnoses.
- Conditions
- Abdominal Neoplasm, Abdominal Injury, Ascites
- Trial name
- CEUS (NCT07113808)
- Testing
- contrast-enhanced ultrasound examination, SonoVue®
- Where
- China
- Volunteers
- 108 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Refractory Malignant Ascites
Intraperitoneal Injection of Oncolytic Viruses H101 for Patients With Refractory Malignant Ascites
Assessment of effectiveness, safety and local immune activation of Oncolytic Viruses H101 in patients with refractory malignant ascites.
- Trial name
- NCT04771676
- Testing
- Oncorine (H101)
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Fudan University
Malignant Ascites
A Phase I Study of SIM0388 in Participants With Malignant Ascites.
Malignant Ascites is a common complication of malignant tumor. The objective of this study is to evaluate the safety, efficacy, and pharmacokinetic characteristics of intraperitoneal perfusion with Docetaxel Polymeric Micelles…
- Trial name
- SIM0388-101 (NCT07007988)
- Testing
- SIM0388
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Jiangsu Simcere Pharmaceutical Co., Ltd.
Cirrhotic Ascites
Study of Efficacy of a Vasopressin 2 Receptor Antagonist M0002 for Treatment of Ascites in Cirrhotic Subjects With Hypo- or Normonatraemia
M0002, an orally active, selective non-peptidergic antagonist of the vasopressin V2 receptor inhibits vasopressin-induced water reabsorption from the kidney.
- Trial name
- NCT01179607
- Testing
- M0002
- Volunteers
- 15 people
- Sponsor
- Movetis
Decompensated Cirrhosis
Efficacy of Targeted And Response-Guided Albumin Therapy Versus Standard Medical Treatment In Outcomes Of Recurrent Ascites In Patients With Decompensated Cirrhosis.
The current prospective randomized controlled trial would aim to study the efficacy of targeted albumin therapy versus standard medical treatment in reduction in 6-month mortality in recurrent ascites in patients with…
- Trial name
- NCT04679571
- Testing
- Albumin, Standard Medical Treatment
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
End Stage Liver Disease
End Stage Liver Disease and Body Composition Assessment: Utilizing Bioelectric Impedance Analysis (BIA)
The purpose of this research study is to see how effective bioelectric impedance analysis (BIA) is in determining body composition (the amount of fat versus muscle in the body) and nutritional status in patients with End Stage…
- Trial name
- NCT00374582
- Testing
- Bodystat Quadscan 4000, bodystat quadscan 400
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Spontaneous Bacterial Peritonitis
Prediction of SBP in Cirrhotic Patients by Platlet Count, Na and AlBl Index.
This study aims to evaluate whether integrating serum sodium levels and platelet count with the Albumin-Bilirubin (ALBI) score can improve the early prediction of spontaneous bacterial peritonitis (SBP) in cirrhotic patients with…
- Trial name
- NCT07116369
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Cirrhosis, Ascites
Acute Hemodynamics of Albumin Versus Normal Saline in Cirrhosis
Cirrhosis is frequently complicated by derangement of body fluid homeostasis resulting in accumulation of large amounts of extracellular fluid in the peritoneal cavity (ascites) and interstitial tissue (edema).
- Trial name
- NCT00511394
- Testing
- 20% Human Albumin, Normal Saline
- Where
- India
- Volunteers
- 16 people
- Sponsor
- Govind Ballabh Pant Hospital
Pleural Effusion, Malignant
IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites
The purpose of this study was to evaluate the efficacy of IFN- Y combined with T cells in the treatment of refractory malignant pleural effusion and acties, using a multicenter, single-arm, open design.
- Trial name
- NCT05268172
- Testing
- IFN-γ and CIK cells, Tcm cells or CAR T cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiangnan University
Hepatorenal Syndrome, Cirrhosis, Liver
Point-of-Care Echocardiography to Assess Impact of Dynamic Cardiac Function, Renal and Cardiac Biomarkers in Cirrhosis With Hepatorenal Syndrome-Acute Kidney Injury
Point-of-care echocardiography (POC-Echo) is used to determine left ventricular systolic and diastolic dysfunction (LVDD), inferior vena cava (IVC) dynamics and volume status in cirrhosis and Acute-on-chronic liver failure ACLF…
- Conditions
- Hepatorenal Syndrome, Cirrhosis, Liver, Acute-On-Chronic Liver Failure, AKI
- Trial name
- NCT05434286
- Testing
- Echocardiographic assessment
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Refractory Ovarian Cancer With Recurrent Symptomatic Malignant Ascites
Phase 1/2a Two-Arm Dose-Escalation Study of BAX69 in Subjects With Malignant Ascites of Ovarian Cancer
The purpose of this study is to evaluate the safety and tolerability of BAX69 monotherapy given either as intraperitoneal (IP) infusion (Single-Route Arm); or as IP infusion after intravenous (IV) infusion (IV+IP) (Double-Route…
- Trial name
- NCT02540356
- Testing
- BAX69 Single-Route Arm, BAX69 Double-Route Arm
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- Baxalta now part of Shire
Liver Cirrhosis
Safety and Efficacy of Small Frequent Paracentesis Using an Indwelling CAtheter Compared With Repeated Large Volume Paracentesis in Cirrhotic Patients With REfractory Ascites
The aim of the study is to assess the efficacy of intermittent small quantity (upto 3L per day) paracentesis through an indwelling catheter for up to 5 days in comparison with large volume paracentesis on decreasing the need for…
- Trial name
- NCT04406298
- Testing
- small quantity paracentesis, Large Volume Paracentesis
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Cirrhosis, Ascites Hepatic
Albumin Assisted Diuresis in Patients with Cirrhosis and Ascites
A small, pilot proof-of-concept placebo-controlled trial to explore the effects of albumin on diuresis in patients with cirrhosis, ascites and lower extremity edema.
- Trial name
- NCT06812390
- Testing
- Albumin infusion (25% albumin), Normal Saline (0.9% NaCl)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Anahita Rabiee MD MHS