Clinical trials: Ascorbic Acid
Periapical Periodontitis
Effect of Injectable Platelet Rich Fibrin Augmented With Vitamin C Compared to Injectable Platelet Rich Fibrin Alone on Healing of Necrotic Mature Single Rooted Teeth With Chronic Peri-apical Periodontitis Following Regenerative Endodontics (A Randomized Controlled Trial)
The purpose of the study is to investigate the effect of injectable platelet rich fibrin augmented with Vitamin C (ascorbic acid) in healing of chronic peri-apical lesion, by assessing it radiographically 2dimensionally and 3…
- Trial name
- NCT05585359
- Testing
- injectable platelet rich fibrin augmented with Vitamin C
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Catheter-Associated Urinary Tract Infection, Ascorbic Acid
Vitamin C for the Prevention of UTI in Women Who Undergo Elective GYN Surgeries
This open-label randomized trial aims at assessing the role of Vitamin C pills in the prevention of catheter-associated urinary tract infections in women undergoing elective gynecological surgeries.
- Trial name
- NCT03800667
- Testing
- Ascorbic Acid 1000 MG
- Where
- Lebanon
- Sponsor
- American University of Beirut Medical Center
Colon Cleansing for Colonoscopy
Sodium Picosulphate/Magnesium Citrate and Low-volume PEG -Ascorbic Acid as Preparation for Colonoscopy
Adequate bowel cleansing is essential for effective colonoscopy. Acceptance of colon preparation affects the quality of colon cleansing.
- Trial name
- NCT01603654
- Testing
- sodium picosulphate magnesium citrate, low-volume PEG -ascorbic acid
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- ASST Fatebenefratelli Sacco
Anemia in Pregnancy
Effect of Ascorbic Acid Supplementation in Pregnancy on Anemia (AAA)
A. Anemia is a common problem affecting pregnancy and can result in profound consequences to both the mother and the growing fetus. Current treatment usually includes administration of oral or IV iron, or blood transfusions.
- Trial name
- AAA (NCT03564756)
- Testing
- Vitamin C
- Where
- United States
- Sponsor
- Fetal Medicine Foundation
Asthma, Pulmonary Function
VCSIP Follow-up Study
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function and decrease wheeze at 5 years of age in their offspring.
- Conditions
- Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
- Trial name
- VCSIPRenewal (NCT03203603)
- Testing
- No active intervention
- Where
- 2 sites in United States
- Volunteers
- 242 people
- Sponsor
- Oregon Health and Science University
Melasma
Comparison Between Efficacy of Topical Tranexamic Acid Vs Topical Ethyl Ascorbic Acid In Treatment Of Melasma
This study is to compare the efficacy of topical tranexamic acid vs topical ethyl ascorbic acid in the treatment of melasma
- Trial name
- NCT07522788
- Testing
- Ethyl ascorbic acid topical application, Tranxemic acid topical application
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Obese, Disorder of Vitamin C
The Effect of Vitamin C on Growth Hormone Secretion
Obesity is associated with reduced growth hormone (GH) secretion. GH secretion is regulated by nutritional stimuli including fasting, insulin, glucose and free fatty acids.
- Conditions
- Obese, Disorder of Vitamin C, Growth Hormone Secretion Abnormality
- Trial name
- NCT01537094
- Testing
- Vitamin C 250 mg once daily, Vitamin C 1,000 mg once daily
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Reperfusion Injury
Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients
It has been shown that the stress that occurs during cardiac surgery leads to early decrease of many of the body's resources such as Vitamin C (ascorbic acid) which may contribute to complications after surgery.
- Trial name
- VitaminC (NCT01167569)
- Testing
- Ascorbic Acid, 5 % Dextrose Water or Normal Saline
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Rutgers, The State University of New Jersey
Sepsis, Septic Shock
Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis
Prospective, experimental, longitudinal cohort study in septic patients treated at ER and ICU at General Hospital Zone 11 IMSS Piedras Negras Coahuila.
- Trial name
- NCT04197115
- Testing
- Vitamin C, Hydrocortisone, Complex B
- Where
- Mexico
- Volunteers
- 19 people
- Sponsor
- IMSS Hospital General de Zona 11, Piedras Negras
Diabetes Type 2
Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes
An unexpected means to prevent microvascular disease in diabetes may be coupled to the function of vitamin C in red blood cells (RBCs) of diabetic participants.
- Trial name
- NCT02107976
- Testing
- Vitamin E, Vitamin C
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Melasma
1064-nm Q-switched Nd:YAG Laser and Intradermal Tranexamic Acid for Melasma
BACKGROUND: Melasma is a chronic, often relapsing skin disorder, with poor long-term results from all current therapies.Q switched 1064nm Nd:YAG laser and intradermal tranexamic acid both showed efficacy on the treatment of…
- Trial name
- NCT03008655
- Testing
- intradermal tranexamic acid, Nd-YAG
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University WanFang Hospital
Covid19, MIS-C Associated With COVID-19
Pediatric COVID Outcomes Study (PECOS)
This is a multisite prospective observational study to evaluate the clinical sequelae of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population, including…
- Conditions
- Covid19, MIS-C Associated With COVID-19, MIS-C Multisystem Inflammatory Syndrome in Children, SARS-CoV2 Infection
- Trial name
- NCT04830852
- Where
- 2 sites in United States
- Volunteers
- 1,097 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Cardiovascular Risk Factor
Vitamin C to Reduce Morning Cardiovascular Risk
This study will test the efficacy of Vitamin C to counteract morning cardiovascular (CV) risk markers in a randomized, double blind, placebo controlled crossover pilot study.
- Trial name
- NCT03290612
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hepatocellular Cancer, Pancreatic Cancer
High Dose Vitamin C Combined With Metformin in the Treatment of Malignant Tumors
This is an open, prospective, single-arm, multi-cohort clinical study to evaluate the efficacy and safety of high-dose vitamin C combined with metformin in the treatment of malignant tumors.
- Conditions
- Hepatocellular Cancer, Pancreatic Cancer, Gastric Cancer, Colorectal Cancer
- Trial name
- NCT04033107
- Testing
- Vitamin C, Metformin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhongnan Hospital
Leukemia (Both ALL and AML), Cancer of Lung
Changing Over Time of Ascorbic Acid After Chemotherapy
Rationale: Recent studies showed that ascorbic acid (AA) stimulates proliferation and maturation of T lymphocytes and NK cells. Chemotherapy results in depletion of those cells and thereby an increased infection rate.
- Conditions
- Leukemia (Both ALL and AML), Cancer of Lung, Myeloma
- Trial name
- NCT02931942
- Testing
- blood withdrawn
- Where
- Netherlands
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Vitamin C Deficiency, Vitamin D Deficiency
Vitamin Deficiency and Blood Pressure in Hospitalized Jewish General Hospital (JGH) Patients
There is suggestive evidence that vitamin C and vitamin D deficiency may increase blood pressure across the range of blood pressures from normal to elevated.
- Trial name
- NCT00921622
- Testing
- Vitamin D, Vitamin C
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Jewish General Hospital
Crohn Disease
Effect of Ileocolonic Delivered Vitamins and an Anti-Inflammatory Diet on Crohn's Disease and Healthy Volunteers
This study will evaluate if the Groningen Anti-Inflammatory Diet and the ileocolonic delivery of vitamin B2, B3 and C can positively influence the course of Crohn's disease and can positively alter the gut microbiome of Crohn's…
- Trial name
- Vita-GrAID (NCT04913467)
- Testing
- Groningen Anti-Inflammatory Diet (GrAID), ColoVit capsule
- Where
- Netherlands
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Colonoscopy
Changes of Serum Electrolytes During Bowel Prep With PEG 3350 + Ascorbic Acid - a Prospective Study
Hypothesis: Patients who undergo bowel preparation with PEG 3350 + ascorbic acid may have significant changes of serum electrolytes.
- Trial name
- NCT01841138
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- Klinik Bogenhausen
Deficiency, Vitamin C
Hypovitaminosis C Prevalence and Risk Factors in an Acute Geriatric Unit
Vitamin C is essential for numerous biological processes as it acts as a cofactor in various hydroxylation reactions, but also as a powerful antioxidant.
- Trial name
- HYPO-VIT-C (NCT05668663)
- Testing
- Plasmatic Vitamin C concentrations (known as ascorbemia) on a single blood sample
- Where
- France
- Volunteers
- 434 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Iron Deficiency, Anemia
The Efficacy of a Local Vitamin-C Rich Fruit (Guava) in Improving Iron Absorption From Mungbean Based Meals and Its Effect on Iron Status of Rural Indian Children (6-10 Years)
Iron deficiency is estimated to affect about one fifth of the world's population, and women and children are among the most severely affected.
- Trial name
- MUGUST_2 (NCT01191463)
- Testing
- Mung Bean Meal, Guava
- Where
- India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wageningen University