Clinical trials: Ascorbic Acid
Cardiothoracic Surgery
A Trial to Assess the Impact of Ascorbic Acid on Cardiac Surgeries Outcomes and Complications''
this study is evaluating the safety and efficacy of ascorbic acid as a drug that can decrease inflammatory complications post surgical in addition to its impact on decreasing risk of arrhythmia and total opioid administration…
- Trial name
- NCT03639519
- Testing
- Ascorbic Acid 500Mg Chew Tab, Carbonated orange beverage
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- El-Galaa Military Medical Complex
Photoaging
The Efficacy and Safety of a Single 70% Glycolic Acid Peel With Vitamin C for the Treatment of Photoaging
Our study involves the evaluation of a high potency peel in its efficacy for skin rejuvenation in the treatment of photoaging. This chemical peel regime is a high potency peel 70% glycolic acid combined with vitamin C that is…
- Trial name
- NCT02126644
- Testing
- 70% glycolic acid
- Where
- Singapore
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Vitamin C Deficiency, Smoking
The Effect of Vitamin C on Wound Healing In Mandibular Fracture Patients
The goal of this study is to perform a randomized clinical trial to assess the effects of vitamin C versus placebo on wound healing in mandibular fracture patients.
- Conditions
- Vitamin C Deficiency, Smoking, Surgery, Surgery--Complications
- Trial name
- NCT03938584
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Hennepin Healthcare Research Institute
COVID-19
The Use of Chinese Herbal Medicine and Vitamin C by Hospital Care Workers in HK to Prevent COVID-19
This is a prospective randomized controlled trial study to explore whether the combination of Chinese herbal medicine and Vitamin C is effective and safe to prevent COVID-19 transmission among health care workers in Hong Kong…
- Trial name
- CHM-Cov-19-RCT (NCT05360004)
- Testing
- Chinese herbal medicine
- Volunteers
- 652 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Prostatic Neoplasms
Vitamin C as an Anti-cancer Drug
Can high dose, intravenous Vitamin C prolong life for patients with metastatic prostate cancer? Prostate cancer is the most common cancer (excluding skin cancer) in men in Denmark and the Unites States.
- Trial name
- NCT01080352
- Testing
- Ascorbic Acid (Vitamin C)
- Where
- Denmark
- Volunteers
- 31 people
- Sponsor
- Copenhagen University Hospital at Herlev
Charcot-Marie-Tooth Disease, Hereditary Motor and Sensory Neuropathies
Ascorbic Acid Treatment in CMT1A Trial (AATIC)
Charcot-Marie-Tooth type IA (CMT1A) is the most prevalent hereditary peripheral neuropathy. Demyelination of peripheral nerves is the hallmark of CMT1A.
- Trial name
- AATIC (NCT00271635)
- Testing
- ascorbic acid
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Diabetes
Urinary Vitamin C Loss in Diabetic Subjects
Several studies have reported that diabetic subjects have lower plasma vitamin C concentrations than non-diabetic subjects. Although urinary vitamin C loss in diabetic subjects was reported to be increased in two studies, these…
- Trial name
- NCT00071526
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Clonal Cytopenia of Undetermined Significance, High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements
Ascorbic Acid and Chemotherapy for the Treatment of Relapsed or Refractory Lymphoma, CCUS, and Chronic Myelomonocytic Leukemia
This phase II trial studies the effect of ascorbic acid and combination chemotherapy in treating patients with lymphoma that has come back (recurrent) or does not respond to therapy (refractory), clonal cytopenia of undetermined…
- Conditions
- Clonal Cytopenia of Undetermined Significance, High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Hodgkin Lymphoma
- Trial name
- NCT03418038
- Testing
- Ascorbic Acid, Carboplatin, Cisplatin
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
RSD (Reflex Sympathetic Dystrophy), Algodystrophy
Prophylactic Administration of Vitamin C in Wrist Fractures
Complex Regional Pain Syndrome or posttraumatic dystrophy is a pain syndrome which develops after a trauma, surgery or for unknown reason. The incidence after wrist fractures varies in literature from 2 - 37%.
- Conditions
- RSD (Reflex Sympathetic Dystrophy), Algodystrophy, CRPS Type I
- Trial name
- NCT00296868
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Stichting Achmea Slachtoffer en Samenleving
Temporomandibular Joint Disorders
Exploratory Study To Assess the Efficacy and Safety of a Triple Combination for Acute Pain Treatment in Patients With Temporomandibular Joint Disorders (TMJD).
The objetive of this study is to explore the efficacy and safety of a triple combination of ibuprofen, magnesium and ascorbic acid for acute pain treatment in TMJD patients
- Trial name
- NCT02602483
- Testing
- Ibuprofen, Magnesium, Ascorbic Acid
- Where
- 4 sites in Spain
- Volunteers
- 96 people
- Sponsor
- Spherium Biomed
Wrinkle, Skin Pigmentation
Prospective Study of Topical Vitamin C (THDA) Versus Topical Vitamin C (THDA) With Acetyl Zingerone
The purpose of this study is to asses the impact of topically applying a form of vitamin C known as tetrahexyldecyl Ascorbate (THDA) along with a novel anti-aging ingredient, acetyl zingerone, compared against applying THDA alone.
- Trial name
- NCT05779280
- Testing
- THDA + Acetyl Zingerone Topical Product, THDA
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Anaemia Response to the Treatment, Peripheral Iron Indices
Ascorbic Acid Administration in the Treatment of Anemia in Chronic Hemodialysed Patients
The administration of ascorbic acid seemed to increase the iron available for erythropoiesis, thus improving the anemia response to the treatment.
- Conditions
- Anaemia Response to the Treatment, Peripheral Iron Indices, Oxalemia
- Trial name
- FeVitC (NCT02225886)
- Testing
- Ascorbic Acid
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Anemia Working Group Romania
Oxidative Stress, Ischemia-reperfusion Injury
Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery
Ischemia and reperfusion injury during free flap reconstructive surgery creates a state of increased oxidative stress that can adversely affect the flap outcomes.
- Trial name
- NCT05327348
- Testing
- Intravenous Ascorbate, Normal Saline 10 mL Injection
- Where
- 3 sites in Malaysia
- Volunteers
- 34 people
- Sponsor
- University of Malaya
Hypothyroidism, Primary Hypothyroidism
Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism
Thyroid disease affects almost a quarter of a billion individuals worldwide and more than 50% of them being not aware of this condition.
- Conditions
- Hypothyroidism, Primary Hypothyroidism, Vitamin C Deficiency
- Trial name
- NCT05733078
- Testing
- Vitamin C, Oral Rehydration Salt Formulations
- Where
- United Arab Emirates
- Volunteers
- 40 people
- Sponsor
- Dr Adnan Agha
Type 1 Diabetes Mellitus
Vitamin C and Liraglutide Effects on Hypoglycemia-induced Oxidative Stress, Inflammation and Endothelial Dysfunction in Type 1 Diabetes.
To investigate the effect of liraglutide on vascular injury induced hypoglycemia in patients with type 1 diabetes mellitus. The vascular damage is evaluated at investigating the changes of endothelial function
- Trial name
- DIAB-01 (NCT02109315)
- Testing
- Vitamine C, Liraglutide 6 mg
- Where
- Spain
- Sponsor
- Anna Cruceta
Covid19, MIS-C Associated With COVID-19
Pediatric COVID Outcomes Study (PECOS)
This is a multisite prospective observational study to evaluate the clinical sequelae of symptomatic and asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population, including…
- Conditions
- Covid19, MIS-C Associated With COVID-19, MIS-C Multisystem Inflammatory Syndrome in Children, SARS-CoV2 Infection
- Trial name
- NCT04830852
- Where
- 2 sites in United States
- Volunteers
- 1,097 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Diet, Food
Resistance Training and Hydrolyzed Collagen Supplementation in Middle-aged Adults
The aim of this clinical trial is to investigate the longitudinal effects of hydrolyzed collagen ingestion combined with resistance training on muscle-tendon unit structure and function in middle-aged males and females.
- Conditions
- Diet, Food, Nutrition
- Trial name
- NCT06402890
- Testing
- Resistance training with collagen supplementation
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Oxidative Stress, Polytrauma
Oxidative Stress Expression and Metabolic Imbalance in Critically Ill Polytrauma Patients and the Implications of Antioxidant Therapy on Clinical Outcomes
Critically ill polytrauma patients have a number of physiological disorders secondary to trauma, such as systemic inflammatory response (SIRS), adult respiratory distress syndrome (ARDS), sepsis, oxidative stress (OS), and…
- Trial name
- OSPOL (NCT03218280)
- Testing
- Vitamin C
- Volunteers
- 100 people
- Sponsor
- Romanian Society of Anesthesia and Intensive Care
Multiple Myeloma and Plasma Cell Neoplasm
Arsenic Trioxide, Thalidomide, Dexamethasone, and Ascorbic Acid in Treating Patients With Relapsed or Refractory Multiple Myeloma
RATIONALE: Drugs used in chemotherapy, such as arsenic trioxide, dexamethasone, and ascorbic acid, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00227682
- Testing
- ascorbic acid, arsenic trioxide, dexamethasone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- OHSU Knight Cancer Institute
Respiratory Distress Syndrome, Adult, Covid19
High-Dose Vitamin C Treatment in Critically Ill COVID-19 Patients
Acute respiratory failure due to COVİD-19 pneumonia has poor prognosis and high mortality . Both the lack of an effective antiviral treatment and the low level evidence of the recommendations presented in the guidelines on other…
- Trial name
- NCT04710329
- Testing
- Ascorbic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital