Clinical trials: Ascorbic Acid
Systemic Lupus Erythematosus (SLE)
Efficacy of Vitamin C Supplementation on Serum TNF-α Levels and Disease Activity in SLE Patients
The study aimed to evaluate the efficacy of vitamin C supplementation compared to placebo towards TNF-α levels and disease activity with the MEX-SLEDAI score in Systemic Lupus Erythematosus (SLE) patients.
- Trial name
- NCT07071233
- Testing
- Vitamin C
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Sriwijaya
Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma
Ascorbic Acid and Combination Chemotherapy in Treating Patients With Locally Advanced or Recurrent Pancreatic Cancer That Cannot Be Removed by Surgery
This pilot clinical trial studies the side effects of ascorbic acid and combination chemotherapy in treating patients with pancreatic cancer that has spread to other places in the body, has come back, or cannot be removed by…
- Conditions
- Pancreatic Adenocarcinoma, Recurrent Pancreatic Carcinoma, Stage III Pancreatic Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT02896907
- Testing
- Oxaliplatin, Irinotecan Hydrochloride, Leucovorin Calcium
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Myelodysplastic Syndromes
Study of Association of Arsenic Trioxide (ATO) and Ascorbic Acid in Myelodysplastic Syndromes
This is a prospective, multicenter phase II trial designed to evaluate the safety and activity of the combination of association of arsenic trioxide (ATO) and ascorbic acid in patients with myelodysplastic syndromes
- Trial name
- NCT00803530
- Testing
- ATO + Ascorbic acid
- Where
- 13 sites in Italy
- Volunteers
- 55 people
- Sponsor
- Fondazione Italiana Sindromi Mielodisplastiche-ETS
Haematopoiesis
A Study to Demonstrate the Efficacy and Tolerability of Ferrous Bisglycinate Chelate in Iron Deficiency Anaemia and to Compare These With Those of Ferrous Ascorbate.
Iron deficiency anaemia (Haemoglobin, Hb < 12gm/dl) is one of India's major public health problems particularly in women. Effective control of iron deficiency anaemia decreases the incidence of fatigue, bodyache, headache, lack…
- Trial name
- NCT01160198
- Testing
- ferrous ascorbate, ferrous bisglycinate chelate 1 OD, ferrous bisglycinate chelate 2 OD
- Where
- 7 sites in India
- Volunteers
- 271 people
- Sponsor
- GlaxoSmithKline
Safety and Pharmacokinetics of Intravenous Ascorbate
Evaluation of Intravenous Ascorbic Acid
This Phase I study will be conducted in 2 parts to examine safety and pharmacokinetics of escalating doses of intravenous ascorbic acid (AA) first in healthy volunteers followed by evaluation in oncology subjects.
- Trial name
- NCT01833351
- Testing
- IV Vitamin C
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Quality of Life
Effect of Colon Delivered Vitamin C on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults
Recent studies have shown that many vitamins, if consumed in high daily dosages or delivered to the colon, can modulate the gut microbiota and their metabolites.
- Trial name
- NCT05598619
- Testing
- Vitamin C
- Where
- Ireland
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
HIV-1-infection, AIDS
Protect and Improve Cluster of Differentiation 4 (CD4) Cells and B Cells Lymphocytes
This is a plant-based medication used to increase the amount, protect, and reduce HIV's impact on T and B lymphocytes.
- Trial name
- NCT04770701
- Testing
- Ahah Drug
- Where
- Vietnam
- Sponsor
- Trieu, Nguyen Thi, M.D.
Post Operative Atrial Fibrillation
The Impact of Oral Vitamin C in Prevention for Post Operative Atrial Fibrillation (POAF) in Coronary Artery Bypass Surgery (CABG) Patients
Post operative atrial fibrillation (POAF) is one of the most common complications that takes place worldwide after coronary artery bypass surgeries (CABG).
- Trial name
- NCT06074367
- Testing
- Vitamin C 500 MG Oral Capsule(High dose 2g daily), Vitamin C 500 MG Oral Capsule(Low-dose 1g daily)
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Helwan University
Sepsis
High Dose Intravenous Ascorbic Acid in Severe Sepsis
Despite an organized treatment approach outlined in expert-consensus guidelines for sepsis with fluid resuscitation to treat hypovolemia, antibiotics to target the infectious insult, and vasopressors for hypotension, mortality…
- Trial name
- NCT02734147
- Testing
- Ascorbic Acid, Normal Saline
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Christiana Care Health Services
Diabetes Mellitus, Type 2
Effect of Vitamin C, D and Zinc Supplementation on the Immune and Inflammatory Process in Type 2 Diabetic Subjects
Type 2 Diabetes Mellitus According to the World Health Organization (WHO), there are more than 346 million individuals with diabetes, of which 90% are type 2.
- Trial name
- NCT03734445
- Testing
- Vitamin Supplement
- Volunteers
- 120 people
- Sponsor
- Universidad Autonoma del Estado de Mexico
Covid19
High-dose Intravenous Vitamin C (HDIVC) as Adjuvant Therapy in Critical Patients With Positive COVID-19. A Pilot Randomized Controlled Dose-comparison Trial.
The objective of this study is to evaluate the impact of this HDIVC therapy in the first treatment of symptomatic Covid-19 patients in a time period of one week.
- Trial name
- HDIVC (NCT05029037)
- Testing
- High doses of intravenous vitamin C, Dextrose 500 mL
- Volunteers
- 160 people
- Sponsor
- Hugo Galindo
Atrial Fibrillation
Influence of Vitamin C on Post-operative Atrial Fibrillation
Post-operative atrial fibrillation (POAF) is the most common arrhythmia which typically develops 2-3 days after cardiac surgery.
- Trial name
- NCT03592680
- Testing
- Vitamin C
- Where
- Belgium
- Volunteers
- 600 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Type 1 Diabetes Mellitus
Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes
The endothelium is the lining of the blood vessels that helps prevent damage to the vessels. The endothelium does not function as well as it should in adolescents with type 1 diabetes. This causes future diabetes complications.
- Trial name
- NCT02019186
- Testing
- Vitamin C, Vitamin E
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Nationwide Children's Hospital
Kidney Failure, Chronic
Can Intravenous Vitamin C Improve Skin Hyperpigmentation in Long-Term Hemodialysis Patients?
Intravenous vitamin C may improve skin hyperpigmentation in chronic hemodialysis patients
- Trial name
- NCT00172302
- Testing
- vitamin C, intravenous injection
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Multiple Myeloma, Stem Cell Transplantation
Arsenic Trioxide With Ascorbic Acid and Melphalan for Myeloma Patients
1. To evaluate the toxicity and safety of a combination of arsenic trioxide with ascorbic acid and high-dose Melphalan in patients with multiple myeloma 2.
- Trial name
- NCT00661544
- Testing
- Arsenic Trioxide, Melphalan, Ascorbic Acid
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- M.D. Anderson Cancer Center
Enterocutaneous Fistulas
Vitamin C and Zinc in Patients With Enterocutaneous Fistulas.
Various micronutrients play an important role in the process of closure and recurrence of enterocutaneous fistulas, such as Vitamin C and Zinc.
- Trial name
- VITAC (NCT06009744)
- Testing
- Low-dose vitamin C and zinc, High-dose vitamin C and zinc
- Where
- Mexico
- Volunteers
- 76 people
- Sponsor
- Hospital Juarez de Mexico
Respiratory Tract Infection Viral
Echinacea Junior vs Vitamin C in Children 4-12 Years Old
Aim of this study is to investigate efficacy and safety of Echinaforce Junior Tablets (250mg) in comparison with Vitamin C tablets in the prevention of acute viral respiratory tract infections.
- Trial name
- NCT02971384
- Testing
- Echinaforce
- Where
- Switzerland
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- A. Vogel AG
Sepsis, Septic Shock
Ascorbic Acid (Vitamin C) Infusion in Human Sepsis
The major goal of this project is to determine whether intravenously infused ascorbic acid is safe for use as a viable therapeutic strategy in adult humans with sepsis.
- Conditions
- Sepsis, Septic Shock, Hypotension, Acute Lung Injury
- Trial name
- NCT01434121
- Testing
- Ascorbic Acid
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Virginia Commonwealth University
Hypochlorhydria
Assessment of Gastric pH Changes Induced by Ascorbic Acid Tablets
This study evaluates the use of ascorbic acid, vitamin C, to temporary reduce gastric pH in individuals with omeprazole induced hypochlorhydria.
- Trial name
- NCT04199624
- Testing
- Omeprazole 20mg, Vitamin C
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Indiana University
Interventional
The Effect of Exercise and Presleep Nutrition on Muscle Connective Tissue Remodelling
The primary objective of this study will be to determine the influence of a presleep vitamin C-enriched, collagen-modelled supplement (CVC) on the metabolic fate of dietary glycine using a [2H5]glycine tracer within the…
- Trial name
- NCT06054620
- Testing
- Collagen and Vitamin C
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Toronto