Clinical trials: Ascorbic Acid
Linear Atrophic Scars
Comparative Analysis of Intralesional Platelet-Rich Plasma, NPH Insulin, and Vitamin C- A New Horizon and Future Hope for Linear Atrophic Scar Management
The aim of this clinical trial is to evaluate the efficacy and safety of platelet-rich plasma, insulin and vitamin C in the management of linear atrophic scars.
- Trial name
- NCT07901283
- Testing
- Intradermal injection of autologous platelet rich plasma, Intradermal injection of NPH insulin, Intradermal injection of Vitamin C
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Aya Ashraf Fouda
Sepsis, Septic Shock
The Effect of High Dose Parenteral Ascorbic Acid On Microcirculation In Sepsis
The purpose of this study is to evaluate the effect of high-dose ascorbic acid on microcirculation in sepsis.
- Trial name
- NCT04773717
- Testing
- Ascorbic acid
- Where
- Lithuania
- Volunteers
- 60 people
- Sponsor
- Lithuanian University of Health Sciences
Metastatic Pancreatic Adenocarcinoma
Vitamin C to Chemotherapy Related Anemia in Pancreatic Cancer
The purpose of this study is to evaluate the efficacy of low-dose vitamin C on improving the quality of life for metastatic pancreatic cancer patients receiving gemcitabine and nab-paclitaxel chemotherapy.
- Trial name
- PTCA199-3 (NCT06018883)
- Testing
- Ascorbate, Nab paclitaxel, Gemcitabine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Skin Condition, Anti-Oxidative Stress
Efficacy Evaluation Study of Vitamin C and Glutathione Liquid Sachet
The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.
- Trial name
- NCT07379216
- Testing
- Vitamin C and Glutathione Liquid Sachet
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Keratoconus
The Role of Antioxidant Supplementation in Keratoconus Patients
Keratoconus is the most common primary cornea ectasia, where the cornea undergoes structural changes, leading to loss of tissue integrity and vision loss. The prevalence of Keratoconus is 1:2000 in the general population.
- Trial name
- NCT02827747
- Testing
- Antioxidants (Vitamins A,C,E) plus GSH, Centrum, Dietary Sources
- Where
- United States
- Sponsor
- University of Miami
Autism, Severe Behavior Disorder
Study of Glutathione, Vitamin C and Cysteine in Children With Autism and Severe Behavior Problems
This is a double-blind, placebo-controlled crossover study to evaluate the safety and efficacy of glutathione alone or glutathione, vitamin C and NAC treatment in children with autism who also have severe behavior problems.
- Trial name
- NCT00889538
- Testing
- glutathione, glutathione, vit C and NAC
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Louisville
Severe Acute Pancreatitis
High-dose Intravenous Vitamin C for the Treatment of Severe Acute Pancreatitis
This study is a prospective, randomized, double-blinded, parallel-controlled, multi-central clinical trial for patients with severe acute pancreatitis (SAP).
- Trial name
- NCT06897384
- Testing
- Saline (NaCl 0,9 %), Vitamin C (Ascorbic Acid)
- Where
- China
- Volunteers
- 388 people
- Sponsor
- Ruijin Hospital
Pancreatic Neoplasms, Cancer of Pancreas
A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1)
This clinical trial adds high-dose ascorbate (vitamin C) to the standard of care regimen for metastatic pancreatic adenocarcinoma (a type of pancreatic cancer).
- Conditions
- Pancreatic Neoplasms, Cancer of Pancreas, Cancer of the Pancreas, Neoplasms, Pancreatic
- Trial name
- NCT02905578
- Testing
- Gemcitabine, nab-paclitaxel, Pharmacological ascorbate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Iowa
Iron Deficiency Anemia
Nutrient Fortified Oat Drink
This study will follow a randomized, double-blind, placebo-controlled, parallel-group design to test if an oat beverage fortified with iron, zinc vitamin A and vitamin C will improve nutrient status and iron deficiency in young…
- Trial name
- NCT01418898
- Testing
- Dietary Intervention
- Where
- Philippines
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Iron Absorption in Presence of Polyphenols
Polyphenols in Sorghum and Iron Absorption
Iron deficiency and iron deficiency anemia are two major public health problems in developing countries. In these countries, the use of monotonous plant-based diets, low in animal source food but high in iron absorption…
- Trial name
- NCT01162616
- Testing
- labeled iron solutions
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Hemodialysis Access Failure
Ascorbic Acid on Restenosis of Dysfunctional Hemodialysis Vascular Access
To investigate the effect of ascorbic acid on angiographic restenosis after percutaneous transluminal angioplasty (PTA) for dysfunctional dialysis vascular access.
- Trial name
- NCT03524846
- Testing
- Ascorbic Acid 300 MG, Ascorbic Acid 600 MG, Normal saline
- Volunteers
- 93 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Stage IV Colorectal Cancer
Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA
This protocol is a phase I/II, study of ascorbic acid (AA) infusions combined with treatment with irinotecan versus treatment with irinotecan alone in patients with recurrent or advanced colorectal cancer who have failed at least…
- Trial name
- NCT01550510
- Testing
- Ascorbic Acid, Irinotecan
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Thomas Jefferson University
COVID-19
Efficacy and Safety of High-dose Vitamin C Combined With Chinese Medicine Against Coronavirus Pneumonia (COVID-19)
In December 2019, coronavirus pneumonia (COVID-19) was detected in many cases in Wuhan, China. With the rapid spread of the coronavirus, cases of COVID-19 were also reported in other cities of China and other countries.
- Trial name
- NCT04664010
- Testing
- Alpha-interferon alpha, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste, fumigation/inhalation of vitamin C, Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and 5% glucose, Alpha-interferon, abidol, ribavirin, Buzhong Yiqi plus and minus formula, Huhuang Detoxicity Paste, Baimu Qingre Jiedu Paste and high-dose vitamin C treatment
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xi'an International Medical Center Hospital
Premature Ovarian Insufficiency, Ovarian Reserve Function
Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging
The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C.
- Trial name
- NCT06794060
- Testing
- Vitamin C (Ascorbic Acid)
- Volunteers
- 354 people
- Sponsor
- Peking University Third Hospital
Iron Deficiency Anemia
Effectiveness and Acceptability of LISEFEX® (Liposomal Iron With Vitamin C and Fiber) in People With Iron Deficiency Anemia.
Observational, descriptive, prospective, longitudinal, multicenter, non-interventionist and multicentric study in Mexican subjects diagnosed with mild to moderate iron deficiency anemia (ADH).
- Trial name
- NCT07483645
- Where
- Mexico
- Volunteers
- 74 people
- Sponsor
- Carnot Laboratories
NAFLD
Rutin and Vitamin C in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)
evaluate the combined effects of Rutin and Vitamin C versus Vitamin C alone on selected oxidative stress markers, inflammation, hepatic steatosis regression, and associated metabolic parameters in patients with MASLD
- Trial name
- NCT07310407
- Testing
- Rutin + Vitamin C, Vitamin C 500mg, Lifestyle Intervention
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Migraine, Headaches
Effect on Migraine Frequency of Combined Anti-oxidant Therapy: The MIGRANT Study.
Migraine affects 15% of Western Australians and is a leading cause of suffering and disability in our community (1,2). Research suggests that inflammation of the brain's coverings (meninges) by nerve cell inflammation and the…
- Trial name
- MIGRANT (NCT02629536)
- Testing
- N-acetyl cysteine 600 mg, VitE 250 IU, VitC 500 mg tablet
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame Australia
Systemic Lupus Erythematosus (SLE)
Efficacy of Vitamin C Supplementation on Serum TNF-α Levels and Disease Activity in SLE Patients
The study aimed to evaluate the efficacy of vitamin C supplementation compared to placebo towards TNF-α levels and disease activity with the MEX-SLEDAI score in Systemic Lupus Erythematosus (SLE) patients.
- Trial name
- NCT07071233
- Testing
- Vitamin C
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Sriwijaya
Healthy Volunteers
The Body's Affect on Vitamin C
Pharmacokinetics is the term used for how the body affects a drug once it is taken. Vitamin C, also known as ascorbic acid, is an essential water soluble vitamin.
- Trial name
- NCT00001309
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Septic Shock
Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock
This study has been approved as a nested substudy of a multicenter trial (CORVICTES, Clinicaltrials.gov Identifier: NCT03592693).
- Trial name
- CORVICTES-ΥΜ (NCT03649633)
- Testing
- Stress-dose Hydrocortisone plus Vitamin C
- Where
- Greece
- Volunteers
- 26 people
- Sponsor
- University of Athens