Clinical trials: Ascorbic Acid
Sepsis and Septic Shock
Thiamine, Ascorbic Acid, and Their Combination on MMP-9/TIMP-1 and Inflammatory Balance in Sepsis
This two-center, open-label randomized controlled trial evaluated the effect of adjunctive thiamine, ascorbic acid, and their combination compared with 0.9% saline on the extracellular matrix-remodeling axis (matrix…
- Trial name
- NCT07786350
- Testing
- Thiamine, Ascorbic Acid Injectable Product, Normal Saline 0.9% Injectable Solution
- Where
- 2 sites in Indonesia
- Volunteers
- 40 people
- Sponsor
- Universitas Sumatera Utara
Abdominal Hysterectomy
Intravenous Ascorbic Acid Administration in Hysterectomy
vitamin C or ascorbic acid has known role in tissue repair. due to it's properties(water_soluble), vitamin c is not stored in the body and when depleted, the bleeding tendency will increase due to dysfunctional connective tissues…
- Trial name
- NCT03965637
- Testing
- vitamin C
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Bladder Cancer
Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients
Bladder cancer is a common disease with high rates of mortality, especially at advanced stages. Neo-adjuvant cisplatin-based chemotherapy (NAC) followed by radical cystectomy is considered standard of care for patients with…
- Trial name
- NCT04046094
- Testing
- Ascorbic Acid
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Kansas Medical Center
Diabetic Neuropathies
Vitamin C Supplementation as a Preventive Treatment of Diabetic Peripheral Neuropathy
The purpose of this pilot study is to determine whether vitamin C supplementation is beneficial in treating and/or preventing diabetic peripheral neuropathy in people with type 2 diabetes.
- Trial name
- NCT00634998
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington State University
Post-acne Erythema
Comparison of Fractional CO2 Laser Monotherapy and Its Combination With Either Topical Vitamin C or Topical Timolol in the Treatment of Post-Acne Erythema: A Split Face Study
Acne is very common, especially among young adults. After acne heals, some people are left with persistent red or pink marks, called post-acne erythema (PAE).
- Trial name
- NCT07884565
- Testing
- topical Timolol maleate 0.5% eye drops, topical Vitamin C 15%, Fractional CO2 laser
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis
Effects of Antioxidant Dentifrice on Gingivitis
The purpose of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt on gingival inflammation, gingival bleeding and gingival redness.
- Trial name
- NCT02102295
- Testing
- Experimental toothpaste, Control toothpaste
- Where
- 4 sites in Japan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Lion Corporation
Finger Stiffness, Distal Radius Fracture
Does Vitamin C Reduce Finger Stiffness After Distal Radius Fractures?
The reported prevalence of disproportionate pain and disability among patients recovering from a fracture of the distal radius varies widely.
- Trial name
- NCT02216812
- Testing
- 500 mg vitamin c, 1 pill per day for 6 weeks
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
This is a two arm RCT evaluating the effect of intravenous vitamin C versus placebo in patients with incurable non-small cell lung cancer.
- Trial name
- AIVAA (NCT05849129)
- Testing
- Ascorbic acid, Normal Saline
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Metabolic Diseases, Oxidative Stress
Effect of an Anti-Oxidant Treatment on Resistin Serum Levels.A Randomized Study
The aim of the present study was to evaluate whether an in vivo treatment with an antioxidant vitamin (vitamin C) might substantially affect serum levels of resistin, a recently described adipokine, whose clinical significance is…
- Trial name
- NCT00387114
- Testing
- Vitamin C
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Colorectal Cancer, Colon Adenoma
A Randomized Prospective Trial Comparing Low-volume Bowel Preparation Methods
Colonoscopy is a common screening method to detect polyps and CRC. With the early detection of CRC through screening colonoscopy, patients could have better therapeutic effects and outcomes.
- Trial name
- NCT02250196
- Testing
- PEG-Asc, SPMC 2
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Korea University Anam Hospital
Inguinal Hernia
Effects of Oral Supplementation of Arginine, Zinc and Vitamin C on Collagen Synthesis in Inguinal Hernia Patients
Collagen synthesis is depressed systemically in the immediate postoperative period. Arginine, zinc and vitamin C impact collagen synthesis.
- Trial name
- NCT03221686
- Testing
- Intervention, Control
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Lars Nannestad Jorgensen
Jaundice
Grape Seed Powder and Vitamin C Supplementation for Liver Disease (Acquired Hepatic Jaundice)
Jaundice is a frequent medical problem that affects people of all ages. It is important to note that jaundice is not an actual sickness as such itself but rather a symptom of liver illness brought on by an increase in the…
- Trial name
- AHJ (NCT07575789)
- Testing
- Grape-C supplement
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- University of Lahore Hospital (ULH)
Hepatitis C
A Pilot Study of High-Dose, Intravenous Ascorbic Acid (Vitamin C) to Treat Hepatitis C
The purpose of this pilot study is to learn whether high doses of ascorbic acid (vitamin c), given intravenously to patients with chronic hepatitis due to infection with the genotype 1 version of the hepatitis C virus, are safe…
- Trial name
- NCT01250743
- Testing
- ascorbic acid (vitamin C)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Health Innovations, Frontier Research Institute
Sepsis, Septic Shock
Ascorbic Acid (Vitamin C) Infusion in Human Sepsis
The major goal of this project is to determine whether intravenously infused ascorbic acid is safe for use as a viable therapeutic strategy in adult humans with sepsis.
- Conditions
- Sepsis, Septic Shock, Hypotension, Acute Lung Injury
- Trial name
- NCT01434121
- Testing
- Ascorbic Acid
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Virginia Commonwealth University
Deficiency, Vitamin C, Chronic Disease
A Long-term Observational Study to Describe the Use of Vitamin-C Injektopas® 7.5 g in Patients With Vitamin C Deficiency
The goal of this observational study is to learn more about the disease and the symptoms where the product will use and in which patient groups. Further on, it is interesting to know clinical pictures, the symptoms improve.
- Conditions
- Deficiency, Vitamin C, Chronic Disease, Acute Disease
- Trial name
- NCT06983847
- Where
- Austria
- Volunteers
- 1,000 people
- Sponsor
- Pascoe Pharmazeutische Praeparate GmbH
Corona Virus Infection
Role of Mega Dose of Vitamin C in Critical COVID-19 Patients
Vitamin C (ascorbic acid) is a water-soluble vitamin having anti-inflammatory, immunomodulatory, anti-oxidative, antithrombotic and antiviral properties.
- Trial name
- NCT04682574
- Testing
- Vitamin C
- Where
- Pakistan
- Volunteers
- 278 people
- Sponsor
- University of Lahore
CABG-Induced Oxidative Stress
Comparison of Ascorbic Acid and Grape Seed Extract in Oxidative Stress Induced by on Pump Heart Surgery
Study aimed to compare the effect of grape seed extract and ascorbic acid in oxidative stress induced by on pump coronary artery by pass grafting surgery.
- Trial name
- NCT00839085
- Testing
- GSE, Vit C (Ascorbic Acid)
- Where
- Iran
- Volunteers
- 72 people
- Sponsor
- Tabriz University
Necrotizing Soft Tissue Infection, Sepsis
HAT for the Treatment of Sepsis Associated With NASTI
Evaluate the impact of HAT therapy versus placebo in the treatment of patients with an acute NSTI and sepsis.
- Trial name
- NCT05157360
- Testing
- HAT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ascension Health
Sepsis, Septic Shock
Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial
In this study, we aim to determine whether the combination of Ascorbic Acid (Vitamin C), Thiamine (Vitamin B1), and Corticosteroids improves the trajectory of organ failure and reduces mortality in patients with sepsis and septic…
- Conditions
- Sepsis, Septic Shock, Metabolic Disturbance
- Trial name
- NCT03389555
- Testing
- vitamin C, vitamin B1, hydrocortisone, Normal saline
- Where
- 13 sites in United States
- Volunteers
- 205 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hyperuricemia, Gout
Hmong Microbiome ANd Gout, Obesity, Vitamin C (HMANGO-C)
Investigators seek to quantify the impact of vitamin C on patient outcomes, including serum urate level, gout-related symptoms, and obesity (measured by BMI) in both healthy Hmong adults and in Hmong patients with hyperuricemia…
- Trial name
- NCT04938024
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Minnesota