Clinical trials: Ascorbic Acid
Post Operative Pain
Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.
The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.
- Trial name
- NCT05478044
- Testing
- Ascorbic acid, saline
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Adequate Vitamin C Status, Inadequate Vitamin C Status
Anti-inflammatory Activities of Vitamin C Supplementation on the Gut Barrier Function in Adults With Obesity
This study is testing whether taking vitamin C every day can help improve gut health and reduce inflammation in adults with obesity.
- Trial name
- NCT07151105
- Testing
- Vitamin C Supplement + Low Vitamin C Diet
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Ohio State University
Septic Shock
Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock
Preliminary studies show that giving a "cocktail" of intravenous vitamin C, vitamin B1, and steroids to critically ill patients with septic shock may dramatically improve mortality in those patients.
- Trial name
- NCT03828929
- Testing
- Vitamin C, Normal saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Diabetes Type 2
Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes
An unexpected means to prevent microvascular disease in diabetes may be coupled to the function of vitamin C in red blood cells (RBCs) of diabetic participants.
- Trial name
- NCT02107976
- Testing
- Vitamin E, Vitamin C
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Inflammation, Oxidative Stress
Antioxidants Combined With Cryotherapy on Inflammatory Response After Resistance Exercise in Untrained Volunteers
Acutely resistance exercise induces inflammatory responses and leukocytosis arising of oxidative stress, that clinically manifested by pain and/or delayed onset muscle soreness (DOMS).
- Conditions
- Inflammation, Oxidative Stress, Pain
- Trial name
- NCT02902315
- Testing
- Cryotherapy, Vitamins C and E, Vitamins C and E associated with cryotherapy
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Vasoplegia Syndrome
Effects of Vitamin C on Shock Duration and Microcirculation in Patients With Vasoplegia Syndrome After Cardiac Surgery
This pilot study intends to observe the effect of intravenous vitamin C on the prognosis and sublingual microcirculation in patients with vasoplegia syndrome after cardiac surgery through a prospective randomized controlled study…
- Trial name
- NCT06723626
- Testing
- Vit C, Standard Preparation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Colonoscopy
Changes of Serum Electrolytes During Bowel Prep With PEG 3350 + Ascorbic Acid - a Prospective Study
Hypothesis: Patients who undergo bowel preparation with PEG 3350 + ascorbic acid may have significant changes of serum electrolytes.
- Trial name
- NCT01841138
- Where
- Germany
- Volunteers
- 190 people
- Sponsor
- Klinik Bogenhausen
Collagen Synthesis, Rate of Force (RFD) Development
Effects of Hydrolyzed Collagen and Vitamin C on Explosive Performance
Determine whether supplementation with a combined dose of 20 g of hydrolyzed collagen and 50 mg vitamin C, along with a power training exercise program, increases rate of force development (RFD) and performance in athletes
- Trial name
- NCT04437758
- Testing
- Collagen and Vitamin C powder mix nutritional intervention, Maximum power training exercise
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Anaplastic Astrocytoma, Anaplastic Oligodendroglioma
Temozolomide and Ascorbic Acid in Treating Patients With Recurrent High-Grade Glioma
This phase I trial studies the side effects and best dose of ascorbic acid when given together with temozolomide in treating patients with high-grade glioma that has come back.
- Conditions
- Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Oligoastrocytoma, Glioblastoma
- Trial name
- NCT02168270
- Testing
- ascorbic acid, temozolomide, quality-of-life assessment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Nebraska
Noise-Induced Hearing Loss
Micronutrients to Prevent Noise-induced Hearing Loss
Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue. Studies in animals have allowed us to identify mechanisms contributing to NIHL, including direct mechanical trauma, free radicals formed in…
- Trial name
- NCT00808470
- Testing
- beta-carotene, vitamins C and E, magnesium
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Gingival Pigmentation
Efficacy of Microneedling With Vitamin C in Performing Gingival Depigmentation
The present study will be carried to clinically evaluate the efficacy of microneedling with vitamin C in performing gingival depigmentation in comparison with conventional scalpel and diode laser.
- Trial name
- NCT07070024
- Testing
- Vitamin C, Microneedling, Diode laser
- Volunteers
- 30 people
- Sponsor
- Fayoum University
C-reactive Protein, Inflammation
Obesity, Inflammation and Oxidative Stress
The purpose of this study is to determine whether or not Vitamin C (1000 mg/day) can reduce markers of inflammation, especially C-reactive protein (CRP), in obese persons with baseline CRP greater than 1 mg/dl.
- Conditions
- C-reactive Protein, Inflammation, Obesity, Oxidative Stress
- Trial name
- NCT01028976
- Testing
- Vitamin C (ascorbic acid)
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Osteopenia or Osteoporosis
Effect of Consumption of Supplements and Enriched Olive Paste on Bone Metabolism Indices
It was a prospective randomized controlled trial. A sample of 115 apparently healthy post-menopausal women(45 -75 years of age) randomized into four groups and received supplements of Ca, Vitamin D and Mg with or without enriched…
- Trial name
- Osteoporosis (NCT06135831)
- Testing
- Functional olive paste, Calciovitmag (CDCaMg), Phosporovitmag (PDCaMg)
- Where
- Greece
- Volunteers
- 115 people
- Sponsor
- University of the Aegean
Thin Gingival Biotype
Comparative Evaluation of Vitamin C and Injectable-platelet Rich Fibrin in the Management of Thin Gingival Phenotype
The goal is to compare between the effect of vitamin C and Injectable-platelet rich fibrin in the management of thin gingival phenotype.
- Trial name
- NCT05841303
- Testing
- Vit C, injectable PRF
- Where
- Egypt
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cairo University
Newly Diagnosed Glioblastoma Who Underwent at Least Partial Resection of the Tumor Surgically
Potentiation of Chemotherapy in Brain Tumors by Zinc
Glioblastoma (GB) is the most common and aggressive type of primary malignant brain tumor in adults. Despite advances in surgical resection, radiotherapy and chemotherapy, prognosis remains very poor.
- Trial name
- NCT04488783
- Testing
- zinc and ascorbate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Gingival Pigmentation, Depigmentation
Gingival Hyperpigmentation Treatment
It is a clinical study conducted to evaluate the effect of vitamin C and Glucathonine injection of pigmented gingival tissue versus surgical removal by scalpel
- Conditions
- Gingival Pigmentation, Depigmentation, Vitamin C, Glutathione
- Trial name
- NCT07595705
- Testing
- Vitamin c and glutathione, Surgical depigmentation
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pancreatic Neoplasms
A Research Trial of High Dose Vitamin C and Chemotherapy for Metastatic Pancreatic Cancer
This study is designed to determine the maximum tolerated dose of vitamin C when given with a standard chemotherapy for people who have metastatic pancreatic cancer.
- Trial name
- NCT01049880
- Testing
- Gemcitabine with escalating ascorbic acid
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Joseph J. Cullen
Diet, Food
Acute Resistance Exercise and Hydrolyzed Collagen Supplementation
This study aimed to investigate the effect of different doses of hydrolyzed collagen (HC) with resistance exercise (RE) on whole body collagen synthesis in middle-aged males and females.
- Conditions
- Diet, Food, Nutrition
- Trial name
- NCT06236659
- Testing
- Consumption of three different doses of hydrolyzed collagen (HC) with resistance exercise, Consumption of two different doses of hydrolyzed collagen (HC) with reistance exercise
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rob Erskine
COVID-19, Hypoxia
Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation
Previous research has shown that high dose intravenous vitamin C (HDIVC) may benefit patients with sepsis, acute lung injury (ALI), and the acute respiratory distress syndrome (ARDS).
- Trial name
- AVoCaDO (NCT04357782)
- Testing
- L-ascorbic acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Nutrition, Healthy
Effects of Liposomal Encapsulation on Vitamin C Absorption and Metabolism
Vitamin C is an important antioxidant in the human body and plays many important roles. It is currently known that vitamin C has the functions of treating scurvy, assisting in collagen synthesis, whitening, and increasing…
- Trial name
- NCT06372171
- Testing
- Satge 1, Stage 2
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University