Clinical trials: Ascorbic Acid
Burns
The Effect of High Dose Vitamin C in Burn Patients
The purpose of this study is to see if intravenous Vitamin C will decrease the amount of IV fluids needed following burn injury in the first 48 hours.
- Trial name
- Vitamin C (NCT00350077)
- Testing
- Intravenous Vitamin C, Vitamin C
- Where
- United States
- Sponsor
- United States Army Institute of Surgical Research
Socket Preservation
Evaluation of Dentin Graft and I-PRF With and Without Vitamin C for Post-extraction Socket Preservation
The aim of the study is to evaluate radiographic ridge width change following autogenous demineralized dentin graft (ADDG) and i-PRF addition with and without vitamin C (AA) for post extraction socket preservation.
- Trial name
- NCT06569264
- Testing
- Alveolar ridge preservation using autogenous demineralized dentin graft and i-PRF, Alveolar ridge preservation using vitamin C with dentin graft and i-PRF
- Where
- Egypt
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cairo University
Squamous Cell Cancer, Squamous Cell Carcinoma
Topical Ascorbic Acid for Treatment of Squamous Cell Skin Cancer
Randomized comparative trial of a 30% solution of ascorbic acid in 95% dimethylsulfoxide applied topically twice a day for 8 weeks vs 5% imiquimod cream in the treatment of biopsy proven squamous cell carcinomas of the skin in…
- Conditions
- Squamous Cell Cancer, Squamous Cell Carcinoma, Skin Cancer, Non-melanoma Skin Cancer
- Trial name
- NCT05932511
- Testing
- 30% ascorbic acid in DMSO
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Center for Biomedical Research, Inc.
Lupus or SLE, Spondyloarthritis
Evaluation of Plasma Vitamin C Levels in a Population of Chronic Rheumatism in Immuno-Rheumatology
Scurvy is an almost forgotten carential pathology, caused by a deep vitamin C (or ascorbic acid) deficiency, a priori exceptional in industrialized countries.
- Trial name
- VitCRIC (NCT05345899)
- Testing
- Evaluation of vitamin C level in plasma, Evaluation of quality of life
- Where
- France
- Volunteers
- 107 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Colorectal Neoplasms
Vitamin C Intravenously With Chemotherapy in Advanced Colorectal Cancer
Preclinical study has shown that human colorectal cancer cells harboring KRAS or BRAF mutations are selectively killed by high levels of ascorbic acid (AA). High dose of AA aslo impairs tumor growth in Apc/KRASG12D mutant mice.
- Trial name
- Vitality (NCT02969681)
- Testing
- ascorbic acid, Chemotherapy
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Sun Yat-sen University
Myelodysplastic Syndrome, Secondary Acute Myeloid Leukemia
Plasmatic L-AScorbic Acid in MYelodyplastic Syndroms and Controls
Myelodysplastic syndromes (MDS) is a group of heterogeneous diseases characterised by the clonal evolution of dysplastic hematopoietic stem cells.
- Trial name
- PLASMYC (NCT02809222)
- Testing
- Samples, Quality of life questionnaire
- Where
- 2 sites in France
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Peripheral Arterial Disease
Clinical Utility of Endothelial Dysfunction in PAD
This study will seek to determine whether non-invasive measures of endothelial function have utility as surrogate markers of cardiovascular risk in patients with peripheral arterial disease undergoing vascular surgery.
- Trial name
- NCT00491751
- Testing
- atorvastatin, ascorbic acid
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Boston University
Vitamin C Anemia, Pregnancy Anemia
The Effect of Vitamin C for Iron Supplementation During Pregnancy with Risk of Anemia
Anemia is a common problem during pregnancy. Most studies have demonstrated that anemia during pregnancy have adverse effects on their pregnancy outcome, which is important and should pay attention to prevent and solve such…
- Trial name
- NCT05975125
- Testing
- Vitamin C 500 MG Oral Tablet
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Variant Angina
ANti-Oxidant in Variant Angina (ANOVA) Trial
Purpose Objectives 1. To evaluate the anti-oxidant effect of long-term Vitamin C+E therapy on coronary vasospasm improvement. 2. To evaluate the anti-oxidant effect of long-term statin therapy on coronary vasospasm improvement.
- Trial name
- NCT03228238
- Testing
- Vitamin C and Vitamin E, Statin, Standard medication for variant angina
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Seoul National University Hospital
Exercise and Non-exercise Effect Upon Vitamins E and C
The Effects of Vitamin E and Vitamin C and Exercise
Moderate exercise is thought to be one of the best known means to improve how insulin works in people. Taking vitamin C and vitamin E is also thought to have the same effect.
- Trial name
- NCT01369043
- Testing
- Vitamin E and Vitamin C
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Premature Ovarian Insufficiency
4-step ASCOT in POI Women to Promote Follicular Rescue
To promote follicular development in POI women, G-CSF mobilized activated platelet rich plasma will be directly injected into the ovarian medulla.
- Trial name
- NCT04475744
- Testing
- G-CSF treatment for Bone marrow derived stem cell Mobilization, Platelet Rich Plasma ovarian injection
- Where
- 2 sites in Spain
- Volunteers
- 42 people
- Sponsor
- Fundación IVI
Complex Regional Pain Syndrome I of Lower Limb
"Liposomal Encapsulated Vitamin C in Complex Regional Pain Syndrome"
Abstract: Complex regional pain syndrome (CRPS) is a significant complication in operated osteoarticular pathology and may adversely affect patient's quality of life. Vitamin C is an anti-oxidant and a neuro-modulating agent.
- Trial name
- NCT04204200
- Testing
- liposomal vitamin C, standard vitamin C
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier de Ham
Oxidative Stress
Study of the Ability of Clarithromycin to Induce Oxidative Stress
The purpose of the study is to examine whether Klacid® (Clarithromycin) will induce oxidative stress (stress from oxygen) in healthy subjects.
- Trial name
- CLAROX (NCT00707330)
- Testing
- Clarithromycin
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation.
The hypothesis that is being tested is that the supplementation of L-arginine plus Vitamin C to multidisciplinary pulmonary rehabilitation (PR) in patients with a previous diagnosis of chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT06439875
- Testing
- effect of L-arginine and liposomial vitamin C on pulmonary rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 101 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer
This phase Ib trial tests the safety, side effects, and effectiveness of botensilimab, and balstilimab in combination with a fasting mimicking diet and high dose vitamin C in treating patients with KRAS-mutant metastatic…
- Trial name
- NCT06336902
- Testing
- Balstilimab, Biospecimen Collection, Botensilimab
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Southern California
Postmenopausal, Insulin Resistance
Effect of Resveratrol and Vitamin C on Insulin Resistance Among Postmenopausal Women
Hormonal and metabolic changes because of postmenopause increase body weight, central abdominal fat, alter lipid profile and insulin resistance, those factors increase the risk up to 60% to develop metabolic syndrome, diabetes…
- Trial name
- NCT03090997
- Testing
- vitamin C (500 mg / day) and resveratrol (500 mg / day)
- Where
- Mexico
- Volunteers
- 45 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Common Cold, Gastroenteritis
Echinacea, Propolis and Vitamin C for URI Prevention in Preschoolers
We hypothesize the herbal preparation will enhance the preschoolers' immune response and when taken prophylactically for 12 weeks will decrease episodes of upper respiratory infections and gastroenteritis in the active versus the…
- Trial name
- NCT00231218
- Testing
- dietary supplement--echinacea, propolis, and vitamin c
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Postpolypectomy Bleeding
Efficacy of Vitamin C Administration for the Prevention of Postpolypectomy Bleeding
Postpolypectomy bleeding is the most common major complication following a colonoscopic polypectomy procedure. The incidence rate ranging from 0.3 to 6.1%.
- Trial name
- NCT03400020
- Testing
- Ascorbic acid, Normal Saline
- Where
- Iran
- Volunteers
- 156 people
- Sponsor
- Ilam University of Medical Sciences
Uremia, Inflammation
Influence of Oral Vitamin C Supplement on the Inflammation Status in Dialysis Patients
Subclinical inflammation is a common phenomenon in patients receiving maintenance hemodialysis (MHD). This is because various pro-inflammatory cytokines are promoted due to metabolic acidosis, volume overload, and / or…
- Trial name
- NCT01356433
- Testing
- oral vitamin C
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Atrial Fibrillation Ablation
Vitamin C in Atrial Fibrillation Ablation
Single-center, double-blinded, randomized, controlled safety and feasibility pilot study of high dose IV ascorbic acid (200mg/kg) over 24 hours, divided into four doses and administered every six hours with a 30 minute IV…
- Trial name
- VitC-AF (NCT03148236)
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University