Clinical trials: Aseptic Inflammation
Myelodysplastic Syndromes
Sterile Inflammation and Molecular Aberrations in MDS
The objective of this study is the description of the possible association between genetic mutation/aberration profiles, inflammatory tonus and clinical phenotype based on PROMs and HRQoL.
- Trial name
- InflamGen (NCT04313231)
- Testing
- Next Generation Sequencing, Tumorimmunological examinations - multiplex assays/quantitative polymerase chain reaction, flow cytometry
- Where
- Austria
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Skeletal Muscle Damage, Skeletal Muscle Performance
NAC Supplementation and Skeletal Muscle Performance
In this investigation the investigators utilized NAC administration to foster GSH availability during an 8-day period following eccentric exercise-induced muscle damage in order to test our hypotheses: i) antioxidant…
- Conditions
- Skeletal Muscle Damage, Skeletal Muscle Performance, Intgracellular Signaling in Skeletal Muscle, Inflammatory Status
- Trial name
- NCT01778309
- Testing
- n-acetylcysteine supplementation
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation
Aloe Vera Ointment Application and Skeletal Muscle Recovery
Aloe vera, sometimes described as pharmaceutical aloe, is a flowering succulent plant with many therapeutic properties such as wound and burn wound healing, treatment of diabetes and reduction of blood lipid profile.
- Conditions
- Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Performance
- Trial name
- NCT03934762
- Testing
- Natural Aloe Vera, Aloe vera soup
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation
Protein Supplementation and Skeletal Muscle Healing Process
In this study the investigators utilized protein supplementation over an 8-day period following eccentric exercise-induced muscle damage in order to test the initial hypotheses : i) protein supplementation after exercise-induced…
- Conditions
- Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Skeletal Muscle Performance, Intracellular Signaling in Skeletal Muscle
- Trial name
- NCT02816411
- Testing
- Milk protein isolate
- Where
- Greece
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Inflammatory Response
Inhibition of Sterile Inflammation by Digoxin
To investigate the effect of digoxin on pyruvate kinase isoform 2 (PKM2) binding to pro-inflammatory loci and innate immune inflammatory responses in the peripheral blood in healthy subjects.
- Trial name
- NCT03559868
- Testing
- Digoxin
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Yale University
Edematous, Synovitis
Double-Blinded Clinical Trial Using Apatone®B for Symptomatic Postoperative Total Joint Replacements
This research study is being conducted to determine if taking oral (by mouth in pill form) Apatone®B (a combination of Vitamins C and K3) will reduce chronic joint discomfort and improve function of non-infected symptomatic…
- Conditions
- Edematous, Synovitis, Foreign Body Reaction, Osteolysis
- Trial name
- Apatone-B (NCT01272830)
- Testing
- Apatone®B
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- IC-MedTech Corporation
Periodontal Disease, Gingivitis and Periodontal Diseases
Hippo Signaling Pathway Proteins in Gingival Crevicular Fluid of Individuals With Periodontal Disease
Periodontal disease is a chronic inflammatory condition of the tooth-supporting tissues in which the host inflammatory response drives the destruction of alveolar bone and periodontal attachment.
- Conditions
- Periodontal Disease, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- BYHN-GCF-HIPPO (NCT07759466)
- Testing
- ELISA Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Inonu University
Sepsis Newborn, Infection
Glove-based Care in the NICU to Prevent Late Onset Sepsis
Babies that get an infection after 3 days of age while in the Neonatal Intensive Care Unit is not related to their delivery but to the hospital environment.
- Trial name
- GloveCare (NCT03078335)
- Testing
- Glove based care, Standard of Care - Hand Hygiene
- Where
- Canada
- Volunteers
- 786 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation
NAC Supplementation and Soccer Specific Performance
In this investigation the investigators utilized NAC supplementation to boost GSH availability during an one-week-microcycle consisting of three soccer games, in order to test the hypotheses that: i) antioxidant supplementation…
- Conditions
- Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Skeletal Muscle Performance, Antioxidant Status
- Trial name
- NCT04523675
- Testing
- N-acetylcysteine
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Satellite Cells, Redox Status
Redox Regulation of Satellite Cells and Skeletal Muscle Healing
Skeletal muscle stem cells (Satellite cells) are indispensable for muscle growth and remodeling following myofibril damage. Skeletal muscle trauma is present in numerous catabolic conditions, characterized by elevated proteolysis…
- Conditions
- Satellite Cells, Redox Status, Exercise-induced Muscle Trauma, Aseptic Inflammation
- Trial name
- NCT03711838
- Testing
- N-Acetylcysteine
- Where
- Greece
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Aseptic Meningitis
Aseptic Meningoencephalitis in Slovenia
The main objective of this study is: to establish etiology of acute aseptic meningitis/meningoencephalitis in Slovenia to assess the clinical course and outcome of tick-borne encephalitis and Lyme neuroborreliosis to characterize…
- Trial name
- NCT02328469
- Testing
- symptomatic therapy, Ceftriaxone or Doxycycline, questionnaire
- Where
- 2 sites in Slovenia
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Skeletal Muscle Damage, Aseptic Inflammation
Redox Status and Immune Function
In this investigation the investigators utilized N-acetylcysteine (NAC) supplementation to enhance reduced glutathione (GSH) stores during an 8-day recovery period from a strenuous eccentric exercise protocol in order to test the…
- Conditions
- Skeletal Muscle Damage, Aseptic Inflammation, Skeletal Muscle Function
- Trial name
- NCT02930031
- Testing
- n-acetylcysteine
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens