Clinical trials: Aseptic Loosening
Obesity, Aseptic Loosening
Analysis of Varus Collapse in Obese Patients With Stem and Non-Stem Tibial Components Following Primary Total Knee Arthroplasty
The purpose of this study is to compare rates of varus collapse, aseptic loosening, and implant failure in female obese patients undergoing total knee arthroplasty (TKA) and will review the degree of influence of stemmed tibial…
- Conditions
- Obesity, Aseptic Loosening, Varus Collapse
- Trial name
- SvNS (NCT06019832)
- Testing
- Total Knee Arthroplasty (TKA), Stemmed Tibial Implant, Non-stemmed tibial implant
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Jacob M. Elkins
Aseptic Loosening, Infection
Maxx Orthopedics' PCK Revision TKA Study of Component Survivorship
The objectives of this clinical investigation are to evaluate the safety and performance of the Freedom Total Knee® PCK System.
- Conditions
- Aseptic Loosening, Infection, Bone Loss, MCL - Medial Collateral Ligament Rupture of the Knee
- Trial name
- NCT03312088
- Testing
- Freedom Knee PCK Components
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maxx Orthopedics Inc
Aseptic Loosening of Prosthetic Joint
Artificial Intelligence to Detect Early Total Knee Replacement Implant Failure
The goal of this trial is to investigate whether Machine Learning (ML) can be used to detect small degrees of loosening, lucent zones, or any other changes on radiographs that might predict early failure following NexGen total…
- Trial name
- NCT06724094
- Volunteers
- 2,105 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint
The Use of CCK vs PS in Revision TKAs
This study aims to compare the clinical impact of Constrained Condylar versus Posterior Stabilized Knee (PS) bearings on patient satisfaction and surgical outcomes including mid-term survivorship among patients undergoing…
- Conditions
- Aseptic Loosening of Prosthetic Joint, Instability of Prosthetic Joint, Reimplantation for Periprosthetic Joint Infection, Femoral Revision Indicated
- Trial name
- NCT06782295
- Testing
- Constrained Condylar bearing, posterior stabilized bearing
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Rush University Medical Center
Infection of Total Knee Joint Prosthesis, Aseptic Loosening of Prosthetic Joint
Surgical / Economic Effect of the Aquamantys System in Blood Management for Aseptic and Septic Revision TKA
To assess the surgical and economic effectiveness of the Aquamantys System in managing intra- and post-operative blood loss, and reducing transfusion needs in patients undergoing both aseptic and septic revision total knee…
- Trial name
- NCT02266407
- Testing
- Aquamantys System
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medtronic Surgical Technologies
Hip Arthrosis
Locally Administered Clodronate in the Prevention of Aseptic Implant Loosening
Periprosthetic bone-loss after total hip arthroplasty (THA), detected as an early migration of the prosthesis, may predict later loosening.
- Trial name
- NCT03803839
- Testing
- Clodronate, Saline
- Volunteers
- 19 people
- Sponsor
- University of Oulu
Knee Osteoarthritis, Knee Arthropathy
Radiostereometry in Knee Arthroplasty
The innovative aspect of this research is the possibility of combining the data collected with radiostereometric model based Radiostereometry with the data collected through the Galeazzi Institute Registry.This opens the prospect…
- Conditions
- Knee Osteoarthritis, Knee Arthropathy, Aseptic Loosening
- Trial name
- NCT04960111
- Testing
- RSA
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Aseptic Loosening, Arthropathy of Knee
Economic-demographic Assessment of the Aseptic Mobilization of Knee Prostheses Through the RIPO Registry and Radiographic Analysis of the Case Series From the II Clinic of IOR
The increase in life expectancy is leading to an increase in the average age of patients undergoing total knee arthroplasty (TKA), and, consequently, an increase in the number of revisions.
- Trial name
- AL-TKA (NCT06821581)
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Istituto Ortopedico Rizzoli
Prosthesis Loosening
Investigating Proximal Migration in Trabecular Metal Cups Used In Acetabular Revision Surgery
This study is intended to compare the proximal migration of the tantalum design (TM) with a cemented cup used in conjunction with bone allografting in cases with major bone loss.
- Trial name
- NCT02237482
- Testing
- Trilogy cup, Trabecular metal cup (TM), ZCA cup
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
Osteoarthritis
Effect of Cemented Stem Design on Periprosthetic Bone Mass Following Primary Total Hip Arthroplasty
Total hip replacement is a common procedure for the treatment of osteoarthrosis of the hips, the aims of this study are to determine the effect of implant stem design on bone quality surrounding the implant using three stem…
- Trial name
- NCT00293605
- Testing
- Total Hip Replacement
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Arthroplasty Complications
Evaluation of Metal-on-conventional-polyethylene vs Ceramic-on-ceramic Articulating Surfaces in Total Hip Arthroplasty
Polyethylene wear debris from metal-on-polyethylene articulations are one of the main causes of periprosthetic bone loss and non-infectious loosening in total hip arthroplasty.
- Trial name
- NCT03692364
- Testing
- Ceramic-on-ceramic uncemented hip arthroplasty, Metal-on-polyethylene uncemented total hip arthroplasty
- Volunteers
- 104 people
- Sponsor
- Sahlgrenska University Hospital
Aseptic Loosening, Aseptic Loosening of Prosthetic Joint
DIGITAL-KNEE Study: Adequately Diagnosing Total Knee Arthroplasty Loosening by Evaluating the AtMoves Knee System in a Routine Clinical Setting
The goal of the clinical trial is to evaluate the efficacy of the AtMoves Knee System in the clinical diagnostic process of aseptic loosening in patients with a knee prosthesis.
- Conditions
- Aseptic Loosening, Aseptic Loosening of Prosthetic Joint, Aseptic Loosening of Orthopaedic Hardware, Knee Arthroplasty, Total
- Trial name
- DigitalKnee (NCT06839807)
- Testing
- AtMoves Knee System
- Where
- 7 sites in Netherlands
- Volunteers
- 124 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cancer of Bone, Trauma
Mg OSTEOCRETE Post-Treatment Outcomes
Mg OSTEOCRETE is a bone substitute used to fill a defect in bone caused by excision of a tumor, orthopaedic hardware that has become loosened, or a trauma-related condition.
- Conditions
- Cancer of Bone, Trauma, Aseptic Loosening of Orthopaedic Hardware
- Trial name
- NCT06720142
- Testing
- Mg OSTEOCRETE as a bone void filler
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Santiago Lozano-Calderon
Aseptic Loosening of the Hip Prosthesis
Bisphosphonates and Impaction Grafting in Hip Revision
The primary focus of this study is to investigate whether increased bone density of the graft in revision arthroplasty of the hip can cause a decreased micromotion of the implant relative to the femur.
- Trial name
- NCT00658268
- Testing
- Clodronate
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Region Skane
Loosening, Prosthesis
Identification of Infections in Hip Arthroplasty Loosening.
Recent data showed that the rate of periprosthetic infections in patients undergoing a hip arthroplasty revision for aseptic loosening is higher than what can be ascertained with conventional methods.
- Trial name
- NCT04773054
- Testing
- Microbiological analysis of periprosthetic tissue, Histological analysis of periprosthetic tissue, Characterization of tissue microbiota
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- Istituto Ortopedico Rizzoli
Periprosthetic Fracture Around Prosthetic Joint Implant, Aseptic Loosening of Prosthetic Joint
Follow-Up of the Prevision® Hip Stem
The main objective of this study is to represent the treatment reality at the study site and to draw conclusions from cases of failure or suboptimal outcome.
- Trial name
- PRESPECT (NCT04833634)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Aesculap AG
Knee Osteoarthritis
Total Knee Arthroplasty With Vitamin E Polyethylene
The aim of this observational study is to investigate if there is any difference in survival rate, clinical and radiological results after total knee replacement with vitamin E-blended polyethylene in comparison to conventional…
- Trial name
- NCT05810285
- Testing
- GKS Prime Flex Mobile knee
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- Permedica spa
Complications; Arthroplasty, Mechanical, Aseptic Loosening
Fluoroscopic and RSA Evaluation of the Triathlon Total Knee Prosthetic Design
The goal of this study is to compare the fixed bearing (FB) Triathlon knee (Stryker, USA) and the mobile bearing (MB) Triathlon knee (Stryker, USA) and study the effect of implant design on kinematics and micromotion.
- Trial name
- NCT02924961
- Testing
- Triathlon PS total knee system with mobile-bearing, Triathlon PS total knee system with fixed-bearing
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Leiden University Medical Center
Revision Hip Arthroplasty, Aseptic Loosening of Prosthetic Joint
Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Revision Hip Prosthesis System
This is a multicenter, prospective, observational, post-market clinical follow-up (PMCF) study designed to evaluate the safety and clinical performance of the Tipmed™ Revision Hip Prosthesis System in adult participants…
- Conditions
- Revision Hip Arthroplasty, Aseptic Loosening of Prosthetic Joint, Prostheses-related Infections, Joint Instability
- Trial name
- NCT07653295
- Testing
- Tıpmed™ Revision Hip Prosthesis System
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- TIPMED Medical Device Manufacturing Ltd. Co.
Total Knee Arthroplasty, Reinfection
Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies
A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University.
- Conditions
- Total Knee Arthroplasty, Reinfection, Aseptic Loosening, Revision
- Trial name
- NCT07232771
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University