Clinical trials: Asherman Syndrome
Infertility, Asherman's Syndrome
Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair
Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant…
- Trial name
- PRP-E (NCT02825849)
- Testing
- Intrauterine infusion of platelet rich plasma
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Endometrium; Atrophy, Intrauterine Synechiae
AD-SVF Therapy for Refractory Endometrial Infertility
The purpose of this study is to initially explore the efficacy of adipose-derived stromal vascular fraction (AD-SVF) therapy in the treatment of refractory endometrial infertility.
- Trial name
- NCT07230600
- Testing
- AD-SVF
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Intrauterine Adhesion
The Efficacy and Safety of Disposable Balloon Uterine Stent in Patients With Asherman Syndrome
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03330873
- Testing
- disposable balloon uterine stent, Foley catheter
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Intrauterine Adhesion
Comparing the Efficacy of Two Methods for the Therapy of Uterine Adhesion
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03329898
- Testing
- dried biological amnion graft, disposable balloon uterine stent, estradiol valerate tablets
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Asherman's Syndrome
Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions
The purpose of this study is to compare the outcome of loop intrauterine contraceptive device and heart-shaped intrauterine balloon for the adjunctive treatment of severe intrauterine adhesions in patients with infertility.
- Trial name
- ROABTIPWSIUA (NCT02708277)
- Testing
- loop-shaped intrauterine contraceptive device, intrauterine balloon (Cook Medical)
- Volunteers
- 93 people
- Sponsor
- Yuqing Chen
Asherman Syndrome
Effects of Platelet Rich Plasma on Endometrium
Intrauterine platelet rich plasma will be injected in the endometrial region via the vaginal route after the cessation of menstrual period.
- Trial name
- NCT04424160
- Testing
- PRP injection in the endometrium
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Acibadem University
Asherman Syndrome
Establishment and Application of Endometrial 3D-organoid in Endometrial Injury Repair
Normal endometrial repair occurs without scar formation; however, in some women, these normal repair mechanisms are aberrant, resulting in intrauterine adhesion (IUA) formation.
- Trial name
- NCT05521932
- Testing
- endometrium collected
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Asherman's Syndrome, Thin Endometrial Lining
Senescent Endometrial Cells in Patients with Thin Endometrial Lining
The goal of this observational study is to determine if thin endometrial lining that is unresponsive to estrogen might be associated with the presence of senescent cells in patients following long-term use of oral contraceptives.
- Conditions
- Asherman's Syndrome, Thin Endometrial Lining, Cell Senescence
- Trial name
- NCT06450301
- Testing
- Endometrial Biopsy
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Trio Fertility
Asherman Syndrome, Intrauterine Adhesion
Evaluate Formation of IUAs After Third-generation Endometrial Ablation, With and Without Intrauterine Adhesion Barrier
Evaluate the formation of adhesions after third-generation endometrial ablation, with and without the intrauterine adhesion barrier.
- Trial name
- CLEAN (NCT05414760)
- Testing
- Womed Leaf
- Where
- 2 sites in Netherlands
- Volunteers
- 1 people
- Sponsor
- Remko P. Bosgraaf
Intrauterine Adhesion
Comparing the Efficacy of Two Methods in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
Asherman's syndrome is characterized by the presence of intrauterine adhesions (IUA) as well as symptoms such as amenorrhea, hypomenorrhea, pelvic pain, and infertility.
- Trial name
- NCT03346317
- Testing
- disposable balloon uterine stent, dried biological amnion graft, estradiol valerate tablets+dydrogesterone tablets
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Infertility, Female, Infertility of Uterine Origin
Autologous Bone Marrow-derived Mesenchymal Stem Cells for Atrophic Endometrium in Patients With Repeated IVF Failures
Investigators will examine safety and efficiency of the cell product of autologous bone marrow-derived mesenchymal stem cells (MSC) for patients with repeated IVF failures and hypoplastic or/and fibrosis process of endometrium
- Conditions
- Infertility, Female, Infertility of Uterine Origin, Asherman Syndrome
- Trial name
- NCT03166189
- Testing
- bone marrow-derived MSC and HRT, hormonal replacement therapy
- Where
- Russia
- Volunteers
- 46 people
- Sponsor
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Intrauterine Adhesions
Efficiency of Amnion Graft to Prevent Intrauterine Adhesions After Hysteroscopic Surgery
The purpose of the study is to evaluate whether human amnion graft reduces the reformation of severe intrauterine adhesions (IUA) following hysteroscopic adhesiolysis.
- Trial name
- NCT02132104
- Testing
- Uterine application of amnion membrane, Foley balloon, Femoston
- Where
- 2 sites in China
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Asherman Syndrome
CURENDO (Cord-blood Uterine Regeneration Endometrium): Platelet-rich Plasma Therapy Derived From Umbilical Cord Blood for the Treatment of Endometrial Pathologies (Asherman Syndrome / Endometrial Atrophy / Thin Endometrium)
In recent years, platelet-rich plasma (PRP) has emerged as a promising alternative for treating endometrial pathologies that affect the endometrial lining.
- Trial name
- CURENDO (NCT07697924)
- Testing
- Umbilical cord platelet-rich plasma (hUC-PRP)
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Fundación IVI
Asherman Syndrome, Abortion Late
Prevalence of Intrauterine Adhesions After D&C With or Without Antiadhesion Gel After Abortion in Second Trimester.
Only patients who sign an informed consent will be included. Patients after a miscarriage in the 2nd trimester of pregnancy who need to perform an instrumental revision of the uterine cavity (RCUI, revisio cavi uteri…
- Trial name
- ADAB (NCT04671914)
- Testing
- Hyaluronic Acid 20 MG/ML Injectable Solution, Dilation and curretage
- Where
- 3 sites in Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
Infertility, Asherman Syndrome
Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells
This study evaluates the addition of collagen scaffold loaded with autologous bone marrow mononuclear cells(ABMNC) to Foley catheter balloon after hysteroscopic adhesiolysis in the treatment of severe asherman syndrome.
- Trial name
- NCT02680366
- Testing
- collagen/ABMNC scaffold, Foley catheter balloon
- Where
- China
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Asherman Syndrome, Endometrial Atrophy
Use of PRP in Endometrial Reconstruction
Infertility, which affected 48.5 million couples worldwide in 2010 alone, has many causes; some causes result from issues related to the endometrium.
- Trial name
- NCT03249415
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Fundación IVI
Intrauterine Adhesion
The Efficacy of G-CSF Against Adhesion Reformation After Hysteroscopic Adhesiolysis
The purpose of this study is to investigate the efficacy of Granulocyte Colony Stimulating Factor(G-CSF) on decreasing adhesion reformation and improving fertility outcomes after hysteroscopic adhesiolysis in patients with…
- Trial name
- NCT02855632
- Testing
- G-CSF, Normal saline, hormone therapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Sir Run Run Shaw Hospital
Infertility, Female
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
The purpose of this study is to investigate the effect of G-CSF on endometrial thickness in women who have failed reaching minimal endometrial thickness by standard treatments, to assess how many reach embryo transfer and what…
- Trial name
- NCT01202643
- Testing
- G-CSF, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Asherman Syndrome
Impact of Mindfulness Based Stress Reduction on Anxiety, Depression and QOL in Women With Intrauterine Adhesion.
The purpose of this study is to determine whether mindfulness based stress reduction are effective on improve anxiety, depression and quality of life in women with intrauterine adhesion
- Trial name
- IMBSRADQWIUA (NCT02746679)
- Testing
- Mindfulness Based Stress Reduction
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Yuqing Chen
Adhesion; Uterus, Internal
Use of an Intra Uterine Balloon to Prevent Recurrent Adhesions (REpAIR)
Patients suffering of subfertility as a consequence of intrauterine adhesions could be treated with hysteroscopic adhesiolysis. Adhesion recurrence may occur postoperative.
- Trial name
- NCT03446755
- Testing
- intra uterine Cook balloon
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent