Clinical trials: Aspergillosis
Mycoses
Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041)
This study is designed to evaluate the safety, tolerance and efficacy of Posaconazole (SCH 56592) under an open label, treatment protocol for subjects with invasive fungal infections: A: which are refractory or resistant to…
- Trial name
- NCT00034658
- Testing
- Posaconazole
- Volunteers
- 336 people
- Sponsor
- Merck Sharp & Dohme LLC
Aspergillosis
Surveillance of Fungal Infections During Construction Activity
Fungal infections in immunocompromised patients occuring during construction activities in hospitals have repeatedly been reported.
- Trial name
- NCT00473252
- Where
- Switzerland
- Volunteers
- 340 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Allergic Bronchopulmonary Aspergillosis (ABPA), Machine Learning
Multi-Omics Inflammatory Phenotype for ABPA Recurrence Risk Prediction
To develop and externally validate a machine learning model for predicting the 1-year risk of relapse in patients with stable ABPA, and to further evaluate its value in risk stratification and clinical decision-making.
- Conditions
- Allergic Bronchopulmonary Aspergillosis (ABPA), Machine Learning, Multi-omics, Multicenter Study
- Trial name
- NCT07611838
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Invasive Aspergillosis, Haematological Cancer Patients
Influence of a Combined Pharmacogenetic Score on Through Plasma Voriconazole Concentrations in Haematological Patients
Hypothesis: A pharmacogenetic score integrating both CYP3A genotypes could be influence initial trough voriconazole plasma concentrations and thus useful to adapt a priori voriconazole dosing in order to get adequate voriconazole…
- Conditions
- Invasive Aspergillosis, Haematological Cancer Patients, Voriconazole
- Trial name
- VORIGENE (NCT03067350)
- Where
- France
- Volunteers
- 47 people
- Sponsor
- University Hospital, Grenoble
Cystic Fibrosis, Fungal Infection
Immune Profiles in CF Fungal Infection
This study is investigating the role of allergic (Th2) inflammation in patients with Cystic Fibrosis (CF) and history of fungal infection and/or Allergic Bronchopulmonary Aspergillosis.
- Conditions
- Cystic Fibrosis, Fungal Infection, Allergic Bronchopulmonary Aspergillosis
- Trial name
- NCT04476758
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Chronic Obstructive Pulmonary Disease
Relationship Between Degree of Domestic Environmental Fungal Exposure and Clinical Symptoms of Patients With Chronic Obstructive Pulmonary Disease
Exposure to Aspergillus spores is associated with symptoms of asthma or airway inflammation (Chaudhary \& Marr, 2011; Smith \& Denning, 2011), leading to the possible onset of severe fungal complications with acute or chronic…
- Trial name
- BPCO-Myc (NCT05456178)
- Testing
- Electrostatic wipe
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Hospices Civils de Lyon
Allergic Bronchopulmonary Aspergillosis
Multicenter Registration Study on Allergic Bronchopulmonary Aspergillosis
To understand the current diagnosis and treatment status of ABPA patients, observe their clinical characteristics, prognosis, and treatment outcomes, and identify the relevant factors for poor prognosis in patients.
- Trial name
- NCT06645210
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Pulmonary Aspergillosis, Surgery-Complications
Uniportal VATS Resection for Pulmonary Aspergilloma : Evaluation of Prognostic Factors in a Single Center Experience
The objective of this study was to report our experience with U-VATS resection and to evaluate our surgical outcomes with an analysis of postoperative complications.
- Conditions
- Pulmonary Aspergillosis, Surgery-Complications, Thoracic Diseases
- Trial name
- NCT06564727
- Testing
- Uniportal VATS approach, VATS approach
- Where
- Morocco
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hassan II University
Allergic Bronchopulmonary Aspergillosis, ABPA
Real-World Effectiveness of Depemokimab in Allergic Bronchopulmonary Aspergillosis With Severe Eosinophilic Asthma
An open-label study will evaluate effects of Depemokimab in the treatment of severe eosinophilic asthma in patients with allergic bronchopulmonary aspergillosis
- Conditions
- Allergic Bronchopulmonary Aspergillosis, ABPA, Severe Eosinophilic Asthma
- Trial name
- NCT07828327
- Testing
- Depemokimab
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Qianfoshan Hospital
Invasive Aspergillosis
Assessment of Volatile Organic Compounds (VOC) for the Diagnosis of Invasive Aspergillosis (IA) in Lung Transplant Recipients
Prospective observational pilot study to evaluate the utility of breath VOCs to detect invasive aspergillosis in lung transplant recipients that are suspected of invasive fungal disease (IFD).
- Trial name
- UHN (NCT06344117)
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Owlstone Ltd
Candidemia, Aspergillosis Invasive
Performance Evaluation of the Fujifilm Wako Beta-D-glucan Technique in the Diagnosis of Major Invasive Fungal Infections (IFI)
Invasive fungal infections (IFI) are a major concern for immunocompromised or vulnerable patients. Associated mortality is significant and depends on the timeliness of diagnostic and therapeutic management.
- Conditions
- Candidemia, Aspergillosis Invasive, Pneumocystosis; Pneumonia (Etiology), IFI
- Trial name
- NCT07272915
- Testing
- Beta-1,3/1,6-D-Glucan
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Central Hospital, Nancy, France
Acute Myeloid Leukemia, Aspergillosis
Pre-hospital Risk Factors for Invasive Fungal Infection
SEIFEM 2010 study is a prospective, multicenter registry designed to identify and analyze risk factors for developing an invasive fungal infection in patients with newly diagnosed Acute Myeloid Leukemia, with particular interest…
- Conditions
- Acute Myeloid Leukemia, Aspergillosis, Candidiasis, Mycoses
- Trial name
- SEIFEM 2010 (NCT01315925)
- Where
- 42 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Catholic University of the Sacred Heart
Leukemia, Leukemia, Myeloid
Breath Analysis for the Detection of Invasive Fungal Infections
Patients with leukemia and concomitant neutropenia are at high risk of developing invasive fungal infections (IFI) that are associated with high morbidity and mortality.
- Conditions
- Leukemia, Leukemia, Myeloid, Leukemia, Lymphoblastic, Neutropenia
- Trial name
- REDEFINE (NCT06537726)
- Testing
- Secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS)
- Where
- Switzerland
- Volunteers
- 130 people
- Sponsor
- University of Zurich
Cystic Fibrosis, Allergic Bronchopulmonary Aspergillosis
Mechanisms of Immune Tolerance and Inflammation in Patients With Cystic Fibrosis With ABPA
The goal of this study is to identify the immunological factors that influence a patient's response to the presence of the fungus Aspergillus fumigatus (A. fumigatus) in the lungs.
- Trial name
- ABPA (NCT00585364)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Invasive Fungal Infections
Evaluate F901318 (Olorofim) Treatment of Invasive Fungal Infections in Participants Lacking Treatment Options
A study to evaluate olorofim (F901318) for the treatment of invasive fungal infections in participants lacking suitable alternative treatment options.
- Trial name
- FORMULA-OLS (NCT03583164)
- Testing
- Olorofim
- Where
- 82 sites in United States, Australia and 15 more
- Volunteers
- 203 people
- Sponsor
- F2G Biotech GmbH
Allergic Broncho-Pulmonary Aspergillosis
Protocol TARC-ABPA
The main objective of this study is to determine if a doubling of serum TARC (compared to baseline) is associated with the occurrence of exacerbations of ABPA. The secondary objectives of the study are : 1.
- Trial name
- NCT01710930
- Testing
- Study of predictive factors
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Invasive Aspergillosis
Evaluation of Immediate Release Tablet
Single dose comparison of liquid and solid formulation, followed by study of effect of high fat breakfast. Evaluation of multiple dose pharmacokinetics and tolerability
- Trial name
- NCT02808741
- Testing
- F901318 SDD, F901318 IR, F901318 IR Fasting
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- F2G Ltd
Chronic Pulmonary Aspergillosis, Aspergillosis
Interferon-gamma as Adjunctive Therapy in Chronic Pulmonary Aspergillosis: a Randomised Feasibility Study
This study explores the role of treatment with interferon-gamma to improve outcomes in chronic pulmonary aspergillosis (CPA). CPA is a progressive infection caused by the fungus Aspergillus affecting patients with chronic lung…
- Trial name
- INCAS (NCT05653193)
- Testing
- Interferon Gamma-1B 0.1 MG Per 0.5 ML Injection PLUS antifungals as standard of care, Antifungals as standard of care
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Manchester University NHS Foundation Trust
Invasive Aspergillosis
Exhaled Breath Analysis in the Early Detection of Aspergillosis
Although the clinical outcome in patients with Invasive Aspergillosis (IA) is largely dependent on early initiation of effective treatment with antifungal drugs, diagnosing IA is still a critical problem.
- Trial name
- AENEASII (NCT02106117)
- Where
- 2 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Invasive Aspergillosis, Pleural Effusion
Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing
Diagnostic accuracy of biomarker testing (galactomannan (GM), (1
- Conditions
- Invasive Aspergillosis, Pleural Effusion, Immunosuppression
- Trial name
- EFFU-ASP (NCT02104479)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Heidelberg University