Clinical trials: Asphyxia Perinatal
Perinatal Asphyxia , Moderate to Severe HIE
Magnesium Sulphate in Perinatal Asphyxia
Magnesium sulphate has been shown to be neuroprotective. The investigators hypothesize that magnesium sulphate infusion given to babies with perinatal asphyxia should improve outcome in the immediate neonatal period.
- Trial name
- Magsulf (NCT00553072)
- Testing
- Magnesium sulphate, Normal saline
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Perinatal Depression, Perinatal Anxiety
Feasibility Study and Pilot Hybrid Effectiveness-Implementation Trial for the Universal Prevention of Maternal Perinatal Mental Disorders as Normalized Routine Practice (e-Perinatal Pilot)
This study is part of the e-Perinatal project, funded by the European Research Council. This research project will follow the first three phases recommended by the Medical Research Council (MRC) framework for the development and…
- Trial name
- NCT06640907
- Testing
- e-Perinatal personalized mHealth intervention integrated into routine maternal care, Standard routine maternal care with general perinatal health information
- Where
- Spain
- Volunteers
- 96 people
- Sponsor
- University of Seville
COVID-19 Pandemic, Health Knowledge, Attitudes, Practice
Baby2Home (B2H) Mobile Health Application
The COVID-19 pandemic has transformed healthcare delivery; arguably, the fields of obstetrics and pediatrics have experienced some of the greatest changes as they have transitioned away from their role as a medical home and into…
- Conditions
- COVID-19 Pandemic, Health Knowledge, Attitudes, Practice, Perinatal Depression, Mental Health Wellness
- Trial name
- NCT05595486
- Testing
- Baby2Home Mobile Application
- Where
- 2 sites in United States
- Volunteers
- 642 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Major Depressive Disorder, Perinatal Depression
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health
Hormonal transitions such as across pregnancy and postpartum may trigger depressive episodes in some women. It is not known why, but estrogen sensitivity may play a critical role.
- Trial name
- NCT03795688
- Testing
- Pregnancy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vibe G Frøkjær, MD, PhD
Postpartum Depression
Perinatal Depression Treatment in a Pediatric Setting- Pilot Phase
The purpose of this project is to test whether a new model of collaborative care depression treatment adapted to the needs and preferences of low-income, urban mothers with perinatal depression and to a pediatric clinic setting…
- Trial name
- MITT (NCT00804739)
- Testing
- Mother-Infant Treatment Team
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Rochester
Swallowing Disorder, Perinatal Asphyxia
Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia
The transition period to full oral feeding in infants with perinatal asphyxia is important in predicting long-term outcomes. The transition to independent oral feeding is accepted as a discharge criterion by the American Academy…
- Conditions
- Swallowing Disorder, Perinatal Asphyxia, Feeding; Difficult, Newborn, Feeding Disorder of Infancy or Early Childhood
- Trial name
- NCT05687708
- Testing
- Non-Nutritive Sucking
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medipol University
Perinatal Depression, Stress
Medicaid Enhanced Prenatal/Postnatal Services Using a Nurse-Community Health Worker Team
Our objective was to test whether there were advantages to Nurse-CHW team home visiting designed to combine the strengths of both visitors, with a focus on maternal stress and mental health, when compared with standard of…
- Conditions
- Perinatal Depression, Stress, Prenatal Health Risk Behaviors, Child Development
- Trial name
- NCT00536159
- Testing
- Medicaid Maternal and Infant Support Services, Nurse-CHW team
- Where
- United States
- Volunteers
- 613 people
- Sponsor
- Michigan State University
Cerebral Palsy, Hypoxic-Ischemic Encephalopathy
Early Virtual Intervention for Infants With CP Following HIE Diagnosis
This will be a five year study that will be a prospective, randomized, controlled trial (RCT) to assess the effect of a virtual early intervention care delivery model in the provision of therapy to enhance the neurodevelopmental…
- Conditions
- Cerebral Palsy, Hypoxic-Ischemic Encephalopathy, Brain Injuries, Perinatal Hypoxia
- Trial name
- RECOVER (NCT04913324)
- Testing
- Virtual Care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- The Hospital for Sick Children
Labor Pain, Satisfaction, Consumer
Community Based Doulas for Migrant Women in Labour and Birth in Sweden - a Randomised Controlled Trial
One initiative to address communication problems between migrant women not fluent in Swedish and caregivers throughout childbirth is to provide language assistance, cultural interpretation and labour support to the woman through…
- Conditions
- Labor Pain, Satisfaction, Consumer, Language, Birth Depression
- Trial name
- NCT03461640
- Testing
- Community-based doula support for labour, Standard labour support
- Where
- Sweden
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Depression, Depression, Postpartum
Use of Omega-3 Fatty Acids for Perinatal Depression
This study will evaluate the effectiveness of using omega-3 fatty acids to treat women with perinatal depression.
- Trial name
- NCT00402389
- Testing
- Omega-3 Fatty Acids (EPA plus DHA), Supportive psychotherapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Arizona
Hypoxic Ischaemic Encephalopathy
Correlation of Risk Factors and Severity of Hypoxic-ischaemic Encephalopathy
The first aim of this study is to analyse perinatal risk factors leading to hypoxic ischaemic encephalopathy in term and near term neonates born in Switzerland who were admitted to the neonatal and intensive care units offering…
- Trial name
- NCT02800018
- Testing
- risk factors
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- University Children's Hospital, Zurich
Depression, Postpartum, Efficacy, Self
A Dyadic Approach to Perinatal Depression in Primary Care: Maternal Infant and Dyadic Care
The purpose of this study is to assess the effectiveness of a parenting intervention+usual care compared to usual care on postpartum depression and other mental health and parenting outcomes, as well as the feasibility and…
- Conditions
- Depression, Postpartum, Efficacy, Self, Anxiety
- Trial name
- MInD (NCT04998721)
- Testing
- Promoting First Relationships-Brief, Perinatal Collaborative Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Childbirth Problems, Perinatal Depression
Daring Birth - Digital Coaching Solution to Improve Childbirth Experience
The aim of the study is to investigate the effectiveness of the Daring Birth digital coaching solution (the Natal Mind app) in enhancing the experience of childbirth.
- Conditions
- Childbirth Problems, Perinatal Depression, Anxiety in Pregnancy, Pregnancy Related
- Trial name
- NCT06585839
- Testing
- Digital coaching solution to improve childbirth experience, Application for the control group
- Where
- Finland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aalto University
Hypoxic-Ischaemic Encephalopathy, Perinatal Asphyxia
Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With Inhalative CO2
This is a Phase I, open-label, single center trial to evaluate the feasibility and safety of low concentration CO2 gas mixture (5% CO2 + 95% air) inhalation in asphyxiated, cooled, mechanically ventilated newborns at risk of…
- Conditions
- Hypoxic-Ischaemic Encephalopathy, Perinatal Asphyxia, Hypocapnia
- Trial name
- HENRIC (NCT02700854)
- Testing
- 5% carbon-dioxide inhalation
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Semmelweis University
Infant, Premature, Diseases, Congenital Abnormalities
Esophageal Motility and Airway Defenses Among Infants
Feeding difficulties and airway related consequences contribute significantly to the infant mortality and morbidity. Some of these problems may be dependent on neural control and muscular function.
- Conditions
- Infant, Premature, Diseases, Congenital Abnormalities, Perinatal Asphyxia
- Trial name
- NCT00062452
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Mother-Infant Interaction
The Effect of the Newborn Behavioral Observations System on Maternal Sensitivity
The study evaluates if the Newborn Behavioral Observation system, a relationship building tool, delivered to at risk mothers will have, on one site, an effect on maternal sensitivity and the other site on Childs responsiveness…
- Trial name
- NCT04739332
- Testing
- The Newborn behavioral observations system
- Where
- Iceland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Center for Parents and Infants, Iceland
Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia
Umbilical Cord Milking Versus Immediate Cord Clamping in Full Term Neonates (≥ 37 Weeks) Requiring Resuscitation
The objective of the study is to compare the incidence of Hypoxic ischemic encephalopathy (all stages) among singleton term neonates (≥ 37 weeks) requiring resuscitation who will undergo Umbilical cord milking as compared to…
- Trial name
- NCT06090968
- Testing
- Umbilical cord milking, Immediate cord clamping
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Lady Hardinge Medical College
Perinatal Anxiety, Anxiety Sensitivity
Reaching Calm: A Digital Intervention to Prevent Perinatal Anxiety Disorders
The goal of this clinical trial is to find out if a digital program called Reaching Calm can help prevent anxiety in women who are pregnant.
- Conditions
- Perinatal Anxiety, Anxiety Sensitivity, Perinatal Depression
- Trial name
- NCT07458698
- Testing
- Digital mental health intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Massachusetts, Worcester
Postpartum Depression, Depression
Determining Relationships Among Maternity Stress & Sleep
Psychosocial factors, including a previous history of depression, recent stressful life events, sleep disturbances during pregnancy, and depression and/or anxiety during pregnancy have been shown to be associated with an…
- Trial name
- DREAMSS (NCT02133963)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Perinatal Depression, Postpartum Depression (PPD)
Parents and Babies Pilot
The goal of this study will be piloting the Parents and Babies perinatal depression prevention intervention to examine its feasibility and acceptability and to obtain preliminary data on its efficacy.
- Trial name
- PAB (NCT07607613)
- Testing
- Parents and Babies Virtual Group Intervention, Parents and Babies Hybrid Group Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwestern University