Clinical trials: Aspiration, Respiratory
Inflammatory Response
Systemic Inflammatory Response Evaluation With the Use of Inhaled Anesthetic Sevoflurane During CPB
Cardiac surgery has evolved considerably after the advent of cardiopulmonary bypass (CPB), a feature that allowed more precision and tranquility to the heart surgeon.
- Trial name
- NCT02672345
- Testing
- Sevoflurane
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
HEALTHY PREADOLESCENT MALE, Effects of Running on Daily Variation in Healthy Adolescent Children
The Effects of Mornıng and Evenıng Runnıng on Respıratory Functıon and Lower Extremıty Strength in Pre-Adolescent Male Footballers
The objective of this study was to examine the impact of eight weeks of morning and evening running on lower extremity strength and respiratory function in 10-12-year-old male soccer players.
- Trial name
- NCT06817486
- Testing
- RUNNİNG TRAİNİNG, TRAİNİNG
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Coşkun YILMAZ
Pulmonary Aspiration of Gastric Contents
Gastric Content After 6 vs 4 Hours of Preoperative Fasting in Children
The primary objective of the study is to compare the risk of increased stomach contents after tube feeding (Enteral feeding) 6 and 4 hours before anesthesia using antrum measured by ultrasound.
- Trial name
- ENGUS (NCT05695066)
- Testing
- Preoperative fasting instruction
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Uppsala University Hospital
Mechanical Ventilation
Comparison of Lma-Protector With Endotracheal Tube: Evaluation of Respiratory Mechanical Parameters During Controlled Ventilation & Possibility of Pulmonary Aspiration
The aim of this prospective, randomized, comparative, controlled clinical study is to compare laryngeal mask airway ProtectorTM with the endotracheal tube, regarding to the respiratory mechanical parameters during controlled…
- Trial name
- NCT06474559
- Testing
- LMA Protector, Endotracheal tube
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital of Patras
Sleep Apnea
Mapping for Acute Transvenous Phrenic Nerve Stimulation Study
The Mapping for Transvenous Phrenic Nerve Stimulation Study (MAPS) is being conducted to evaluate the feasibility of transvascular stimulation of phrenic nerves via an electrophysiology (EP) catheter advanced into the great veins.
- Trial name
- MAPs (NCT01981590)
- Testing
- Stimulating the phrenic nerve intravenously using high frequency electrical pulses using an EP catheter connected to external pulse stimulator.
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 15 people
- Sponsor
- Medtronic BRC
Deglutition Disorders, Respiratory Aspiration
Cold Liquids Fed to Preterm Infants: Efficacy and Safety After 10 Minutes of Exposure
A previous study revealed that dysphagia preterm infants show statistically significant improvements in their swallowing mechanism when fed cold liquid barium when compared to room temperature liquid barium.
- Trial name
- NCT02935946
- Testing
- Cold Liquid Barium
- Where
- United States
- Volunteers
- 4,043 people
- Sponsor
- NYU Langone Health
Asthma
Effects Of Repeat Inhaled Doses Of GW597901X On Patient Safety And Lung Function In Asthmatic Subjects
This study is designed to look at the safety aspects and effects of repeat inhaled doses of GW597901X in asthmatics to develop this drug for its use in asthma and Chronic Obstructive Pulmonary Disease(COPD).
- Trial name
- NCT00354042
- Testing
- GW597901X
- Volunteers
- 24 people
- Sponsor
- GlaxoSmithKline
Lung Cancer
US NAB With ROSE Versus US FNAB With no ROSE
This is an investigator-initiated, single center, controlled, randomized clinical trial with two parallel arms in a 1:1 ratio. The objective of the study is to systematically assess the influence of rapid on-site evaluation…
- Trial name
- NCT04618874
- Testing
- Rapid on-site evaluation
- Where
- Italy
- Volunteers
- 136 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infant, Newborn, Infant, Low Birth Weight
Inhaled Nitric Oxide for Preterm Infants With Severe Respiratory Failure
This multicenter trial tested whether inhaled nitric oxide would reduce death or the need for oxygen in preterm infants (less than 34 weeks gestational age) with severe lung disease.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Preemie iNO (NCT00016523)
- Testing
- Inhaled nitric oxide
- Where
- 17 sites in United States
- Volunteers
- 420 people
- Sponsor
- NICHD Neonatal Research Network
Cardiac Arrest
Monitoring of Intubation and Ventilation During Resuscitation
Airway control and ventilation is vital during cardiopulmonary resuscitation (CPR) in cardiac arrest. Endotracheal intubation is the gold standard for airway control, but several studies have shown high rates of unrecognized…
- Trial name
- NCT00204217
- Testing
- endotracheal intubation
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- University of Oslo
Acute Respiratory Distress Syndrome, Respiration, Artificial
Impact of Decreasing Respiratory Rate on Lung Injury Biomarkers in ARDS Patients
Acute respiratory distress syndrome (ARDS) is a form of acute lung injury of inflammatory origin, which represents a public health problem worldwide due to its prevalence, and its high mortality rate, close to 40%.
- Conditions
- Acute Respiratory Distress Syndrome, Respiration, Artificial, Ventilator-Induced Lung Injury
- Trial name
- NCT04641897
- Testing
- Respiratory rate modification
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Cancer Uterus Cervix
Respiration After Robot Assisted Laparoscopic Hysterectomy
The study will investigate how respiratory function is affected by robot-assisted surgery. Previous studies have investigated the impact after open and laparoscopic surgery, but there are no studies yet after robot-assisted…
- Trial name
- REHYR (NCT06806280)
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Chronic Obstructive Pulmonary Disease, Muscle Oxygenation
The Effect of Clinical Parameters on Muscle Oxygenation in Patients With COPD
The aim of this study is to examine the peripheral muscle oxygenation of patients with Chronic Obstructive Pulmonary Disease at rest, during submaximal exercise and recovery, and to examine the effects of disease severity and…
- Conditions
- Chronic Obstructive Pulmonary Disease, Muscle Oxygenation, Disease Severity, Respiratory Function
- Trial name
- NCT06041126
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Bandırma Onyedi Eylül University
Respiration, Artificial, Critical Care
Weaning Algorithm for Mechanical VEntilation
To compare the duration of mechanical ventilation and the weaning period between two groups of patients managed with either Standard Care or with mechanical ventilation adjusted according to the Beacon Caresystem, in patients…
- Conditions
- Respiration, Artificial, Critical Care, Respiratory Insufficiency, Intensive Care (ICU) Myopathy
- Trial name
- WAVE (NCT03697785)
- Testing
- Beacon Care System
- Where
- 2 sites in United Kingdom
- Volunteers
- 286 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Apnea
Laryngeal Mask Ambu Aura Once vs. Supreme in Children
The purpose of this study is determine safety and efficiency of mechanical ventilation in children with two different types of single use laryngeal masks (Ambu AuraOnce vs. LMA Supreme).
- Trial name
- NCT01718782
- Testing
- laryngeal mask Ambu AuraOnce, laryngeal mask LMA Supreme
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Respiratory Disease, Artificial Respiration
Non-invasive Assessment of Inspiratory Effort and Tidal Distension During Non-invasive Ventilation (INSPIRE)
The goal of this observational study is to evaluate whether the airway occlusion pressure recorded during a sudden end-expiratory breath-hold (ΔPocc) is correlated with esophageal swing in pressure and the reliability of P0.1…
- Trial name
- INSPIRE (NCT06344234)
- Testing
- End-inspiratory Maneuvers
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Bari
Smoke Inhalation, Exposure, Inhalation
Lung Cancer Screening CT for Firefighters
Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational…
- Conditions
- Smoke Inhalation, Exposure, Inhalation, Exposure to Pollution, Exposure Occupational
- Trial name
- NCT06836414
- Testing
- Low-dose Computerized tomography (CT) of Chest, Questionnaires, Medical History
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Respiration, Artificial
The Correlational Study of PPV in Various VT in Mechanically Ventilated Patients
Mesquida, J et al showed there was a significant linear correlation between pulse pressure variations under tidal volume 6 ml/kg and 8 ml/kg in patients after the resuscitation phase of severe sepsis and septic shock.
- Trial name
- NCT01950949
- Testing
- 300 ml Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection infusing in 15 minutes if PPV under VT 8 ml/kg was larger than 13% in the initial investigation
- Volunteers
- 69 people
- Sponsor
- Yi Liu
Tracheostomy, Airway Management
Reducing Decannulation Time: Limitation of Decannulation Capping Trials (REDECAP)
Multicenter randomized trial centered on critically-ill tracheostomized patients, comparing two different decannulation protocols: 1. based on capping trials to decide decannulation, 2.
- Conditions
- Tracheostomy, Airway Management, Respiratory Therapy
- Trial name
- REDECAP (NCT02512744)
- Testing
- Decannulation protocol., High flow conditioned oxygen therapy
- Where
- 5 sites in Spain
- Volunteers
- 330 people
- Sponsor
- Hospital Virgen de la Salud
Respiratory Insufficiency, Pneumonia, Aspiration
Feeding Children Nasogastrically Versus Nasojejunally While Receiving Noninvasive Positive Pressure Ventilation
The investigators are studying whether it is safe and effective to provide enteral nutrition to critically ill children via the nasogastric route, as opposed to the nasojejunal route, while they are receiving noninvasive positive…
- Conditions
- Respiratory Insufficiency, Pneumonia, Aspiration, Nutrition Disorders
- Trial name
- FeedNIV (NCT01301352)
- Testing
- Route of feeding (nasogastric vs. nasojejunal)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
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