Clinical trials: Aspiration, Respiratory
Orthostatic Hypotension
Breathing Device for Orthostatic Hypotension (OH)
The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease blood pressure drops on standing in patients with orthostatic hypotension.
- Trial name
- NCT00962884
- Testing
- Inspiratory Threshold Device (Res-Q-Gard ITD)
- Where
- United States
- Sponsor
- Alfredo Gamboa
Critical Illness
Effect of Early Physical Exercise on Pulmonary Ventilation and Recruitment
In the critically patient bed rest and immobilization are some of the responsable of the development of respiratory complications.
- Trial name
- EFRA (NCT02226406)
- Testing
- A: Chair - Leg Cycle ergometer, B: Chair - Arm Cycle ergometer, C: Walk in place
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sternotomy
The Benefit of Preparation in Respiratory Physiotherapy Before a Sternotomy in the Context of Cardiac Surgery
The sternotomy has some influence on the respiratory system after cardiac surgery, considerably increasing the risk of perioperative and postoperative breathing.
- Trial name
- NCT06153550
- Testing
- preparation in Respiratory Physiotherapy
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
COVID-19 Infection
Clazakizumab vs. Placebo - COVID-19 Infection
The purpose of this study is to investigate the effectiveness and safety of treatment with clazakizumab compared to a placebo (inactive substance).
- Trial name
- NCT04494724
- Testing
- Clazakizumab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Methodist Hospital Research Institute
Musculoskeletal Pain, Ankle Injuries
Video Aided Mindful Deep Breathing for Pain Management
Chronic ankle instability (CAI) is the most common musculoskeletal injury in sports and the rate of CAI accounts for 85% of ankle injuries.
- Conditions
- Musculoskeletal Pain, Ankle Injuries, Joint Instability
- Trial name
- NCT04812158
- Testing
- standard ankle physiotherapy or rehabilitation for chronic ankle instability
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Ultrasound-guided Regional Anesthesia, Shoulder Surgery
Distant Extrafascial Injection vs Subfascial Injection for Interscalene Block: Acute Pain Outcomes and Rates of Complications
The objective of this randomized controlled trial is to compare the analgesic efficacy and the safety profile between two techniques of injection for the interscalene block.
- Conditions
- Ultrasound-guided Regional Anesthesia, Shoulder Surgery, Interscalene Block, Postoperative Analgesia
- Trial name
- NCT02074397
- Testing
- Distant extrafascial injection, Subfascial injection
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Aspiration Pneumonia
Nocturnal Nasal Continuous Positive Airway Pressure in Aspiration Pneumonia
Numerous elderly patients are suffering from aspiration pneumonia due to anatomical or functional predisposing factors including enteral tube feeding, swallowing difficulties, and gastroesophageal reflux disease (GERD).
- Trial name
- NAP (NCT03844568)
- Testing
- nocturnal nasal continuous positive airway pressure
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Cardiac Arrest
Monitoring of Intubation and Ventilation During Resuscitation
Airway control and ventilation is vital during cardiopulmonary resuscitation (CPR) in cardiac arrest. Endotracheal intubation is the gold standard for airway control, but several studies have shown high rates of unrecognized…
- Trial name
- NCT00204217
- Testing
- endotracheal intubation
- Where
- Norway
- Volunteers
- 15 people
- Sponsor
- University of Oslo
COVID-19
The Safety, Tolerability, and Pharmacokinetics of Inhaled TLC19 in Healthy Volunteers
Phase 1 randomized, vehicle-controlled, blinded study to assess the safety, tolerability, and PK of single ascending doses of inhaled TLC19 in healthy volunteer subjects.
- Trial name
- NCT04697654
- Testing
- TLC19, TLC19 Vehicle
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taiwan Liposome Company
Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch
Vascular ARDS Recruitment After Inhaled Nitric Oxide
Acute respiratory distress syndrome (ARDS) is when a person's lungs become inflamed, which can be caused by infection, trauma, surgery, blood transfusion, or burn.
- Trial name
- NCT05801224
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Respiration, Artificial, Respiratory Distress Syndrome, Adult
Weaning From Mechanical Ventilation Using Permissive Hypercarbia
Some patients receiving mechanical ventilation have difficulty weaning off the ventilator because of physiological factors such as pre-existing lung disease, respiratory distress syndrome, and trauma among others.
- Trial name
- NCT00357929
- Testing
- Permissive hypercarbia
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Lung Cancer (Non-Small Cell), Lung Metastases From Any Primary
Evaluation of Efficacy of Minimally Invasive Local Therapy for Lung Tumors and Its Impact on Breathing Function
This clinical study is evaluating different treatment options for patients with malignant lung tumors, including both primary lung cancer and tumors that have spread to the lungs from other parts of the body.
- Trial name
- NCT07272356
- Testing
- Surgery, Ablation, SBRT
- Where
- Lithuania
- Volunteers
- 68 people
- Sponsor
- Aurimas Macionis
Chronic Obstructive Pulmonary Disease
Examination of Acute Effects of Different Intensity Respiratory Muscle Training on Respiratory Muscle Activations
It has been observed in the literature that respiratory muscle electromyography activations at certain threshold loads have been examined in individuals with chronic obstructive pulmonary disease.
- Trial name
- NCT04974788
- Testing
- Low Intensity Respiratory Muscle Training, Medium Intensity Respiratory Muscle Training, High Intensity Respiratory Muscle Training
- Volunteers
- 20 people
- Sponsor
- Abant Izzet Baysal University
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia
At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min.
- Trial name
- NCT07670923
- Testing
- Propofol Injection, Ciprofol Injection
- Where
- China
- Volunteers
- 108 people
- Sponsor
- General Hospital of Ningxia Medical University
Asthma in Children, Pollution; Exposure
AIM to Improve Asthma: Airflow Improvements During Meal-Prep
The investigators propose a pilot trial of kitchen ventilation in the homes of children using a youth engaged research strategy.
- Trial name
- AIM (NCT04464720)
- Testing
- Cooking Ventilation Intervention
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of California, Berkeley
Respiratory Tract Disease, Kidney Transplantation
Evaluation of the Respiratory Function in Renal Transplanted Children
Objectives: While a respiratory abnormality was found in 50% of pediatric renal transplant recipients in a study conducted in Belgium and the Netherlands in 2008, the respiratory status of transplanted children in France remains…
- Conditions
- Respiratory Tract Disease, Kidney Transplantation, Pediatric
- Trial name
- SPIROKID (NCT03571542)
- Testing
- pulmonary function
- Where
- 5 sites in France
- Volunteers
- 385 people
- Sponsor
- Nantes University Hospital
Multiple Sclerosis
Inspiratory Muscle Training in Multiple Sclerosis
Objective: To evaluate the effectiveness of a low-intensity protocol of inspiratory muscle training (IMT) to improve respiratory strength, spirometric parameters and dyspnea in patients with multiple sclerosis (MS).
- Trial name
- NCT03887546
- Testing
- Inspiratory muscle trainer, Respiratory exercise
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Peritonsillar Abscess
Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud
Peritonsillar abscess (PTA) has a relatively high incidence of 41 per 100,000/year in Denmark. In spite of that, there is no regional or national consensus on treatment of PTA.
- Trial name
- NCT03326661
- Testing
- Aspiration, Tonsillectomy a chaud, Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
- Where
- Denmark
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Lung Cancer, Lymph Nodes
Transbronchial Needle Forceps for Endobronchial Ultrasound
Prove the feasibility of a needle forceps in patients with enlarged mediastinal lymph nodes
- Trial name
- NCT01145924
- Testing
- EBUS TBNF
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
Severe Persistent Asthma
Inhaled Steroids and Control of Severe Asthma
Investigational device: AKITA 2 device versus conventional metered-dose inhaler (MDI) Objectives: To explore if inhalative fluticasone application by means of the AKITA technology would result in a better symptom control in…
- Trial name
- INHALE (NCT01197482)
- Where
- 3 sites in Germany
- Volunteers
- 6 people
- Sponsor
- University of Giessen