Clinical trials: Aspiration Pneumonitis
Silent Aspiration, Post-Extubation Dysphagia
Silent Aspiration Following Extubation in the ICU
Post-extubation dysphagia is common in critically ill patients and may lead to silent aspiration, which often remains undetected because patients do not exhibit overt clinical signs such as coughing or choking.
- Conditions
- Silent Aspiration, Post-Extubation Dysphagia, Deglutition Disorders, Critical Illness
- Trial name
- SAFE-ICU (NCT07635888)
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing (FEES)
- Where
- United Arab Emirates
- Volunteers
- 274 people
- Sponsor
- Cleveland Clinic Abu Dhabi
Dysphagia, Aspiration Pneumonia
FEES to Determine Neurological Intensive Care Patients' Oral Diet
Dysphagia is associated with high rates of mortality and morbidity. Adjusting the oral diet of ICU-patients based on flexible endoscopic evaluation of swallowing (FEES) findings might reduce pneumonia rate, mortality and need for…
- Conditions
- Dysphagia, Aspiration Pneumonia, Deglutition Disorders, Intensive Care Neurological Disorder
- Trial name
- NCT03753841
- Testing
- Adjustment of oral diet
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- University of Giessen
Head and Neck Cancer
Efficacy of Prophylactic Treatment With Antibiotics During Concomitant Chemoradiotherapy in Patients With Head and Neck Cancer to Prevent Aspiration Pneumonia
Patients with locally advanced head and neck cancer treated with chemo-radiotherapy have (during and shortly after this treatment) a high risk of developing pneumonia by aspiration.
- Trial name
- PANTAP (NCT01598402)
- Testing
- amoxicillin/clavulanic acid suspension
- Where
- 6 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Aspiration Pneumonias, Tube Feeding
Percutaneous Endoscopic Gastrostomy Versus Percutaneous Endoscopic Gastrostomy With Jejunal Extension
The goal of this clinical trial is to learn if placing a feeding tube with a small bowel extension (called Percutaneous Endoscopic Gastrostomy With Jejunal Extension [PEG-J]) is better at preventing pneumonia than a standard…
- Conditions
- Aspiration Pneumonias, Tube Feeding, Enteral Feeds
- Trial name
- NCT06717321
- Testing
- (Arm 1): PEG, (Arm 2): PEG-J
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Jerry Dang
Respiration Disorders, Swallowing Disorder
Artificial Intelligence in Diagnosing Dysphagia Patients
In this prospective study we extracted acoustic parameters using PRAAT from patient's attempt to phonate during the clinical evaluation using a digital smart device.
- Conditions
- Respiration Disorders, Swallowing Disorder, Phonation Disorder, Stroke
- Trial name
- NCT05098808
- Testing
- Acoustic features (from signals obtained during phonation)
- Where
- South Korea
- Volunteers
- 449 people
- Sponsor
- The Catholic University of Korea
Aspiration Pneumonias
Continuous Supraglottic Aspiration in Intubated and Mechanically Ventilated Patients: the "SUPRAtube" Device
Purpose of the trial: Evaluate the efficacy and safety of the device of self-invention of continuous oropharyngeal aspiration denominated "SUPRAtube" in patients with orotracheal intubation and mechanical ventilation.
- Trial name
- Supratube (NCT03573635)
- Testing
- Supratube, Reference
- Where
- Colombia
- Volunteers
- 38 people
- Sponsor
- Fundación Cardiovascular de Colombia
Dysphagia After Stroke, Aspiration Pneumonias
Tongue Brush (Orabrush) for Reducing Aspiration Pneumonia in Stroke Patients
The investigators conduct a controlled prospective experimental intervention study to examine whether the use of a tongue brush (Orabrush) can improve the rate of aspiration pneumonia and dysphagia in patients with ischemic…
- Conditions
- Dysphagia After Stroke, Aspiration Pneumonias, Ischemic Stroke
- Trial name
- StrOra (NCT06765018)
- Testing
- Tongue Brush (Orabrush)
- Where
- Germany
- Volunteers
- 252 people
- Sponsor
- University Hospital Marburg
Aspiration Pneumonia
Dynamic Laryngotracheal Separation for Aspiration
People who aspirate after neurologic insults such as stroke often develop fatal pneumonia. This study examines the effects of dynamic vocal cord closure on swallowing.
- Trial name
- NCT00580346
- Testing
- Placement of laryngeal implant
- Where
- United States
- Sponsor
- University Hospitals Cleveland Medical Center
Aspiration Pneumonia
Ultrasound Assessment of Gastric Residual Volume in Obese Patients
Gastric emptying is a major risk factor for aspiration of gastric contents.Aspiration into the lungs represents a fatal complication that can occur during anesthesia.
- Trial name
- NCT04544371
- Testing
- gastric ultrasound, nasogastric tube insertion
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Stroke
Reflexive Coughing Force in Severe Aspirators
To assess coughing force during reflex coughing test in those with severe dysphagia and severe aspiration and compare them to than those with stroke patients with no signs of dysphagia/aspiration.
- Trial name
- NCT02080988
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Nosocomial Pneumonia, Healthcare-Associated Pneumonia
Effect of Oral Decontamination Using Chlorhexidine or Potassium Permanganate in ICU Patients
Oropharyngeal bacteria play an important role in the pathogenesis of nosocomial pneumonia in critically ill patients. Oral cleansing with chlorhexidine has been shown to decrease incidence of pneumonia in patients undergoing open…
- Conditions
- Nosocomial Pneumonia, Healthcare-Associated Pneumonia, Aspiration Pneumonia, Ventilator-Associated Pneumonia
- Trial name
- NCT00610324
- Testing
- Chlorhexidine gluconate, Potassium permanganate
- Where
- India
- Volunteers
- 512 people
- Sponsor
- King Edward Memorial Hospital
Acute Ischemic Stroke, Stroke-Associated Pneumonia (SAP)
Oropharyngeal Flushing Suction Tube With Laryngoscope for Stroke-Associated Pneumonia
Stroke-associated pneumonia is a common and clinically important complication after acute ischemic stroke, especially in non-intubated patients with impaired consciousness and reduced cough or swallowing reflexes.
- Trial name
- OFST-SAP (NCT07647666)
- Testing
- Oropharyngeal Flushing Suction Tube, Laryngoscope-Guided Oropharyngeal Suction, Standard Suction Catheter
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Pudong New Area Gongli Hospital
Dysphagia, Oropharyngeal, Dysphagia
Slow-Stream Expiratory Muscle Strength Training for Veterans With Dysphagia Living in Long-term Care
Sunnybrook Veterans Centre (VC) is a long-term care (LTC) facility with many elderly residents living with swallowing disorders who are at high risk of developing pneumonia from aspirating food/liquid into their lungs.
- Conditions
- Dysphagia, Oropharyngeal, Dysphagia, Dysphagia, Progressive, Aging
- Trial name
- NCT04064333
- Testing
- Slow-Stream Expiratory Muscle Strength Training
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
Aspiration Pneumonia
Gastric POCUS for Airway Management in Patients Using Glucagon-like Peptide-1 Receptor Agonist (Multicentric)
1. Introduction Scheduled surgery requires patients to undergo a preoperative fasting period of at least 6 hours to reduce the risk of perioperative pulmonary aspiration.
- Trial name
- POCUS (NCT06666049)
- Testing
- Gastric Ultrasound
- Where
- 2 sites in Spain
- Volunteers
- 39 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Aspiration Pneumonia
Eating Rehabilitation Training for Timely Removal of Nasogastric Tube in Elderly Patients
Aspiration pneumonia is a common complication in senior patients with high morbidity and mortality rate. The decline of physical function among elders can easily lead to swallowing disorders, and nasogastric (NG) tube insertion…
- Trial name
- NCT05810688
- Testing
- eating rehabilitation training
- Where
- Taiwan
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Gastrostomy, Aspiration Pneumonia
The Effect of Semi-solid Feeding After Percutaneous Endoscopic Gastrostomy (PEG) on the Incidence of Aspiration Pneumonia and Postoperative Length of Stay
Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure for long-term enteral tube feeding in patients with insufficient oral intake.
- Trial name
- NCT02858596
- Testing
- Semi-solid feed (Terumo PG soft), Liquid feed (Meibalance)
- Volunteers
- 136 people
- Sponsor
- Hiroshima Kyoritsu Hospital
Aspiration Pneumonia
Ultrasound Assessment of Metoclopramide Effect on Gastric Volume in Cesarean Section
the risk of aspiration pneumonitis during cesarean sections has significantly decreased. Nevertheless, precaution against gastric aspiration is still vital in patients in whom regional anesthesia contraindicated or in whom…
- Trial name
- NCT04157998
- Testing
- normal saline, Metoclopramide 10mg
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Aspiration Pneumonia
Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
The two most common consequences resulting from aspiration are chemical pneumonitis and bacterial aspiration pneumonia. Both entities present with comparable clinical signs and symptoms.
- Trial name
- APAPI (NCT03763799)
- Testing
- PCR-based microbiological diagnosis strategy, Standard microbiological diagnosis strategy
- Where
- 2 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Lille
Aspiration, Aspiration Pneumonia
Early Antibiotics After Aspiration in ICU Patients
The purpose of this study is to evaluate the use of early antibiotics in ICU patients who appear to have aspirated, to help determine whether this improves outcomes by reducing the later incidence of pneumonia and other negative…
- Trial name
- NCT05079620
- Testing
- Ceftriaxone, Amoxicillin clavulanic acid, Cefepime
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UConn Health
Aspiration
Routine Point of Care Ultrasound (POCUS) Assessment of Antral Gastric Contents in Traumatic Surgical Patients for Prevention of Aspiration Pneumonitis
Pulmonary aspiration of gastric contents is uncommon in the elective, surgical populations, but highly prevalent in trauma patients who requires emergency surgery as trauma impair gastric motility and emptying.1 Presence of…
- Trial name
- NCT04083677
- Testing
- SONAR
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University