Clinical trials: Aspirin Sensitivity
Asthma, Aspirin-Induced
Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD)
The purpose of this phase 2 study is to assess the safety and efficacy of oral ifetroban for the treatment of aspirin-exacerbated respiratory disease (AERD).
- Trial name
- NCT03028350
- Testing
- Ifetroban Oral Capsule
- Where
- 16 sites in United States
- Volunteers
- 54 people
- Sponsor
- Cumberland Pharmaceuticals
Asthma, Aspirin-Induced, Chronic Rhinosinusitis With Nasal Polyps
Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)
Primary objective: to investigate the efficacy of Mepolizumab 100 milligram (mg) every month compared to placebo in reducing validated Sinonasal Outcome Test -22 score and on reducing endoscopic Nasal Polyp Score.
- Trial name
- AirGOs-biol (NCT04823585)
- Testing
- Mepolizumab
- Where
- Finland
- Volunteers
- 95 people
- Sponsor
- Helsinki University Central Hospital
Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma
Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
Aspirin Exacerbated Respiratory Disease (AERD) is a relatively homogeneous disease characterized by adult-onset severe asthma, development of non-cancerous growths in the nasal canal (i.e. nasal polyps) and aspirin allergy.
- Conditions
- Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma, Nasal Polyps
- Trial name
- AERD (NCT04261582)
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Aspirin-exacerbated Respiratory Disease, Aspirin-Sensitive Asthma With Nasal Polyps
Effects of a High or Low Salycilate Diet on Urinary LTE4 and Clinical Features in AERD
On day one, two groups of nine patients each will respectively recieve the tree daily meals (breakfast, Lunch and dinner) in a controled clinical setting.
- Conditions
- Aspirin-exacerbated Respiratory Disease, Aspirin-Sensitive Asthma With Nasal Polyps, Samter's Syndrome, Widal Syndrome
- Trial name
- AERD (NCT03973749)
- Testing
- Low salycilate diet
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Instituto Nacional de Enfermedades Respiratorias
AERD - Aspirin Exacerbated Respiratory Disease
Effect of Dupilumab on Aspirin Intolerance
To test the efficacy of dupilumab in patients with AERD regarding the intolerance to salicylic acid after 6 months. This will be evaluated by oral drug provocation testing with low dose salicylic acid after 6 months of dupilumab…
- Trial name
- NCT04442256
- Testing
- Dupilumab
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Nasal Polyps, Asthma, Aspirin-Induced
Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease
The overall aim of the study is to determine the clinical efficacy and mechanisms of action of anti-IL-4a (dupilumab) as treatment for patients with Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) and Aspirin-Exacerbated…
- Conditions
- Nasal Polyps, Asthma, Aspirin-Induced, Aspirin-Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma With Nasal Polyps
- Trial name
- MARINER (NCT05575037)
- Testing
- Dupilumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Acute Chest Syndrome
Effect of Platelet Inhibition and / or Lipid Lowering in Non-ACS-patients With Positive Troponin
The study evaluates the effect of platelet inhibition and / or lipid lowering in non-ACS-patients with symptoms suggestive for ACS, and elevated high-sensitivity troponin values
- Trial name
- GRAY-ZONE (NCT03820466)
- Testing
- Aspirin, Atorvastatin
- Where
- 7 sites in Germany
- Volunteers
- 68 people
- Sponsor
- Dr. med. Mahir Karakas
Asthma, Aspirin-Induced
The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases
The purpose of this study is to determine the effect of aspirin desensitization on symptoms and immunologic profile of patients with aspirin-exacerbated respiratory diseases (AERD).
- Trial name
- NCT01867281
- Testing
- aspirin
- Where
- Iran
- Volunteers
- 32 people
- Sponsor
- Tehran University of Medical Sciences
Aspirin Sensitivity
Asprin Dosing Estimator in Healthy Adults
Understanding sources of variability in human drug dosing is important to the beneficial and safe use of any drug. Understanding and applying the science of individualizing a drug dose to a patient is called precision medicine.
- Trial name
- NCT04040465
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Utah
Healthy
In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction
Purpose of the present research project is to study a new in-vivo test for abnormal platelet function and to study the effect of certain drugs on clinical bleeding.
- Trial name
- Aspirin-BVT (NCT01047722)
- Testing
- Aspirin ingestion followed by doing a Bleeding Volume Test
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Klein, Jeffrey A., M.D.
Hypersensitivity, Coronary Artery Disease
Physiopathology of Rapid Aspirin Desensitization
Aspirin is very effective in protecting patients with coronary artery disease against adverse cardiac events, because it is a potent "antiplatelet agent".
- Trial name
- NCT01118546
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sinusitis, Chronic, Asthma
Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)
This randomized study compares operative techniques in chronic rhinosinusitis with polyposis (CRSwNP) surgery. It aims to evaluate outcomes in asthma and CRSwNP, safety and costs.
- Conditions
- Sinusitis, Chronic, Asthma, Nasal Polyps, Aspirin Sensitivity
- Trial name
- NCT03704415
- Testing
- Extended endoscopic sinus surgery, Limited endoscopic sinus surgery
- Where
- 3 sites in Finland, Netherlands
- Volunteers
- 97 people
- Sponsor
- Helsinki University Central Hospital
Aspirin Sensitivity
Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization
This is a 24 week double-blind study in which subjects will be randomized 2:1 to receive Xolair (Omalizumab) or placebo. 14 subjects will receive Xolair and 7 will receive placebo. Xolair injections will occur every 2-4 weeks.
- Trial name
- NCT00555971
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- David Lang
Aspirin-exacerbated Respiratory Disease
Mechanisms of Dupilumab in AERD
Aspirin-Exacerbated Respiratory Disease (AERD), although uncommon in the general population, is an important phenotype of severe asthma and nasal polyposis where it occurs in 15% of severe asthmatics, and up to 30% of those with…
- Trial name
- NCT05031455
- Testing
- Aspirin Challenge
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Scripps Clinic
Aspirin Sensitivity, Surgery
Routine Minimally Invasive Thoracic Surgery Without Aspirin Withdraw
Surgeons are increasingly confronted by patients on long-term low-dose acetylsalicylic acid (ASA). However, the perioperative management of these patients undergo non-cardiac surgery has not yet been clear.
- Trial name
- NCT05511441
- Testing
- Surgery Without Aspirin Withdraw
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Shandong University
Aspirin Hypersensitivity
Aspirin Desensitization Registry in Patients With Aspirin Hypersensitivity
Data about aspirin desensitization for patients with coronary artery disease undergoing percutaneous coronary intervention are sparse.
- Trial name
- ADAPTED (NCT02848339)
- Testing
- aspirin
- Volunteers
- 330 people
- Sponsor
- Italian Society of Cardiology
Asthma Aspirin-sensitive, ASA Intolerant Asthma
Challenge Test for Acetylsalicylic Acid Hypersensitivity
The investigators want to find new challenge test for Acetylsalicylic hypersensitivity / Aspirin hypersensitivity. The investigators suggest that this new test will be as efficient as the already established protocols in terms of…
- Conditions
- Asthma Aspirin-sensitive, ASA Intolerant Asthma, Asthma, Aspirin-Induced, Asthma, Nasal Polyps, and Aspirin Intolerance
- Trial name
- NCT01681615
- Testing
- Acetylsalicylate, Isotonic NaCl
- Where
- 2 sites in Norway
- Volunteers
- 50 people
- Sponsor
- Helse Stavanger HF
Aspirin Exacerbated Respiratory Disease (AERD)
Trial to Determine the Safety of Oral Ifetroban in Patients With a History of Aspirin Exacerbated Respiratory Disease
The primary objective of the study is to determine the safety of oral ifetroban compared to placebo as measured by a > 20% decrease in FEV1 compared to baseline following a dose of Investigational Medicinal Product (IMP) (Study…
- Trial name
- NCT02216357
- Testing
- Ifetroban, Oral Capsule
- Where
- 3 sites in United States
- Volunteers
- 19 people
- Sponsor
- Cumberland Pharmaceuticals
Aspirin Sensitivity, Aspirin-exacerbated Respiratory Disease
Characteristics of Patients Diagnosed With NSAID Sensitivity in Thailand
Study clinical characteristics and phenotypes of patients diagnosed with NSAID sensitivity in Thailand
- Conditions
- Aspirin Sensitivity, Aspirin-exacerbated Respiratory Disease, Aspirin-Induced Angioedema-Urticaria, Aspirin Allergy
- Trial name
- NCT03849625
- Testing
- aspirin, NSAIDs, paracetamol
- Where
- Thailand
- Volunteers
- 158 people
- Sponsor
- Chulalongkorn University
Asthma, Aspirin-Induced
Role of Inflammatory Mediators in AERD
The purpose of this research study is to learn new information about the underlying cause of aspirin-exacerbated respiratory disease (AERD) and the benefit of high-dose aspirin therapy.
- Trial name
- NCT02824523
- Testing
- aspirin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Brigham and Women's Hospital