Clinical trials: Asplenia, active
Splenectomy; Status
Meningococcal B Vaccine in Patients with Asplenia
Patients without a spleen (asplenia) experience an increased risk for septicaemia from encapsulated bacteria, which is associated with a high mortality rate.
- Trial name
- NCT06025487
- Testing
- Bexsero
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Splenectomized Patients, Splenectomy
Evaluation of the Effectiveness of an Educational Intervention in Splenectomized Patients
The absence or dysfunction of the spleen is associated with a substantially increased risk of invasive infections that may rapidly progress to fulminant sepsis, including overwhelming post-splenectomy infection (OPSI), a medical…
- Conditions
- Splenectomized Patients, Splenectomy, Splenectomy; Status, Asplenia
- Trial name
- SPLE-VAC (NCT07354893)
- Testing
- Educational intervention for asplenic patients
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Disease, Immunocompromised
Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients
AMBU-VAX is a prospective, single-center observational study designed to develop and implement an organizational model for delivering recommended vaccinations within a hospital setting.
- Conditions
- Chronic Disease, Immunocompromised, HIV Infection, Chronic Kidney Disease
- Trial name
- AMBU-VAX (NCT07391046)
- Testing
- Hospital-Based Vaccination Pathway
- Volunteers
- 1,500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Asplenia
Assessment of Complication Risk Factors in a French National Cohort of Asplenic Patients
Spleen could have been surgically removed for trauma, cancer, auto-immune disease, or to perform a diagnosis. Spleen could be non-functional due to radiotherapy or splenic artery embolism.
- Trial name
- SPLEEN (NCT04199403)
- Where
- 12 sites in France
- Volunteers
- 6,000 people
- Sponsor
- Poitiers University Hospital
Splenectomy
Research Trial Assessing the Immunogenicity and Safety of Three Meningococcal B Vaccine Strategies Among Patients With Asplenia.
The purpose of the study is to evaluate the immunological response and tolerance of 3 vaccine strategies against meningococcus B, a potentially fatal invasive infection.
- Trial name
- SPLEMENGO (NCT04166656)
- Testing
- Trumenba®, Bexsero®
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Splenectomy; Status, Asplenia
Development of an Italian Questionnaire for Splenectomized Patients Using a Delphi Consensus Method
This study aims to develop an Italian-language questionnaire assessing awareness, knowledge of infectious risk prevention strategies, and vaccination attitudes among splenectomized individuals.
- Conditions
- Splenectomy; Status, Asplenia, Splenectomized Patients
- Trial name
- NCT07428005
- Testing
- Delphi Consensus Process
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Asplenia
Immunologic Response to Pneumococcal Polysaccharide Vaccine in Splenic Injury Patients
Persons without a spleen are susceptible to potentially lethal infections from certain bacteria, with pneumococcus being the most prevalent.
- Trial name
- NCT02232191
- Testing
- Pneumovax-23
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of California, Davis
Heterotaxy Syndrome, Congenital Heart Defects
Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
The goal of this study is to obtain specimens and data from individuals and their families with heterotaxy and related congenital heart defects in order to clarify the molecular genetics of this disorder.
- Trial name
- NCT02432079
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Indiana University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health