Clinical trials: Assessment Evaluation
Caries, Dental Trauma
Lithium Disilicate Crowns Study
CAD-CAM crowns made of experimental lithium disilicate (shades A1, A2 and A3) are placed in patients by using either a dual-curing adhesive or a self-adhesive luting material in combination with total etch/universal bonding agent.
- Trial name
- NCT05070416
- Testing
- Lithium disilicate crowns
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Ivoclar Vivadent AG
Herpes Zoster
Immunogenicity and Safety of Recombinant Herpes Zoster Vaccine (CHO Cells) in Healthy Subjects Aged 30 Years and Above
The purposes of the study are to evaluate the immunogenicity and safety of different dose levels of recombinant herpes zoster vaccine (CHO Cells) with 2 doses at 2-month intervals in healthy subjects aged 30 years and older.
- Trial name
- NCT05856084
- Testing
- Low dose Recombinant Herpes Zoster Vaccine (CHO cells), High dose Recombinant Herpes Zoster Vaccine (CHO cells), Positive control
- Where
- China
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- MAXVAX Biotechnology Limited Liability Company
Blood Cholesterol Lowers, LDL-C
Effects of Arterin Cholesterol for Reduction of Lipid Levels
The main objective of this double-blind, randomised, placebo-controlled study is to assess the benefit and tolerability of Arterin Cholesterol in subjects with elevated lipid levels within a 12-week period of use.
- Trial name
- NCT04749784
- Testing
- High Dose Arterin Cholesterol, Low Dose Arterin Cholesterol
- Where
- Germany
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Perrigo CSCI
Friedreich's Ataxia
Safety and Pharmacology Study of VP 20629 in Adults With Friedreich's Ataxia
The objectives of the study are: To evaluate the safety and tolerability of single and multiple oral doses of VP 20629 in subjects with Friedreich's ataxia (FA).
- Trial name
- NCT01898884
- Testing
- VP 20629
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Shire
Erectile Dysfunction
LEVITRA® 20mg Special Drug Use Investigation (Long-term)
This investigation targets either the patients of 18 years-old or older and under 65 years-old with organic or mixed erectile dysfunction (ED) who cannot obtain sufficient efficacy by dose 10mg of Levitra, and the target patients…
- Trial name
- NCT00909233
- Testing
- Vardenafil, (Levitra, BAY38-9456)
- Where
- Japan
- Volunteers
- 1,221 people
- Sponsor
- Bayer
Postoperative Analgesia
Evaluation of Safety and Efficacy of Nalbuphine Versus Morphine for Postoperative Analgesia
Evaluation of safety and efficacy of Nalbuphine versus Morphine patient controlled intravenous analgesia (PCIA) for the treatment of postoperative analgesia
- Trial name
- NCT06949852
- Testing
- Nalbuphine Hydrochloride Injection, Morphine Hydrochloride Injection
- Where
- 24 sites in China
- Volunteers
- 289 people
- Sponsor
- Yangtze River Pharmaceutical Group Jiangsu Zilong Pharmaceutical Co. Ltd
Psoriasis
A Multiple Dose Escalation Study of ASKP1240 in Subjects With Moderate to Severe Plaque Psoriasis
The purpose of this study is to explore the safety and tolerability of multiple doses of ASKP1240 compared to placebo and determine Pharmacokinetics and Pharmacodynamics in subjects with moderate to severe psoriasis.
- Trial name
- NCT01585233
- Testing
- ASKP1240
- Where
- 13 sites in Australia, Canada and 1 more
- Volunteers
- 60 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Healthy
To Investigate the Safety, Tolerability, Pharmacokinetics and the Relative Bioavailability of BI 1026706
To investigate the safety, tolerability, pharmacokinetics and the relative bioavailability of BI 1026706
- Trial name
- NCT01763333
- Testing
- BI 1026706
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Dermatological Evaluation of Topic Compatibility-Dermacyd Tina Gel Tangerina Mix
The purpose of this study is to demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd Tina Gel Tangerina Mix
- Trial name
- NCT00669058
- Testing
- Lactic acid (Dermacid)
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sanofi
Myopia
In-vivo Wettability Grading and Assessment Study
The purpose of this study is to investigate the front surface wettability of soft contact lenses while on eye.
- Trial name
- CIAN (NCT01010555)
- Testing
- lotrafilcon B, balafilcon A, senofilcon A
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- CIBA VISION
Inositol, Testosterone
Evaluation of D-chiro-inositol Treatments
Healthy women will take tablets containing 600 mg D-chiro-inositol twice per day for one month. We will evaluate metabolic and hormonal.parameters, as insulienmia, glycemia, estradiol, testosterone.
- Conditions
- Inositol, Testosterone, Insulin, Ovulation
- Trial name
- NCT05448378
- Testing
- D-chiro-inositol
- Where
- 2 sites in Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lo.Li.Pharma s.r.l
Mixed Astigmatism
Study of the MEL 80 Excimer Laser Using LASIK in the Treatment of Mixed Astigmatism
The purpose of this study is to determine whether the MEL 80 Excimer Laser is effective in the treatment of mixed astigmatism up to 6.0 D, when used as part of the Laser In Situ Keratomileusis (LASIK) procedure.
- Trial name
- NCT00761826
- Testing
- MEL 80 Mixed Astigmatism Treatment
- Where
- 5 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Carl Zeiss Meditec, Inc.
Dysphagia, Malnutrition
IDDSI Nutritional Drink for Dysphagia Study
This study will evaluate the gastrointestinal (GI) tolerance, compliance , acceptability and safety of a ready-to-use oral nutritional supplement drink for patients with dysphagia.
- Trial name
- NCT03679078
- Testing
- IDDSI nutritional supplement drink
- Where
- 8 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Nutricia UK Ltd
Overweight and Obesity
Evaluate the Safety and Efficacy of CPX101 in Overweight and Obese Subjects Without Diabetes Mellitus
The study is designed to evaluate the preliminary efficacy, safety, population PK profile, and immunogenicity of CPX101 in subjects with obesity or overweight with weight related comorbidities but without diabetes mellitus.
- Trial name
- NCT06532578
- Where
- Australia
- Volunteers
- 240 people
- Sponsor
- Guangzhou Chia Tai Innovative Pharmaceutical Co., Ltd.
Cervical Intraepithelial Neoplasia Grade 2/3
Efficacy and Safety of Cevira® in Patients With Cervical Histologic High-grade Squamous Intraepithelial Lesions (HSIL)
A double blind, prospective, randomized, placebo controlled, multi-center phase 3 study to evaluate efficacy and safety of Cevira® in patients with cervical histologic high-grade squamous intraepithelial lesions (HSIL).
- Trial name
- APRICITY (NCT04484415)
- Testing
- Cevira®
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Asieris MediTech (Hong Kong) Co., Ltd.
B-cell Acute Lymphoblastic Leukemia
Evaluation of ProALL miRs in Blood Specimen for Prediction of ALL Relapse Risk
Previous findings have shown that a biomarker comprised of the three microRNAs (miRs) miR-451, miR-151-5p and miR-1290 can independently predict precursor B-cell acute lymphoblastic leukemia (B- ALL) patients' risk for relapse…
- Trial name
- NCT03000335
- Where
- 2 sites in Israel
- Volunteers
- 65 people
- Sponsor
- Curewize Health Ltd.
Crohn's Disease
Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease
To evaluate the long-term maintenance of response, safety and tolerability of repeated administration of adalimumab in subjects with Crohn's disease who participated in and successfully completed Protocol M02-404 or Protocol…
- Trial name
- NCT00195715
- Testing
- Adalimumab
- Where
- 111 sites in United States, Australia and 13 more
- Volunteers
- 777 people
- Sponsor
- Abbott
Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma
Safety and Antitumor Activity Study of Loncastuximab Tesirine and Durvalumab in Diffuse Large B-Cell, Mantle Cell, or Follicular Lymphoma
The purpose of this phase 1 study is to evaluate the safety and anti-tumor activity of Loncastuximab Tesirine (ADCT-402) and Durvalumab in participants with Advanced Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma, or…
- Conditions
- Diffuse Large B-Cell Lymphoma, Mantle Cell Lymphoma, Follicular Lymphoma
- Trial name
- NCT03685344
- Testing
- Loncastuximab Tesirine and Durvalumab
- Where
- 14 sites in United States, Spain
- Volunteers
- 13 people
- Sponsor
- ADC Therapeutics S.A.
Atrial Fibrillation, Percutaneous Coronary Intervention
Evaluation of Dual Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With AF That Undergo a PCI With Stenting (REDUAL-PCI)
The main objective of this study is to compare a Dual Antithrombotic Therapy (DAT) regimen of 110mg dabigatran etexilate b.i.d. plus clopidogrel or ticagrelor (110mg dabigatran etexilate (DE) DAT) and 150mg dabigatran etexilate…
- Trial name
- NCT02164864
- Testing
- Dabigatran Etexilate 110mg, Warfarin 3mg, Aspirin
- Where
- 421 sites in United States, Argentina and 39 more
- Volunteers
- 2,725 people
- Sponsor
- Boehringer Ingelheim
Leg Ulcer
A Study to Evaluate the Clinical Effectiveness of a Collagen-ORC Antimicrobial Matrix in Venous Leg Ulcers
This is a randomized (1:1), prospective, open label, multicenter, comparative study to be examine the effectiveness of Collagen-ORC Antimicrobial matrix, a new wound dressing, on venous leg ulcers.
- Trial name
- NCT00235209
- Testing
- Collagen ORC Antimicrobial Matrix (CAM)
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Ethicon, Inc.
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