Clinical trials: Assisted Reproductive Technique
In Vitro Fertilization (IVF), Infertility
Working IVF Patients' Quality of Life
Infertility affects approximately 1 in 6 couples and may require the use of Medically Assisted Reproduction techniques. In France, there were more than 60,000 in vitro fertilization (IVF) attempts in 2016.
- Trial name
- WIQoL (NCT04966091)
- Testing
- Completion of questionnaires
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Infertility
Sperm Selection for Infertility Treatment (SSA)
Infertility is considered a disease by the World Health Organization and it is increasing worldwide affecting more than 70 million couples. About 50% of the cases are due to male inability to fertilize the oocyte.
- Trial name
- SSA (NCT02867111)
- Testing
- Sperm Selection Assay, Attractant Substance, ICSI
- Where
- 2 sites in Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Córdoba
Infertility, Male
The Aim of This Study is to Determine the Incidence of Alterations in Fluorescent In Situ Hybridisation (FISH) of Spermatozoa and to Evaluate the Efficacy of the Use of Annexin Columns (MACS®) in Patients With Altered FISH Undergoing In Vitro Fertilisation Techniques
250 petitions for FISH of spermatozoa were requested, determining the total and particular incidence in each of the indications collected. The effect of annexin columns was evaluated in 10 couples with altered FISH.
- Trial name
- NCT06524102
- Testing
- Magnetic Activated Cell Sorting
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Pulmonary Embolism, Venous Thromboembolism
Risk of Pulmonary and Venous Thromboembolism in Pregnancies After in Vitro Fertilization
Occurrence of venous thromboembolism during in Vitro Fertilization (IVF) pregnancies has been reported in numerous case reports and in two small consecutive series.
- Trial name
- NCT01524393
- Where
- Sweden
- Volunteers
- 140,458 people
- Sponsor
- Danderyd Hospital
Investigative Techniques, Reproductive Techniques
Does Letrozole Improve Pregnancy Outcome in Fresh Embryo Transfer IVF/ICSI Cycle?
Letrozole (Femara), is an aromatase inhibitor which is used in the treatment of hormonally-responsive breast cancer after surgery.
- Conditions
- Investigative Techniques, Reproductive Techniques, Reproductive Techniques, Assisted
- Trial name
- IVF/ICSI (NCT03901170)
- Testing
- Letrozole 2.5mg
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Infertility, Female, Infertility, Male
Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles
The aim of this randomized controlled trial is to compare the efficacy of oral dydrogesterone vs. micronized vaginal progesterone for luteal phase support in frozen-thawed embryo transfer cycles.
- Conditions
- Infertility, Female, Infertility, Male, Embryo Transfer, Fertilization in Vitro
- Trial name
- NCT04124913
- Testing
- Dydrogesterone 10 MG Oral Tablet, Progesterone Vaginal Gel [Crinone]
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Memorial Sisli Hospital, Istanbul
Neonatal SEPSIS, Perinatal Mortality
Outcomes in Spontaneous and ART Twin Pregnancies
During the last decades, assisted reproductive technique has been transformed from a miracle to real and has become widely used for treatment human infertility. this was associated with increased the rate of twin pregnancies
- Conditions
- Neonatal SEPSIS, Perinatal Mortality, Maternal Morbidity
- Trial name
- NCT03590483
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Hawler Medical University
In Vitro Fertilization, Intracytoplasmic Sperm Injection
Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI
Selection of developmentally competent oocytes enhances IVF efficiency. Usually, oocyte quality is determined based on its nuclear maturation and the presence of specific cytoplasmic and extracytoplasmic morphologic features.
- Conditions
- In Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility
- Trial name
- NCT04724486
- Testing
- Triptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
- Where
- Syria
- Volunteers
- 50 people
- Sponsor
- Damascus University
Effect of Adding GnRHa as Luteal Phase Support in Antagonist ART Cycles
Role of Triptorelin 0.1 mg as a Luteal Phase Support in Assisted Reproductive Technique After Embryo Transfer : a Randomized Controlled Trial
There is still controversy over the best LPS agent and protocol and its dose and duration as well as the time of initiation and cessation.
- Trial name
- NCT04087408
- Testing
- Effect of adding gonadotropins releasing hormone agonist to progesterone for luteal phase support in assisted reproductive technique )antagonist cycles(: a randomized controlled trial
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Moustafa Mohammed Abouelea
Frozen Embryo Transfer (FET), Assisted Reproductive Techniques
Direct Warming Frozen Embryo Transfer Outcomes in Assisted Reproductive Technology
The goal of this clinical trial is to evaluate whether the direct warming method for frozen embryo transfers (FET) can improve live birth and pregnancy outcomes in women aged 18-45 undergoing IVF treatments.
- Conditions
- Frozen Embryo Transfer (FET), Assisted Reproductive Techniques, In Vitro Fertilization (IVF), Cryopreservation of Embryos
- Trial name
- DW-FET-RCT (NCT06741748)
- Testing
- Direct Warming Method, Conventional Multi-step Thawing Method
- Where
- 3 sites in Hong Kong, United Kingdom
- Volunteers
- 578 people
- Sponsor
- Chinese University of Hong Kong
Reproductive Techniques, Assisted
Efficacy of Urinary Vs Recombinant FSH in Oocyte Donors Based on Receptor N680S FSH Gene Polymorphism (Genodon Trial)
Exploratory, prospective, randomized, comparative, open trial with control group treated to assess whether the effective use of urinary FSH (uFSH) or recombinant FSH (rFSH) can be influenced by genotype of receptor N680S FSH Gene…
- Trial name
- GENODON (NCT02625519)
- Testing
- Urinary follicle-stimulating hormone, Recombinant follicle-stimulating hormone
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Infertility Assisted Reproductive Technology, Sexual Behavior
Effects of Infertility and Assisted Reproductive Technology on Sexual Function and Behavior
This cross-sectional observational study examines how infertility and the use of assisted reproductive technology (ART) are related to sexual function and sexual behaviors in women seeking fertility treatment.
- Conditions
- Infertility Assisted Reproductive Technology, Sexual Behavior, Sexual Function, Sexual Dysfunction and Infertility
- Trial name
- NCT07376109
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Infertility
Clinical Tests to Predict the Success of Assisted Reproductive Techniques
Today, it is evident that vitamin D has more widespread effects than the classical actions related to bone mineralization and calcium homeostasis.
- Trial name
- NCT02437578
- Where
- Denmark
- Volunteers
- 542 people
- Sponsor
- Martin Blomberg Jensen
Infertility
US Eeva™ Pregnancy Investigational Clinical Study (US EPIC)
The purpose of this clinical investigation is to gather data to evaluate the impact of using Eeva with traditional morphology grading on implantation rates.
- Trial name
- US EPIC (NCT01671657)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Progyny, Inc.
Birth Rate, Embryo Implantation
EFFects of Thrombophilia on the Outcomes of Assisted Reproduction Technologies
Both hereditary and acquired thrombophilia have been associated with recurrent miscarriage and pregnancy complications. Thrombophilia could favor the development of thrombosis of the maternal vasculature and obstacle…
- Conditions
- Birth Rate, Embryo Implantation, Reproductive Techniques, Thrombophilia
- Trial name
- NCT02407730
- Where
- Italy
- Volunteers
- 687 people
- Sponsor
- G. d'Annunzio University
Assisted Reproductive Techniques
Gamete Donation Conception and Disclosure to Children : Towards an Evaluation of the Practices (AMP)
Assisted reproductive techniques (ART) is very framed in France by principles initially stated by the french CECOS Federation of (Centre d'Etude et de Conservation des Oeufs et du Sperme) and then included in the bioethic law.
- Trial name
- AMP (NCT03801018)
- Testing
- Questionnary and Interviews
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Infertility
Tailored Ovarian Stimulation Based on BMI, AMH, AFC
The study objective is to develop a tailored based strategy for ovarian stimulation in IVF patients using AMH, BMI, antral follicle count (AFC). 300 patients will be randomized in 2 arms: 1. control group: standard care rec FSH.
- Trial name
- NCT02430740
- Testing
- recFSH
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Endometritis
Diagnosis of Chronic Endometritis in Endometrial Fluid Using Molecular Techniques to Improve the Outcomes of Assisted Reproductive Treatments
Chronic endometritis (CE) is a persistent inflammation of the endometrial lining caused by the infection of the uterine cavity mainly by bacterial pathogens.
- Trial name
- ChEndometritis (NCT03169621)
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Controlled Ovarian Stimulation, Infertility
Study to Examine Effect of Recombinant Luteinizing Hormone (r-Lh) and Recombinant Human Chorionic Gonadotropin (r-hCG) for Ovarian Stimulation in Assisted Reproduction Techniques (ART)
The study is a prospective, randomised, controlled, and non-blinded multi-center pilot study to evaluate endocrine efficacy of recombinant luteinizing hormone versus recombinant human chorionic gonadotropin administered during…
- Trial name
- NCT01339299
- Testing
- recombinant luteinizing hormone (r-LH), recombinant human chorionic gonadotropin (r-hCG)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Regionshospitalet Viborg, Skive
Male Infertility, Oligoasthenospermia
Investigation of the Effects of Stem Cell Supportive Treatment on Semen Parameters and Assisted Reproductive Techniques (ICSI) in Infertile Male Patients With Oligoasthenospermia(Decrease Sperm Number and Quality)
This study evaluated whether Stemregen® dietary supplementation could improve sperm quality and assisted reproductive treatment outcomes in men with severe oligoasthenozoospermia who had previously experienced at least one failed…
- Trial name
- STEMRN (NCT07800052)
- Testing
- Stemregen
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University