Clinical trials: Assisted Reproductive Technique
Infertility, Infertility, Male
Scanning the Meiotic Spindle in Assisted Reproductive Techniques to Assess Oocyte Quality
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality.
- Conditions
- Infertility, Infertility, Male, Infertility, Female
- Trial name
- SMART (NCT06539585)
- Testing
- Meiotic spindle status observation in polarized light, ICSI
- Where
- Czechia
- Volunteers
- 164 people
- Sponsor
- Charles University, Czech Republic
Infertility
Observational Post-Authorisation Study on the Use of Bemfola® in Human Assisted Reproductive Techniques in Spain.
Non-comparative, observational, ambispective post-authorisation study (EPA-SP).
- Trial name
- BIRTH (NCT02941341)
- Testing
- r-hFSH
- Where
- Spain
- Volunteers
- 1,222 people
- Sponsor
- Finox AG
Assisted Reproductive Techniques, Pregnancy
Incidence of Pulmonary and Venous Thromboembolism in IVF Pregnancies After Fresh and Frozen Embryo Transfer
In vitro fertilization (IVF) is associated with an increased risk of venous thromboembolism and in particular pulmonary embolism during the first trimester.
- Conditions
- Assisted Reproductive Techniques, Pregnancy, Pulmonary Embolism, Venous Thromboembolism
- Trial name
- NCT03660007
- Testing
- Fresh or frozen embryo transfer IVF
- Volunteers
- 902,891 people
- Sponsor
- Karolinska Institutet
Infertility, Male
Oral Astaxanthin and Semen Quality, Fertilization and Embryo Development in Assisted Reproduction Techniques Procedures
The purpose of the study is to determine whether administration of dietary supplement of astaxanthin with vitamin E improves the quality of sperm, fertilization and embryo development in Assisted Reproduction Techniques (ART)…
- Trial name
- Astax-ART (NCT02310087)
- Testing
- astaxanthin with vitamin E
- Where
- Slovenia
- Volunteers
- 80 people
- Sponsor
- University Medical Centre Ljubljana
Fertility Preservation, Cancer Remission
Long-term Evaluation of Fertility Preservation Options in Women in Cancer Remission or Haematological Pathology
Cancer treatments, despite their increasing effectiveness, carry a significant risk of gamete toxicity. Women of reproductive age are commonly offered fertility preservation (FP) before starting their treatment.
- Conditions
- Fertility Preservation, Cancer Remission, Reproductive Outcomes, Reproductive Health
- Trial name
- FERT-ISSUES (NCT07312058)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Ovarian Stimulation
Lutropin Alfa in Women at Risk of Poor Response
Evaluate the effectiveness of adding lutropin alfa (recombinant human luteinizing hormone [r-hLH]) in the middle of the follicular phase compared to no addition, in infertile women at risk of poor response stimulated with…
- Trial name
- NCT01112358
- Testing
- r-FSH, r-hLH, Analogous GnRH antagonist
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Assisted Reproductive Techniques
Trial Comparing Subcutaneous Natural Progesterone (Prolutex) vs. Cetrorelix Acetate for Luteinizing Hormone Surge Suppression in Freeze-All IVF Cycles.
The prevention of premature luteinizing hormone (LH) surge during controlled ovarian stimulation (COS) is critical for optimizing outcomes in assisted reproductive technology (ART).
- Trial name
- IVF ART (NCT07350317)
- Testing
- Control Group (A):, Test Group (B):
- Volunteers
- 230 people
- Sponsor
- Trust Fertility Clinic
Breast Cancer Female
Combining Interventions of Fertility Preservation to Mitigate Fertility Loss After Breast Cancer
This clinical prospective randomised controlled trial will evaluate the impact of an ovarian biopsy on the oocyte yield after controlled ovarian stimulation before chemotherapy in view of breast cancer.
- Trial name
- Coimbra (NCT04586686)
- Testing
- Ovarian biopsy via laparoscopy, Transvaginal oocyte retrieval
- Where
- 2 sites in Belgium
- Volunteers
- 41 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Infertility, Female
Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo Ploidy
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Unexplained
- Trial name
- SMARTAI (NCT06539104)
- Testing
- arteficial inteligence evaluation of oocyte and embryo development
- Where
- 4 sites in Czechia
- Volunteers
- 1,000 people
- Sponsor
- Charles University, Czech Republic
PCOS, OHSS
Prediction of High Ovarian Response After Assisted Reproductive Techniques
Polycystic ovarian syndrome (PCOS) patients have an increased risk of ovarian hyperstimulation syndrome (OHSS) after assisted reproduction techniques (ART).
- Trial name
- HighART (NCT02358421)
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Reproductive Techniques, Assisted, Family
ARTLifeLine: Assisted Reproduction Technology (ART) Family Health and Development Trajectory Cohort (ARTLL)
The goal of this observational study is to study the health status of infertile couples and their offspring using assisted reproductive technologies. The main questions it aims to answer are: 1.
- Conditions
- Reproductive Techniques, Assisted, Family, Cohort Studies, Development, Infant
- Trial name
- NCT06786871
- Testing
- IVF treatment
- Where
- 2 sites in China
- Volunteers
- 100,000 people
- Sponsor
- Peking University Third Hospital
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
ReceptIVFity & Immunology in ART
The goal of this clinical non-invasive observational pilot study is to improve the prediction of pregnancy success after In Vitro Fertilisation (IVF)/IVF -Intracytoplasmic Sperm Injection (ICSI) treatment by examining the vaginal…
- Trial name
- R-IMinART (NCT06709976)
- Testing
- Vaginal microbiome swab, Menstrual Blood Collection via Menstrual Cup
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Fertilization
Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART
Oocyte activation is an imperative stage in the initiation of embryo development during the fertilization. Indeed, the entrance of sperm into the oocyte causes sequences of calcium oscillations in its cytoplasm, regulating a…
- Trial name
- NCT04519918
- Testing
- AOA
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
MACS Technique Efficacy
Application of MACS and Time-lapse Technology in Good-prognosis Patients
The MACS technique (magnetic-activated cell sorting) is based on the usage of microbeads, magnetic particles with a diameter of 35 nanometers joined to the compound annexin V.
- Trial name
- NCT01908569
- Testing
- MACS, NO MACS
- Where
- Spain
- Volunteers
- 66 people
- Sponsor
- Vida Recoletas Sevilla
Infertility, Fertility
A Trial to Compare the Efficacy and Safety of Ovarian Stimulation With GONAL-f® and Luveris® Starting on Day 1 Versus Day 6 in Women Undergoing Assisted Reproductive Technique
This is a phase IIIb, interventional, multicenter, multinational, randomised, open-label, comparative trial which primary objective is to generate data on the ovarian stimulation profile obtained when Luveris® is started either…
- Conditions
- Infertility, Fertility, Follicle Stimulating Hormone Deficiency
- Trial name
- NCT01497197
- Testing
- GONAL-f®, Luveris®, Recombinant human chorionic gonadotropin (r-hCG)
- Where
- United Arab Emirates
- Volunteers
- 174 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Reproductive Techniques, Assisted
Clinical Trial Comparing Endometrial Transformation With Subcutaneous Progesterone Versus Intramuscular Progesterone
Study the endometrial predecidualization by using subcutaneous progesterone 25 mg/day versus intramuscular progesterone 50 mg/day, to determine whether there are differences in the endometrial transformation and endometrial…
- Trial name
- NCT02567552
- Testing
- Subcutaneous progesterone, Intramuscular progesterone
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- IVI Barcelona
Infertility of Uterine Origin
Development of a Microbiome Non-invasive Diagnosis Tool
Although the endometrium tissue has been traditionally considered free of bacteria, recent studies have documented the presence of an endometrial microbiome.
- Trial name
- ERA-niMIC (NCT03330444)
- Testing
- Endometrial biopsy and endometrial fluid collection
- Where
- 13 sites in United States, Argentina and 6 more
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Igenomix
Reproductive Techniques, Assisted, Artificial Intelligence
Retrospective Evaluation Blastocyst Development by Artificial Intelligency
In assisted reproductive technology (ART), selecting the most viable embryos from a large number of fertilized eggs is crucial. While techniques like morphological assessment, time-lapse monitoring systems, and pre-implantation…
- Conditions
- Reproductive Techniques, Assisted, Artificial Intelligence, Embryo Transfer
- Trial name
- EBAI (NCT07383480)
- Where
- France
- Volunteers
- 333 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility Assisted Reproductive Technology
The Feasibility of taVNS on Pregnancy Outcomes of Infertility Patients Undergoing IVF
To assess the feasibility of taVNS on pregnancy outcomes of infertility subjects undergoing IVF, the primary aim of this trial will focus on encompassing recruitment, compliance, and preliminary engagement outcomes.
- Trial name
- NCT06742788
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Contraceptive Usage, Contraceptive Behavior
A Web-Based Tool to Help People With Health Conditions Make Contraceptive Decisions
Among people who do not want to get pregnant, some do not use any birth control. This is also called contraceptive nonuse. Common reasons for contraceptive nonuse include concerns about birth control safety or side effects.
- Conditions
- Contraceptive Usage, Contraceptive Behavior, Chronic Disease, Chronic Condition
- Trial name
- NCT07075536
- Testing
- My Health, My Choice Web-Based Contraceptive Decision Tool, Usual Contraceptive Care
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 795 people
- Sponsor
- University of Michigan