Clinical trials: Associated Conditions
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Chronic Myeloproliferative Disorders, Leukemia
Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant
RATIONALE: Studying immune response to flu vaccine in patients who have undergone a stem cell transplant may help doctors plan the best treatment.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00964821
- Testing
- trivalent influenza vaccine, Immunoenzyme technique, Laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 459 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Prevention of Nausea Associated With Motion Sickness, Treatment of Nausea Associated With Motion Sickness
Study of the Safety and Efficacy of DPI-386 Nasal Gel on Ocean-Going Vessels
This multi-site Phase 3 clinical trial is a randomized, double-blind, placebo-controlled study to identify the safety and efficacy of DPI 386 nasal gel (intranasal scopolamine gel) for the prevention and treatment of nausea…
- Trial name
- INSCOP (NCT03920644)
- Testing
- Scopolamine Transdermal Patch [Transderm Scop], Scopolamine
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Naval Aeromedical Research Unit, Dayton
Obesity
What is the Maximum Amount of Carbohydrates That is Still Able to Induce Ketosis and Suppress Appetite?
Two dietary approaches, very low energy diets (VLEDs) and ketogenic low carbohydrate diets (KLCDs), have the ability to suppress appetite.
- Trial name
- NCT02944253
- Testing
- Low energy diet 70 gram carbohydrates, Low energy diet 100 gram carbohydrates, Low energy diet 130 gram carbohydrates
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Pain, Hypoglycemia
Outcomes Study of MTM in a Medicare ACO
This is a non-randomized, prospective, quasi-experimental study designed to assess the impact of pharmacist-provided medication management on total cost of care and clinical outcomes (ie, hospitalizations, emergency department…
- Trial name
- NCT02875925
- Testing
- MTM
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- HealthEast Care System
Coenzyme Q10, Oxidative Stress
Bioavailability and Impact of Coenzyme Q10 in Stressing Exercise in Senescence Athletes
It is proposed to establish a group of subjects composed of 10 healthy individuals of> 50 years and <65, physically active, without metabolic or inflammatory pathology.
- Conditions
- Coenzyme Q10, Oxidative Stress, Aging
- Trial name
- CoQ10Sport (NCT03893864)
- Testing
- Administration of a product with Fitosomed Ubiquinone, Coenzyme Q10 level in muscle biopsies, Coenzyme Q10 level in plasma, blood cells, urine cells
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre d'Alt Rendiment
Maternal Morbidity and Mortality
Creating VIP Corps to Reduce Maternal Deaths
The goal of this observational study is to create and rigorously evaluate a violence intervention and prevention corps (VIP Corps) training using a randomized controlled trial among undergraduate and professional students; and to…
- Trial name
- NCT06089109
- Testing
- The Big 3, Implementation and Effectiveness of VIP Corps Training
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- Ann Coker
Low Back Pain, Kinesio Taping
Acute Effect of Myofascial Release and Kinesiology Taping
Chronic low back pain (LBP) is one of the leading causes of activity limitation and disability. The prevalence of chronic CBA among young adults is known to increase, and a recent epidemiological study reported a rate of 42.4%…
- Conditions
- Low Back Pain, Kinesio Taping, Myofascial Release Technique
- Trial name
- NCT05319184
- Testing
- Myofascial Release Technique and Kinesiology Taping
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Coronavirus Infections, Healthcare Associated Infection
NO Prevention of COVID-19 for Healthcare Providers
Thousands of healthcare workers have been infected with SARS-CoV-2 and contracted COVID-19 despite their best efforts to prevent contamination. No proven vaccine is available to protect healthcare workers against SARS-CoV-2.
- Trial name
- NOpreventCOVID (NCT04312243)
- Testing
- Inhaled nitric oxide gas
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV Infections, Candidiasis, Oral
Oral Manifestations of Human Immunodeficiency Virus Infection in High Risk Groups
OBJECTIVES: I. Evaluate the development of oral manifestations of human immunodeficiency virus infection in relationship to the onset of immunologic alterations and systemic symptoms in different risk groups: gay/bisexual men…
- Trial name
- NCT00004781
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Root Canal Sealers, Post Operative Pain
Evaluation of Post Obturation Pain Associated With Calcium Hydroxide-based Root Canal Sealers and Resin-based Root Canal Sealer: a Single Visit Root Canal Treatment
The objective of this study is to evaluate the post obturation pain associated with calcium hydroxide-based root canal sealer and resin-based root canal sealer after single visit root canal treatment following endodontic…
- Conditions
- Root Canal Sealers, Post Operative Pain, Irreversible Pulpitis
- Trial name
- NCT06798467
- Testing
- Endodontic sealer, post obturation pain
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jinnah Sindh Medical University
Gut Health
Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms
The purpose of this study is the assess the effectiveness and safety of a Butyrate formulation and a Butyrate + Polyphenol formulation on gut health, permeability and associated symptoms
- Trial name
- NCT06419231
- Testing
- Butyrate Formulation, Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Intellectual Disability, Neurodevelopmental Disorders
Physical Activity and Community EmPOWERment Project
Purpose: Conduct a wait-list randomized controlled trial (RCT) of an inclusive physical activity program called PACE for adults with intellectual disability (ID) who are not yet showing signs of Alzheimer's Disease…
- Conditions
- Intellectual Disability, Neurodevelopmental Disorders, Autism Spectrum Disorder, Down Syndrome
- Trial name
- PACE (NCT06740162)
- Testing
- PACE Program
- Where
- 2 sites in United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tourette Syndrome
Brain Activity Associated With Tics in Patients With Tourette Syndrome
This study will examine brain activity associated with the involuntary urges or uncontrolled movements, called "tics," experienced by people who have Tourette syndrome (TS).
- Trial name
- NCT00141869
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Kidney Injury, Kidney Disease, Chronic
Early Diagnosis of Kidney Damage Associated With Tobacco Use
Tobacco consumption is associated with the appearance of several pathologies, the best known are Chronic Obstructive Pulmonary Disease, several types of cancer and cardiovascular diseases.
- Conditions
- Kidney Injury, Kidney Disease, Chronic, Tobacco Toxicity
- Trial name
- NCT03850756
- Testing
- Early kidney damage biomarkers, Predisposition to kidney injury biomarkers, Tobacco consumption
- Where
- 2 sites in Spain
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Healthy Volunteers, Cryopyrin Associated Periodic Syndrome
Safety and Tolerability, Pharmacokinetic and Pharmacodynamic Study With IZD334
This is a first in human (FIH), single-centre, double -blind, randomised, cross-over, SAD followed by a MAD study of IZD334 conducted in healthy adult participants as well as an open-label cohort in adult patients with CAPS.
- Trial name
- NCT04086602
- Testing
- IZD334
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Inflazome UK Ltd
Sarcopenia
Bioindicators Associated With Sarcopenia Before and After Intensive Lifestyle Intervention
The goal of this clinical trial is to explore whether the bioindicators of body composition, nutrition-related indicators (lymphocytes, albumin), lipids, and thyroid hormones are associated with sarcopenia and the changes in…
- Trial name
- NCT06128577
- Testing
- 3-month intensive intervention
- Where
- China
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Lijun Yang
Foot Fracture, Ankle Fractures
Use of Sterile HemaClear Tourniquet Below Calf Versus Pneumatic Tourniquet at the Thigh for Ankle and Foot Surgery
This is a Randomized controlled trial evaluating the effects of the use of Sterile HemaClear Tourniquet Below Calf Versus Pneumatic Tourniquet at the Thigh for Ankle and Foot Surgery The trial will randomize 60 patients into an…
- Conditions
- Foot Fracture, Ankle Fractures, Ankle Injuries, Foot Injuries and Disorders
- Trial name
- HemaClear (NCT04818775)
- Testing
- HemaClear, Pneumatic Tourniquet
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital do Coracao
Vasomotor Symptoms Associated With Menopause
Herbal Alternatives for Menopause Symptoms (HALT Study)
Surveys indicate that 25 to 33% of women have moderate to severe menopausal symptoms including hot flashes, night sweats, and disturbed sleep.
- Trial name
- NCT00169299
- Testing
- Black cohosh, Multibotanical preparation, Multibotanical preparation + dietary soy counseling
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Analgesia, Obstetrical
SKIN WHEAL - Subcutaneous or Intradermal Lidocaine in Epidural for Laboring Pain.
The purpose of this study is to explore the differences between the pain associated with epidural Tuohy needle insertion with prior administration of subcutaneous or intradermal lidocaine using two different pain assessment tools…
- Trial name
- NCT06236126
- Testing
- 1% Lidocaine Injection
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Ohio State University