Clinical trials: Asthenia
Amyotrophic Lateral Sclerosis, Respiratory Muscle Weakness
ALS and Airway Clearance (ALSAC) Therapy
Patients will receive one of three respiratory therapy interventions for airway clearance assistance: 1) High frequency chest wall oscillation (HFCWO) and mechanical insufflation/exsufflation (MIE), 2) HFCWO or 3) MIE.
- Trial name
- ALSAC (NCT04947436)
- Testing
- High Frequency Chest Wall Oscillation, Mechanical insufflation/exsufflation
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Poor Performance Status, Muscle Weakness
SR-WBV Training for Frail Elderly in the Skilling up Stage
This randomized controlled study aims to examine long term effects in the skilling up phase over 4 weeks on physical functional performance and strength of mechanical SR-WBV and dance therapy intervention in a frail elderly…
- Trial name
- NCT01704976
- Testing
- SR-WBV
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Muscle Weakness
Electromyography in Patients on Chronic Pyridostigmine Therapy
We intend to measure evoked EMG at two sites in subjects who are chronically taking pyridostigmine.
- Trial name
- NCT02364180
- Testing
- Electromyography (EMG)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Toledo Health Science Campus
Child, Intensive Care Unit Acquired Weakness
Clinical Effectiveness of the "PICU Up!" Multifaceted Early Mobility Intervention for Critically Ill Children
While mortality in U.S. pediatric intensive care units (PICUs) is improving, surviving children frequently develop persistent physical, cognitive, and psychological impairments.
- Conditions
- Child, Intensive Care Unit Acquired Weakness, Critical Illness, Hospital Acquired Pressure Ulcer
- Trial name
- PICU Up! (NCT04989790)
- Testing
- PICU Up!
- Where
- 11 sites in United States
- Volunteers
- 1,470 people
- Sponsor
- Johns Hopkins University
Cerebrovascular Accident
Mechanisms of Upper-Extremity Motor Recovery in Post-stroke Hemiparesis
The results of this study will provide sound, scientific evidence of physiologic mechanisms responsible for upper-extremity weakness; evidence of the processes involved in neuromuscular adaptation; and will elucidate the…
- Trial name
- NCT00125658
- Testing
- Control, Experimental
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Fecal Incontinence
Evaluation of Outcomes of Restoring Pelvic Floor Support With TOPAS in Women With Moderate Fecal Incontinence Symptoms
The study purpose is to gain experience with the TOPAS system, a minimally- invasively delivered self-fixating mesh for the treatment of pelvic floor weakness in women with symptoms of moderate fecal incontinence
- Trial name
- TOPAS (NCT00565136)
- Testing
- TOPAS
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- ASTORA Women's Health
Muscle Weakness
Best Practice Using Rocuronium and Reversal With Neostigmine or Sugammadex
This is an estimation study, prospectively evaluating the incidence of postoperative residual neuromuscular blockade (PRNB) when a best practice protocol is implemented for a cohort of abdominal surgery and orthopedic surgery…
- Trial name
- NCT03543826
- Testing
- Protocol for rocuronium neuromuscular block
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- University of Washington
Muscle Cramp, Ache
7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
Over 40 million Americans take statins to reduce their risk of atherosclerotic cardiovascular disease (ASCVD). Unfortunately, 10 to 20% stop taking them due to statin-associated muscle symptoms (e.g.
- Conditions
- Muscle Cramp, Ache, Weakness, Muscle, Statin Adverse Reaction
- Trial name
- NCT04507373
- Testing
- Simvastatin 40mg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Myasthenia Gravis
A Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness
This is a randomized, double-blind, placebo-controlled, multicenter Phase II study to evaluate the safety, efficacy, and pharmacokinetics of ARGX-113 for the treatment of autoimmune Myasthenia Gravis (MG) with generalized muscle…
- Trial name
- NCT02965573
- Testing
- ARGX-113
- Where
- 19 sites in United States, Belgium and 6 more
- Volunteers
- 24 people
- Sponsor
- argenx
Upper Extremity Weakness, Stroke
A Study to Evaluate Lower Extremity Sleeve and Pump Device to Treat Hemiparesis
The primary purpose of this study is to establish that application of a Sequential Compression Device (SCD) and lower extremity (LE) sleeve applied to a hemi-paretic upper extremity is safe.
- Trial name
- NCT05535257
- Testing
- Sequential Compression Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Post-acute COVID-19 Syndrome
Сlinical Trial of Efficacy and Safety of Prospekta in the Treatment of Post-COVID-19 Asthenia.
The multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial. The objective of this study is to evaluate the efficacy and safety of Prospekta in the treatment of asthenia in patients after the…
- Trial name
- NCT05074888
- Testing
- Prospekta
- Where
- 32 sites in Russia
- Volunteers
- 676 people
- Sponsor
- Materia Medica Holding
Generalized Myasthenia Gravis
A Safety and Tolerability Study of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness.
This is a Long-Term, Single-Arm, Open-Label, Multicenter Phase 3 follow-on trial of the ARGX-113-1704 study to evaluate the safety and tolerability of ARGX-113 in patients with gMG.
- Trial name
- ADAPT+ (NCT03770403)
- Testing
- ARGX-113
- Where
- 52 sites in United States, Belgium and 13 more
- Volunteers
- 151 people
- Sponsor
- argenx
Arm Weakness as a Consequence of Stroke
Effects of Post-Stroke Upper Extremity Assistance
The purpose of this study is to quantify the improvement of post- stroke individuals' ability to move their arms during and after robot assisted therapy.
- Trial name
- NCT05036642
- Testing
- Compliant Passive Arm Support
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Muscle Weakness
Functional Change With MMS
Evaluate the safety and efficacy of magnetic muscle stimulation (MMS) of abdominal muscle.
- Trial name
- FMS (NCT04506502)
- Testing
- The ZELTIQ System
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Zeltiq Aesthetics
Stroke
Internally Versus Externally Guided Body Weight-Supported Treadmill Training (BWSTT) for Locomotor Recovery Post-stroke
The overriding goal of this proposal is to identify the critical physiological and biomechanical effects of BWSTT for promoting improved locomotor function in persons with post-stroke hemiparesis.
- Trial name
- NCT00125619
- Testing
- Locomotor training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Covid19, Anosmia
Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN)
The main aim of this study is to determine the effects of short-term treatment with hesperidin on COVID-19 symptoms in comparison with a placebo.
- Conditions
- Covid19, Anosmia, Fever, Cough
- Trial name
- Hesperidin (NCT04715932)
- Testing
- Hesperidin
- Where
- Canada
- Volunteers
- 216 people
- Sponsor
- Montreal Heart Institute
Muscle Weakness
Effects of Creatine Supplementation on Muscle Mass and Function Among Older Women Subjected to Resistance Training
To determine, in a double blind trial, the effects of creatine supplementation during 12 weeks on muscle mass and function of community living older women subjected to resistance training.
- Trial name
- NCT02188849
- Testing
- Resistance exercise training, Creatine
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Chile
ICU Acquired Weakness (ICUAW)
Feasibility and Safety of Digital Rehab Platform for Bedridden Patients
Study Title Rehabilitation Program for Bedridden Patients Using Digital Devices Study Purpose This study aims to evaluate the effectiveness of a rehabilitation program using digital devices and apps for bedridden patients in a…
- Trial name
- NCT06849765
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Asan Medical Center
Generalized Myasthenia Gravis
An Efficacy and Safety Study of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness
A randomized, double-blind, placebo controlled, multicenter Phase 3 trial to evaluate the efficacy, safety, tolerability, quality of life and impact on normal daily activities of ARGX-113 in patients with gMG.
- Trial name
- ADAPT (NCT03669588)
- Testing
- ARGX-113
- Where
- 66 sites in United States, Belgium and 14 more
- Volunteers
- 167 people
- Sponsor
- argenx