Clinical trials: Asthma Chronic
Chronic Obstructive Pulmonary Disease, Bronchial Asthma
Influence of Bag Volume Variation on the Reproducibility of Inert Gas Rebreathing
Non-invasive inert gas rebreathing (IGR) based on the Fick Principle showed promising results in the determination of pulmonary blood flow (PBF).
- Conditions
- Chronic Obstructive Pulmonary Disease, Bronchial Asthma, Restrictive Pulmonary Disease
- Trial name
- NCT01762917
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Asthma, COPD
Bioequivalence Study to Assess Systemic Exposure of FP and SAL FDC From Different DPIs
This is a crossover study to assess the systemic pharmacokinetics of fluticasone propionate (FP) and salmeterol (SAL). Study medication will be administered as fixed dose combinations (250 µg FP and 50 µg SAL) from the Advair®…
- Trial name
- NCT02215122
- Testing
- MGR001, Advair® Diskus®, Seretide™ Accuhaler™
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mylan Pharma UK Ltd.
Asthma, COPD
Evaluation of 3D Magnetic Resonance Spirometry: Comparison with Spirometry in Healthy Subjects and Patients with Respiratory Pathologies (asthma, COPD, Bilateral Lung Transplant)
Spirometry is now the gold standard technique for assessing lung function in humans. From the shape of a flow-volume curve measured while the patient, trained by the practitioner, performs forced breaths, the forced vital…
- Conditions
- Asthma, COPD, BOS
- Trial name
- gb-Spiro3D (NCT05724745)
- Testing
- 1. Standard spirometry, 2. 3D dynamic lung MRI at UTE in prone and supine positions, 3. Reversibility test with salbutamol
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Commissariat A L'energie Atomique
Type 1 Diabetes, T1D
DASH-Obesity: Explainable AI for Family-Centric Personalized Weight Control in Adolescents and Young Adults With Obesity and Chronic Conditions
This prospective single-arm feasibility study evaluates the Adhera Caring Digital Program for Obesity (ACDP-O), a family-centered digital health intervention designed to support adolescents and young adults with…
- Conditions
- Type 1 Diabetes, T1D, Obesity & Overweight, Obesity Type 2 Diabetes Mellitus
- Trial name
- DASH-Obesity (NCT07638345)
- Testing
- Adhera Caring Digital Program-Obesity (ACDP-O)
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Adhera Health, Inc.
Asthma, COPD
Novel Biomarkers in Chronic Airway Diseases
The purpose of this study is: To define The differences of bio-chemical phenotypes in chronic airway inflammatory diseases. To identify novel biomarkers in chronic airway inflammatory diseases as a screening, diagnostic, or…
- Trial name
- NCT00849836
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University
COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis)
Creation of a Biological Collection of BRonchiaI and Pulmonary Tissues From Surgical wastE
The biological samples and associated data will facilitate the successful implementation of the research collaboration between Bordeaux University Hospital and the University of Bordeaux on the pathophysiology of bronchopulmonary…
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Asthma (Diagnosis), Safe Volunteers
- Trial name
- BRISE (NCT07780630)
- Testing
- Fiberscopic samples, Sputum, Nasal brushing
- Where
- France
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Asthma, COPD
Can we Reduce Hospital Attendance Without Compromising Care by the Use of Telephone Consultation
Consultation time in busy respiratory clinics is inevitably limited and attendance is often disruptive to patients' lives; involves time, expense, travel, and waiting; and can have effects upon occupation.
- Conditions
- Asthma, COPD, Sleep Apnea Syndromes, Interstitial Lung Diseases
- Trial name
- NCT00129701
- Testing
- Telephone consultation
- Where
- United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Imperial College London
COPD, Asthma
LungVITamin D and OmegA-3 Trial (lungVITAL)
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,871 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Conditions
- COPD, Asthma, Pulmonary Function, Pneumonia
- Trial name
- lungVITAL (NCT01728571)
- Testing
- Vitamin D3, fish oil
- Where
- United States
- Volunteers
- 25,871 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
COPD, Asthma
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD).
- Conditions
- COPD, Asthma, Airway Disease
- Trial name
- RETAIN (NCT06144476)
- Where
- United Kingdom
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis)
Breathlessness Perceptions Within Respiratory Diseases
Breathlessness is a complex symptom that results in poor quality of life, increased hospitalisations and increased mortality. Breathlessness is influenced by physiological, psychological and functional factors but these are…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Asthma (Diagnosis), Interstitial Lung Disease (ILD), Bronchiectasis
- Trial name
- BiRD (NCT07648082)
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
COPD, Hypertension
Sleepiz One+ Versus Capnography and Electrocardiography
EtCO2, or exhaled carbon dioxide, is a non-invasive and commonly used measure for respiratory rate and function. It can be easily monitored using a device called a capnograph, which consists of a sensor that is placed near the…
- Conditions
- COPD, Hypertension, Sleep Apnea, Asthma
- Trial name
- SPZCAP (NCT05712226)
- Testing
- Sleepiz One+
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Sleepiz AG
COPD, Respiratory Symptoms
Expansion of the COPD At-risk Module in 4 States BRFSS Telephone Health Surveys
This cross-sectional survey study is intended to describe the characteristics of adults in 4 US states with regards to respiratory symptoms and tobacco exposure, utilizing an existing state-administered, CDC overseen Behavioral…
- Conditions
- COPD, Respiratory Symptoms, Tobacco Use, Asthma
- Trial name
- NCT02991391
- Testing
- None, use of a questionnaire
- Volunteers
- 40,690 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Obstructive Pulmonary Disease, Asthma
Lung Deposition of Beclometasone Dipropionate/Formoterol Fumarate/Glycopyrronium Bromide Administered Via pMDI in Healthy, Asthmatic and COPD Patients
The purpose of this study is to investigate the lung deposition and distribution pattern of Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium Bromide using a Gamma-scintigraphic technique after inhalation of a single…
- Trial name
- NCT02975843
- Testing
- Beclometasone dipropionate/Formoterol Fumarate/Glycopyrronium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
A Thorough QT (TQT) Study of CHF5993 pMDI in Healthy Volunteers (HV)
The purpose of this study is to evaluate the potential for cardiac repolarization, according to electrocardiographic monitoring (including QT and QTc intervals), of two dose levels of CHF5993 pMDI (beclomethasone…
- Trial name
- NCT05830071
- Testing
- CHF5993, CHF5259, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Asthma, Pulmonary Disease, Chronic Obstructive
Teaching Inhaler Use With the INCA Device in a Community Pharmacy Setting
The purpose of this trial is to discover whether providing feedback to patients from a device that records when and how well a patient uses a Seretide Diskus inhaler will lead to: Improved compliance with prescribed inhaler use…
- Trial name
- NCT02203266
- Testing
- Feedback, Education
- Where
- Ireland
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Beaumont Hospital
Chronic Rhinosinusitis (Diagnosis), Nasal Polyps
NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a condition resulting in varying degrees of nasal congestion, nasal secretion, facial pain and reduced or absent sense of smell.
- Conditions
- Chronic Rhinosinusitis (Diagnosis), Nasal Polyps, Asthma, Obstructive Sleep Apnea
- Trial name
- NCT03963648
- Testing
- Fractioned Exhaled Nitrogen Oxide measurements
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Christian von Buchwald
Chronic Obstructive Pulmonary Disease - COPD
Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of AZD8871 in Healthy Male Japanese Subjects
AZD8871 is a new chemical entity possessing long-acting dual-pharmacology (muscarinic receptor antagonist and β2 adrenoceptor agonist [MABA]) in a single molecule.
- Trial name
- NCT03159442
- Testing
- AZD8871
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease, Asthma
Novel Endpoints in Cough Challenge Testing
The sensitivity of a person's cough reflex can be measured by getting them to breathe in (inhale) irritant chemicals. There are different methods by which subjects are asked to inhale these chemicals, either by taking one deep…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Healthy, Chronic Cough
- Trial name
- NEAT (NCT01566968)
- Testing
- Cough challenge test, 24 hour ambulatory cough recording, Cough quality of life questionnaire
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Asthma, Breast Cancer
Collaborative Self-Management Support in Chronic Conditions - Qualitative Study
The management of chronic conditions is a challenge for health systems worldwide, particularly in the context of an aging population, and requires urgent improvement of health services.
- Conditions
- Asthma, Breast Cancer, Stroke
- Trial name
- CoSMaS-ql (NCT03262428)
- Testing
- Semi-structured interviews
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon