Clinical trials: Asthmatic Crisis
Infection, Heart Failure
Prediction of Expected Length of Hospital Stay Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04784351
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Childhood Asthma With Status Asthmaticus
Status Asthmaticus on the PICU; Intravenous Salbutamol
Although IV salbutamol is frequently used in children in a wide range, pharmacodynamic data are scarce. To date, there is an insufficient evidence base to guide initial and subsequent dosing recommendation for its IV use in…
- Trial name
- STATIC IV (NCT03493503)
- Testing
- Salbutamol, Sodium Chloride 0.9%
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Erasmus Medical Center
Asthma
Efficacy and Safety of Combivent® Aerosol and Spacer, in Adult Patients With Moderate to Severe Asthma Crisis
Study to evaluate the bronchodilator efficacy and safety of a fixed combination of salbutamol sulfate (120 mcg) + ipratropium bromide (20mcg) (Combivent® MDI) in aerosol plus spacer in adult patients with moderate-to-severe…
- Trial name
- NCT02182700
- Testing
- salbutamol sulfate + ipratropium bromide
- Volunteers
- 47 people
- Sponsor
- Boehringer Ingelheim
Asthmatic Crisis, Wheezing
Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT)
Vitamin D deficiency is highly prevalent in the UK. Research shows that vitamin D enhances the immune system and may help protect against chest infections that can cause wheezing illness or worsen asthma symptoms.
- Trial name
- OPTIVIT (NCT02880930)
- Testing
- Fultium-D3 drops (Internis)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Pediatric Obesity, Asthma in Children
Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus
Single center, open-label, non-randomized study to assess the pharmacokinetic profile of methylprednisolone in healthy children 2-20 years of age admitted for asthma exacerbation.
- Trial name
- NCT04874610
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Status Asthmaticus
Pleth Variability and Asthma Severity in Children
Research has shown that pleth variability can be used to assess asthma severity in children with status asthmaticus. The investigators would like to use an FDA-cleared monitor (Masimo Radical 7) which measures Pleth Variability…
- Trial name
- NCT02302261
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Northwell Health
Status Asthmaticus
Intravenous Terbutaline in Severe Status Asthmaticus
Terbutaline is a medication that is used to treat serious asthma attacks (status asthmaticus). The purpose of this study is to determine if terbutaline is effective and safe when given as a continuous intravenous infusion to…
- Trial name
- NCT00750568
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Wayne State University
Child, Asthma Crisis
Physiotherapy Efficiency on Child Asthma
The study aim is to compare usual asthma crisis treatment of hospitalized children with usual treatment associated to sophrology.
- Trial name
- NCT02114398
- Testing
- usual treatment, usual treatment + sophrology
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Montpellier
Bronchial Asthma, Asthma
HFCWO in Hospitalized Asthmatic Children
To determine whether or not high frequency chest wall oscillation (in the form of the VestTM) is superior to regular asthma therapy in the management of children hospitalized with moderate to severe asthma.
- Conditions
- Bronchial Asthma, Asthma, Status Asthmaticus
- Trial name
- NCT00722020
- Testing
- VEST
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Hill-Rom
Asthma Acute, Asthma Childhood
ASMact: Study on Management of Bronchial Asthma
Standardization According to GINA 2025 Recommendations for the Treatment, Management, and Follow-up of Acute Asthma Attacks: Observational, Multicenter Cohort Study.
- Conditions
- Asthma Acute, Asthma Childhood, Asthma in Children, Asthma Crisis
- Trial name
- NCT07412769
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Status Asthmaticus
Effectiveness and Cost Study Comparing Two Ways to Deliver Albuterol for the Treatment of Asthma in the Hospital
This study will be conducted as a randomized, double blinded, controlled trial. The control group will receive albuterol delivered by a nebulizer along with placebo treatments delivered by a metered dose inhaler (MDI) with a…
- Trial name
- NCT00623688
- Testing
- Metered Dose Inhaler & Optichamber Advantage Valve Holding Chamber (VHC), Airlife Sidestream High Efficiency Nebulizer
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Akron Children's Hospital
Infection, Heart Failure
Rural Home Hospital: Proof of Concept
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04531280
- Testing
- Home hospital care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Acute Asthma
Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma
Our study is a prospective double-blind randomized study performed in the Emergency Department (ED). The objective of our study was to demonstrate the additive effect of high and repeated doses of inhaled budesonide combined with…
- Trial name
- NCT04016220
- Testing
- Budesonide, normal saline
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University of Monastir
Acute Asthma Exacerbation
Acute Montelukast in Asthma
Patients presenting to hospital with an acute asthma exacerbation severe enough to require admission would receive full standard treatment according to British Thoracic Society guidelines in addition they would be offered the…
- Trial name
- AcMk (NCT01011452)
- Testing
- Montelukast
- Where
- United Kingdom
- Volunteers
- 87 people
- Sponsor
- University of East Anglia
Asthma in Children, Status Asthmaticus
BPAP in Pediatric Asthma Pilot Study
The investigators aim to study the effect and safety of bilevel positive airway pressure (BPAP) in children with moderate to severe asthma exacerbations - by examining the effects of early initiation of BPAP in pediatric patients…
- Trial name
- NCT04656587
- Testing
- Philips Respironics V60 Non-invasive ventilator, BPAP, Standard Therapy
- Sponsor
- Columbia University
Acute Severe Asthma
Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
- Trial name
- NCT02112305
- Testing
- isotonic magnesium sulphate, 50% magnesium sulphate
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Status Asthmaticus
Early Noninvasive Positive Pressure Ventilation in Children With Status Asthmaticus
Status asthmaticus is recognized as a common cause of morbidity in children in the United States. In recent years, hospitalization rates have reached an all time high.
- Trial name
- NCT01188473
- Testing
- NPPV plus standard of care
- Where
- United States
- Sponsor
- Southern Illinois University
Asthma, Asthmatic Crisis
Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis
The purpose of this study is to determine whether extra fine formoterol/beclomethasona are more effective in the treatment of asthmatic crisis when added to conventional treatment compared with conventional treatment alone.
- Trial name
- NCT02345993
- Testing
- Extra fine Formoterol/Beclomethasone
- Where
- Mexico
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Respiratory Diseases, Mexico
Asthma
Estimating Quality of Life in People With Asthma
The aim of this project is to estimate the quality of life for people with asthma and specifically the loss in quality of life associated with an asthma-related crisis event (accident and emergency (A\&E) attendance or admission).
- Trial name
- NCT02771678
- Where
- 3 sites in United Kingdom
- Volunteers
- 121 people
- Sponsor
- University of East Anglia
Infection, Heart Failure
Prediction of Patient Deterioration Using Machine Learning
This is a retrospective observational study drawing on data from the Brigham and Women's Home Hospital database. Sociodemographic and clinic data from a training cohort were used to train a machine learning algorithm to predict…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT05045742
- Testing
- Traditional vital sign alarms versus the BioVitals Index vs the National Early Warning Score 2
- Where
- 2 sites in United States
- Volunteers
- 526 people
- Sponsor
- Brigham and Women's Hospital