Clinical trials: Asthmatics
Asthma
Singulair(R) In Asthma And Allergic Rhinitis (0476-383)
Effectiveness of adding montelukast to inhaled corticosteroids in adult subjects with both uncontrolled asthma and allergic rhinitis.
- Trial name
- NCT00545844
- Testing
- montelukast sodium
- Volunteers
- 313 people
- Sponsor
- Organon and Co
Asthma Attack
Nebulized Versus Intravenous Magnesium Sulfate in Treatment of Asthma Exacerbation
A prospective study in Beni-Seuf University Hospital that was conducted on 123 adult patients with acute asthma exacerbations. Patients were classified into group (I): received IV magnesium sulfate, group (II): received nebulized…
- Trial name
- NCT05908864
- Testing
- Magnesium sulfate
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Beni-Suef University
Asthma
Pharmacokinetic Pilot Study on Budesonide/Formoterol Device-metered Dry Powder Inhalers
Due to the complexity of orally inhaled products (combination of a formulation and a device)and the topical nature of drug delivery to the lung for efficacy in vitro-in vivo correlation(IVIVC) for inhaled dosage forms is not…
- Trial name
- Reco-Pilot (NCT01181063)
- Testing
- Budesonide/formoterol 320/9 μg and 400/12 μg inhalers
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Asthma
A Study to Investigate the Safety, Tolerability and Effects of AZD8630 in Healthy Subjects and Subjects With Asthma on Inhaled Corticosteroids and Long-acting Beta-agonists
This is a first in human (FIH) clinical study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8630 in healthy adults (Part A) and adult asthma patients on medium to high dose inhaled…
- Trial name
- NCT05110976
- Testing
- AZD8630
- Where
- 29 sites in United States, Germany and 1 more
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma
A Study of RO5036505 in Patients With Moderate to Severe Asthma
This randomized, double-blind, placebo-controlled study will evaluate the efficacy, safety and tolerability of RO5036505 in patients with inadequately controlled moderate to severe asthma.
- Trial name
- NCT00967590
- Testing
- RO5036505
- Where
- 16 sites in United States, United Kingdom
- Sponsor
- Hoffmann-La Roche
Proctitis, Proctosigmoiditis
Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis
The purpose of this study is to establish the efficacy profile of rectally administered budesonide foam, as compared to an equivalent volume of rectally administered placebo foam over the same dosing schedule, in participants who…
- Trial name
- NCT01008410
- Testing
- Budesonide
- Where
- 63 sites in United States
- Volunteers
- 265 people
- Sponsor
- Bausch Health Americas, Inc.
Asthma
Efficacy of Ciclesonide Versus Placebo Administered Either as Once Daily or Twice Daily in Patients Treated Previously With an Inhaled Corticosteroid
To investigate the efficacy of ciclesonide MDI either as once daily or a twice daily regimen in patients with mild to moderate asthma, who have previously been treated with an inhaled corticosteroid.
- Trial name
- NCT00174733
- Testing
- Ciclesonide (XRP1526)
- Where
- United States
- Volunteers
- 456 people
- Sponsor
- Sanofi
Asthma Exacerbation, Emergency Department
Continuous Versus Intermittent Nebulization Therapy in Acute Asthma Exacerbation at Emergency Department
The goal of this clinical is to compare treatment outcomes between continuous nebulization and intermittent therapy in the management of acute exacerbation of asthma in the emergency department(ED).
- Conditions
- Asthma Exacerbation, Emergency Department, Nebulization
- Trial name
- NCT06291740
- Testing
- continuous nebulization, Intermittent nebulization
- Volunteers
- 40 people
- Sponsor
- Thammasat University
Exercise Induced Asthma, House Dust Mite Allergy
Epigenetic Regulation of Exercise Induced Asthma
The purpose of this study is to investigate the micro ribonucleic acid (mRNA) profiles of patients with EIA without allergic sensitization and EIA with house dust mite sensitization compared to that of healthy controls.
- Trial name
- NCT05174689
- Testing
- Exercise challenge in the cold chamber (ECC), mRNA profile, standard diagnostic
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Asthma in Children
N-WATCH: Nottingham Wheeze Assessment in Tidal Children
Children with long-term lung diseases like asthma need better techniques for diagnosis and monitoring of their disease. With better monitoring, it is anticipated that children and their carers will be able to manage their disease…
- Trial name
- N-WATCH (NCT07833826)
- Testing
- N-Tidal
- Where
- 2 sites in United Kingdom
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Asthma (Diagnosis), Breathing Exercises
Comparative Effect of Box Breathing And Buteyko Breathing on Pulmonary Functions in Asthma
The aim of this study was to evaluate the Effectiveness of Box Breathing Technique and Buteyko breathing techniques in patients with Asthma, using both Clinical Pulmonary tests as well as Patient reported outcomes.
- Trial name
- NCT07140458
- Testing
- Buteyko Breathing, Box breathing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Asthma
Ventilation and Perfusion in Asthmatics
Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation…
- Trial name
- NCT07426458
- Testing
- Albuterol Sulfate, Albuterol-Budesonide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Asthma, Asthma Attack
Genomics and Metagenomics of Asthma Severity
The Genomics and Metagenomics of Asthma Severity (GEMAS) study aims to assess the role of genomics, the microbiome, and the interaction between them in the development of asthma exacerbations in European patients with asthma.
- Trial name
- GEMAS (NCT04501926)
- Where
- 6 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Maria Pino-Yanes
Asthma
A Study to Evaluate the Relationship Between Use of Albuterol Multidose Dry Powder Inhaler With an eModule (eMDPI) and Exacerbations in Participants With Asthma
This is a Phase 3B, 12-week, multicenter, open-label study to evaluate the relationship between albuterol sulfate (ABS) eMDPI and clinical asthma exacerbation (CAE) in adult participants at least 18 years of age with…
- Trial name
- NCT02969408
- Testing
- Albuterol Sulfate
- Where
- 44 sites in United States
- Volunteers
- 397 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Pneumonia Childhood, Childhood Asthma
Optimization and Testing of ALRITE, a Clinical Decision Support Tool for Management of Respiratory Illnesses in Young Children in Primary Care Health Facilities in Uganda
The goal of this study is to pilot test the feasibility of a mobile health clinical decision support tool called ALRITE for the diagnosis and management of acute lower respiratory illnesses in young children in Uganda.
- Conditions
- Pneumonia Childhood, Childhood Asthma, Acute Lower Respiratory Illness, Wheezing Lower Respiratory Illness
- Trial name
- NCT07369817
- Testing
- ALRITE
- Where
- Uganda
- Volunteers
- 48 people
- Sponsor
- University of Washington
Asthma
Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations
Previous investigations and anecdotal experience have shown safety and utility of Noninvasive Positive Pressure Ventilation/Bilevel Positive Airway Pressure (NIPPV/BiPAP) for the treatment of asthma in children.
- Trial name
- RCT BiPAP (NCT01497691)
- Testing
- NIPPV (PALMtop PTV), Volumetric CO2 (NM3), USCOM
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Asthma
Inflammation Following Mepolizumab and Oral Corticosteroids in Asthma
The aim of the project is to study the persistence of inflammation after addition of an interleukin-5 (IL-5) blocker in severe eosinophilic asthma as a study of untreated pathways in these patients.
- Trial name
- MAPLE (NCT03610685)
- Testing
- Prednisolone
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Asthma, Allergic Rhinitis
Effects of Lipoic Acid on Oxidative, Inflammatory and Functional Markers in Asthmatic Patients
The aim of the study is to use the antioxidant and antiinflammatory effects of lipoic acid to improve the quality of life of patients with asthma.
- Trial name
- NCT01221350
- Testing
- Lipoic acid
- Where
- 2 sites in Mexico
- Volunteers
- 55 people
- Sponsor
- Centro Universitario de Ciencias de la Salud, Mexico
Asthma Exacerbation
Study of Preventive Treatment With Symbicort or Budicort Turbohaler in Childhood Asthma Return to School Epidemic
During the second week of September( week 38 of the year)there are recorded data of exacerbation of asthma all over the world, including Israel.
- Trial name
- NCT01179152
- Testing
- Budesonide turbuhaler, Budesonide+Formoterol turbuhaler
- Where
- Israel
- Volunteers
- 225 people
- Sponsor
- Meir Medical Center
Allergic Rhinitis Due to Cat Allergy
A Study to Examine the Efficacy and Safety of Anti-Fel d 1 Antibodies Injections in Cat-allergic Adolescent and Adult Patients With Allergic Rhinitis Who Live With a Cat
The primary objective of the study is to determine the efficacy of REGN1908-1909, as compared to placebo, to reduce allergic rhinitis/conjunctivitis symptoms and allergy rescue medication use during natural cat exposure.
- Trial name
- NCT04981717
- Testing
- REGN1908-1909
- Where
- 92 sites in United States, Belgium and 4 more
- Volunteers
- 446 people
- Sponsor
- Regeneron Pharmaceuticals
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