Clinical trials: Atheroma
Coronary Artery Disease, Systemic Inflammatory Response
CCTA Coronary Hemodynamics, Systemic Inflammation and Vulnerable Plaques (COHESIVE)
Although there are numerous studies that have demonstrated the impact of systemic inflammation on coronary plaque vulnerability, there are few literature data regarding the influence of coronary plaque localization within the…
- Conditions
- Coronary Artery Disease, Systemic Inflammatory Response, Chronic Coronary Syndrome, Atherosclerosis
- Trial name
- COHESIVE (NCT05488249)
- Testing
- Cardiac imaging tests, Venous blood sample collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Ascending Aortic Atheromatous Plaque
Risk Factors of Ascending Aortic Atheromatous
Background Incidence of perioperative stroke In cardiac surgery is 2.6-5.2%. Ascending aortic atheromatous plaque and stroke are strongly associated.
- Trial name
- NCT03381222
- Testing
- epiaoryic scan
- Where
- Thailand
- Volunteers
- 239 people
- Sponsor
- Mahidol University
Carotid Atheroma
Carotid Plaque Characterization Using Innovative Ultrasound Techniques
Strokes are the second leading cause of disability and death worldwide (according to World Health Organization in 2019). They are ischemic in origin in 80% of cases.
- Trial name
- CARPUS (NCT06804707)
- Testing
- blood sampling, ultrasound imaging exam, High resolution MRI plaque exam
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hospices Civils de Lyon
Coronary Atherosclerosis
Atheroma Progression and Vulnerability Under Continuous Glucose Monitoring
The OPTIMAL is a single-center, randomized trial to evaluate the efficacy of CGM-based glycemic control on atheroma progression in T2DM patients with CAD by using serial intravascular ultrasound (IVUS) and near-infrared…
- Trial name
- OPTIMAL (NCT04559191)
- Testing
- continuous glucose monitoring (CGM)
- Where
- Japan
- Volunteers
- 90 people
- Sponsor
- National Cerebral and Cardiovascular Center, Japan
Carotid Artery Disease, Atherosclerosis
Telerobotic Ultrasound for Carotid Imaging - Feasibility Study
In this proposal, the investigators will demonstrate the feasibility and noninferiority of telerobotic ultrasonography as compared to traditional manual acquisition in performing a limited carotid Duplex examination and in…
- Conditions
- Carotid Artery Disease, Atherosclerosis, Atheromatous Plaques, Arteriosclerosis
- Trial name
- NCT05654935
- Testing
- Ultrasound for Carotid Arteries, Telerobotic Ultrasound for Carotid Arteries
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Coronary Artery Disease, Calcified Atheroma
Comparison of Coronary Lithoplasty and Rotablation
This study compares a new method of treating severely calcified coronary lesions, the intracoronary lithoplasty, with the current gold standard, the rotablation.
- Trial name
- NCT04047368
- Testing
- Rotablation, Coronary Lithoplasty
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University of Giessen
Branch Atheromatous Disease, Cognitive
Cognitive Outcomes in BAD-related Stroke
Branch atheromatous disease (BAD) is a distinct subtype of ischemic stroke that is particularly prevalent among Chinese and other Asian populations.
- Conditions
- Branch Atheromatous Disease, Cognitive, Deterioration, Clinical
- Trial name
- NCT07761182
- Testing
- END exposure
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking Union Medical College Hospital
Coronary Artery Disease, Atherosclerotic Plaque
STabilization of Atheroma by Lipid-reducing Effect of Drug-Coated Balloon (STABLE-DCB)
This study aims to investigate whether DCB angioplasty, compared to statin-based medical treatment alone, will lead to more reduction in plaque lipid burden as assessed by near infrared spectroscopy (NIRS) at 6-9 months following…
- Conditions
- Coronary Artery Disease, Atherosclerotic Plaque, De Novo Stenosis
- Trial name
- STABLE-DCB (NCT05438121)
- Testing
- SeQuent Please Neo
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Korea University Ansan Hospital
Gout, Coronary Atheroma
The Correlation Between Sodium Urate (MSU) Deposition and Coronary Atherosclerosis in Patients With Foot Gout
This observational study aims to evaluate the association between sodium urate deposition volume and coronary atherosclerotic plaques in patients with foot gout using dual-energy CT (DECT) and coronary CTA.
- Trial name
- NCT07784049
- Testing
- DECT;CCTA
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Internal Carotid Artery, Atheromatous Stenosis
Assessment of Vulnerability to Carotid Stenosis by MultiModal Imaging and Cellular and Molecular Biology Analysis
Cerebrovascular accidents (CVA) are the second leading cause of death in France, and the most frequent cause of acquired physical and mental disability.
- Trial name
- EVA3M (NCT05190510)
- Testing
- Data collection, collection of the carotid plaque (surgical specimen), anatomopathological, histological, cellular and molecular biology examinations (metabolomics and transcriptomics) on surgical specimens
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Metabolic Syndrome X, Overweight
Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS)
Metabolic syndrome consists of a group of co-occuring conditions that increase an individual's risk of developing heart disease, stroke, and diabetes.
- Conditions
- Metabolic Syndrome X, Overweight, Hypertension, Dyslipidemias
- Trial name
- ARCH-MS (NCT00455403)
- Testing
- Chloroquine
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Washington University School of Medicine
Variant Angina
ANti-Oxidant in Variant Angina (ANOVA) Trial
Purpose Objectives 1. To evaluate the anti-oxidant effect of long-term Vitamin C+E therapy on coronary vasospasm improvement. 2. To evaluate the anti-oxidant effect of long-term statin therapy on coronary vasospasm improvement.
- Trial name
- NCT03228238
- Testing
- Vitamin C and Vitamin E, Statin, Standard medication for variant angina
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Seoul National University Hospital
Diabetes, Atherothrombosis
Atherothrombosis Markers in Diabetics
Intraplaque hemorrhage is the driving force of atherothrombotic plaque vulnerability to rupture and associated clinical complications.
- Conditions
- Diabetes, Atherothrombosis, Cardiovascular Disease
- Trial name
- MADI (NCT02898467)
- Testing
- diabetics, non-diabetics
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Femoral Artery Occlusion, Atheromatous Plaques
Evaluation of Atherectomy in the Management of Occlusive Lesions of the Common Femoral Arteries
Thromboendarterectomy is the standard technique for the treatment of symptomatic occlusive lesions of the common femoral artery.
- Trial name
- RAFAL (NCT07142330)
- Testing
- Atherectomy
- Where
- France
- Volunteers
- 120 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Popliteal Artery Stenosis, Atheroma
DAART vs PTA/SUPERA STENTING FOR POPLITEAL ARTERY LESIONS
The purpose of this study was to compare the results of directional atherectomy with antirestenotic therapy (DAART technique) and angioplasty/Supera stenting for the treatment of popliteal atherectomy lesions.
- Trial name
- NCT05617053
- Testing
- DAART, ATP/Supera stenting
- Volunteers
- 143 people
- Sponsor
- Vascular Investigation Network Spanish Society for Angiology and Vascular Surgery
Coronary Disease
Coronary Disease and the Effect of High-intensity Interval Training
The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of…
- Trial name
- CENIT (NCT02494947)
- Testing
- high intensity interval-based aerobic exercise, Usual care
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Branch Atheromatous Disease, Acute Ischemic Stroke
Early Identification and Diagnosis of BAD-related Stroke
Branch atheromatous disease (BAD)-related stroke is an important subtype of acute ischemic stroke involving penetrating arteries and is associated with early neurological deterioration.
- Conditions
- Branch Atheromatous Disease, Acute Ischemic Stroke, Cerebral Infarction
- Trial name
- SMART-BAD (NCT07693816)
- Testing
- Multisource clinical-imaging artificial intelligence diagnostic assessment
- Where
- 11 sites in China
- Volunteers
- 1,602 people
- Sponsor
- Peking Union Medical College Hospital
Acute Myocardial Infarction, Severe Periodontitis
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental…
- Conditions
- Acute Myocardial Infarction, Severe Periodontitis, Carotid Atherosclerosis
- Trial name
- PAROCARD (NCT04046237)
- Testing
- Periodontal treatment
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Coronary Stenosis
Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma Assessment
This investigation is to see if the new Novasight Hybrid imaging catheter can safely and accurately provide two different types of images (IVUS and OCT) of the inside of heart vessels at the same time.
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Plaque, Atherosclerotic
- Trial name
- MOUSA (NCT05753085)
- Testing
- Conavi Medical Novasight Hybrid System intervention
- Where
- United Kingdom
- Sponsor
- Barts & The London NHS Trust
Acute Coronary Syndrome
IVUS Assessment of Atheroma Burden After Acute Coronary Syndrome
Coronary angioplasty is rather frequently performed in such situations, presumably because, changes in the atherosclerotic plaque under drug treatment, have remained poorly described so far.
- Trial name
- OPTIVUS (NCT01578005)
- Where
- 3 sites in France
- Volunteers
- 79 people
- Sponsor
- University Hospital, Toulouse