Clinical trials: Atheromatosis
Mesenteric Ischemia, Bowel; Ischemic
Copenhagen Mesenteric Stent Study - A Randomized Trial of Stent Versus Covered Stent Treatment for Chronic Mesenteric Ischemia
Chronic mesenteric ischemia (CMI) is often caused by narrowings in the arteries providing blood to the intestines. Endovascular stent placement is considered the preferred treatment for this condition.
- Conditions
- Mesenteric Ischemia, Bowel; Ischemic, Superior Mesenteric Atherosclerosis, Mesenteric Artery Stenosis
- Trial name
- COMESS (NCT05244629)
- Testing
- BMS vs. CS
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Non-Obstructive Coronary Atherosclerosis, Ischemia
INOCA Spanish National Registry
Coronary atherosclerosis is the most common cause of ischaemic heart disease. About 40-50% of patients with symptoms and documented ischaemia on non-invasive tests do not show obstructive coronary artery disease on coronary…
- Conditions
- Non-Obstructive Coronary Atherosclerosis, Ischemia, Coronary Disease
- Trial name
- ESP-INOCA (NCT06327672)
- Where
- 3 sites in Spain
- Volunteers
- 1,000 people
- Sponsor
- Eva Rumiz González
Rheumatoid Arthritis
Atherosclerosis in Rheumatoid Arthritis and Lupus: Restoring Cholesterol Balance
Hypothesis: SLE and RA increase risk of myocardial infarction (MI, heart attack). Immune reactants in the circulation of SLE patients downregulate cholesterol efflux proteins 27-hydroxylase and ABCA1 and upregulate scavenger…
- Trial name
- NCT01180361
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Coronary Stenosis, Cerebral Stenosis
Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis
Intracranial atherosclerosis is common vascular lesion in Asian acute stroke patients and intracranial atherosclerosis patients have high rate of coronary artery disease (CAD).
- Trial name
- NCT02315924
- Testing
- simultaneous coronary and cerebral intervention, staged coronary and cerebral intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Capital Medical University
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
The Young Heart Study
The purpose of our project is to better understand the characteristics of the young patients with coronary artery disease presenting for cardiac catheterization at our institution and to put forth a program to optimize their risk…
- Trial name
- NCT04462159
- Testing
- Risk Reduction Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Coronary Artery Disease, Image
Concurrent OCT and FFR-guided PCI in CAD
The present study is a prospective randomized clinical trial aimed to compare the therapeutic strategy of angiography-guided versus concurrent OCT/FFR-guided intervention in patients with coronary artery disease.
- Conditions
- Coronary Artery Disease, Image, Atheroscleroses, Coronary
- Trial name
- OPTICARE-CAD (NCT06182683)
- Testing
- optical coherence tomography and fractional flow reserve, Coronary angiography
- Where
- South Korea
- Volunteers
- 700 people
- Sponsor
- Korea University Guro Hospital
Coronary Disease
Red Wine and Ageing and Atherosclerosis
The investigators will evaluate 100 regular red wine consumer men and 100 abstainers men from 50 years-old to 70 years-old by coronary risk prevalence, mood status, anthropometric measures, daily caloric ingest, lipid profile…
- Trial name
- NCT01268254
- Where
- Brazil
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Coronary Artery Disease, Hiv
How Does Antiretroviral Therapy Affect Coronary Atherosclerosis: a Serial CT Study
Combined antiretroviral therapy (cART) is thought to promote coronary artery disease via a number of mechanisms: abnormal lipid profiles, endothelial dysfunction, hypertension, insulin resistance and renal impairment are the main…
- Trial name
- HART CT (NCT03986697)
- Testing
- Biktarvy
- Where
- United Kingdom
- Sponsor
- University of Liverpool
Peripheral Arterial Disease, Critical Lower Limb Ischemia
An All-Comers Observational Study of the MicroStent™ Peripheral Vascular Stent System in Subjects With Peripheral Arterial Disease
Non-randomized, multicenter, combined prospective and retrospective cohort analysis consisting of a single arm treated with the MicroStent™ System.
- Trial name
- HEAL (NCT04110327)
- Testing
- MicroStent
- Where
- 10 sites in Austria, Belgium and 3 more
- Volunteers
- 300 people
- Sponsor
- Micro Medical Solution, Inc.
Peripheral Arterial Disease, Chronic Limb Ischemia
Improving Radiological Outcomes in Arterial Disease - A Pilot Evaluation of the Pedra Tissue Perfusion Monitoring System
The Pedra Technologies' PedraTM device is a non-invasive, diagnostic device intended to measure foot perfusion by assessing blood flow.
- Trial name
- IROAD (NCT03294902)
- Testing
- Pedra Tissue Perfusion Monitor
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- Pedra Technology, PTE LTD
Atherosclerosis, Ischemia
Clinical Of Drug-eluting Stent Versus Excimer Laser Ablation Combined Drug-coated Balloon To Treat Arteriosclerosis Occlusive Disease Of Lower Extremity
This is a Prospective randomized controlled study to evaluate the difference of safety，effectiveness between Excimer Laser Ablation Combined Drug-coated Balloon and drug-eluting stent in treatment of femoral-popliteal artery…
- Trial name
- NCT05575245
- Testing
- Drug-eluting Stent, Excimer Laser Ablation Combined Drug-coated Balloon
- Where
- China
- Sponsor
- Xuanwu Hospital, Beijing
Acute Coronary Syndromes
Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome
The purpose of this study is to investigate whether a pure heart rate-lowering agent (Ivabradine) reduces vascular inflammatory stress in patients with acute coronary syndromes
- Trial name
- NCT00815100
- Testing
- Ivabradine
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Hospital Universitario de Canarias
Atherosclerosis, Coronary Artery Disease
Treatment of Patients With Atherosclerotic Disease With Methotrexate-associated to LDL Like Nanoparticles
The investigators propose a prospective, randomized, double-blind, placebo-controlled study. The purpose of the study is to evaluate the safety and efficacy of an anti-inflammatory agent methotrexate in a cholesterol-rich…
- Conditions
- Atherosclerosis, Coronary Artery Disease, Inflammation
- Trial name
- NCT04616872
- Testing
- Methotrexate-LDE
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Peripheral Artery Disease, Peripheral Vascular Diseases
Impact of Nrf2 Activation on Macrovascular, Microvascular & Leg Function & Walking Capacity in Peripheral Artery Disease
Peripheral artery disease (PAD) is associated with elevated oxidative stress, and oxidative stress has been implicated as the cause of reduced endothelial reactivity in individuals with PAD.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Diseases, Peripheral Arterial Disease, Peripheral Arterial Occlusive Disease
- Trial name
- NCT06319339
- Testing
- Vumerity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Critical Limb Ischemia, Malnutrition
Nutrition in Patient With Critical Limb Ischemia
A prospective pilot study examining nutritional supplements among vascular surgery patients with Critical Limb Ischemia (CLI). CLI patients have a high rate of malnutrition and has the potential to benefit greatly from…
- Conditions
- Critical Limb Ischemia, Malnutrition, Nutritional Supplements
- Trial name
- NutriVasc (NCT03529019)
- Testing
- Ensure Surgery Immunonutrition Shake, Ensure Enlive Advanced Nutrition Shake
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Boston Medical Center
Peripheral Arterial Disease
Auryon Atherectomy System With Standard Balloon Angioplasty Versus Standard Balloon Angioplasty Alone in Europe
The goal of this clinical trial is to learn if the Auryon Atherectomy System with balloon angioplasty safe and effective in treating lower limb blockages.
- Trial name
- AMBITION BTK (NCT07472439)
- Testing
- Auryon Atherectomy System, Balloon Angioplasty
- Volunteers
- 50 people
- Sponsor
- Angiodynamics, Inc.
Peripheral Artery Disease
Intermittent Pneumatic Compression With and Without Exercise to Improve Functioning in Peripheral Artery Disease
The INTERCEDE randomized trial will establish whether six-months of intermittent pneumatic compression combined with walking exercise improves walking endurance at six-month follow-up, compared to walking exercise + sham…
- Trial name
- INTERCEDE (NCT03871075)
- Testing
- intermittent pneumatic compression, exercise, Health Education
- Where
- 4 sites in United States
- Volunteers
- 211 people
- Sponsor
- Northwestern University
Peripheral Arterial Disease
AbsorbaSeal (ABS 5.6.7) Vascular Closure Device Trial
This study investigates the efficacy and safety of the AbsorbaSeal (ABS 5.6.7.) Vascular Closure device (VCD) for the closure of access site of patients requiring percutaneous diagnostic or interventional procedures.
- Trial name
- NCT04635501
- Testing
- ABS 5.6.7
- Where
- 2 sites in Belgium
- Volunteers
- 61 people
- Sponsor
- ID3 Medical
Intermittent Claudication, Peripheral Arterial Disease
Transcutaneous Electrostimulation for Intermittent Claudication Supervised Walking Therapy for Intermittent cLAudication
Prospective mono-centric trial on patients with peripheral arterial disease and intermittent claudication that receive supervised exercise therapy (group 1) vs.
- Trial name
- TESLA (NCT03512912)
- Testing
- transcutaneous electrical calf muscle stimulation + supervised walking therapy
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Heart Disease
The Estrogen Replacement and Atherosclerosis Trial ; Primary Outcome Measure is Mean Minimal Coronary Artery Diameter After Avg of 3.2 Yrs.
Background: Heart disease is a major cause of illness and death in women. To understand better the role of estrogen in the treatment and prevention of heart disease, more information is needed about its effects on coronary…
- Trial name
- ERA (NCT03097120)
- Testing
- 0.625 mg of conjugated equine estrogen, 0.625 mg of conjugated equine estrogen plus 2.5 mg of medroxyprogesterone acetate
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- Wake Forest University Health Sciences
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