Clinical trials: Atheromatosis
Congenital Heart Disease, Atherosclerosis
Cardiovascular Disease Screening
This study will evaluate volunteers 18 years of age and older to see if they qualify for one of NHLBI s research studies. Tests include the following: General medical evaluation, which may include blood tests, chest x-ray…
- Conditions
- Congenital Heart Disease, Atherosclerosis, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT00483951
- Testing
- Toshiba Aquilion ONE CT, SWiemens MRI scanner
- Where
- 2 sites in United States
- Volunteers
- 1,325 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Artery Disease, Peripheral Vascular Disease
Investigational Device Exemption Study to Determine the Safety and Efficacy of the Astron and Pulsar Stents
The objective of this study is to separately demonstrate the safety and efficacy of BIOTRONIK's Astron and Pulsar stents. The Pulsar stent will be used for the treatment of femoro-popliteal lesions, located in the native…
- Trial name
- BIOFLEX-I (NCT01319812)
- Testing
- Astron Stents, Pulsar Stents
- Where
- 35 sites in United States, Canada
- Volunteers
- 463 people
- Sponsor
- Biotronik, Inc.
Atherosclerosis, Cardiovascular Diseases
Non-Traditional Cardiovascular Risk Factors in Type 2 Diabetes Mellitus - Ancillary to VA Study of Glycemic Control
To test whether novel cardiovascular risk factors are related to the presence and development of atherosclerosis and macrovascular events in Type 2 diabetes mellitus and to determine whether intensive glucose lowering therapy…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- NCT00021944
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Arterial Disease
BioMimics 3D Stent Clinical Investigation: The Mimics Study
Primary purpose of the Mimics Study is to evaluate the safety and performance of the BioMimics 3D Stent System in the treatment of symptomatic SFA/proximal popliteal disease.
- Trial name
- Mimics (NCT02163863)
- Testing
- Femoropopliteal stenting
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Veryan Medical Ltd.
Coronary Disease
Bile Acids and Gut Microbiota as Potent Coronary Atheroma Risk Factors: a Prospective Study in Human
The purpose of this study is to describe the composition of bile acids and the gut microbiota comparing two populations: patients with coronary atheroma and the healthy subjects.
- Trial name
- MABAC (NCT02375893)
- Testing
- No intervention, Healthy subject
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intracranial Atherosclerosis ICAS, Hemodynamic
Digital Angiography-Derived Fractional Flow Assessment for Intracranial Stenosis
The goal of this observational study is to learn whether a digital angiography derived fractional flow reserve (DPR) measurement can improve the prediction of stroke risk in adults with symptomatic intracranial atherosclerotic…
- Conditions
- Intracranial Atherosclerosis ICAS, Hemodynamic, Stroke
- Trial name
- CASSISS-DPR (NCT07309705)
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Hypertriglyceridemia, Atherosclerotic Cardiovascular Disease
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia
The purpose of the study was to evaluate the effect of olezarsen on percent change in fasting triglyceride (TG) levels compared to placebo at Months 6 and 12 and the proportion of participants who achieve different thresholds in…
- Conditions
- Hypertriglyceridemia, Atherosclerotic Cardiovascular Disease, Severe Hypertriglyceridemia
- Trial name
- NCT05355402
- Testing
- Olezarsen
- Where
- 24 sites in United States, Canada
- Volunteers
- 154 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Microvascular Angina
Microvascular Assessment of Ranolazine in Non-Obstructive Atherosclerosis (MARINA)
The purpose of this study is to look at the effects of the drug Ranolazine compared to Placebo on symptoms of chest pain or chest tightness (known as angina), exercise endurance and ability, and changes in blood flow to the very…
- Trial name
- MARINA (NCT02147067)
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Emory University
Cardiovascular Disease, Coronary Artery Calcification
7 Year Follow-up Study of the DanRisk Population
OBJECTIVES: To investigate the incidence of cardiovascular events as well as progression of coronary artery calcium (CAC) in healthy middle-aged subjects over a period of 7 years, and the relation to traditional as well as new…
- Conditions
- Cardiovascular Disease, Coronary Artery Calcification, Atherosclerosis
- Trial name
- NCT02913144
- Volunteers
- 1,257 people
- Sponsor
- Odense University Hospital
Peripheral Artery Disease
Dietary Nitrates and Vascular Function in Patients With Peripheral Artery Disease
The overarching question addressed in the current project is: Does dietary nitrate supplementation (8 weeks) improve physiological function in patients with peripheral arterial disease (PAD)? The investigators will specifically…
- Trial name
- NCT01983826
- Testing
- Sodium Nitrate
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Iowa
Atherosclerosis, Aneurysm
A Feasibility Study of the Cordis Neurovascular Self Expanding Stent System in Intracranial Arteries
Feasibility study to assess safety of treating patients with self expanding stent in intracranial arteries.
- Trial name
- NCT00349908
- Testing
- Cordis Neurovascular ENTERPRISE Self Expanding Stent System
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Codman & Shurtleff
Aging, Menopause
Gonadal Hormone, Gonadotropin and Cardiovascular Events
Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated.
- Trial name
- NCT02810821
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Atherosclerosis, Coronary Artery Disease
Prospective, Randomized, Multicenter Trial to Assess PROMUS™ Element™ Stent
The purpose of this study is to evaluate the safety and effectiveness of the PROMUS™ Element™ Everolimus-Eluting Coronary Stent System for the treatment of subjects in China with a single de novo atherosclerotic coronary artery…
- Trial name
- PTChina (NCT01285999)
- Testing
- PROMUS Element Coronary Stent System, TAXUS Liberté Coronary Stent System
- Where
- 15 sites in China
- Volunteers
- 500 people
- Sponsor
- Boston Scientific Corporation
Systemic Lupus Erythematosus
Regulatory BCells in Systemic Lupus Erythematosus
Systemic lupus erythematosus , the archetypal multisystem autoimmune disease, presents many diagnostic and management challenges.
- Trial name
- NCT03178721
- Testing
- blood sample
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Type 2 Diabetes, Coronary Artery Disease
Semaglutide Treatment On Coronary Progression
The purpose of this research study is to see the effect of the diabetes medicine Semaglutide on a condition called atherosclerosis.
- Trial name
- STOP (NCT03985384)
- Testing
- Semaglutide 2 MG/1.5 ML Subcutaneous Solution
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Critical Limb Ischemia
External Compression Therapy for Secondary Prevention of Lower-Limb Loss and Cardiovascular Mortality
In this clinical research study the investigators will test the efficacy of an innovative, non-invasive methodology to reduce mortality and lower limb loss among high-risk medically-underserved patients with cardiovascular…
- Trial name
- ArtAssist (NCT02054416)
- Testing
- ArtAssist© Device
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Temple University
Coronary Artery Disease, Hypertension
Effect of Intensive Blood Pressure Control on Progression of Coronary Atherosclerosis: Randomized Evaluation by Intravascular Ultrasound
The purpose of this study is to evaluate the effect of intensive blood pressure control compared to standard blood pressure control on progression of coronary atherosclerosis by intravascular ultrasound in hypertensive patients…
- Trial name
- PREVUS (NCT01230216)
- Testing
- control systolic blood pressure less than 120 mmHg, control systolic blood pressure less than 140 mmHg
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Takeshi Morimoto
ICAS - Intracranial Atherosclerosis
IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)
A multicenter, open-label, blinded-endpoint, prospective, randomized controlled clinical trial with an "all comers" design.
- Trial name
- NCT05974033
- Testing
- Stenting plus medical therapy, Medical therapy alone
- Volunteers
- 536 people
- Sponsor
- Changhai Hospital
Polyvascular Disease, Atherosclerosis
Clinical Register Studying the therApeutic Patient Population With Multifocal Atherosclerosis
Аn international, multicenter, non-interventional real-life clinical practice Register studying the Actual therapeutic patient population with Multifocal Atherosclerosis in the Russian Federation and Eurasian countries
- Conditions
- Polyvascular Disease, Atherosclerosis, Atherosclerosis Generalized, Cardiovascular Diseases
- Trial name
- KAMMA (NCT05189847)
- Where
- Russia
- Volunteers
- 3,059 people
- Sponsor
- Eurasian Association of Therapists
Cardiovascular Diseases, Atherosclerosis
Reduction of Triglycerides in Women on Hormone Replacement Therapy
The purpose of this study is to test the effect of lifestyle intervention on subclinical cardiovascular disease measures in women taking hormone replacement therapy (HRT).
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Postmenopause, Heart Diseases
- Trial name
- NCT00023543
- Testing
- Diet, fat-restricted, Exercise
- Where
- United States
- Volunteers
- 508 people
- Sponsor
- University of Pittsburgh
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