Clinical trials: Atheromatosis
Critical Limb Ischemia
Stellarex DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries
The purpose is to demonstrate the safety and effectiveness of the Stellarex DCB for the treatment of stenosis or occlusions of below-the-knee arteries.
- Trial name
- ILLUMENATE-BTK (NCT03175744)
- Testing
- Stellarex DCB, PTA Catheter
- Where
- 21 sites in United States, Australia and 3 more
- Volunteers
- 82 people
- Sponsor
- Spectranetics Corporation
Coronary Artery Disease, Peripheral Arterial Disease
Evaluation of Platelet Aggregability in Patients With Previous Acute Myocardial Infarction or Concomitant Lower Extremity Peripheral Artery Disease
After an episode of acute ischemic syndrome, patients with concomitant peripheral arterial disease have a worse short- and long-term prognosis compared to patients with isolated coronary disease, but the mechanisms responsible…
- Trial name
- NCT06454045
- Testing
- Clopidogrel
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo
Atherosclerosis, Cardiovascular Diseases
Atherosclerosis in Rheumatoid Arthritis
To test the theory that accelerated inflammation-promoted atherosclerosis occurs in patients with rheumatoid arthritis (RA).
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Inflammation
- Trial name
- NCT00037336
- Sponsor
- Vanderbilt University
Inflammatory Marker, Gut Microbiome
The Effects of Jing-Si Herbal Tea Liquid Packets and Jing-Si Herbal Tang Heng Power Drink
Through empirical research evaluating the effects of "JING SI HERBAL TEA LIQUID PACKETS" and "JING SI HERBAL TANG HENG POWDER DRINK" as adjunctive treatments for various cardiovascular diseases, we aim to provide sufficient…
- Conditions
- Inflammatory Marker, Gut Microbiome, Trimethylamine N-oxide, HbA1c
- Trial name
- NCT06522412
- Testing
- JING SI HERBAL TEA LIQUID PACKETS, JING SI HERBAL TANG HENG POWDER DRINK
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Atherosclerosis
Study to Gain Insights in Treatment Patterns and Outcomes in Patients With Atherosclerosis Prescribed to Xarelto in Combination With Acetylsalicylic Acid
In this study researchers want to gain more information on treatment patterns of patients treated with Xarelto in combination with acetylsalicylic acid (ASA). Both drugs reduce the risk of blood clots via different pathways.
- Trial name
- XATOA (NCT03746275)
- Testing
- Rivaroxaban (BAY59-7939, Xarelto), Acetylsalicylic acid
- Where
- 18 sites in Argentina, Brazil and 16 more
- Volunteers
- 5,798 people
- Sponsor
- Bayer
Type 2 Diabetes Mellitus, Endothelial Dysfunction
Huangqi Gegen Decoction for Endothelial Function in Type 2 Diabetes at Very High ASCVD Risk
This clinical trial evaluates whether Huangqi Gegen Decoction can improve blood vessel function in adults with type 2 diabetes mellitus who are at very high risk of atherosclerotic cardiovascular disease and meet the traditional…
- Conditions
- Type 2 Diabetes Mellitus, Endothelial Dysfunction, Cardiovascular Risk
- Trial name
- NCT07775664
- Testing
- Huangqi Gegen Decoction Granules, Conventional Treatment
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Putuo Hospital, Shanghai University of Traditional Chinese Medicine
Atherosclerosis
Multiple-Dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of BMS-779788 in Healthy Subjects
The primary purpose of this study is to evaluate the safety and tolerability of multiple oral doses of BMS-779788 in healthy subjects
- Trial name
- NCT00836602
- Testing
- BMS-779788
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Peripheral Arterial Disease
Electrical Stimulation in Peripheral Arterial Disease
The investigators wish to investigate the effects of neuromuscular stimulation on intermittent claudication.
- Trial name
- PAD (NCT02136537)
- Testing
- Bilateral NMES legs, Best medical therapy
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Imperial College London
Peripheral Arterial Disease
Post-Market Clinical Follow Up of Rotarex®S Catheter
Post-Market Clinical Follow Up of the Rotarex®S Catheter
- Trial name
- NCT04010123
- Testing
- Atherectomy/Thrombectomy
- Where
- 13 sites in Czechia, Estonia and 3 more
- Volunteers
- 220 people
- Sponsor
- Straub Medical AG
Atherosclerosis, Percutaneous Coronary Intervention
Blood Endothelium Biomarkers to Predict Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention
In stent restenosis and myocardial infarction are have been linked the balance between injury and healing of the endothelium These processes can be measured respectively using the number of circulating endothelial cells and…
- Conditions
- Atherosclerosis, Percutaneous Coronary Intervention, Cardiovascular Diseases
- Trial name
- NCT00725868
- Testing
- Data private hospitals, angioplasty, sampling of blood
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Atherosclerosis of Artery
Screening for Atherotic Plaques by Ultrasound for Assessing Cardiovascular Risk
Cardiovascular disease is a common diagnosed and treated condition in private practices of primary health care. There is growing evidence that atherosclerotic plaques as predictors for stroke and heart attack are more prevalent…
- Trial name
- NCT03499496
- Testing
- ultrasound guided detection of atherosclerotic plaques
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cabinet de Medecine Interne Générale Demetrio Pitarch
Atherosclerosis
IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI.
- Trial name
- IMPROVE (NCT04221815)
- Testing
- Eagle Eye Platinum digital IVUS catheter with optional SyncVision, Resolute Onyx Drug Eluting Stent, Onyx Frontier Drug Eluting Stent
- Where
- 61 sites in United States, Cyprus and 6 more
- Volunteers
- 3,100 people
- Sponsor
- Medstar Health Research Institute
Carotid Artery Diseases, Carotid Atherosclerosis
The ENROUTE Transcarotid Neuroprotection System (ENROUTE Transcarotid NPS) DW-MRI Evaluation
The goal of this evaluation is to document the incidence of post procedure DW-MRI lesions (relative to baseline) in patients treated with the transcarotid artery revascularization (TCAR) procedure.
- Conditions
- Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Stenosis, Carotid Artery Plaque
- Trial name
- DW-MRI-US (NCT03982420)
- Testing
- Transcarotid Revascularization (TCAR)
- Where
- 6 sites in United States, Spain
- Volunteers
- 55 people
- Sponsor
- Silk Road Medical
Peripheral Arterial Disease
Paclitaxel Eluting Stent or Exercise for Thigh Atherosclerosis
This randomized clinical study is intended to evaluate the use of Zilver PTX stents for treatment of thigh atherosclerosis. Research question: Is there an adjuvant benefit of angioplasty and stenting using the new paclitaxel…
- Trial name
- PESETA (NCT02033135)
- Testing
- Angioplasty with Zilver PTX, Best medical treatment, Zilver PTX
- Where
- Denmark
- Volunteers
- 84 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Angina Pectoris
Prevention of Instent Renarrowing With Aggressive Glucose Lowering With Pioglitazone in Diabetic Patients
Patients with diabetes have worse outcomes after percutaneous coronary intervention (PCI) procedures, compared to those patients without diabetes.
- Conditions
- Coronary Artery Disease, Angina Pectoris, Type 2 Diabetes Mellitus, Percutaneous Coronary Intervention
- Trial name
- PPAR-G (NCT00819325)
- Testing
- pioglitazone, oral hypoglycemic agents
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Queen Elizabeth II Health Sciences Centre
Peripheral Arterial Disease
RESveratrol To Improve Outcomes in oldeR pEople With PAD (the RESTORE Trial)
The RESTORE trial will determine whether resveratrol supplementation can improve walking performance in older people with lower extremity peripheral arterial disease (PAD).
- Trial name
- RESTORE (NCT02246660)
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Northwestern University
Cardiovascular Diseases, Heart Diseases
Family Heart Study - Subclinical Atherosclerosis Network (FHS-SCAN)
To determine familial and non-familial causes for susceptibility to atherosclerosis and the inflammatory response.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Coronary Arteriosclerosis
- Trial name
- NCT00024596
- Volunteers
- 3,389 people
- Sponsor
- Washington University School of Medicine
Atherosclerosis
Vitamin D and Zinc Levels in Patients Undergoing Ergometry Test
Low vitamin D levels were found to be associated with cardiovascular morbidity and mortality. Low zinc levels are associated with an increased atherosclerotic burden.
- Trial name
- NCT01080274
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Peripheral Arterial Disease
Gut Microbiota in Patients With Peripheral Arterial Disease and Chronic Limb-threatening Ischemia
Microbiota has been associated with risk factors for cardiovascular diseases (hypertension, obesity, dyslipidemia, diabetes mellitus, heart failure).
- Trial name
- NCT05757297
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Atherosclerosis
Diet and Omega-3 Intervention Trial on Atherosclerosis
The study was actuated to evaluate the effects of a 3-year intervention with diet and/or very long chain omega-3 (VLC n-3 PUFA), in a randomized 2x2 factorial design on the progression of atherosclerosis in a high risk…
- Trial name
- DOIT (NCT00764010)
- Testing
- No dietary counseling and omega-3 capsules, Omega-3 capsules and dietary counseling
- Where
- Norway
- Volunteers
- 563 people
- Sponsor
- Ullevaal University Hospital
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