Clinical trials: Atheromatosis
Critical Limb Ischemia
Study to Explore the Effect of Lowering Blood Viscosity in Patients With Treatment-resistant Critical Limb Ischemia
PAD is caused by an increased flow resistance in atherosclerotic ischemic limbs. The investigators hypothesize that reducing blood viscosity (through controlled phlebotomy), thereby increasing the deformability of red blood…
- Trial name
- CLI-PH (NCT01758874)
- Testing
- phlebotomy
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul Veterans Hospital
Atherosclerotic Cardiovascular Disease
Impact of Optimal Pharmacotherapy on Lipid Profile and Qualitative Features of Atherosclerotic Plaques
Lipid accumulation, with mostly emphasized role of low-density lipoprotein cholesterol (LDL-C), is the pathogenetic cornerstone of atherosclerotic cardiovascular disease.
- Trial name
- NCT05639218
- Testing
- Inclisiran
- Where
- Latvia
- Volunteers
- 50 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Atherosclerosis of Artery, Metabolic Syndrome
Carotid Atherosclerotic Plaque Load and Neck Circumference
The aim of this study is to establish a deep learning model to automatically detect the presence and scoring of carotid plaques in neck CTA images, and to determine whether this model is compatible with manual interpretations.
- Conditions
- Atherosclerosis of Artery, Metabolic Syndrome, Machine Learning
- Trial name
- NCT05040958
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Cardiovascular Diseases, COPD
The Cartagena Cohort Study
Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not…
- Conditions
- Cardiovascular Diseases, COPD, Lung Function Decreased, Atherosclerosis
- Trial name
- CaReS (NCT05339048)
- Testing
- Genetic risk variants, Diet, Physical activity
- Where
- Colombia
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- Universidad de Cartagena
Peripheral Arterial Disease
Trial of Pantheris System, an Atherectomy Device That Provides Imaging While Removing Plaque in Lower Extremity Arteries
To evaluate the safety and effectiveness of the Pantheris System to perform atherectomy while using directional visualization and imaging as an adjunct to fluoroscopy to aid removal of plaque from diseased lower extremity…
- Trial name
- COMBINE-II (NCT02126540)
- Testing
- Pantheris Atherectomy System
- Where
- New Zealand
- Sponsor
- Avinger, Inc.
Critical Limb Ischemia, Drug Effect
Comparison of Sirolimus vs Paclitaxel Drug Eluting Balloon for Below-the-knee Angioplasty in Critical Limb Ischemia
The objective of this study is to compare the remote patency of paclitaxel versus sirolimus eluting balloons in patients with CLI undergoing tibial artery revascularization.
- Trial name
- DebateBTKDuell (NCT04594889)
- Testing
- angioplasty
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Ospedale San Donato
Cardiovascular Diseases, Atherosclerosis
Inflammatory Genomics in Human Carotid Artery Disease
To investigate the relationship between genetic variation in genes for inflammation and carotid artery atherosclerosis.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Carotid Artery Diseases, Inflammation
- Trial name
- NCT00070668
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Artery Disease
Tack Optimized Balloon Angioplasty Study of the Tack Endovascular System™ in Femoropoliteal Arteries
This is a prospective, multi-center, single-arm, non-blinded study designed to investigate the safety and efficacy of the Tack Endovascular System in subjects with post-balloon angioplasty (post-PTA) dissection(s) type(s) A…
- Trial name
- TOBA II (NCT02522884)
- Testing
- Tack Endovascular System
- Where
- 39 sites in United States, Austria and 1 more
- Volunteers
- 213 people
- Sponsor
- Philips Clinical & Medical Affairs Global
Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA
Effectiveness and Tolerability of a Treat-to-Target Versus Fixed-Dose Statin Strategy in Patients With Atherosclerotic Cardiovascular Disease: A Randomized Controlled Trial
To compare the efficacy of fixed-dose versus treat-to-target statin regimens in achieving the predefined LDL-C target at 12 weeks in patients with established ASCVD.
- Conditions
- Dyslipidemia, Hypercholesterolemia, Hypertriglyceridemia, Stroke (CVA) or TIA, Cardio Vascular Disease
- Trial name
- NCT07909915
- Testing
- Dose adjustment of statins, no dose adjustment
- Where
- Pakistan
- Volunteers
- 178 people
- Sponsor
- Rehman Medical Institute - RMI
Atherosclerosis, Angioplasty
Resistance to Antithrombotic Therapy
Clopidogrel plays a pivotal role in the antithrombotic regimen after percutaneous intervention with stent implantation. However, response to clopidogrel shows a wide interindividual variability and a high on-treatment residual…
- Trial name
- Vienna REACT (NCT00858715)
- Testing
- aspirin, clopidogrel
- Where
- Austria
- Volunteers
- 46 people
- Sponsor
- Medical University of Vienna
Peripheral Artery Disease
Drug Eluting Balloon (DEB) and Long Lesions of Superficial Femoral Artery (SFA) Ischemic Vascular Disease
The primary purpose of this study is to assess safety and efficacy of the Drug Eluting Balloon (DEB) technology for the treatment of the Superficial Femoral Artery (SFA) ischemic obstructive vascular disease in patients…
- Trial name
- DEB-SFA-LONG (NCT01658540)
- Where
- 6 sites in Italy
- Volunteers
- 105 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Peripheral Arterial Disease(PAD), Aneurysmal Disease
Transverse Versus Longitudinal Groin Incision in Vascular Surgery
The purpose of the study is to examine whether incision type has an influence on the development of groin wound complications after operation in the groin in vascular surgery.
- Trial name
- NCT06631378
- Testing
- Transverse groin incision, Longitudinal incision
- Where
- Denmark
- Volunteers
- 232 people
- Sponsor
- Kolding Sygehus
Essential Hypertension, Atherosclerotic Cardiovascular Disease
Olmesartan Medoxomil in Atherosclerosis
This is a study in hypertensive patients with atherosclerosis and increased cardiovascular risk. The efficacy of olmesartan medoxomil on atherosclerosis is measured.
- Trial name
- NCT00185185
- Testing
- Olmesartan medoxomil, Atenolol, Hydrochlorothiazide
- Where
- Germany
- Volunteers
- 165 people
- Sponsor
- Sankyo Pharma Gmbh
Peripheral Arterial Disease
Artificial Intelligence for Early Detection of Peripheral Artery Disease
The goal of this clinical trial is to test an AI-based screening tool that will help to identify patients at high risk of having undiagnosed peripheral artery disease.
- Trial name
- (AID-PAD) (NCT06505317)
- Testing
- AI-based PAD screening intervention
- Volunteers
- 7,800 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Heart Disease
Contribution of Hepatic and Intestinal Lipoproteins to Human Atherosclerosis
This study will use excess tissue from endoscopic or surgical procedures to examine the elements of plaque that are found in the carotid walls of patients who have a type of heart and blood vessel disease called atherosclerosis.
- Trial name
- Carotid (NCT01321476)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Piedmont Healthcare
Peripheral Artery Disease
Framing Clinical Trial Enrollment for Patients With Peripheral Artery Disease
It is uncertain whether opt-out framing will increase participation in a clinical trial intended to promote physical activity in patients with peripheral artery disease (PAD).
- Trial name
- NCT04536038
- Testing
- Opt-out
- Where
- United States
- Volunteers
- 5,176 people
- Sponsor
- University of Pennsylvania
Healthy Subjects, Dyslipidaemias
Study To Evaluate The Effects Of GW856553 On Endothelial Function/Vascular Compliance In Subjects With Dyslipidaemia.
The rationale for this study is to determine whether GW856553 (7.5mg BD for 28 days) has an effect on endothelial function in dyslipidaemic subjects as assessed by venous occlusion plethysmography using brachial artery…
- Conditions
- Healthy Subjects, Dyslipidaemias, Dyslipidaemia
- Trial name
- NCT00474864
- Testing
- GW856553
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Limb Threatening Ischaemia
Duplex UltraSound afTer Endo Revascularisation - Feasibility Randomised Control Trial (DUSTER)
17, 000 people every year in the UK develop foot pain or wounds from blocked leg arteries. If left untreated, this can lead to amputation.
- Trial name
- DUSTER (NCT06702306)
- Testing
- Ultrasound Surveillance
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Peripheral Arterial Disease, Popliteal Artery Stenosis
Vessel Deformations and Restenosis After Stenting of the Popliteal Artery
The femoro-popliteal (FP) artery is the most frequently treated vascular segment in patients with symptomatic peripheral artery disease (PAD), for which endovascular therapy became an established treatment option during the last…
- Trial name
- FIRESTEP (NCT04700371)
- Testing
- Interwoven stent, Laser-cut stent
- Sponsor
- Kantonsspital Aarau
Cardiovascular Diseases, Diabetes Mellitus, Non-insulin Dependent
Dyslipidemia and Risk of Cardiovascular Disease in Diabetic Men and Women
To determine the role of dyslipidemia, markers of endothelial dysfunction genetic susceptibility, and dietary fat intake on the development of cardiovascular disease (CVD) complications in Type II diabetes mellitus.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Non-insulin Dependent, Heart Diseases, Atherosclerosis
- Trial name
- NCT00037258
- Sponsor
- Brigham and Women's Hospital
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