Clinical trials: Atherosclerosis, Cerebral
Atherosclerosis, Cardiovascular Diseases
Epidemiology of Vascular Inflammation & Atherosclerosis
To investigate the relationship of vascular cell phenotypes to atherosclerosis.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis
- Trial name
- NCT00087893
- Volunteers
- 931 people
- Sponsor
- University of Vermont
Cardiovascular Diseases, Heart Diseases
Early Atherosclerosis Change in Two Clinical Trials
To complete end point analysis for the Monitored Atherosclerosis Regression Study (MARS) and to compare coronary versus carotid treatment effect relationships in MARS to coronary versus carotid treatment effect relationships in…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases, Coronary Disease
- Trial name
- NCT00005696
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Vascular Diseases, Peripheral Arterial Disease
Post-market, Prospective Evaluation of PHOTO-oxidized Bovine Pericardium in Vascular Surgery
The objective of this post-market clinical follow-up study is to evaluate the clinical outcomes of patients receiving PhotoFix as a patch within a vascular repair or reconstruction procedure.
- Conditions
- Vascular Diseases, Peripheral Arterial Disease, Hemodialysis Access Failure (Disorder), Carotid Artery Diseases
- Trial name
- PHOTO-V (NCT03669042)
- Testing
- PhotoFix
- Where
- 9 sites in United States
- Volunteers
- 94 people
- Sponsor
- Artivion Inc.
Carotid Artery Stenosis Asymptomatic, Carotid Atherosclerosis
Carotid Plaque RADS vs CPVH: Diagnostic Accuracy Comparison
This study compares two methods for assessing carotid artery plaques - deposits of cholesterol and other substances that can build up in the neck arteries and potentially lead to stroke.
- Trial name
- CPVH-P-RADS (NCT07870512)
- Testing
- Carotid Ultrasound with CPVH and Carotid Plaque RADS Assessment
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Limited Liability Company "European Institute of Family Health"
Ischemic Stroke, Atrial Fibrillation
Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients-(AFCAS)
The main aim of the study is to investigate the prevalence and characteristics of ischemic stroke patients with atrial fibrillation and concurrent carotid atherosclerosis.
- Conditions
- Ischemic Stroke, Atrial Fibrillation, Carotid Stenosis
- Trial name
- AFCAS (NCT04821700)
- Testing
- Carotid Stenosis
- Where
- Greece
- Volunteers
- 3,000 people
- Sponsor
- University of Thessaly
Cardiovascular Diseases, Heart Diseases
Pawtucket Heart Health Program
To conduct a community-based research and demonstration project in cardiovascular disease prevention in the town of Pawtucket, Rhode Island.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypercholesterolemia, Hypertension
- Trial name
- NCT00005151
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Intracranial Atherosclerosis, Stroke, Ischemic
Role of GLP1 RA Dulaglutide on Severe Intracranial Atherosclerosis
One important mechanism of action of GLP1 RA is the improvement in endothelial function, which may be evaluated by the assessment of cerebral vasodilatory reserve (CVR) in patients with severe ICAD.
- Trial name
- RADIANT (NCT07282041)
- Testing
- Dulaglutide
- Where
- Singapore
- Volunteers
- 130 people
- Sponsor
- National University of Singapore
Stroke, Ischemic
Effect of Remote Ischemic Preconditioning on Collaterals of Atherosclerosis Stroke
The goal of this clinical trial is to explore the influence of chronic RIC on collateral status evaluated by DSA in ischemic stroke patients with LAA etiology.
- Trial name
- RICAS (NCT06170944)
- Testing
- Remote ischemic preconditioning
- Where
- China
- Volunteers
- 300 people
- Sponsor
- General Hospital of Shenyang Military Region
Cardiovascular Diseases, Heart Diseases
Strong Heart Study
To determine morbidity and mortality from cardiovascular disease among American Indians and to compare cardiovascular disease risk factor levels among Indian groups living in different geographic areas.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Asthma
- Trial name
- NCT00005134
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Left Ventricular Diastolic Dysfunction
Assessment of the Possible Association Between Left Ventricular Diastolic Dysfunction and Carotid Atherosclerosis and Brain White Matter Damage
Left ventricular diastolic dysfunction is caused by impaired relaxation and increased left ventricular stiffness with a consequent increase in filling pressures.
- Trial name
- NCT04549298
- Testing
- No interventions
- Volunteers
- 88 people
- Sponsor
- Neuromed IRCCS
Artery Disease, Peripheral, Aortic Diseases
Relationship Between Morbimortality and Basal Activated Clotting Time (ACT) in Patients Undergoing Vascular Surgery
Check whether patients with higher comorbidity and risk of complication, estimated using the V (p) -POSSUM score, ACS NSQIP and the ASA classification, present higher baseline activated clotting time values.
- Conditions
- Artery Disease, Peripheral, Aortic Diseases, Carotid Artery Diseases, Other Disease
- Trial name
- NCT04703582
- Testing
- Activated clotting time
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Peripheral Arterial Disease, Atherosclerosis of Extremities
Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk
The Low dose ColchicinE in pAtients with peripheral Artery DiseasE to address residual vascular Risk (LEADER-PAD) trial will evaluate if anti-inflammatory therapy with colchicine will reduce vascular events in patients with…
- Conditions
- Peripheral Arterial Disease, Atherosclerosis of Extremities, Inflammation
- Trial name
- LEADER-PAD (NCT04774159)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- 86 sites in United States, Australia and 8 more
- Volunteers
- 6,150 people
- Sponsor
- Population Health Research Institute
Cardiovascular Diseases, Heart Diseases
Diabetes, Lipoproteins and Accelerated Vascular Disease
To better understand the excess cardiovascular disease associated with diabetes mellitus.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Atherosclerosis
- Trial name
- NCT00005479
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Columbia University
Atherosclerosis
A Trial of the Safety and Efficacy of K-604 for the Treatment of Atherosclerosis
The purpose of this study is to evaluate the safety and efficacy of K-604 for the treatment of atherosclerosis.
- Trial name
- NCT00851500
- Testing
- K-604
- Where
- 19 sites in United States
- Volunteers
- 210 people
- Sponsor
- Kowa Research Institute, Inc.
Carotid Atherosclerosis
Microflow3D - Non-invasive Mapping of Coronary Arteries and the Cerebral Vascular Network Using 3D Ultrasound Localization Microscopy in Patients With Atherosclerosis Prior to Carotid Endarterectomy Surgery
There is a need to simplify the assessment of coronary and cerebral vascular networks in patients selected for carotid endarterectomy in order to prevent potential complications during and after surgery.
- Trial name
- Microflow3D (NCT07193225)
- Testing
- Ultrasound localization microscopy, circle of Willis, Ultrasound localization microscopy, coronary arteries
- Where
- France
- Volunteers
- 37 people
- Sponsor
- French Cardiology Society
Carotid Artery Occlusion
Effectiveness of Surgical and Diagnostic Methods in Cerebral Vascular Occlusive Disease
This study attempts to improve surgical treatment outcomes among people with chronic carotid artery occlusive disease by conducting a comprehensive review of neuroradiological, clinical, and cognitive data.
- Trial name
- NCT07396025
- Testing
- Revascularization/Conservative management
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- National Centre for Neurosurgery, Republic of Kazakhstan
Atherosclerosis, Stroke
Evaluation of Vascular Structure in Elderly Using High-frequency Ultrasound and Construction of a Multimodal Risk Assessment System for Cardiovascular Diseases: a Multicenter Study
Coronary heart disease(CHD), stroke, and hypertension are major diseases that seriously affect human health.Pathologic changes in the arteries involved in the above diseases mainly occur in the intimal or medial layer of the…
- Conditions
- Atherosclerosis, Stroke, Coronary Disease
- Trial name
- NCT06221618
- Testing
- High-frequency carotid arteries ultrasound, CCTA, Cranial MRA
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Cardiovascular Disease, Hypertension
Stop Atherosclerosis in Native Diabetics Study
Compared to standard treatment goals achieving lower targets for LDL cholesterol (bad cholesterol) and blood pressure in people with diabetes will slow the progression of atherosclerosis as measured by carotid artery thickness…
- Conditions
- Cardiovascular Disease, Hypertension, Hyperlipidemia, Diabetes
- Trial name
- SANDS (NCT00147251)
- Testing
- FDA approved drugs to treat blood pressure and cholesterol
- Where
- 4 sites in United States
- Volunteers
- 548 people, healthy volunteers welcome
- Sponsor
- Cynthia West
Intracranial Atherosclerosis
Remote Ischemic Conditioning for Avoiding Recurrence of Symptomatic Intracranial Atherosclerotic Stenosis (sICAS)
The primary objective of the study will be to determine whether remote limb ischemic conditioning (RLIC) compared with sham RLIC (placebo) treatment reduces the 12-month risk of recurrent IS in patients with a recent TIA or IS…
- Trial name
- NCT02534545
- Testing
- Doctormate® (200mmHg), Doctormate® (60mmHg)
- Where
- 50 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Ji Xunming,MD,PhD
Vertebrobasilar Ischemia
Remote Ischemic Conditioning for Reducing Stroke Risk of Symptomatic Vertebrobasilar Lesion of Atherosclerosis
The purpose of this study is to investigate whether remote ischemic conditioning(RIC) would reduce the stroke risk of patients with symptomatic vertebrobasilar lesion of atherosclerosis,then we would observe the haemodynamics and…
- Trial name
- NCT02971462
- Testing
- ischemic conditioning
- Volunteers
- 80 people
- Sponsor
- Ji Xunming