Clinical trials: Atherosclerosis, Cerebral
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Dyslipidemia, Coronary Heart Disease
Comparative Efficacy Evaluation of Lipids When Treated With Niaspan & Statin or Other Lipid-Modifying Therapies-COMPELL
The purpose of this study is to evaluate the effectiveness of first-line treatment using Niaspan (an extended release version of niacin) and statins versus other drugs that lower lipid levels, in subjects with elevated fat levels…
- Conditions
- Dyslipidemia, Coronary Heart Disease, Atherosclerosis, Stroke
- Trial name
- NCT00079638
- Testing
- Niacin, Atorvastatin, Simvastatin
- Volunteers
- 300 people
- Sponsor
- Kos Pharmaceuticals
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS)
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death.
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Trial name
- SurvSCA (NCT07112547)
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Intracranial Atherosclerosis
Vessel Wall and Perfusion Imaging in Intracranial Atherosclerosis
Intracranial atherosclerotic disease (ICAD) is an important cause of ischemic stroke. The occurrence of stroke caused by symptomatic ICAD is significantly different compared with asymptomatic ICAD (19% vs 3.5%), suggesting that…
- Trial name
- NCT02719652
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xiuhai Guo
Intracranial Atherosclerosis
Pilot Study of Pre-Ischemic Conditioning for Intracranial Atherosclerosis
The purpose of this study is to determine the effects of the Doctormate device, a specialized blood pressure cuff used to perform remote limb ischemic conditioning, on cerebral blood flow in subjects with intracranial…
- Trial name
- PICASSO (NCT03208166)
- Testing
- Doctormate, Usual Care
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Medical University of South Carolina
Type 2 Diabetes Mellitus, Carotid Atherosclerosis
Effect of Cilostazol on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes
To investigate the effect of cilostazol compared with aspirin on carotid atherosclerosis in patients with type 2 diabetes mellitus
- Trial name
- NCT03248401
- Testing
- Cilostazol, Aspirin
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Bundang Hospital
TIA, Ischemic Stroke
Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy
The study aims to observe the short term effect (3-month) of sleep disordered breathing (SDB) on cardiovascular parameters, heart rate variability, endothelial function and surrogate markers of atherosclerosis after acute…
- Trial name
- SAS-CARE (NCT01097967)
- Testing
- CPAP
- Where
- 5 sites in Germany, Italy and 1 more
- Volunteers
- 246 people
- Sponsor
- Prof. Claudio Bassetti
Arteriosclerosis, Atherosclerosis
Early Detection of Arteriosclerosis
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or…
- Conditions
- Arteriosclerosis, Atherosclerosis, Myocardial Infarction, Stroke
- Trial name
- NCT00863967
- Volunteers
- 269 people
- Sponsor
- Kantonsspital Baselland Bruderholz
Hypertension
A Trial of Telmisartan Prevention of Cardiovascular Disease
The present research is conducted as a randomized, parallel-group, controlled, open study (using the PROBE method) to primarily verify the effects on various biomarkers in high-risk hypertensive patients treated with ARB…
- Trial name
- ATTEMPT-CVD (NCT01075698)
- Testing
- Non-ARB (standard therapy), ARB (Telmisartan)
- Where
- Japan
- Volunteers
- 1,228 people
- Sponsor
- Kumamoto University
Intracranial Atherosclerosis, Stent Stenosis
Elucidate Outcomes of Elective High-grade/Total Occlusion Intracranial Arteries Using Low-profile Self-expanding Stent
Intracranial atherosclerotic disease (ICAD) is a high prevalent cause of stroke, especially in Asian population and can be categorized as either symptomatic (resulting in acute ischemic stroke) or asymptomatic.
- Conditions
- Intracranial Atherosclerosis, Stent Stenosis, Ischemic Stroke
- Trial name
- NCT05947994
- Testing
- Intracranial stenting with Credo® stent
- Where
- Vietnam
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Can Tho Stroke International Services Hospital
Stroke, Ischemic, Genetic Disease
CUHK Stroke Biobank
The purpose of the study are: 1. To make quality, characterized samples and related data available for future studies, including Genome Wide Association Studies (GWAS), genomics, and biomarker research; 2.
- Conditions
- Stroke, Ischemic, Genetic Disease, Atherosclerosis, Cerebral
- Trial name
- NCT03291392
- Testing
- Gene expression or biomarkers exploration
- Where
- Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Acute Ischemic Stroke AIS, Intracranial Atherosclerosis ICAS
Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )
A prospective, multicenter, cohort study to explore the stroke mechanisms of symptomatic intracranial atherosclerosis, the dynamic changes under aggressive medical treatment and their associations with clinical events using…
- Trial name
- SIPS-ICAS (NCT03719820)
- Testing
- aggressive medical management
- Where
- 38 sites in China
- Volunteers
- 550 people
- Sponsor
- Wei-Hai Xu
Cardiovascular Diseases, Heart Diseases
Niacin Plus Statin to Prevent Vascular Events
The purpose of this study is to determine whether raising "good cholesterol" with a drug based on the vitamin niacin, while lowering "bad cholesterol" with a statin drug, can prevent more heart disease than the statin alone.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Cerebrovascular Accident, Coronary Disease
- Trial name
- NCT00120289
- Testing
- Extended release niacin, Simvastatin
- Where
- 91 sites in United States, Canada
- Volunteers
- 3,414 people
- Sponsor
- Axio Research. LLC
TIA, Carotid Artery Plaque
The Effect of Low-dose Interleukin-2 on the Immune Landscape of Human Atherosclerotic Plaques at Single Cell Resolution.
The goal of this clinical trail is to compare the differences in carotid plaque Treg cells' gene signature for activation, proliferation, and suppressive function using scRNA-seq in patients treated with IL-2 compared to control.
- Conditions
- TIA, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- ELLIPSE (NCT05975554)
- Testing
- Interleukin-2 [IL-2], Standard care - Carotid Endarterectomy
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Carotid Stenosis, Carotid Artery Diseases
Carotid Stenosis Management During COVID-19 Era - Pilot Study
Carotid endarterectomy (CEA) and carotid stenting (CAS) are often performed for subgroups of patients for whom procedural benefit has not been established in randomised trials and despite evidence of serious procedural risk.
- Conditions
- Carotid Stenosis, Carotid Artery Diseases, Carotid Atherosclerosis, Carotid Embolus
- Trial name
- CASCOM-Pilot (NCT04947046)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital
Atherosclerosis, Cardiovascular Diseases
Multi-Ethnic Study of Atherosclerosis (MESA)
The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the characteristics of subclinical cardiovascular disease and the risk factors that predict progression to clinically overt cardiovascular disease or progression of…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease
- Trial name
- NCT00005487
- Volunteers
- 6,418 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Ischemic Stroke, Peripheral Artery Disease
Diabetic Artery Obstruction: is it Possible to Reduce Ischemic Events With Cilostazol?
Investigation of the clinical efficacy and safety of dual antiplatelet therapy with clopidogrel and cilostazol versus clopidogrel alone in preventing ischemic vascular events in patients with type 2 diabetes and symptomatic…
- Conditions
- Ischemic Stroke, Peripheral Artery Disease, Diabetes Mellitus, Type 2
- Trial name
- DORIC (NCT02983214)
- Testing
- Clopidogrel, Cilostazol
- Where
- Greece
- Volunteers
- 826 people
- Sponsor
- University of Ioannina
Atherosclerosis, LDL-hypercholesterolemia
Effect of Mipomersen on LDL-Cholesterol Levels in Patients Treated by Regular Apheresis
Elevated LDL-cholesterol is a major risk factor for heart disease. In patients with heart disease LDL-cholesterol should be lowered to levels below 70 mg/dl to prevent progression of disease.
- Trial name
- MICA (NCT01598948)
- Testing
- mipomersen
- Where
- Germany
- Volunteers
- 17 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Stroke
Blood Proteome Profiling Identifies Biomarkers in Ischemic Stroke
Endovascular thrombectomy and intravenous thrombolysis have become key therapeutic approaches for acute ischemic stroke. However, due to time window limitations, many patients are unable to receive reperfusion therapy, and the…
- Trial name
- NCT06729385
- Testing
- The blood Proteome Profiling
- Where
- 4 sites in China
- Volunteers
- 80 people
- Sponsor
- Capital Medical University
Atherosclerosis of Artery, Carotid Endarterectomy
Associations of Carotid Plaque Characteristics With Brain Perfusion and Cognitive Function in Patients Undergoing CEA
Stroke is one of the leading causes of death and disability-adjusted life-years worldwide. Carotid high-risk atherosclerotic plaques are considered to be one of the major sources of ischemic stroke.
- Trial name
- NCT04955015
- Testing
- carotid endarterectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking University Third Hospital