Clinical trials: Atherosclerosis Cardiovascular Disease
Healthy Subjects, Dyslipidaemias
Study To Evaluate The Effects Of GW856553 On Endothelial Function/Vascular Compliance In Subjects With Dyslipidaemia.
The rationale for this study is to determine whether GW856553 (7.5mg BD for 28 days) has an effect on endothelial function in dyslipidaemic subjects as assessed by venous occlusion plethysmography using brachial artery…
- Conditions
- Healthy Subjects, Dyslipidaemias, Dyslipidaemia
- Trial name
- NCT00474864
- Testing
- GW856553
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Peripheral Arterial Disease
Personalised Antiplatelet Therapy for Patients With Symptomatic Peripheral Arterial Disease
Peripheral arterial disease (PAD) is a condition where the blood vessels in the legs get blocked. It affects one out of every five adults over the age of 65.
- Trial name
- NCT06047002
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Leicester
Atherosclerosis, Coronary Artery Disease
COroNary CT Angiography Evaluation For Clinical Outcomes: An InteRnational Multicenter Registry (CONFIRM)
The CONFIRM study was developed to examine the prognostic value of cardiac computed tomographic angiography (CCTA) findings for prediction of future adverse cardiac events related to coronary artery disease (CAD) in a large…
- Conditions
- Atherosclerosis, Coronary Artery Disease, Cardiovascular Disease
- Trial name
- CONFIRM (NCT01443637)
- Where
- 20 sites in United States, Austria and 5 more
- Volunteers
- 34,000 people
- Sponsor
- Weill Medical College of Cornell University
Peripheral Artery Disease
AcoArt Ⅱ/ BTK China: Drug-eluting Balloon for Below-The-Knee Angioplasty Evaluation in China
The purpose of this study is to determine whether DEB is more effective than common PTA balloon using under in long-term vessel patency and inhibiting restenosis in the infrapopliteal artery.
- Trial name
- NCT02137577
- Testing
- DEB catheter, common PTA balloon catheter
- Where
- 11 sites in China
- Volunteers
- 120 people
- Sponsor
- Acotec Scientific Co., Ltd
Peripheral Arterial Disease
Treadmill Exercise and GM-CSF Study to Improving Functioning in Peripheral Artery Disease (PAD)
The PROPEL study will test the hypothesis that GM-CSF combined with supervised treadmill exercise will significantly improve functional performance in patients with PAD more than GM-CSF alone or supervised treadmill exercise…
- Trial name
- PROPEL (NCT01408901)
- Testing
- Supervised Treadmill Exercise Therapy, Health education sessions (Control), granulocyte macrophage colony stimulating factor (GM-CSF)
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Peripheral Arterial Disease, Aging
SMART Exercise for PAD
Supervised exercise therapy (SET), consisting of treadmill exercise conducted three times weekly at a center while supervised by healthcare personnel, is first line therapy for people disabled by lower extremity peripheral artery…
- Conditions
- Peripheral Arterial Disease, Aging, Peripheral Vascular Diseases, Walking, Difficulty
- Trial name
- NCT06032065
- Testing
- Supervised Treadmill Exercise, Home-Based Exercise, Nitrate-rich beetroot Juice
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Atherosclerosis, Inflammation
Specifying the Anti-inflammatory Effects of Ziltivekimab
The goal of this randomized, double blind, placebo controlled trial is to study whether ziltivekimab therapy reduces arterial wall inflammation as assessed by imaging, and reduces the systemic inflammatory tone as assessed by…
- Trial name
- SPIDER (NCT06263244)
- Testing
- Ziltivekimab
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Peripheral Arterial Disease
Digital Support for Supervised Exercise Therapy in Peripheral Arterial Disease
The individual restrictions of daily life for patients with PAD are more important than statistical facts for mortality and morbidity.
- Trial name
- TrackPAD (NCT04947228)
- Testing
- trackPAD
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Essen
Atherosclerotic Cardiovascular Disease
A Research Study Looking at How NNC0385-0434 Tablets Work to Lower Blood Cholesterol in People With Heart Disease or a High Risk of Heart Disease
This study looks at how well a new medicine, NNC0385-0434, works to lower blood cholesterol levels. Participants will either get NNC0385-0434 as a tablet (a potential new medicine), or placebo as a tablet (a dummy medicine that…
- Trial name
- NCT04992065
- Testing
- NNC0385-0434 A 15 mg, NNC0385-0434 A 40 mg, NNC0385-0434 A 100 mg
- Where
- 44 sites in United States, Belgium and 5 more
- Volunteers
- 267 people
- Sponsor
- Novo Nordisk A/S
Cardiovascular Diseases, Coronary Disease
Computed Tomography (CT)--An Epidemiologic Study in the Young
To investigate the relationship between coronary heart disease risk factors and coronary artery calcification in middle age adults from the Muscatine Study.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Atherosclerosis, Heart Diseases
- Trial name
- NCT00005354
- Sponsor
- University of Iowa
Peripheral Arterial Disease
PAD Screening Study
Peripheral arterial disease (PAD) due to atherosclerotic narrowing of arteries of the lower limb is common and associated with increased cardiovascular mortality and morbidity.
- Trial name
- NCT05584072
- Testing
- Active pedal plantarflexion (APP) test
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Peripheral Arterial Disease
Intermediate and Long-term Efficacy of Endovascular Treatment for TASC C&D Aortoiliac Occlusive Disease
This is a prospective, multicenter, real-world, registry study, which aims to observe the intermediate and long-term efficacy of different endovascular treatments for TASC C\&D aortoiliac occlusive disease.
- Trial name
- ALLIANCE (NCT04966767)
- Volunteers
- 800 people
- Sponsor
- Shanghai Zhongshan Hospital
Peripheral Arterial Disease
Efficacity Study With the Protégé EverFlex Stent in Popliteal Lesions
This study will assess the results up to 12 months with the Protégé EverFlex stent (ev3) in patients presenting with a narrowing or blocking at the level of the knee artery, which leads to a limited walking distance, rest pain or…
- Trial name
- DUR-POP (NCT01412450)
- Testing
- nitinol stent
- Where
- 4 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Flanders Medical Research Program
Critical Limb Ischemia
UT-15C SR in the Treatment of Critical Limb Ischemia
This study will evaluate UT-15C sustained release tablets in subjects experiencing ischemic lower limb rest pain related to advanced peripheral arterial disease.
- Trial name
- NCT00445159
- Testing
- UT-15C SR (treprostinil diethanolamine) 1mg oral tablets
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Southern Arizona Vascular Institute
Carotid Atherosclerosis, Stroke
Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque
The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor…
- Conditions
- Carotid Atherosclerosis, Stroke, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT00636766
- Testing
- atorvastatin, rimonabant, rosiglitazone
- Where
- Greece
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Cardiovascular Diseases, Coronary Disease
Genetics of Atherosclerosis in Mexican Americans
To identify individual genes that contribute to variation in susceptibility to coronary heart disease (CHD) in Mexican Americans.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Obesity, Atherosclerosis
- Trial name
- NCT00005462
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Artery Disease
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Pentoxifylline Versus Cilostazol
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- NCT05635370
- Testing
- Pentoxifylline, Cilostazol
- Where
- United States
- Volunteers
- 10,398 people
- Sponsor
- Brigham and Women's Hospital
Peripheral Arterial Disease
Investigating a Model for Acute Ischemic Pain in Humans
The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies.
- Trial name
- NCT02192242
- Testing
- acute ischemic pain
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Coronary Disease, Cardiovascular Diseases
Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS])
Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect…
- Trial name
- CHAS (NCT00626379)
- Where
- United States
- Volunteers
- 1,395 people
- Sponsor
- Northwestern University
Cryptogenic Stroke
Cardiac Abnormalities in Stroke Prevention and Risk of Recurrence
This is a multi-center retrospective analysis of consecutive adult patients with cryptogenic stroke patients following a comprehensive workup for the underlying stroke etiology.
- Trial name
- CASPR (NCT06398366)
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Cooper Norcross Health
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